JP2011505363A5 - - Google Patents

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Publication number
JP2011505363A5
JP2011505363A5 JP2010536109A JP2010536109A JP2011505363A5 JP 2011505363 A5 JP2011505363 A5 JP 2011505363A5 JP 2010536109 A JP2010536109 A JP 2010536109A JP 2010536109 A JP2010536109 A JP 2010536109A JP 2011505363 A5 JP2011505363 A5 JP 2011505363A5
Authority
JP
Japan
Prior art keywords
binding affinity
fluoroalkyl
vmat
compounds
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2010536109A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011505363A (ja
Filing date
Publication date
Priority claimed from US11/947,275 external-priority patent/US7910738B2/en
Priority claimed from US11/947,215 external-priority patent/US7902364B2/en
Priority claimed from US12/174,167 external-priority patent/US8053578B2/en
Application filed filed Critical
Publication of JP2011505363A publication Critical patent/JP2011505363A/ja
Publication of JP2011505363A5 publication Critical patent/JP2011505363A5/ja
Ceased legal-status Critical Current

Links

JP2010536109A 2007-11-29 2008-11-25 α−フルオロアルキルテトラベナジン及びジヒドロテトラベナジンイメージング剤並びにプローブ Ceased JP2011505363A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/947,275 US7910738B2 (en) 2007-11-29 2007-11-29 Intermediates for alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes
US11/947,215 US7902364B2 (en) 2007-11-29 2007-11-29 Alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes
US12/174,167 US8053578B2 (en) 2007-11-29 2008-07-16 Alpha-fluoroalkyl dihydrotetrabenazine imaging agents and probes
PCT/US2008/084601 WO2009070552A1 (en) 2007-11-29 2008-11-25 Alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes

Publications (2)

Publication Number Publication Date
JP2011505363A JP2011505363A (ja) 2011-02-24
JP2011505363A5 true JP2011505363A5 (enExample) 2014-01-09

Family

ID=40297912

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010536109A Ceased JP2011505363A (ja) 2007-11-29 2008-11-25 α−フルオロアルキルテトラベナジン及びジヒドロテトラベナジンイメージング剤並びにプローブ

Country Status (5)

Country Link
US (1) US8053578B2 (enExample)
EP (2) EP2594568A1 (enExample)
JP (1) JP2011505363A (enExample)
CN (1) CN101878213B (enExample)
WO (1) WO2009070552A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011153157A2 (en) * 2010-06-01 2011-12-08 Auspex Pharmaceutical, Inc. Benzoquinolone inhibitors of vmat2
WO2013041621A1 (de) * 2011-09-20 2013-03-28 Basf Se Niedermolekulare modulatoren des kälte-menthol-rezeptors trpm8 und deren verwendung
JP6362601B2 (ja) 2012-09-18 2018-07-25 オースペックス・ファーマシューティカルズ・インコーポレイテッドＡｕｓｐｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 小胞モノアミン輸送体２の重水素化ベンゾキノリン阻害剤の製剤薬物動態
US9550780B2 (en) 2012-09-18 2017-01-24 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
EP2951178A4 (en) * 2013-01-31 2016-07-06 Auspex Pharmaceuticals Inc VMAT2 INHIBITORS OF BENZOQUINOLONE TYPE
WO2015048370A1 (en) * 2013-09-27 2015-04-02 Auspex Pharmaceuticals, Inc. Benzoquinolone inhibitors of vmat2
WO2015077521A1 (en) * 2013-11-22 2015-05-28 Auspex Pharmaceuticals, Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
CA2930744A1 (en) 2013-12-03 2015-06-11 Auspex Pharmaceuticals, Inc. Methods of manufacturing benzoquinoline compounds
MX2016009817A (es) * 2014-01-27 2017-02-28 Auspex Pharmaceuticals Inc Inhibidores de benzoquinolina del transportador vesicular de monoaminas 2.
IL288712B2 (en) 2015-03-06 2024-01-01 Auspex Pharmaceuticals Inc Methods for the treatment of abnormal involuntary movement disorders
HRP20250868T1 (hr) * 2021-03-22 2025-09-26 Neurocrine Biosciences, Inc. Vmat2 inhibitori i postupci za uporabu

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1068261B (de) * 1959-11-05 F. Hoffmann-La Roche £v Co. Aktiengesellschaft, Basel (Schweiz) Verfahren zur Herstellung von substituierten 2-Oxobenzo-chinollizinen
US2843591A (en) 1958-07-15 Method for preparing same
HU175890B (en) 1977-06-15 1980-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 1,2,3,4,6,7-hexahydro-11-b-alpha-benzo-square bracket-a-square brecket closed-quinolyzine derivatives
US5278308A (en) 1992-02-28 1994-01-11 The Trustees Of The University Of Pennsylvania Iodine derivatives of tetrabenazine
GB2410947B (en) * 2004-02-11 2008-09-17 Cambridge Lab Ltd Pharmaceutical compounds
CA2623794A1 (en) 2005-06-29 2007-01-11 The Trustees Of Columbia University In The City Of New York Use of dtbz for imaging endocrine pancreas and beta cell mass in type 1 diabetes
US20110257220A1 (en) 2005-08-06 2011-10-20 Cambridge Laboratories (Ireland) Limited 3,11 b-cis-Dihydrotetrabenazine for the Treatment of Schizophrenia and Other Psychoses
BRPI0711481A8 (pt) 2006-05-02 2017-11-28 Univ Michigan Regents derivados radiomarcados de dihidrotetrabenzeno e seu uso como agente de imagens
US8008500B2 (en) 2007-06-08 2011-08-30 General Electric Company Intermediates useful for making tetrabenazine compounds
US7902364B2 (en) * 2007-11-29 2011-03-08 General Electric Company Alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes

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