JP2011515494A5 - - Google Patents
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- Publication number
- JP2011515494A5 JP2011515494A5 JP2011502063A JP2011502063A JP2011515494A5 JP 2011515494 A5 JP2011515494 A5 JP 2011515494A5 JP 2011502063 A JP2011502063 A JP 2011502063A JP 2011502063 A JP2011502063 A JP 2011502063A JP 2011515494 A5 JP2011515494 A5 JP 2011515494A5
- Authority
- JP
- Japan
- Prior art keywords
- topical ophthalmic
- ophthalmic composition
- eyelid
- composition according
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000744 eyelid Anatomy 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 32
- 230000000699 topical effect Effects 0.000 claims description 20
- 229920000642 polymer Polymers 0.000 claims description 16
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 12
- 208000010217 blepharitis Diseases 0.000 claims description 10
- 230000003232 mucoadhesive effect Effects 0.000 claims description 9
- 239000004098 Tetracycline Substances 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 238000009472 formulation Methods 0.000 claims description 8
- 210000004561 lacrimal apparatus Anatomy 0.000 claims description 8
- 229960002180 tetracycline Drugs 0.000 claims description 8
- 229930101283 tetracycline Natural products 0.000 claims description 8
- 235000019364 tetracycline Nutrition 0.000 claims description 8
- 150000003522 tetracyclines Chemical class 0.000 claims description 8
- 230000003115 biocidal effect Effects 0.000 claims description 7
- 229960005475 antiinfective agent Drugs 0.000 claims description 6
- 239000004599 antimicrobial Substances 0.000 claims description 6
- 210000004534 cecum Anatomy 0.000 claims description 6
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 5
- 229920002307 Dextran Polymers 0.000 claims description 4
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 150000004676 glycans Chemical class 0.000 claims description 4
- 210000004175 meibomian gland Anatomy 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 229920001282 polysaccharide Polymers 0.000 claims description 4
- 239000005017 polysaccharide Substances 0.000 claims description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 239000000375 suspending agent Substances 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims description 2
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims description 2
- 206010020843 Hyperthermia Diseases 0.000 claims description 2
- 229920000148 Polycarbophil calcium Polymers 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 claims description 2
- 235000015872 dietary supplement Nutrition 0.000 claims description 2
- 229960003722 doxycycline Drugs 0.000 claims description 2
- 230000036031 hyperthermia Effects 0.000 claims description 2
- 229960004023 minocycline Drugs 0.000 claims description 2
- 229950005134 polycarbophil Drugs 0.000 claims description 2
- 210000003717 douglas' pouch Anatomy 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 229920002148 Gellan gum Polymers 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 18
- 230000028327 secretion Effects 0.000 description 4
- 241001608562 Chalazion Species 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 201000005547 chronic conjunctivitis Diseases 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 206010023332 keratitis Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7085008P | 2008-03-26 | 2008-03-26 | |
| US61/070,850 | 2008-03-26 | ||
| PCT/US2009/038428 WO2009120881A1 (en) | 2008-03-26 | 2009-03-26 | Methods for improving lid margin and tear film function and treatment of lid margin desease using tetracycline family antibiotics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011515494A JP2011515494A (ja) | 2011-05-19 |
| JP2011515494A5 true JP2011515494A5 (cg-RX-API-DMAC7.html) | 2013-04-18 |
Family
ID=40750879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011502063A Pending JP2011515494A (ja) | 2008-03-26 | 2009-03-26 | テトラサイクリンファミリー抗生物質を用いる、眼瞼縁および涙液膜機能の改善ならびに眼瞼縁疾患の処置のための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110059925A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2285346A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2011515494A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009228205A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2719453A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009120881A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070016256A1 (en) | 2005-07-18 | 2007-01-18 | Korb Donald R | Method and apparatus for treating gland dysfunction |
| US20070060988A1 (en) | 2005-07-18 | 2007-03-15 | Grenon Stephen M | Melting meibomian gland obstructions |
| US7981095B2 (en) * | 2005-07-18 | 2011-07-19 | Tearscience, Inc. | Methods for treating meibomian gland dysfunction employing fluid jet |
| US7981146B2 (en) | 2006-05-15 | 2011-07-19 | Tearscience Inc. | Inner eyelid treatment for treating meibomian gland dysfunction |
| WO2013003594A2 (en) | 2011-06-28 | 2013-01-03 | Tearscience, Inc. | Methods and systems for treating meibomian gland dysfunction using radio-frequency energy |
| US20080114423A1 (en) | 2006-05-15 | 2008-05-15 | Grenon Stephen M | Apparatus for inner eyelid treatment of meibomian gland dysfunction |
| US20090043365A1 (en) * | 2005-07-18 | 2009-02-12 | Kolis Scientific, Inc. | Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma |
| US7981145B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience Inc. | Treatment of meibomian glands |
| US8950405B2 (en) | 2006-05-15 | 2015-02-10 | Tearscience, Inc. | Treatment of obstructive disorders of the eye or eyelid |
| US9314369B2 (en) | 2006-05-15 | 2016-04-19 | Tearscience, Inc. | System for inner eyelid treatment of meibomian gland dysfunction |
| US8128673B2 (en) | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for inner eyelid heat and pressure treatment for treating meibomian gland dysfunction |
| US7976573B2 (en) | 2006-05-15 | 2011-07-12 | Tearscience, Inc. | Inner eyelid heat and pressure treatment for treating meibomian gland dysfunction |
| US7981147B2 (en) | 2006-05-15 | 2011-07-19 | Tearscience, Inc. | Outer eyelid heat and pressure treatment for treating meibomian gland dysfunction |
| US8007524B2 (en) | 2006-05-15 | 2011-08-30 | Tearscience, Inc. | Heat treatment and heat loss reduction for treating meibomian gland dysfunction |
| US8128674B2 (en) | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction |
| US8137390B2 (en) | 2006-05-15 | 2012-03-20 | Tearscience, Inc. | System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction |
| US20130177599A1 (en) * | 2012-01-06 | 2013-07-11 | Insite Vision Incorporated | Methods and kits for extending contact lens use |
| US10842670B2 (en) | 2012-08-22 | 2020-11-24 | Johnson & Johnson Vision Care, Inc. | Apparatuses and methods for diagnosing and/or treating lipid transport deficiency in ocular tear films, and related components and devices |
| EP3744391B1 (en) | 2013-04-30 | 2023-03-01 | Alcon Inc. | Systems for the treatment of eye conditions |
| US9763827B2 (en) | 2013-04-30 | 2017-09-19 | Tear Film Innovations, Inc. | Systems and methods for the treatment of eye conditions |
| WO2016022066A1 (en) | 2014-08-04 | 2016-02-11 | Jerry Tan Eye Surgery Pte Ltd | Pharmaceutical compositions for demodex related blepharitis and eyelid crusting |
| US20170239307A1 (en) * | 2014-09-23 | 2017-08-24 | Agencia Pública Empresarial Sanitaria Hospital Alto Guadalquivir | Composition of doxycycline in liposomes for the prevention, improvement and/or treatment of ocular pathologies |
| US9463201B2 (en) | 2014-10-19 | 2016-10-11 | M.G. Therapeutics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
| AR104177A1 (es) * | 2015-04-03 | 2017-07-05 | Santen Pharmaceutical Co Ltd | Sistema para la administración de fármacos en la glándula lagrimal |
| ES3007759T3 (en) * | 2015-09-28 | 2025-03-20 | Azura Ophthalmics Ltd | Thiol and disulfide-containing agents for increasing meibomian gland lipid secretion |
| JP6919970B2 (ja) | 2016-04-14 | 2021-08-18 | アズーラ オフサルミックス エルティーディー． | マイボーム腺機能不全の処置において使用される二硫化セレン組成物 |
| US10974063B2 (en) | 2016-06-30 | 2021-04-13 | Alcon Inc. | Light therapy for eyelash growth |
| KR102614858B1 (ko) * | 2016-09-22 | 2023-12-18 | 노바리크 게엠베하 | 안검염 치료에 사용되는 약제학적 조성물 |
| US20180221407A1 (en) * | 2017-02-03 | 2018-08-09 | The Administrators Of The Tulane Educational Fund | Ophthalmic compositions for therapeutic and prophylactic uses |
| KR20250057155A (ko) | 2017-12-15 | 2025-04-28 | 타르서스 파마수티칼스, 아이엔씨. | 안검염을 치료하기 위한 이속사졸린 구충제 제제 및 방법 |
| US12502377B2 (en) | 2019-04-04 | 2025-12-23 | Tarsus Pharmaceuticals, Inc. | Method of eradicating ticks that attach to humans using lotilaner formulations |
| EP3741367A1 (en) * | 2019-05-21 | 2020-11-25 | Premark Pharma GmbH | Treatment of ocular disease |
| CA3166357A1 (en) | 2020-01-10 | 2021-07-15 | Azura Ophthalmics Ltd. | Instructions for composition and sensitivity |
| US20220160668A1 (en) | 2020-11-23 | 2022-05-26 | Sight Sciences, Inc. | Formulations and methods for treating conditions of the eye |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1676579T3 (da) * | 1998-05-08 | 2009-03-16 | Univ Miami | Anvendelse af sub-antimikrobielle tetracykliner til behandling af okulær rosacea |
| US7056893B2 (en) * | 1999-03-31 | 2006-06-06 | Insite Vision, Inc. | Topical treatment for prevention of ocular infections |
| IT1313610B1 (it) * | 1999-08-09 | 2002-09-09 | S I F I Societa Ind Farmaceuti | Processo per la preparazione di formulazioni acquose per uso oftalmico |
| US7069084B2 (en) * | 2002-06-14 | 2006-06-27 | Seefit Incorporated | Method and apparatus for preventing and treating eyelid problems |
-
2009
- 2009-03-26 WO PCT/US2009/038428 patent/WO2009120881A1/en not_active Ceased
- 2009-03-26 JP JP2011502063A patent/JP2011515494A/ja active Pending
- 2009-03-26 CA CA2719453A patent/CA2719453A1/en not_active Abandoned
- 2009-03-26 AU AU2009228205A patent/AU2009228205A1/en not_active Abandoned
- 2009-03-26 US US12/934,308 patent/US20110059925A1/en not_active Abandoned
- 2009-03-26 EP EP09724064A patent/EP2285346A1/en not_active Withdrawn
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