JP2011509252A5 - - Google Patents
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- Publication number
- JP2011509252A5 JP2011509252A5 JP2010541101A JP2010541101A JP2011509252A5 JP 2011509252 A5 JP2011509252 A5 JP 2011509252A5 JP 2010541101 A JP2010541101 A JP 2010541101A JP 2010541101 A JP2010541101 A JP 2010541101A JP 2011509252 A5 JP2011509252 A5 JP 2011509252A5
- Authority
- JP
- Japan
- Prior art keywords
- stereoisomer
- tautomer
- indazol
- aminocarbonyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 9
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- CXPSLSYYWGMRQH-MZQXSLHISA-N (E)-but-2-enedioate;2-[4-[(3S)-piperidin-1-ium-3-yl]phenyl]indazole-7-carboxamide Chemical compound [O-]C(=O)\C=C\C([O-])=O.N1=C2C(C(=O)N)=CC=CC2=CN1C(C=C1)=CC=C1[C@@H]1CCC[NH2+]C1.N1=C2C(C(=O)N)=CC=CC2=CN1C(C=C1)=CC=C1[C@@H]1CCC[NH2+]C1 CXPSLSYYWGMRQH-MZQXSLHISA-N 0.000 claims 2
- PCHKPVIQAHNQLW-CQSZACIVSA-O 2-[4-[(3S)-piperidin-1-ium-3-yl]phenyl]indazole-7-carboxamide Chemical compound N1=C2C(C(=O)N)=CC=CC2=CN1C(C=C1)=CC=C1[C@@H]1CCC[NH2+]C1 PCHKPVIQAHNQLW-CQSZACIVSA-O 0.000 claims 2
- MYGUDASFCHBTGF-XZPBZCASSA-N 2-[4-[(3S)-piperidin-1-ium-3-yl]phenyl]indazole-7-carboxamide;sulfate Chemical compound [O-]S([O-])(=O)=O.N1=C2C(C(=O)N)=CC=CC2=CN1C(C=C1)=CC=C1[C@@H]1CCC[NH2+]C1.N1=C2C(C(=O)N)=CC=CC2=CN1C(C=C1)=CC=C1[C@@H]1CCC[NH2+]C1 MYGUDASFCHBTGF-XZPBZCASSA-N 0.000 claims 2
- ACNPUCQQZDAPJH-FMOMHUKBSA-N 4-methylbenzenesulfonic acid;2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide;hydrate Chemical compound O.CC1=CC=C(S([O-])(=O)=O)C=C1.N1=C2C(C(=O)N)=CC=CC2=CN1C(C=C1)=CC=C1[C@@H]1CCC[NH2+]C1 ACNPUCQQZDAPJH-FMOMHUKBSA-N 0.000 claims 2
- 208000008787 Cardiovascular Disease Diseases 0.000 claims 2
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 claims 2
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 claims 2
- PLECLGHOBYKOQA-XZPBZCASSA-N butanedioate;2-[4-[(3S)-piperidin-1-ium-3-yl]phenyl]indazole-7-carboxamide Chemical compound [O-]C(=O)CCC([O-])=O.N1=C2C(C(=O)N)=CC=CC2=CN1C(C=C1)=CC=C1[C@@H]1CCC[NH2+]C1.N1=C2C(C(=O)N)=CC=CC2=CN1C(C=C1)=CC=C1[C@@H]1CCC[NH2+]C1 PLECLGHOBYKOQA-XZPBZCASSA-N 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- LCPFHXWLJMNKNC-PFEQFJNWSA-N 4-methylbenzenesulfonate;2-[4-[(3S)-piperidin-1-ium-3-yl]phenyl]indazole-7-carboxamide Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1.N1=C2C(C(=O)N)=CC=CC2=CN1C(C=C1)=CC=C1[C@@H]1CCC[NH2+]C1 LCPFHXWLJMNKNC-PFEQFJNWSA-N 0.000 claims 1
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 206010053643 Neurodegenerative disease Diseases 0.000 claims 1
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 claims 1
- 206010038435 Renal failure Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 206010057430 Retinal injury Diseases 0.000 claims 1
- 206010038997 Retroviral infection Diseases 0.000 claims 1
- 210000003491 Skin Anatomy 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temodal Chemical group O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims 1
- SBRRKNDQFQNEJP-FFAASGSZSA-N [O-]S([O-])(=O)=O.c1ccccc1.NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@@H]1CCC[NH2+]C1.NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@@H]1CCC[NH2+]C1 Chemical compound [O-]S([O-])(=O)=O.c1ccccc1.NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@@H]1CCC[NH2+]C1.NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@@H]1CCC[NH2+]C1 SBRRKNDQFQNEJP-FFAASGSZSA-N 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 200000000018 inflammatory disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000000302 ischemic Effects 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000002534 radiation-sensitizing agent Substances 0.000 claims 1
- 231100000489 sensitizer Toxicity 0.000 claims 1
- 230000001568 sexual Effects 0.000 claims 1
- 230000037380 skin damage Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229960004964 temozolomide Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical group CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 claims 1
- 201000011528 vascular disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1033308P | 2008-01-08 | 2008-01-08 | |
| US61/010,333 | 2008-01-08 | ||
| PCT/GB2009/000041 WO2009087381A1 (en) | 2008-01-08 | 2009-01-08 | Pharmaceutically acceptable salts of 2-{4-[(3s)-piperidin-3- yl]phenyl} -2h-indazole-7-carboxamide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011509252A JP2011509252A (ja) | 2011-03-24 |
| JP2011509252A5 true JP2011509252A5 (US20070167479A1-20070719-C00034.png) | 2012-02-16 |
| JP5989965B2 JP5989965B2 (ja) | 2016-09-07 |
Family
ID=40404013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010541101A Active JP5989965B2 (ja) | 2008-01-08 | 2009-01-08 | ２−｛４−［（３ｓ）−ピペリジン−３−イル］フェニル｝−２ｈ−インダゾール−７−カルボキサミドの薬学的に許容される塩 |
Country Status (17)
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010045095A1 (en) | 2008-10-14 | 2010-04-22 | Ning Xi | Compounds and methods of use |
| AU2010229147B2 (en) | 2009-03-21 | 2012-07-05 | Sunshine Lake Pharma Co., Ltd. | Amino ester derivatives, salts thereof and methods of use |
| RS55487B1 (sr) | 2010-02-12 | 2017-04-28 | Pfizer | Soli i polimorfi 8-fluoro-2-{4-[(metilamino}metil]fenil}-1,3,4,5-tetrahidro-6h-azepino[5,4,3-cd]indol-6-ona |
| EP2928473B1 (en) * | 2012-12-07 | 2017-06-28 | Merck Sharp & Dohme Corp. | Regioselective n-2 arylation of indazoles |
| SG11201610500WA (en) | 2014-06-17 | 2017-01-27 | Vertex Pharma | Method for treating cancer using a combination of chk1 and atr inhibitors |
| MA41867A (fr) | 2015-04-01 | 2018-02-06 | Anaptysbio Inc | Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3) |
| WO2016172332A1 (en) * | 2015-04-22 | 2016-10-27 | The University Of North Carolina At Chapel Hill | A novel compound for the treatment of ewing sarcoma and high-throughput assays for identifying small molecules that modulate aberrant chromatin accessibility |
| CA3000684A1 (en) | 2015-09-30 | 2017-04-06 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of dna damaging agents and atr inhibitors |
| EP3358347B1 (en) * | 2015-09-30 | 2020-11-18 | Tohoku University | Marker for determining diabetic nephropathy |
| CA3029671C (en) | 2016-06-29 | 2023-08-15 | Tesaro, Inc. | Methods of treating ovarian cancer |
| BR112019001398A2 (pt) | 2016-07-29 | 2019-05-07 | Janssen Pharmaceutica Nv | métodos para tratamento de câncer de próstata |
| CN107663190B (zh) * | 2016-07-29 | 2020-06-09 | 钟桂发 | 一种尼拉帕尼及其中间体的制备方法以及中间体化合物 |
| CN106432057A (zh) * | 2016-09-17 | 2017-02-22 | 青岛云天生物技术有限公司 | 一种制备(3s)‑3‑(4‑氨基苯基)哌啶‑1‑甲酸叔丁酯的方法 |
| KR20190098741A (ko) | 2016-11-01 | 2019-08-22 | 아납티스바이오, 아이엔씨. | T 세포 면역글로불린 및 뮤신 단백질 3(tim-3)에 대한 항체 |
| EP3534950A4 (en) | 2016-11-01 | 2020-05-06 | AnaptysBio, Inc. | ANTIBODIES AGAINST PROGRAMMED DEATH-1 (PD-1) |
| WO2018122168A1 (en) | 2016-12-29 | 2018-07-05 | Bayer Pharma Aktiengesellschaft | Combinations of bub1 kinase and parp inhibitors |
| PT3565844T (pt) | 2017-01-09 | 2023-05-02 | Tesaro Inc | Métodos de tratamento de cancro com anticorpos anti-pd-1 |
| WO2018129553A1 (en) | 2017-01-09 | 2018-07-12 | Tesaro, Inc. | Methods of treating cancer with anti-tim-3 antibodies |
| EA201992162A1 (ru) * | 2017-03-27 | 2020-02-28 | Тесаро, Инк. | Составы на основе нирапариба |
| EA201992177A1 (ru) * | 2017-03-27 | 2020-02-25 | Тесаро, Инк. | Композиции на основе нирапариба |
| WO2018187187A1 (en) * | 2017-04-04 | 2018-10-11 | Combiphos Catalysts, Inc. | Deuterated (s)-2-(4-(piperidin-3-yl)phenyl)-2h-indazole-7-carboxamide |
| JOP20190244A1 (ar) | 2017-04-13 | 2019-10-13 | Janssen Pharmaceutica Nv | تركيبة علاجية لسرطان البروستاتا |
| CA3060715A1 (en) * | 2017-04-24 | 2018-11-01 | Tesaro, Inc. | Methods of manufacturing of niraparib |
| CN110799541A (zh) | 2017-04-27 | 2020-02-14 | 特沙诺有限公司 | 针对淋巴细胞活化基因-3(lag-3)的抗体药剂及其用途 |
| MX2019013755A (es) | 2017-05-18 | 2020-07-20 | Tesaro Inc | Terapias de combinación para el tratamiento del cáncer. |
| CN108530425A (zh) * | 2017-05-27 | 2018-09-14 | 广州科锐特生物科技有限公司 | 一种尼拉帕尼对甲苯磺酸盐水合物晶型及其制备方法 |
| CN109081828B (zh) | 2017-06-14 | 2021-03-26 | 上海时莱生物技术有限公司 | 聚(adp-核糖)聚合酶抑制剂、制备方法及用途 |
| US10927095B2 (en) | 2017-08-14 | 2021-02-23 | Teva Pharmaceuticals International Gmbh | Processes for the preparation of Niraparib and intermediates thereof |
| CN111065922A (zh) * | 2017-09-13 | 2020-04-24 | B.R.A.H.M.S有限公司 | 肾上腺髓质素原作为危重病患者的肾脏替代治疗的指标 |
| ES2913298T3 (es) * | 2017-09-13 | 2022-06-01 | Brahms Gmbh | PCT y proADM como marcadores para el seguimiento del tratamiento antibiótico |
| WO2019053116A1 (en) * | 2017-09-13 | 2019-03-21 | B.R.A.H.M.S Gmbh | FLUID THERAPY GUIDING METHOD BASED ON PROADRENOMEDULLINE |
| CN111278433A (zh) * | 2017-09-26 | 2020-06-12 | 特沙诺有限公司 | 尼拉帕尼制剂 |
| KR20200086664A (ko) | 2017-09-30 | 2020-07-17 | 테사로, 인코포레이티드 | 암을 치료하기 위한 조합 요법 |
| BR112020006845A2 (pt) * | 2017-10-06 | 2020-10-06 | Tesaro, Inc. | terapias combinadas e usos das mesmas |
| CA3087060A1 (en) | 2017-12-27 | 2019-07-04 | Tesaro, Inc. | Methods of treating cancer |
| AU2019215450A1 (en) | 2018-02-05 | 2020-08-27 | Tesaro, Inc | Pediatric niraparib formulations and pediatric treatment methods |
| TW202024638A (zh) | 2018-09-04 | 2020-07-01 | 美商泰沙羅公司 | 治療癌症之方法 |
| US20210347760A1 (en) | 2018-10-03 | 2021-11-11 | Tesaro, Inc. | Niraparib Salts |
| TWI825191B (zh) * | 2018-10-03 | 2023-12-11 | 美商提薩羅有限公司 | 尼拉帕尼（niraparib）游離鹼之結晶形 |
| WO2020072860A1 (en) | 2018-10-05 | 2020-04-09 | Johnson Matthey Public Limited Company | Niraparib solid state form |
| EP3966782A2 (en) | 2019-05-06 | 2022-03-16 | Tesaro, Inc. | Methods for characterizing and treating a cancer type using cancer images |
| CN110407704B (zh) * | 2019-08-19 | 2022-05-17 | 常州沃腾化工科技有限公司 | 一种3-甲酰基-2-硝基苯甲酸甲酯的合成方法 |
| WO2021224471A1 (en) | 2020-05-08 | 2021-11-11 | Janssen Pharmaceutica Nv | Pharmaceutical formulations of abiraterone acetate and niraparib |
| CA3223426A1 (en) | 2021-07-19 | 2023-01-26 | Peter Francis | Treatment of metastatic castration-resistant prostate cancer with niraparib |
| WO2023148345A1 (en) | 2022-02-04 | 2023-08-10 | Janssen Pharmaceutica Nv | Niraparib and abiraterone acetate plus prednisone to improve clinical outcomes in patients with metastatic castration-resistant prostate cancer and hrr alterations |
| WO2023159066A1 (en) | 2022-02-15 | 2023-08-24 | Tesaro, Inc. | Use of niraparib for the treatment of brain cancer |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9404485D0 (en) | 1994-03-09 | 1994-04-20 | Cancer Res Campaign Tech | Benzamide analogues |
| AT401651B (de) * | 1994-06-14 | 1996-11-25 | Biochemie Gmbh | 7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroximinoacetamido)-3-n,n- dimethylcarbamoyloxymethyl-3-cephem-4- |
| NZ313713A (en) | 1995-08-02 | 2001-03-30 | Univ Newcastle Ventures Ltd | Benzimidazole-4-carboxamide derivatives useful as poly(ADP-ribose)polymerase or PARP enzyme inhibitors |
| AU9297998A (en) | 1998-05-15 | 1999-12-06 | Guilford Pharmaceuticals Inc. | Carboxamide compounds, compositions, and methods for inhibiting parp activity |
| DK1124805T3 (da) | 1998-10-30 | 2003-09-15 | Lonza Ag | Fremgangsmåde til fremstilling af 4-[(2',5'-diamino-6'-halogenpyrimidin-4'-yl)amino]cyclopent-2-enylmethanoler |
| EP1391457B1 (de) | 1998-11-03 | 2013-12-25 | AbbVie Deutschland GmbH & Co KG | Substituierte 2-Phenylbenzimidazole und deren Verwendung als PARP Inhibitoren |
| IL143102A0 (en) | 1998-11-17 | 2002-04-21 | Basf Ag | 2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof |
| CZ300148B6 (cs) | 1998-11-27 | 2009-02-25 | Abbott Gmbh & Co. Kg | Derivát substituovaného benzimidazolu, zpusob jeho prípravy a jeho použití |
| DE19918211A1 (de) | 1999-04-22 | 2000-10-26 | Basf Ag | Cycloalkylsubstituierte Benzimidazole, deren Herstellung und Anwendung |
| DE19920936A1 (de) | 1999-05-07 | 2000-11-09 | Basf Ag | Heterozyklisch substituierte Benzimidazole, deren Herstellung und Anwendung |
| WO2001021615A1 (en) | 1999-09-17 | 2001-03-29 | Yamanouchi Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| US6508365B1 (en) * | 1999-12-28 | 2003-01-21 | Pitney Bowes Inc. | Method of removing mail from a mailstream using an incoming mail sorting apparatus |
| AU2001240542A1 (en) | 2000-02-01 | 2001-08-14 | Basf Aktiengesellschaft | Heterocyclic compounds and their use as parp inhibitors |
| DE10022925A1 (de) | 2000-05-11 | 2001-11-15 | Basf Ag | Substituierte Indole als PARP-Inhibitoren |
| JPWO2002068407A1 (ja) | 2001-02-28 | 2004-06-24 | 山之内製薬株式会社 | ベンゾイミダゾール化合物 |
| WO2003007959A1 (en) | 2001-07-16 | 2003-01-30 | Fujisawa Pharmaceutical Co., Ltd. | Quinoxaline derivatives which have parp inhibitory action |
| IL160744A0 (en) * | 2001-09-26 | 2004-08-31 | Pharmacia Italia Spa | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them |
| WO2003062234A1 (fr) | 2002-01-23 | 2003-07-31 | Yamanouchi Pharmaceutical Co., Ltd. | Composes de quinoxaline |
| US20040034078A1 (en) | 2002-06-14 | 2004-02-19 | Agouron Pharmaceuticals, Inc. | Benzimidazole inhibitors of poly(ADP-ribosyl) polymerase |
| DE10228103A1 (de) | 2002-06-24 | 2004-01-15 | Bayer Cropscience Ag | Fungizide Wirkstoffkombinationen |
| JPWO2004014861A1 (ja) | 2002-08-09 | 2005-12-02 | 杏林製薬株式会社 | ４−置換キノリン−８−カルボン酸アミド誘導体とその薬理上許容される付加塩 |
| US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
| US7462641B2 (en) * | 2003-07-21 | 2008-12-09 | Smithkline Beecham Corporation | (2S,4S)-4-fluoro-1-[4-fluoro-beta-(4-fluorophenyl)-L-phenylalanyl]-2-pyrrolidinecarbonitrile p-toluenesulfonic acid salt and anhydrous crystalline forms thereof |
| WO2005047290A2 (en) * | 2003-11-11 | 2005-05-26 | Cellular Genomics Inc. | Imidazo[1,2-a] pyrazin-8-ylamines as kinase inhibitors |
| GB0327740D0 (en) * | 2003-11-28 | 2003-12-31 | Glaxo Group Ltd | Novel compounds |
| EP1706386A1 (en) | 2003-12-22 | 2006-10-04 | Eli Lilly And Company | Bicyclic derivatives as ppar modulators |
| KR100876520B1 (ko) | 2004-09-22 | 2008-12-31 | 화이자 인코포레이티드 | 폴리(ａｄｐ-리보오스) 폴리머라제 억제제의 제조 방법 |
| EP1812439B2 (en) * | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| JP3701964B1 (ja) * | 2005-03-08 | 2005-10-05 | アステラス製薬株式会社 | キヌクリジン誘導体の新規な塩 |
| WO2006110683A1 (en) | 2005-04-11 | 2006-10-19 | Abbott Laboratories | 2-substituted-1h-benzimidazole-4-carboxamides are parp inhibitors |
| TWI375673B (en) | 2005-04-11 | 2012-11-01 | Abbott Lab | 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors |
| DE602006020138D1 (de) | 2005-06-29 | 2011-03-31 | Compumedics Ltd | Sensoranordnung mit leitfähiger brücke |
| EP1957477B1 (en) | 2005-09-29 | 2011-12-07 | Abbott Laboratories | 1h-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent parp inhibitors |
| EP1966157B1 (en) | 2005-11-15 | 2010-03-24 | Abbott Laboratories | Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors |
| EP2007733B1 (en) | 2006-04-03 | 2016-05-25 | MSD Italia S.r.l. | Amide substituted indazole and benzotriazole derivatives as poly(adp-ribose)polymerase (parp) inhibitors |
| ES2385849T3 (es) | 2006-05-02 | 2012-08-01 | Abbott Laboratories | Las 1H-bencimidazol-4-carboxamidas substituidas son potentes inhibidores de la PARP |
| TW200801513A (en) | 2006-06-29 | 2008-01-01 | Fermiscan Australia Pty Ltd | Improved process |
| US7892667B2 (en) * | 2006-09-13 | 2011-02-22 | Altek Corporation | Battery security device |
| MX2009007200A (es) * | 2007-01-10 | 2009-07-15 | Angeletti P Ist Richerche Bio | Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp). |
| JP2008228154A (ja) * | 2007-03-15 | 2008-09-25 | Fujitsu Ltd | 表示装置，および遠隔操作装置 |
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2009
- 2009-01-08 US US12/811,922 patent/US8436185B2/en active Active
- 2009-01-08 CA CA2711491A patent/CA2711491C/en active Active
- 2009-01-08 EP EP09700579.7A patent/EP2240466B1/en active Active
- 2009-01-08 BR BRPI0906020-0A patent/BRPI0906020A2/pt not_active Application Discontinuation
- 2009-01-08 ES ES09700579.7T patent/ES2548131T3/es active Active
- 2009-01-08 JP JP2010541101A patent/JP5989965B2/ja active Active
- 2009-01-08 MX MX2010006593A patent/MX337421B/es active IP Right Grant
- 2009-01-08 CN CN201610345956.4A patent/CN106008460B/zh active Active
- 2009-01-08 RU RU2010133241/04A patent/RU2495035C2/ru active
- 2009-01-08 NZ NZ586675A patent/NZ586675A/en unknown
- 2009-01-08 KR KR1020107015011A patent/KR101653548B1/ko active IP Right Grant
- 2009-01-08 WO PCT/GB2009/000041 patent/WO2009087381A1/en active Application Filing
- 2009-01-08 AU AU2009203598A patent/AU2009203598B2/en active Active
- 2009-01-08 CN CN2009801018616A patent/CN101932572A/zh active Pending
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2010
- 2010-06-01 ZA ZA2010/03902A patent/ZA201003902B/en unknown
- 2010-06-06 IL IL206201A patent/IL206201A/en active Protection Beyond IP Right Term
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2018
- 2018-05-14 FR FR18C1020C patent/FR18C1020I2/fr active Active
- 2018-05-15 NL NL300938C patent/NL300938I2/nl unknown
