JP2011517312A5

JP2011517312A5 -

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Publication number: JP2011517312A5
Authority: JP; Japan
Prior art keywords: binding affinity; vmat; compounds; carbinol compounds; fluoroalkyltetrabenazine
Prior art date: 2008-12-03
Legal status : Granted

Application number

JP2010537023A

Other languages

English (en)

Japanese (ja)

Other versions

JP5597835B2 (ja

JP2011517312A (ja

Filing date

2008-12-03

Publication date

2014-01-09

2007-12-07 Priority claimed from US11/952,325 external-priority patent/US8013161B1/en

2007-12-07 Priority claimed from US11/952,340 external-priority patent/US7919622B2/en

2008-12-03 Application filed filed Critical

2008-12-03 Priority claimed from PCT/US2008/085304 external-priority patent/WO2009073677A1/en

2011-06-02 Publication of JP2011517312A publication Critical patent/JP2011517312A/ja

2014-01-09 Publication of JP2011517312A5 publication Critical patent/JP2011517312A5/ja

2014-10-01 Application granted granted Critical

2014-10-01 Publication of JP5597835B2 publication Critical patent/JP5597835B2/ja

Status Expired - Fee Related legal-status Critical Current

2028-12-03 Anticipated expiration legal-status Critical

Links

OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical class OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
WEQLWGNDNRARGE-DJIMGWMZSA-N (2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol Chemical compound C1CN2C[C@@H](CC(C)C)[C@H](O)C[C@@H]2C2=C1C=C(OC)C(OC)=C2 WEQLWGNDNRARGE-DJIMGWMZSA-N 0.000 description 2
-1 Fluoroalkyl Tetrabenazine Carbinol Compounds Chemical class 0.000 description 2
230000000052 comparative effect Effects 0.000 description 2
229910052739 hydrogen Inorganic materials 0.000 description 2
239000001257 hydrogen Substances 0.000 description 2
238000005259 measurement Methods 0.000 description 2
229960005333 tetrabenazine Drugs 0.000 description 2
DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 description 1
QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 description 1
238000004166 bioassay Methods 0.000 description 1
239000000090 biomarker Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
229910052731 fluorine Inorganic materials 0.000 description 1
239000011737 fluorine Substances 0.000 description 1
125000003709 fluoroalkyl group Chemical group 0.000 description 1
150000002431 hydrogen Chemical class 0.000 description 1
BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 1
229960003147 reserpine Drugs 0.000 description 1
MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1

JP2010537023A 2007-12-07 2008-12-03 イメージング剤及びプローブとしてのフルオロアルキルテトラベナジンカルビノール化合物 Expired - Fee Related JP5597835B2 (ja)