JP2011519893A - 生物活性薬の封入 - Google Patents

生物活性薬の封入 Download PDF

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Publication number
JP2011519893A
JP2011519893A JP2011507898A JP2011507898A JP2011519893A JP 2011519893 A JP2011519893 A JP 2011519893A JP 2011507898 A JP2011507898 A JP 2011507898A JP 2011507898 A JP2011507898 A JP 2011507898A JP 2011519893 A JP2011519893 A JP 2011519893A
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JP
Japan
Prior art keywords
particulate carrier
bioactive agent
antibody
nanoparticles
protein
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Pending
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JP2011507898A
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English (en)
Japanese (ja)
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JP2011519893A5 (https=
Inventor
フィダンボイルー，メフメット
パパニコロウ，イレーネ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
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Glaxo Group Ltd
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Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of JP2011519893A publication Critical patent/JP2011519893A/ja
Publication of JP2011519893A5 publication Critical patent/JP2011519893A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2011507898A 2008-05-06 2009-05-05 生物活性薬の封入 Pending JP2011519893A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5077508P 2008-05-06 2008-05-06
US61/050,775 2008-05-06
US7417108P 2008-06-20 2008-06-20
US61/074,171 2008-06-20
PCT/EP2009/055437 WO2009135854A2 (en) 2008-05-06 2009-05-05 Encapsulation of biologically active agents

Publications (2)

Publication Number Publication Date
JP2011519893A true JP2011519893A (ja) 2011-07-14
JP2011519893A5 JP2011519893A5 (https=) 2012-02-09

Family

ID=43125568

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011507898A Pending JP2011519893A (ja) 2008-05-06 2009-05-05 生物活性薬の封入

Country Status (11)

Country Link
US (1) US20110059167A1 (https=)
EP (1) EP2271324A2 (https=)
JP (1) JP2011519893A (https=)
CN (1) CN102083423A (https=)
AU (1) AU2009245785A1 (https=)
BR (1) BRPI0912536A2 (https=)
EA (1) EA201001567A1 (https=)
IL (1) IL208666A0 (https=)
MX (1) MX2010012141A (https=)
WO (1) WO2009135854A2 (https=)
ZA (1) ZA201007437B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011520802A (ja) * 2008-05-06 2011-07-21 グラクソ グループ リミテッド 生物活性薬の封入
JP2019534897A (ja) * 2016-10-12 2019-12-05 キュリックス インコーポレイテッドＣｕｒｉｒｘ Ｉｎｃ． 治療薬の腸内送達のための製剤

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9802984B2 (en) 2013-06-07 2017-10-31 The Johns Hopkins University Biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis- and lymphangiogenesis-dependent diseases
EP3377115A2 (en) * 2015-11-20 2018-09-26 AbbVie Deutschland GmbH & Co. KG Surface-modified nanospheres encapsulating antigen-binding molecules

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09502191A (ja) * 1993-09-09 1997-03-04 シエーリング アクチエンゲゼルシヤフト 作用物質およびガスを含有する微粒子
JP2002514215A (ja) * 1997-04-17 2002-05-14 アムジエン・インコーポレーテツド 治療薬の徐放送達のための生分解性微粒子

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3462193A (en) * 1993-02-15 1994-08-29 Shield Research Limited Polyalkylcyanoacrylate nanocapsules
US20030152636A1 (en) * 2000-02-23 2003-08-14 Nanopharm Ag Method of treating cancer
US7332159B2 (en) * 2004-09-30 2008-02-19 Board Of Regents Of The University Of Nebraska Method and composition for inhibiting reperfusion injury in the brain
US7597907B2 (en) * 2004-11-05 2009-10-06 Trustees Of The University Of Pennsylvania Antioxidant polymer nanocarriers for use in preventing oxidative injury

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09502191A (ja) * 1993-09-09 1997-03-04 シエーリング アクチエンゲゼルシヤフト 作用物質およびガスを含有する微粒子
JP2002514215A (ja) * 1997-04-17 2002-05-14 アムジエン・インコーポレーテツド 治療薬の徐放送達のための生分解性微粒子

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6013038928; ＶＡＵＴＨＩＥＲ，Ｃ．　ｅｔ　ａｌ: 'Ｄｅｓｉｇｎ　ａｓｐｅｃｔｓ　ｏｆ　ｐｏｌｙ（ａｌｋｙｌｃｙａｎｏａｃｒｙｌａｔｅ）　ｎａｎｏｐａｒｔｉｃｌｅｓ　ｆｏｒ' Ｊｏｕｒｎａｌ　ｏｆ　ｄｒｕｇ　ｔａｒｇｅｔｉｎｇ Ｖｏｌ．１５，　Ｎｏ．１０, 2007, ｐ．６４１-６３ *
JPN6013038930; ＬＩ，Ｙ．Ｐ．　ｅｔ　ａｌ: 'ＰＥＧｙｌａｔｅｄ　ｐｏｌｙｃｙａｎｏａｃｒｙｌａｔｅ　ｎａｎｏｐａｒｔｉｃｌｅｓ　ａｓ　ｔｕｍｏｒ　ｎｅｃｒｏｓｉｓ　ｆａｃｔｏｒ-ａｌｐｈａ　ｃａｒｒｉｅｒｓ' Ｊｏｕｒｎａｌ　ｏｆ　ｃｏｎｔｒｏｌｌｅｄ　ｒｅｌｅａｓｅ　：　ｏｆｆｉｃｉａｌ　ｊｏｕｒｎａｌ　ｏｆ　ｔｈｅ　Ｃｏｎｔｒｏｌｌｅｄ　Ｒｅｌｅａｓｅ　Ｓｏｃｉｅｔｙ Ｖｏｌ．７１，　Ｎｏ．３, 2001, ｐ．２８７-２９６ *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011520802A (ja) * 2008-05-06 2011-07-21 グラクソ グループ リミテッド 生物活性薬の封入
JP2019534897A (ja) * 2016-10-12 2019-12-05 キュリックス インコーポレイテッドＣｕｒｉｒｘ Ｉｎｃ． 治療薬の腸内送達のための製剤
JP7046081B2 (ja) 2016-10-12 2022-04-01 キュリックス インコーポレイテッド 治療薬の腸内送達のための製剤
US12594246B2 (en) 2016-10-12 2026-04-07 Curioralrx, Llc Formulations for enteric delivery of therapeutic agents

Also Published As

Publication number Publication date
EP2271324A2 (en) 2011-01-12
WO2009135854A2 (en) 2009-11-12
MX2010012141A (es) 2010-12-17
WO2009135854A3 (en) 2010-11-04
US20110059167A1 (en) 2011-03-10
BRPI0912536A2 (pt) 2018-10-16
IL208666A0 (en) 2010-12-30
AU2009245785A1 (en) 2009-11-12
EA201001567A1 (ru) 2011-08-30
CN102083423A (zh) 2011-06-01
ZA201007437B (en) 2012-03-28

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