JP2011515495A

JP2011515495A - オピエートアゴニスト及びアゴニスト−アンタゴニストの乱用抑制経皮製剤

オピエートアゴニスト及びアゴニスト−アンタゴニストの乱用抑制経皮製剤 Download PDF

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Publication number: JP2011515495A
Authority: JP; Japan
Prior art keywords: opioid; antagonist; prodrug; opioid agonist; abuse
Prior art date: 2008-03-26
Legal status : Pending

Application number

JP2011502067A

Other languages

English (en)

Japanese (ja)

Other versions

JP2011515495A5 (enExample

Inventor

リンスティンチコーム，オウドラ

リーバンクス，スタン

Original Assignee

オールトランツインコーポレイティド

Priority date

2008-03-26

Filing date

2009-03-26

Publication date

2011-05-19

2009-03-26 Application filed by オールトランツインコーポレイティド filed Critical オールトランツインコーポレイティド

2011-05-19 Publication of JP2011515495A publication Critical patent/JP2011515495A/ja

2012-05-24 Publication of JP2011515495A5 publication Critical patent/JP2011515495A5/ja

Status Pending legal-status Critical Current

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239000005557 antagonist Substances 0.000 title claims description 106
239000003402 opiate agonist Substances 0.000 title claims description 87
238000002360 preparation method Methods 0.000 title 1
239000000203 mixture Substances 0.000 claims abstract description 152
239000000651 prodrug Substances 0.000 claims abstract description 130
229940002612 prodrug Drugs 0.000 claims abstract description 130
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229960003086 naltrexone Drugs 0.000 claims abstract description 111
RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims abstract description 102
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238000000034 method Methods 0.000 claims abstract description 37
229940005483 opioid analgesics Drugs 0.000 claims abstract description 10
239000003401 opiate antagonist Substances 0.000 claims description 74
239000003814 drug Substances 0.000 claims description 46
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WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 claims description 7
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UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 claims description 7
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 7
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