JP2011511076A5 - - Google Patents
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- Publication number
- JP2011511076A5 JP2011511076A5 JP2010545895A JP2010545895A JP2011511076A5 JP 2011511076 A5 JP2011511076 A5 JP 2011511076A5 JP 2010545895 A JP2010545895 A JP 2010545895A JP 2010545895 A JP2010545895 A JP 2010545895A JP 2011511076 A5 JP2011511076 A5 JP 2011511076A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- peptidomimetic macrocycle
- amino acid
- polypeptide
- linking agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000002678 macrocyclic compounds Chemical class 0.000 claims 12
- 239000000816 peptidomimetic Substances 0.000 claims 12
- 239000003431 cross linking reagent Substances 0.000 claims 8
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 239000004971 Cross linker Substances 0.000 claims 2
- 230000005875 antibody response Effects 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims 2
- 230000009851 immunogenic response Effects 0.000 claims 2
- 238000005462 in vivo assay Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2732608P | 2008-02-08 | 2008-02-08 | |
| US12038008P | 2008-12-05 | 2008-12-05 | |
| PCT/US2009/000837 WO2009099677A2 (en) | 2008-02-08 | 2009-02-09 | Therapeutic peptidomimetic macrocycles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014244169A Division JP2015078208A (ja) | 2008-02-08 | 2014-12-02 | 治療用ペプチド模倣大環状分子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011511076A JP2011511076A (ja) | 2011-04-07 |
| JP2011511076A5 true JP2011511076A5 (cg-RX-API-DMAC7.html) | 2012-03-29 |
Family
ID=40952614
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545895A Pending JP2011511076A (ja) | 2008-02-08 | 2009-02-09 | 治療用ペプチド模倣大環状分子 |
| JP2014244169A Pending JP2015078208A (ja) | 2008-02-08 | 2014-12-02 | 治療用ペプチド模倣大環状分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014244169A Pending JP2015078208A (ja) | 2008-02-08 | 2014-12-02 | 治療用ペプチド模倣大環状分子 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20090275519A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2242503A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2011511076A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20100126361A (cg-RX-API-DMAC7.html) |
| CN (2) | CN104474529A (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0907754A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2714251C (cg-RX-API-DMAC7.html) |
| DE (1) | DE112009000300T5 (cg-RX-API-DMAC7.html) |
| GB (1) | GB2471588A (cg-RX-API-DMAC7.html) |
| IL (2) | IL207421A0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009099677A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201005741B (cg-RX-API-DMAC7.html) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2489360A1 (en) * | 2006-11-15 | 2012-08-22 | Dana-Farber Cancer Institute, Inc. | Stabilized MAML peptides and uses thereof |
| CN105061577A (zh) * | 2006-12-14 | 2015-11-18 | 爱勒让治疗公司 | 双巯基大环化系统 |
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| CA2677045C (en) | 2007-01-31 | 2016-10-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| CN104086641A (zh) | 2007-02-23 | 2014-10-08 | 爱勒让治疗公司 | 三唑大环系统 |
| CA2682174C (en) | 2007-03-28 | 2021-04-06 | President And Fellows Of Harvard College | Stitched polypeptides |
| CN104474529A (zh) | 2008-02-08 | 2015-04-01 | 爱勒让治疗公司 | 治疗性的拟肽大环化合物 |
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| KR20130115108A (ko) | 2010-05-28 | 2013-10-21 | 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 올리고－벤즈아미드 화합물 및 이의 용도 |
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| EP2651964B1 (en) | 2010-12-15 | 2018-02-28 | The Research Foundation of State University of New York | Cross-linked peptides and proteins, methods of making same, and uses thereof |
| CN108929375A (zh) | 2011-10-18 | 2018-12-04 | 爱勒让治疗公司 | 拟肽大环化合物 |
| US8835493B2 (en) | 2011-11-23 | 2014-09-16 | Board Of Regents, The University Of Texas System | Oligo-benzamide compounds for use in treating cancers |
| WO2013078277A1 (en) | 2011-11-23 | 2013-05-30 | The Board Of Regents Of The University Of Texas System | Oligo-benzamide compounds and their use in treating cancers |
| US9464125B2 (en) | 2012-02-03 | 2016-10-11 | The Trustees Of Princeton University | Engineered potent cytotoxic stapled BH3 peptides |
| CA2864120A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| CN112500466B (zh) | 2012-02-15 | 2022-05-03 | 艾瑞朗医疗公司 | 拟肽大环化合物 |
| MX367055B (es) * | 2012-06-26 | 2019-08-02 | Del Mar Pharmaceuticals | El uso de una composición que comprende dianhidrogalactitol, diacetildianhidrogalactitol, y dibromodulcitol, y análogos o derivados de cada uno para el tratamiento de malignidades resistentes a inhibidores de tirosina cinasa. |
| CN104812384B (zh) | 2012-11-01 | 2020-09-18 | 爱勒让治疗公司 | 二取代的氨基酸及其制备和使用方法 |
| WO2014138429A2 (en) | 2013-03-06 | 2014-09-12 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and use thereof in regulating hif1alpha |
| CN105492011A (zh) | 2013-04-08 | 2016-04-13 | 丹尼斯·M·布朗 | 不理想给药化学化合物的治疗增效 |
| JP6822839B2 (ja) | 2013-09-13 | 2021-01-27 | ザ・スクリップス・リサーチ・インスティテュート | 修飾された治療剤、及びその組成物 |
| CA2933701C (en) | 2013-12-18 | 2022-05-31 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| WO2015153761A2 (en) * | 2014-04-02 | 2015-10-08 | University Of Rochester | Macrocyclic peptidomimetics for alpha-helix mimicry |
| SG11201608303QA (en) | 2014-04-04 | 2016-11-29 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| US10905739B2 (en) * | 2014-09-24 | 2021-02-02 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and formulations thereof |
| EP3197478A4 (en) * | 2014-09-24 | 2018-05-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| US11142554B2 (en) | 2015-03-18 | 2021-10-12 | Massachusetts Institute Of Technology | Selective Mcl-1 binding peptides |
| SG11201707750YA (en) | 2015-03-20 | 2017-10-30 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| WO2017004548A1 (en) | 2015-07-01 | 2017-01-05 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CN108368161A (zh) * | 2015-09-10 | 2018-08-03 | 艾瑞朗医疗公司 | 作为mcl-1调节剂的拟肽大环化合物 |
| US10286079B2 (en) | 2015-09-22 | 2019-05-14 | The Regents Of The University Of California | Modified cytotoxins and their therapeutic use |
| MX380314B (es) | 2015-09-22 | 2025-03-12 | Univ California | Citotoxinas modificadas y su uso terapeutico. |
| AU2016347456B2 (en) | 2015-10-27 | 2018-12-13 | F. Hoffmann-La Roche Ag | Peptide macrocycles against acinetobacter baumannii |
| WO2017075349A2 (en) * | 2015-10-30 | 2017-05-04 | Massachusetts Institute Of Technology | Selective mcl-1 binding peptides |
| SMT202200173T1 (it) | 2016-06-01 | 2022-05-12 | Athira Pharma Inc | Composti |
| US11198715B2 (en) | 2016-07-22 | 2021-12-14 | Massachusetts Institute Of Technology | Selective Bfl-1 peptides |
| EP3388444A1 (en) | 2017-04-10 | 2018-10-17 | F. Hoffmann-La Roche AG | Anti-bacterial peptide macrocycles and use thereof |
| US11524979B2 (en) | 2017-06-15 | 2022-12-13 | University Of Washington | Macrocyclic polypeptides |
| US11505573B2 (en) | 2018-03-28 | 2022-11-22 | Hoffmann-La Roche Inc. | Peptide macrocycles against Acinetobacter baumannii |
| US11819532B2 (en) | 2018-04-23 | 2023-11-21 | Hoffmann-La Roche Inc. | Peptide macrocycles against Acinetobacter baumannii |
| US11091522B2 (en) | 2018-07-23 | 2021-08-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| US11286299B2 (en) | 2018-09-17 | 2022-03-29 | Massachusetts Institute Of Technology | Peptides selective for Bcl-2 family proteins |
| EP3938051A4 (en) * | 2019-03-15 | 2022-12-07 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| EP4352088A1 (en) | 2021-06-09 | 2024-04-17 | The Scripps Research Institute | Long-acting dual gip/glp-1 peptide conjugates and methods of use |
| WO2023069332A1 (en) * | 2021-10-22 | 2023-04-27 | Merck Sharp & Dohme Llc | Cell permeable macrocyclic peptides useful for eif4e cap-binding site inhibition |
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-
2009
- 2009-02-09 CN CN201410541607.0A patent/CN104474529A/zh active Pending
- 2009-02-09 KR KR1020107020028A patent/KR20100126361A/ko not_active Ceased
- 2009-02-09 CA CA2714251A patent/CA2714251C/en not_active Expired - Fee Related
- 2009-02-09 GB GB1014734A patent/GB2471588A/en not_active Withdrawn
- 2009-02-09 EP EP09707916A patent/EP2242503A4/en not_active Withdrawn
- 2009-02-09 WO PCT/US2009/000837 patent/WO2009099677A2/en not_active Ceased
- 2009-02-09 BR BRPI0907754-5A patent/BRPI0907754A2/pt not_active Application Discontinuation
- 2009-02-09 US US12/378,047 patent/US20090275519A1/en not_active Abandoned
- 2009-02-09 CN CN200980108027XA patent/CN101980718A/zh active Pending
- 2009-02-09 EP EP15153712.3A patent/EP2926827A3/en not_active Withdrawn
- 2009-02-09 JP JP2010545895A patent/JP2011511076A/ja active Pending
- 2009-02-09 DE DE112009000300T patent/DE112009000300T5/de not_active Withdrawn
-
2010
- 2010-08-04 IL IL207421A patent/IL207421A0/en active IP Right Grant
- 2010-08-11 ZA ZA2010/05741A patent/ZA201005741B/en unknown
-
2012
- 2012-01-17 US US13/352,223 patent/US8808694B2/en not_active Expired - Fee Related
-
2014
- 2014-07-08 US US14/325,933 patent/US20150038430A1/en not_active Abandoned
- 2014-12-02 JP JP2014244169A patent/JP2015078208A/ja active Pending
-
2015
- 2015-12-20 IL IL243240A patent/IL243240A/en active IP Right Grant
-
2018
- 2018-06-29 US US16/023,606 patent/US20190071469A1/en not_active Abandoned
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