JP2011505363A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011505363A5 JP2011505363A5 JP2010536109A JP2010536109A JP2011505363A5 JP 2011505363 A5 JP2011505363 A5 JP 2011505363A5 JP 2010536109 A JP2010536109 A JP 2010536109A JP 2010536109 A JP2010536109 A JP 2010536109A JP 2011505363 A5 JP2011505363 A5 JP 2011505363A5
- Authority
- JP
- Japan
- Prior art keywords
- binding affinity
- fluoroalkyl
- vmat
- compounds
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000005259 measurement Methods 0.000 description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/947,275 US7910738B2 (en) | 2007-11-29 | 2007-11-29 | Intermediates for alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes |
| US11/947,215 US7902364B2 (en) | 2007-11-29 | 2007-11-29 | Alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes |
| US12/174,167 US8053578B2 (en) | 2007-11-29 | 2008-07-16 | Alpha-fluoroalkyl dihydrotetrabenazine imaging agents and probes |
| PCT/US2008/084601 WO2009070552A1 (en) | 2007-11-29 | 2008-11-25 | Alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011505363A JP2011505363A (ja) | 2011-02-24 |
| JP2011505363A5 true JP2011505363A5 (enExample) | 2014-01-09 |
Family
ID=40297912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010536109A Ceased JP2011505363A (ja) | 2007-11-29 | 2008-11-25 | α−フルオロアルキルテトラベナジン及びジヒドロテトラベナジンイメージング剤並びにプローブ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8053578B2 (enExample) |
| EP (2) | EP2217599A1 (enExample) |
| JP (1) | JP2011505363A (enExample) |
| CN (1) | CN101878213B (enExample) |
| WO (1) | WO2009070552A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120003330A1 (en) * | 2010-06-01 | 2012-01-05 | Auspex Pharmaceuticals, Inc. | Benzoquinolone inhibitors of vmat2 |
| EP2758041B1 (de) * | 2011-09-20 | 2021-01-13 | Basf Se | Niedermolekulare modulatoren des kälte-menthol-rezeptors trpm8 und deren verwendung |
| US9550780B2 (en) | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| JP6362601B2 (ja) | 2012-09-18 | 2018-07-25 | オースペックス・ファーマシューティカルズ・インコーポレイテッドＡｕｓｐｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 小胞モノアミン輸送体２の重水素化ベンゾキノリン阻害剤の製剤薬物動態 |
| EA202091397A1 (ru) * | 2013-01-31 | 2020-09-04 | Ауспекс Фармацетикалс, Инк. | Бензохинолоновые ингибиторы vmat2 |
| CA2925562A1 (en) * | 2013-09-27 | 2015-04-02 | Auspex Pharmaceuticals, Inc. | Benzoquinolone inhibitors of vmat2 |
| WO2015077521A1 (en) * | 2013-11-22 | 2015-05-28 | Auspex Pharmaceuticals, Inc. | Benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| AU2014357518A1 (en) | 2013-12-03 | 2016-06-09 | Auspex Pharmaceuticals, Inc. | Methods of manufacturing benzoquinoline compounds |
| KR20160111999A (ko) * | 2014-01-27 | 2016-09-27 | 오스펙스 파마슈티칼스, 인코포레이티드 | 소포성 모노아민 수송체 2의 벤조퀴놀린 억제제 |
| PL3265085T3 (pl) | 2015-03-06 | 2022-11-07 | Auspex Pharmaceuticals, Inc. | Sposoby leczenia zaburzeń związanych z nieprawidłowymi ruchami mimowolnymi |
| PE20240822A1 (es) * | 2021-03-22 | 2024-04-18 | Neurocrine Biosciences Inc | Inhibidores de vmat2 y metodos de uso |
| WO2026050236A1 (en) | 2024-08-27 | 2026-03-05 | Neurocrine Biosciences, Inc. | Muscarinic receptor agonist in combination with a vesicular monoamine transporter 2 inhibitor, for use in the treatment of a neurological or psychiatric disorder |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1068261B (de) * | 1959-11-05 | F. Hoffmann-La Roche £v Co. Aktiengesellschaft, Basel (Schweiz) | Verfahren zur Herstellung von substituierten 2-Oxobenzo-chinollizinen | |
| US2843591A (en) * | 1958-07-15 | Method for preparing same | ||
| HU175890B (en) * | 1977-06-15 | 1980-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing new 1,2,3,4,6,7-hexahydro-11-b-alpha-benzo-square bracket-a-square brecket closed-quinolyzine derivatives |
| US5278308A (en) * | 1992-02-28 | 1994-01-11 | The Trustees Of The University Of Pennsylvania | Iodine derivatives of tetrabenazine |
| GB2410947B (en) | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
| CA2623794A1 (en) | 2005-06-29 | 2007-01-11 | The Trustees Of Columbia University In The City Of New York | Use of dtbz for imaging endocrine pancreas and beta cell mass in type 1 diabetes |
| ES2318771T3 (es) | 2005-08-06 | 2009-05-01 | Cambridge Laboratories (Ireland) Limited | 3,11b-cis-dihidrotetrabenazinas para el tratamiento de la esquizofrenia y otras psicosis. |
| ES2525932T3 (es) | 2006-05-02 | 2015-01-02 | The Trustees Of The University Of Pennsylvania | Derivados de dihidrotetrabenazina radiomarcados y su uso como agentes de imagenología |
| US8008500B2 (en) | 2007-06-08 | 2011-08-30 | General Electric Company | Intermediates useful for making tetrabenazine compounds |
| US7902364B2 (en) * | 2007-11-29 | 2011-03-08 | General Electric Company | Alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes |
-
2008
- 2008-07-16 US US12/174,167 patent/US8053578B2/en not_active Expired - Fee Related
- 2008-11-25 CN CN2008801188947A patent/CN101878213B/zh not_active Expired - Fee Related
- 2008-11-25 EP EP08854913A patent/EP2217599A1/en not_active Ceased
- 2008-11-25 WO PCT/US2008/084601 patent/WO2009070552A1/en not_active Ceased
- 2008-11-25 EP EP20130155403 patent/EP2594568A1/en not_active Withdrawn
- 2008-11-25 JP JP2010536109A patent/JP2011505363A/ja not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011517312A5 (enExample) | ||
| Novakova et al. | Transport rankings of non-steroidal antiinflammatory drugs across blood-brain barrier in vitro models | |
| Turner et al. | Cell wall elongation mode in Gram-negative bacteria is determined by peptidoglycan architecture | |
| Tian et al. | A simple and efficient molecularly imprinted electrochemical sensor for the selective determination of tryptophan | |
| JP2013521366A5 (enExample) | ||
| ATE506068T1 (de) | Kohlenstoffnanoröhrchenpulver, kohlenstoffnanoröhrchen und verfahren zu ihrer herstellung | |
| ATE552043T1 (de) | Medien für die membran-ionaustausch- chromatografie | |
| JP2014029453A5 (enExample) | ||
| EA200801285A1 (ru) | Способ производства дихлорпропанола хлорированием глицерина | |
| EA200970580A1 (ru) | Таннат разагилина | |
| BRPI0821453A2 (pt) | Processo para a produção de componentes de combinação da gasolina de baixa volatilidade, alta qualidade | |
| FR2951165B1 (fr) | Procede de preparation d'une composition comprenant un compose a base de vanilline et d'ethylvanilline, composition obtenue et ses applications | |
| WO2009052400A8 (en) | Antibodies that bind to mammalian ngal and uses thereof | |
| FR2932486B1 (fr) | Procede de preparation d'un polyamideimide, polyamideimide et composition comprenant ce polyamideimide. | |
| JP2008290071A5 (enExample) | ||
| Lu et al. | Supramolecular nanocrystalline membranes with well-aligned subnanochannels for enhanced reverse osmosis desalination | |
| Minta et al. | A promising electrochemical platform for dopamine and uric acid detection based on a polyaniline/iron oxide-tin oxide/reduced graphene oxide ternary composite | |
| Ma et al. | Solvent‐induced deformation of aramid nanofibers for ultrahigh‐flux nanofiltration membranes | |
| BRPI0912163A2 (pt) | Composto químico, processo para a produção de um composto, compsição química, e, uso de um composto químico. | |
| Feldner et al. | Conductive molecularly imprinted polymers (cMIPs): rising and versatile key elements in chemical sensing | |
| CA2676907A1 (en) | Tricyclic compounds and their use as glucocorticoid receptor modulators | |
| Chen et al. | Multi-responsive sensor based on porous hydrogen-bonded organic frameworks for selective sensing of ions and dopamine molecules | |
| WO2015051079A3 (en) | Phosphohistidine mimetics and antibodies to same | |
| Gao et al. | Open tubular column immobilized with covalent organic frameworks for rapid separation of small molecular compounds by capillary electrochromatography | |
| Riboni et al. | Supramolecular materials as solid-phase microextraction coatings in environmental analysis |