JP2011519571A5 - - Google Patents
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- Publication number
- JP2011519571A5 JP2011519571A5 JP2011507904A JP2011507904A JP2011519571A5 JP 2011519571 A5 JP2011519571 A5 JP 2011519571A5 JP 2011507904 A JP2011507904 A JP 2011507904A JP 2011507904 A JP2011507904 A JP 2011507904A JP 2011519571 A5 JP2011519571 A5 JP 2011519571A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- cdr
- antibody
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 22
- 102000036639 antigens Human genes 0.000 claims 22
- 108091007433 antigens Proteins 0.000 claims 22
- 239000012634 fragment Substances 0.000 claims 22
- 230000035772 mutation Effects 0.000 claims 9
- 102000006992 Interferon-alpha Human genes 0.000 claims 5
- 108010047761 Interferon-alpha Proteins 0.000 claims 5
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 101100215147 Caenorhabditis elegans aco-1 gene Proteins 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 102220258333 rs138075372 Human genes 0.000 claims 2
- 102200094071 rs72466451 Human genes 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical group COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 101100378191 Caenorhabditis elegans aco-2 gene Proteins 0.000 claims 1
- 102220518434 Enhancer of filamentation 1_T28S_mutation Human genes 0.000 claims 1
- 102220491279 Peripheral myelin protein 22_S76I_mutation Human genes 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 102220486979 Sodium-dependent phosphate transport protein 1_S76N_mutation Human genes 0.000 claims 1
- 230000001594 aberrant effect Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 102220168074 rs200199102 Human genes 0.000 claims 1
- 102220012182 rs373164247 Human genes 0.000 claims 1
- 102200105384 rs387906979 Human genes 0.000 claims 1
- 102220081234 rs41306397 Human genes 0.000 claims 1
- 102220272280 rs777826765 Human genes 0.000 claims 1
- 102220120649 rs886042622 Human genes 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08103847.3 | 2008-05-07 | ||
| EP08103847 | 2008-05-07 | ||
| PCT/EP2009/055448 WO2009135861A2 (en) | 2008-05-07 | 2009-05-06 | Humanized antibodies against human interferon-alpha |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011519571A JP2011519571A (ja) | 2011-07-14 |
| JP2011519571A5 true JP2011519571A5 (https=) | 2012-06-21 |
| JP5766598B2 JP5766598B2 (ja) | 2015-08-19 |
Family
ID=40901961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507904A Expired - Fee Related JP5766598B2 (ja) | 2008-05-07 | 2009-05-06 | ヒトインターフェロン−αに対するヒト化抗体 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8163885B2 (https=) |
| EP (1) | EP2279207B1 (https=) |
| JP (1) | JP5766598B2 (https=) |
| KR (1) | KR101687032B1 (https=) |
| CN (1) | CN102083859B (https=) |
| AU (1) | AU2009245792B2 (https=) |
| BR (1) | BRPI0912570B8 (https=) |
| CA (1) | CA2722622C (https=) |
| ES (1) | ES2549903T3 (https=) |
| IL (1) | IL208979B (https=) |
| MX (1) | MX2010012052A (https=) |
| RU (1) | RU2532832C2 (https=) |
| TW (1) | TWI453032B (https=) |
| WO (1) | WO2009135861A2 (https=) |
| ZA (1) | ZA201008748B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101155831B (zh) | 2005-02-10 | 2015-08-19 | 贝勒研究院 | 抗干扰素α单克隆抗体及其使用方法 |
| BR112013030242A2 (pt) * | 2011-05-25 | 2016-12-06 | Medimmune Llc | método de tratamento de um distúrbio autoimune em um sujeito humano |
| WO2013034160A1 (en) * | 2011-09-06 | 2013-03-14 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. | Methods for analyzing biological macromolecular complexes and use thereof |
| KR20150128849A (ko) | 2013-03-15 | 2015-11-18 | 얀센 바이오테크 인코포레이티드 | 인터페론 알파 및 오메가 항체 길항제 |
| JP6742237B2 (ja) * | 2013-07-03 | 2020-08-19 | イムノキュア アーゲーＩｍｍｕｎｏｑｕｒｅ Ａｇ | ヒト抗ｉｆｎ−アルファ抗体 |
| TWI713453B (zh) | 2014-06-23 | 2020-12-21 | 美商健生生物科技公司 | 干擾素α及ω抗體拮抗劑 |
| US10689703B2 (en) * | 2015-04-27 | 2020-06-23 | National Jewish Health | Methods of identifying and treating subjects having acute respiratory distress syndrome |
| CN108204958A (zh) * | 2016-12-19 | 2018-06-26 | 伊缪泰普有限公司 | 结合测定 |
| JP2022527542A (ja) | 2019-04-04 | 2022-06-02 | ヤンセン バイオテツク，インコーポレーテツド | 抗ＩＦＮ－α／ω抗体の投与方法 |
| BR112022003163A2 (pt) * | 2019-08-19 | 2022-05-17 | Pandion Operations Inc | Imunotolerância alvejada com um agonista de pd-1 |
| RU2737466C1 (ru) * | 2019-12-30 | 2020-11-30 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Гуманизированное нейтрализующее антитело к интерферону-бета человека |
| CN112500476B (zh) * | 2020-12-16 | 2024-02-23 | 南京基蛋生物医药有限公司 | 一种扩增鼠单抗重轻链基因序列的方法及其引物和筛选该引物的方法 |
| CN116355079B (zh) * | 2022-08-19 | 2023-12-26 | 上海迈科康生物科技有限公司 | 检测重组人轮状病毒vp8抗原（vp8 p[8]）的单克隆抗体及其应用 |
| WO2025247924A1 (en) * | 2024-05-28 | 2025-12-04 | Institut National de la Santé et de la Recherche Médicale | ANTI-IFN-α2 MONOCLONAL ANTIBODIES |
| WO2025247918A1 (en) * | 2024-05-28 | 2025-12-04 | Institut National de la Santé et de la Recherche Médicale | ANTI-IFN-α2 MONOCLONAL ANTIBODIES |
| WO2025247917A1 (en) * | 2024-05-28 | 2025-12-04 | Institut National de la Santé et de la Recherche Médicale | ANTI-IFN-α2 AND ANTI-IFN-ω1 MONOCLONAL ANTIBODIES |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4423147A (en) | 1980-04-11 | 1983-12-27 | Secher David S | Monoclonal antibody to interferon-α |
| US4824432A (en) | 1981-03-24 | 1989-04-25 | S.V.S. Laboratories, Inc. | Method for treating AIDS and other immune deficiencies and immune disorders |
| US4605394A (en) | 1982-12-03 | 1986-08-12 | Simon V. Skurkovich | Methods for the treatment of pathological conditions by removing interferon from the organism |
| US4362155A (en) | 1981-03-24 | 1982-12-07 | Skurkovich Simon V | Method and apparatus for the treatment of autoimmune and allergic diseases |
| DE3211263A1 (de) | 1981-03-31 | 1983-01-27 | Otsuka Pharmaceutical Co. Ltd., Tokyo | Human-interferon verwandte peptide, antigene und antikoerper, sowie verfahren zu deren herstellung |
| EP0139676B1 (en) | 1983-02-04 | 1992-11-25 | Cytoclonal Pharmaceutics Inc. | Production and characterization of hybridoma antibodies directed specifically against common determinant(s) present among closely related, but distinct proteins |
| GB2148299B (en) | 1983-09-01 | 1988-01-06 | Hybritech Inc | Antibody compositions of therapeutic agents having an extended serum half-life |
| FR2560212B1 (fr) | 1984-02-24 | 1989-12-29 | Unicet | Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps |
| ES2133285T3 (es) | 1991-04-17 | 1999-09-16 | Medisup Int Nv | Polipeptidos hidrosolubles que tienen una alta afinidad para los interferones alfa y beta. |
| DK0601052T3 (da) | 1991-08-30 | 1996-11-18 | Genentech Inc | Terapeutisk fremgangsmåde til behandling af IDDM |
| EP0563487A1 (en) | 1992-03-31 | 1993-10-06 | Laboratoire Europeen De Biotechnologie S.A. | Monoclonal antibodies against the interferon receptor, with neutralizing activity against type I interferon |
| US5821078A (en) | 1992-09-03 | 1998-10-13 | Yeda Research And Development Co. Ltd. | Nucleic acid encoding interferon-α/β binding protein |
| US5888511A (en) | 1993-02-26 | 1999-03-30 | Advanced Biotherapy Concepts, Inc. | Treatment of autoimmune diseases, including AIDS |
| US5780027A (en) | 1995-07-14 | 1998-07-14 | Meiogen Biotechnology Corporation | Methods of treatment of down syndrome by interferon antagonists |
| IL118096A0 (en) | 1996-05-01 | 1996-09-12 | Yeda Res & Dev | Antibodies against interferon alpha/beta receptor |
| US6713609B1 (en) | 1996-07-16 | 2004-03-30 | Genentech, Inc. | Monoclonal antibodies to type I interferon receptor |
| WO1998006431A2 (en) | 1996-08-16 | 1998-02-19 | Osther Kurt B | Method for treating diabetes |
| US5902321A (en) | 1997-07-25 | 1999-05-11 | Innovasive Devices, Inc. | Device and method for delivering a connector for surgically joining and securing flexible tissue repair members |
| US20030018174A1 (en) | 1997-10-06 | 2003-01-23 | Genentech, Inc. | Monoclonal antibodies to IFNAR2 |
| AU2342900A (en) | 1998-09-23 | 2000-05-01 | Cleveland Clinic Foundation, The | Novel interferon stimulated and repressed genes |
| AUPP670698A0 (en) | 1998-10-23 | 1998-11-19 | Monash University | A method of regulation |
| KR20000034847A (ko) | 1998-11-17 | 2000-06-26 | 성재갑 | 인간 4-1비비 분자에 대한 인간화 항체 및 이를 포함하는 약학조성물 |
| CN1454215B (zh) | 1999-11-15 | 2013-01-02 | 米勒腾尼生物技术有限公司 | 树突状细胞特异的抗原结合片段、组合物及其使用方法、被其识别的抗原及由其获得的细胞 |
| GB0001710D0 (en) | 2000-01-25 | 2000-03-15 | Pharma Pacific Pty Ltd | Therapeutic treatment |
| GB0001712D0 (en) | 2000-01-25 | 2000-03-15 | Pharma Pacific Pty Ltd | Therapeutic peptides |
| US6846486B1 (en) | 2000-02-24 | 2005-01-25 | Advanced Biotherapy Concepts, Inc. | Method of treating allergy by administering an anti-histamine antibody |
| GB0013810D0 (en) * | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
| US6660523B2 (en) | 2000-09-21 | 2003-12-09 | Schering Corporation | Dendritic cells; methods |
| EP1351707B9 (en) | 2001-01-09 | 2012-01-25 | Baylor Research Institute | Methods for treating autoimmune diseases in a subject and in vitro diagnostic assays |
| DE20100503U1 (de) | 2001-01-12 | 2001-05-10 | Josef Schiele oHG, 56651 Niederzissen | Beschichtungsvorrichtung für ein langgestrecktes Werkstück |
| US7087726B2 (en) | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
| FR2822845B1 (fr) | 2001-03-30 | 2003-12-12 | Genodyssee | Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques |
| WO2003068801A2 (en) * | 2002-02-11 | 2003-08-21 | Genentech, Inc. | Antibody variants with faster antigen association rates |
| NZ535425A (en) | 2002-03-13 | 2008-05-30 | Biogen Idec Inc | Anti-alphavbeta6 antibodies |
| US7538195B2 (en) | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| US7438907B2 (en) | 2002-11-15 | 2008-10-21 | Genmab A/S | Human monoclonal antibodies against CD25 |
| KR101225299B1 (ko) | 2003-12-10 | 2013-01-24 | 메다렉스, 인코포레이티드 | 인터페론 알파 항체 및 그의 용도 |
| SV2007002227A (es) * | 2004-09-10 | 2007-03-20 | Wyeth Corp | Anticuerpos anti-5t4 humanizados y conjugados anticuerpo anti-5t4/calicheamicina ref. 040000-0317637 |
| CN101056654A (zh) | 2004-10-07 | 2007-10-17 | 苏黎士大学 | 用于预防和治疗银屑病的i型干扰素阻断剂 |
| US7888481B2 (en) | 2005-02-10 | 2011-02-15 | Baylor Research Institute | Anti-interferon alpha monoclonal antibodies and methods for use |
| CN101155831B (zh) * | 2005-02-10 | 2015-08-19 | 贝勒研究院 | 抗干扰素α单克隆抗体及其使用方法 |
| JP5230022B2 (ja) * | 2006-08-09 | 2013-07-10 | ベイラー リサーチ インスティテュート | 抗インターフェロンアルファモノクローナル抗体及び使用方法 |
-
2009
- 2009-05-06 CN CN200980116496.6A patent/CN102083859B/zh not_active Expired - Fee Related
- 2009-05-06 MX MX2010012052A patent/MX2010012052A/es active IP Right Grant
- 2009-05-06 RU RU2010150105/10A patent/RU2532832C2/ru active
- 2009-05-06 CA CA2722622A patent/CA2722622C/en active Active
- 2009-05-06 ES ES09742079.8T patent/ES2549903T3/es active Active
- 2009-05-06 WO PCT/EP2009/055448 patent/WO2009135861A2/en not_active Ceased
- 2009-05-06 BR BRPI0912570A patent/BRPI0912570B8/pt not_active IP Right Cessation
- 2009-05-06 US US12/597,357 patent/US8163885B2/en not_active Expired - Fee Related
- 2009-05-06 EP EP09742079.8A patent/EP2279207B1/en not_active Not-in-force
- 2009-05-06 JP JP2011507904A patent/JP5766598B2/ja not_active Expired - Fee Related
- 2009-05-06 KR KR1020107027445A patent/KR101687032B1/ko not_active Expired - Fee Related
- 2009-05-06 AU AU2009245792A patent/AU2009245792B2/en not_active Ceased
- 2009-05-07 TW TW098115102A patent/TWI453032B/zh not_active IP Right Cessation
-
2010
- 2010-10-28 IL IL208979A patent/IL208979B/en active IP Right Grant
- 2010-12-06 ZA ZA2010/08748A patent/ZA201008748B/en unknown
-
2012
- 2012-02-01 US US13/363,609 patent/US8361463B2/en not_active Expired - Fee Related
- 2012-12-19 US US13/719,536 patent/US8658771B2/en not_active Expired - Fee Related
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