JP5597835B2 - イメージング剤及びプローブとしてのフルオロアルキルテトラベナジンカルビノール化合物 - Google Patents

イメージング剤及びプローブとしてのフルオロアルキルテトラベナジンカルビノール化合物 Download PDF

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Publication number
JP5597835B2
JP5597835B2 JP2010537023A JP2010537023A JP5597835B2 JP 5597835 B2 JP5597835 B2 JP 5597835B2 JP 2010537023 A JP2010537023 A JP 2010537023A JP 2010537023 A JP2010537023 A JP 2010537023A JP 5597835 B2 JP5597835 B2 JP 5597835B2
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JP
Japan
Prior art keywords
group
fluoroalkyltetrabenazine
compound
carbinol
imaging agent
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2010537023A
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English (en)
Japanese (ja)
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JP2011517312A (ja
JP2011517312A5 (enExample
Inventor
アマラシンゲ，カンデ・カンカナナマラゲ・ダヤラスナ
リシェル，マイケル・ジェームズ
ディン，ショーン・リチャード
ジョンソン，ブルース・フレッチャー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Electric Co
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/952,340 external-priority patent/US7919622B2/en
Priority claimed from US11/952,325 external-priority patent/US8013161B1/en
Application filed by General Electric Co filed Critical General Electric Co
Publication of JP2011517312A publication Critical patent/JP2011517312A/ja
Publication of JP2011517312A5 publication Critical patent/JP2011517312A5/ja
Application granted granted Critical
Publication of JP5597835B2 publication Critical patent/JP5597835B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2010537023A 2007-12-07 2008-12-03 イメージング剤及びプローブとしてのフルオロアルキルテトラベナジンカルビノール化合物 Expired - Fee Related JP5597835B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11/952,325 2007-12-07
US11/952,340 US7919622B2 (en) 2007-12-07 2007-12-07 Intermediates for fluorinated tetrabenazine carbinol compounds imaging agents and probes
US11/952,325 US8013161B1 (en) 2007-12-07 2007-12-07 Fluoroalkyl tetrabenazine carbinol compounds as imaging agents and probes
US11/952,340 2007-12-07
PCT/US2008/085304 WO2009073677A1 (en) 2007-12-07 2008-12-03 Fluoroalkyl tetrabenazine carbinol compounds as imaging agents and probes

Publications (3)

Publication Number Publication Date
JP2011517312A JP2011517312A (ja) 2011-06-02
JP2011517312A5 JP2011517312A5 (enExample) 2014-01-09
JP5597835B2 true JP5597835B2 (ja) 2014-10-01

Family

ID=40342752

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010537023A Expired - Fee Related JP5597835B2 (ja) 2007-12-07 2008-12-03 イメージング剤及びプローブとしてのフルオロアルキルテトラベナジンカルビノール化合物

Country Status (5)

Country Link
EP (1) EP2220085B1 (enExample)
JP (1) JP5597835B2 (enExample)
CN (1) CN101889013B (enExample)
ES (1) ES2451661T3 (enExample)
WO (1) WO2009073677A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201705303D0 (en) * 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705305D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705302D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705304D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705306D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201808464D0 (en) 2018-05-23 2018-07-11 Adeptio Pharmaceuticals Ltd Pharmaceutical compounds for use in treating huntington's disease
CN114288419B (zh) * 2021-12-30 2023-08-18 中山大学附属第八医院（深圳福田） 一种利福平纳米递药系统的制备及其在防治帕金森病方面的应用
WO2026050236A1 (en) 2024-08-27 2026-03-05 Neurocrine Biosciences, Inc. Muscarinic receptor agonist in combination with a vesicular monoamine transporter 2 inhibitor, for use in the treatment of a neurological or psychiatric disorder

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2410947B (en) * 2004-02-11 2008-09-17 Cambridge Lab Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
CN101889013B (zh) 2014-09-03
JP2011517312A (ja) 2011-06-02
ES2451661T3 (es) 2014-03-28
EP2220085B1 (en) 2014-02-12
WO2009073677A1 (en) 2009-06-11
CN101889013A (zh) 2010-11-17
EP2220085A1 (en) 2010-08-25

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