ES2451661T3 - Compuestos carbinólicos de tetrabenazina fluoroalquilada como agentes de formación de imágenes y sondas - Google Patents
Compuestos carbinólicos de tetrabenazina fluoroalquilada como agentes de formación de imágenes y sondas Download PDFInfo
- Publication number
- ES2451661T3 ES2451661T3 ES08856745.8T ES08856745T ES2451661T3 ES 2451661 T3 ES2451661 T3 ES 2451661T3 ES 08856745 T ES08856745 T ES 08856745T ES 2451661 T3 ES2451661 T3 ES 2451661T3
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- Prior art keywords
- tetrabenazine
- fluoroalkylated
- compound
- compounds
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- 150000001875 compounds Chemical class 0.000 title claims description 151
- 239000012216 imaging agent Substances 0.000 title description 33
- 239000000523 sample Substances 0.000 title description 6
- -1 fluoroalkyl tetrabenazine carbinol compound Chemical class 0.000 claims abstract description 156
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 8
- 239000000543 intermediate Substances 0.000 description 8
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- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 8
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US952340 | 2007-12-07 | ||
| US11/952,325 US8013161B1 (en) | 2007-12-07 | 2007-12-07 | Fluoroalkyl tetrabenazine carbinol compounds as imaging agents and probes |
| US952325 | 2007-12-07 | ||
| US11/952,340 US7919622B2 (en) | 2007-12-07 | 2007-12-07 | Intermediates for fluorinated tetrabenazine carbinol compounds imaging agents and probes |
| PCT/US2008/085304 WO2009073677A1 (en) | 2007-12-07 | 2008-12-03 | Fluoroalkyl tetrabenazine carbinol compounds as imaging agents and probes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2451661T3 true ES2451661T3 (es) | 2014-03-28 |
Family
ID=40342752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08856745.8T Active ES2451661T3 (es) | 2007-12-07 | 2008-12-03 | Compuestos carbinólicos de tetrabenazina fluoroalquilada como agentes de formación de imágenes y sondas |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2220085B1 (enExample) |
| JP (1) | JP5597835B2 (enExample) |
| CN (1) | CN101889013B (enExample) |
| ES (1) | ES2451661T3 (enExample) |
| WO (1) | WO2009073677A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201705304D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705302D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705303D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705306D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201808464D0 (en) | 2018-05-23 | 2018-07-11 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compounds for use in treating huntington's disease |
| CN114288419B (zh) * | 2021-12-30 | 2023-08-18 | 中山大学附属第八医院（深圳福田） | 一种利福平纳米递药系统的制备及其在防治帕金森病方面的应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2410947B (en) * | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
-
2008
- 2008-12-03 WO PCT/US2008/085304 patent/WO2009073677A1/en not_active Ceased
- 2008-12-03 EP EP08856745.8A patent/EP2220085B1/en not_active Not-in-force
- 2008-12-03 CN CN200880119947.7A patent/CN101889013B/zh not_active Expired - Fee Related
- 2008-12-03 JP JP2010537023A patent/JP5597835B2/ja not_active Expired - Fee Related
- 2008-12-03 ES ES08856745.8T patent/ES2451661T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5597835B2 (ja) | 2014-10-01 |
| WO2009073677A1 (en) | 2009-06-11 |
| JP2011517312A (ja) | 2011-06-02 |
| EP2220085B1 (en) | 2014-02-12 |
| CN101889013A (zh) | 2010-11-17 |
| EP2220085A1 (en) | 2010-08-25 |
| CN101889013B (zh) | 2014-09-03 |
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