CN101889013B - 作为成像剂和探针的氟烷基丁苯那嗪甲醇化合物 - Google Patents
作为成像剂和探针的氟烷基丁苯那嗪甲醇化合物 Download PDFInfo
- Publication number
- CN101889013B CN101889013B CN200880119947.7A CN200880119947A CN101889013B CN 101889013 B CN101889013 B CN 101889013B CN 200880119947 A CN200880119947 A CN 200880119947A CN 101889013 B CN101889013 B CN 101889013B
- Authority
- CN
- China
- Prior art keywords
- hydrogen
- compound
- group
- enantiomer
- fluoroalkyl tetrabenazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *[C@@](C*(CC*1cc(I)*2*)[C@](C3)c1c2N)[C@@]3(O)I Chemical compound *[C@@](C*(CC*1cc(I)*2*)[C@](C3)c1c2N)[C@@]3(O)I 0.000 description 4
- VOQYWEUJKYJXCS-NRFANRHFSA-N CC(C)OC(C([C@H](c(c(CC1)c2)cc(OC)c2OC)N1C(OC(C)(C)C)=O)C(OC(C)C)=O)=O Chemical compound CC(C)OC(C([C@H](c(c(CC1)c2)cc(OC)c2OC)N1C(OC(C)(C)C)=O)C(OC(C)C)=O)=O VOQYWEUJKYJXCS-NRFANRHFSA-N 0.000 description 1
- WQUJQZQCJQWSRB-MRXNPFEDSA-N CC(C)OC(C[C@H](c(c(CC1)c2)cc(OC)c2OC)N1C(OC(C)(C)C)=O)=O Chemical compound CC(C)OC(C[C@H](c(c(CC1)c2)cc(OC)c2OC)N1C(OC(C)(C)C)=O)=O WQUJQZQCJQWSRB-MRXNPFEDSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/952,325 | 2007-12-07 | ||
| US11/952,340 US7919622B2 (en) | 2007-12-07 | 2007-12-07 | Intermediates for fluorinated tetrabenazine carbinol compounds imaging agents and probes |
| US11/952,325 US8013161B1 (en) | 2007-12-07 | 2007-12-07 | Fluoroalkyl tetrabenazine carbinol compounds as imaging agents and probes |
| US11/952340 | 2007-12-07 | ||
| US11/952,340 | 2007-12-07 | ||
| US11/952325 | 2007-12-07 | ||
| PCT/US2008/085304 WO2009073677A1 (en) | 2007-12-07 | 2008-12-03 | Fluoroalkyl tetrabenazine carbinol compounds as imaging agents and probes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101889013A CN101889013A (zh) | 2010-11-17 |
| CN101889013B true CN101889013B (zh) | 2014-09-03 |
Family
ID=40342752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880119947.7A Expired - Fee Related CN101889013B (zh) | 2007-12-07 | 2008-12-03 | 作为成像剂和探针的氟烷基丁苯那嗪甲醇化合物 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2220085B1 (enExample) |
| JP (1) | JP5597835B2 (enExample) |
| CN (1) | CN101889013B (enExample) |
| ES (1) | ES2451661T3 (enExample) |
| WO (1) | WO2009073677A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201705303D0 (en) * | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705305D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705302D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705304D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705306D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201808464D0 (en) | 2018-05-23 | 2018-07-11 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compounds for use in treating huntington's disease |
| CN114288419B (zh) * | 2021-12-30 | 2023-08-18 | 中山大学附属第八医院（深圳福田） | 一种利福平纳米递药系统的制备及其在防治帕金森病方面的应用 |
| WO2026050236A1 (en) | 2024-08-27 | 2026-03-05 | Neurocrine Biosciences, Inc. | Muscarinic receptor agonist in combination with a vesicular monoamine transporter 2 inhibitor, for use in the treatment of a neurological or psychiatric disorder |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005077946A1 (en) * | 2004-02-11 | 2005-08-25 | Cambridge Laboratories (Ireland) Limited | Dihydrotetrabenazines and pharmaceutical compositions containing them |
-
2008
- 2008-12-03 WO PCT/US2008/085304 patent/WO2009073677A1/en not_active Ceased
- 2008-12-03 CN CN200880119947.7A patent/CN101889013B/zh not_active Expired - Fee Related
- 2008-12-03 ES ES08856745.8T patent/ES2451661T3/es active Active
- 2008-12-03 EP EP08856745.8A patent/EP2220085B1/en not_active Not-in-force
- 2008-12-03 JP JP2010537023A patent/JP5597835B2/ja not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005077946A1 (en) * | 2004-02-11 | 2005-08-25 | Cambridge Laboratories (Ireland) Limited | Dihydrotetrabenazines and pharmaceutical compositions containing them |
Non-Patent Citations (3)
| Title |
|---|
| Fang Zheng,et al..Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2.《Bioorganic & Medicinal Chemistry》.2007,第15卷2975–2992. * |
| Michael R. Kilbourn,et al..Pharmacokinetics of [18F]fluoroalkyl derivatives of dihydrotetrabenazine in rat and monkey brain.《Nuclear Medicine and Biology》.2007,第34卷(第3期),233–237. * |
| Rajesh Goswami,et al..Fluoroalkyl derivatives of dihydrotetrabenazine as positron emission tomography imaging agents targeting vesicular monoamine transporters.《Nuclear Medicine and Biology》.2006,第33卷685–694. * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011517312A (ja) | 2011-06-02 |
| ES2451661T3 (es) | 2014-03-28 |
| EP2220085B1 (en) | 2014-02-12 |
| WO2009073677A1 (en) | 2009-06-11 |
| CN101889013A (zh) | 2010-11-17 |
| JP5597835B2 (ja) | 2014-10-01 |
| EP2220085A1 (en) | 2010-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140903 Termination date: 20151203 |
|
| EXPY | Termination of patent right or utility model |