JP2011518838A5 - - Google Patents

Info

Publication number

JP2011518838A5

JP2011518838A5 JP2011506465A JP2011506465A JP2011518838A5 JP 2011518838 A5 JP2011518838 A5 JP 2011518838A5 JP 2011506465 A JP2011506465 A JP 2011506465A JP 2011506465 A JP2011506465 A JP 2011506465A JP 2011518838 A5 JP2011518838 A5 JP 2011518838A5

Authority

JP

Japan

Prior art keywords

chitosan

fluid layer

pharmaceutical composition

oxidized polysaccharide

tissue

Prior art date

2009-04-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 229920001661 Chitosan Polymers 0.000 claims 14
• 239000012530 fluid Substances 0.000 claims 8
• 150000004676 glycans Chemical class 0.000 claims 6
• 229920001282 polysaccharide Polymers 0.000 claims 6
• 239000005017 polysaccharide Substances 0.000 claims 6
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 210000001519 tissue Anatomy 0.000 claims 4
• 210000003800 pharynx Anatomy 0.000 claims 3
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 2
• 229920002101 Chitin Polymers 0.000 claims 2
• 229920001287 Chondroitin sulfate Polymers 0.000 claims 2
• RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims 2
• 229920002307 Dextran Polymers 0.000 claims 2
• 229920002527 Glycogen Polymers 0.000 claims 2
• 229920002472 Starch Polymers 0.000 claims 2
• 229920002678 cellulose Polymers 0.000 claims 2
• 239000001913 cellulose Substances 0.000 claims 2
• 229940045110 chitosan Drugs 0.000 claims 2
• 229940059329 chondroitin sulfate Drugs 0.000 claims 2
• 229960002086 dextran Drugs 0.000 claims 2
• 229950006191 gluconic acid Drugs 0.000 claims 2
• 229920002674 hyaluronan Polymers 0.000 claims 2
• 229960003160 hyaluronic acid Drugs 0.000 claims 2
• 238000011065 in-situ storage Methods 0.000 claims 2
• FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 230000001681 protective effect Effects 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 239000008107 starch Substances 0.000 claims 2
• 235000019698 starch Nutrition 0.000 claims 2
• 210000003027 ear inner Anatomy 0.000 claims 1
• 210000000959 ear middle Anatomy 0.000 claims 1
• 210000001508 eye Anatomy 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 210000004400 mucous membrane Anatomy 0.000 claims 1
• 210000003928 nasal cavity Anatomy 0.000 claims 1
• 210000001331 nose Anatomy 0.000 claims 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
• 238000005507 spraying Methods 0.000 claims 1