JP2011509094A5 - - Google Patents
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- Publication number
- JP2011509094A5 JP2011509094A5 JP2010542284A JP2010542284A JP2011509094A5 JP 2011509094 A5 JP2011509094 A5 JP 2011509094A5 JP 2010542284 A JP2010542284 A JP 2010542284A JP 2010542284 A JP2010542284 A JP 2010542284A JP 2011509094 A5 JP2011509094 A5 JP 2011509094A5
- Authority
- JP
- Japan
- Prior art keywords
- cadherin
- antagonist
- antibody
- seq
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100024155 Cadherin-11 Human genes 0.000 claims 33
- 108010000953 osteoblast cadherin Proteins 0.000 claims 33
- 239000005557 antagonist Substances 0.000 claims 22
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 9
- 229940123907 Disease modifying antirheumatic drug Drugs 0.000 claims 6
- 208000012659 Joint disease Diseases 0.000 claims 6
- 239000002260 anti-inflammatory agent Substances 0.000 claims 6
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 6
- 239000002988 disease modifying antirheumatic drug Substances 0.000 claims 6
- 230000002757 inflammatory effect Effects 0.000 claims 6
- 210000004408 hybridoma Anatomy 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 238000004220 aggregation Methods 0.000 claims 3
- 230000002776 aggregation Effects 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 101000762236 Homo sapiens Cadherin-11 Proteins 0.000 claims 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
- 102000014128 RANK Ligand Human genes 0.000 claims 2
- 108010025832 RANK Ligand Proteins 0.000 claims 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 2
- 210000000845 cartilage Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229960000485 methotrexate Drugs 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 102000029816 Collagenase Human genes 0.000 claims 1
- 108060005980 Collagenase Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 102000004890 Interleukin-8 Human genes 0.000 claims 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 claims 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000033464 Reiter syndrome Diseases 0.000 claims 1
- 102000012479 Serine Proteases Human genes 0.000 claims 1
- 108010022999 Serine Proteases Proteins 0.000 claims 1
- 230000023549 cell-cell signaling Effects 0.000 claims 1
- 229960002424 collagenase Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 230000003628 erosive effect Effects 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000009545 invasion Effects 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000000816 peptidomimetic Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 208000002574 reactive arthritis Diseases 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1073408P | 2008-01-11 | 2008-01-11 | |
| US61/010,734 | 2008-01-11 | ||
| PCT/US2009/000162 WO2009089062A2 (en) | 2008-01-11 | 2009-01-09 | Cadherin-11 ecl domain antagonists for treating inflammatory joint disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011509094A JP2011509094A (ja) | 2011-03-24 |
| JP2011509094A5 true JP2011509094A5 (enExample) | 2012-02-23 |
| JP5511684B2 JP5511684B2 (ja) | 2014-06-04 |
Family
ID=40602259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010542284A Expired - Fee Related JP5511684B2 (ja) | 2008-01-11 | 2009-01-09 | 炎症性関節障害を治療するためのカドヘリン−１１ｅｃｌドメインアンタゴニスト |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US8591888B2 (enExample) |
| EP (2) | EP2242769B1 (enExample) |
| JP (1) | JP5511684B2 (enExample) |
| CN (1) | CN101952316B (enExample) |
| AU (1) | AU2009204467B2 (enExample) |
| BR (1) | BRPI0906492A2 (enExample) |
| CA (1) | CA2711394A1 (enExample) |
| DK (1) | DK2242769T3 (enExample) |
| ES (1) | ES2611102T3 (enExample) |
| HU (1) | HUE031207T2 (enExample) |
| IL (1) | IL206880A (enExample) |
| MX (1) | MX2010007551A (enExample) |
| PL (1) | PL2242769T3 (enExample) |
| SI (1) | SI2242769T1 (enExample) |
| WO (1) | WO2009089062A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE031207T2 (hu) * | 2008-01-11 | 2017-07-28 | Adheron Therapeutics Inc | Cadherin-11 EC1 domén elleni antitestek gyulladásos ízületi rendellenességek kezeléséhez |
| EP3138915A1 (en) * | 2010-05-04 | 2017-03-08 | The Brigham and Women's Hospital, Inc. | Detection and treatment of fibrosis |
| US8877188B2 (en) | 2010-05-04 | 2014-11-04 | The Brigham And Women's Hospital, Inc. | Detection and treatment of non-dermal fibrosis |
| CA2805112A1 (en) * | 2010-07-15 | 2012-01-19 | Synovex Corporation | Humanized antibodies targeting the ec1 domain of cadherin-11 and related compositions and methods |
| EP2819672A1 (en) | 2012-02-29 | 2015-01-07 | Pulmatrix, Inc. | Inhalable dry powders |
| KR20130142025A (ko) * | 2012-06-18 | 2013-12-27 | 한국생명공학연구원 | 카드헤린―１１ 단백질의 발현 또는 활성 억제제를 포함하는 대장암 치료 또는 전이 억제용 약학적 조성물 |
| US11097005B2 (en) | 2014-12-15 | 2021-08-24 | The Brigham And Women's Hospital, Inc. | Use of cadherin-11 antagonists to treat metabolic disorders and/or increase insulin sensitivity |
| EP3302530B1 (en) * | 2015-05-29 | 2022-05-25 | Children's Hospital Medical Center | Cdh26 based therapeutic agents and their use |
| KR101654526B1 (ko) * | 2015-10-19 | 2016-09-06 | 한국생명공학연구원 | 카드헤린―１１ 단백질의 발현 또는 활성 억제제를 포함하는 대장암 치료 또는 전이 억제용 약학적 조성물 |
| EP3402572B1 (en) | 2016-01-13 | 2022-03-16 | Children's Hospital Medical Center | Compositions and methods for treating allergic inflammatory conditions |
| US11859250B1 (en) | 2018-02-23 | 2024-01-02 | Children's Hospital Medical Center | Methods for treating eosinophilic esophagitis |
| EP3781588B1 (en) | 2018-04-20 | 2024-10-30 | Children's Hospital Medical Center | Blood biomarker for eosinophilic gastrointestinal disorders |
| US12297501B2 (en) | 2019-02-25 | 2025-05-13 | Children's Hospital Medical Center | Methods for diagnosing and treating eosinophilic gastritis |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US215482A (en) * | 1879-05-20 | Improvement in spring be d-bottoms | ||
| US229199A (en) * | 1880-06-22 | Wood-working machine | ||
| US248220A (en) * | 1881-10-11 | Machine for graining and dicing leather | ||
| US8323A (en) * | 1851-08-26 | colne | ||
| US110755A (en) * | 1871-01-03 | Improvement in spike-machines | ||
| US96746A (en) * | 1869-11-09 | Improvement in mechanical movements | ||
| US229811A (en) * | 1880-07-13 | dtjnlop | ||
| US248219A (en) * | 1881-10-11 | Panorama-toy | ||
| US253200A (en) * | 1882-02-07 | Timothy guilford | ||
| US4172124A (en) | 1978-04-28 | 1979-10-23 | The Wistar Institute | Method of producing tumor antibodies |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| EP0232262A4 (en) | 1985-08-15 | 1989-09-19 | Stauffer Chemical Co | TRYPTOPHANE GENERATING MICROORGANISM. |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| EP1695978A1 (en) | 1990-06-11 | 2006-08-30 | Gilead Sciences, Inc. | Nucleic acid ligands |
| DE10075010I2 (de) | 1990-06-28 | 2004-01-29 | Hoechst Ag | Fusionsproteine mit immunglobulinanteilen, ihre Herstellung und Verwendung. |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5440021A (en) | 1991-03-29 | 1995-08-08 | Chuntharapai; Anan | Antibodies to human IL-8 type B receptor |
| EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
| EP0605522B1 (en) | 1991-09-23 | 1999-06-23 | Medical Research Council | Methods for the production of humanized antibodies |
| CA2115811A1 (en) | 1993-02-17 | 1994-08-18 | Claus Krebber | A method for in vivo selection of ligand-binding proteins |
| CU22584A1 (es) | 1995-11-17 | 1999-11-03 | Centro Inmunologia Molecular | Composiciones farmacéuticas que contienen un anticuerpo monoclonal que reconoce el antígeno de diferenciación leucocitario humano cd6 y sus usos para el diagnóstico y tratamiento de la psoriasis |
| US5859136A (en) * | 1997-11-03 | 1999-01-12 | E. I. Du Pont De Nemours And Company | Coating composition containing an amine functional dispersed polymer and an isocyanate curing agent |
| EP1075494A2 (en) * | 1998-05-05 | 2001-02-14 | Adherex Technologies, Inc. | Compounds and methods for modulating nonclassical cadherin-mediated functions |
| US7481999B2 (en) * | 1998-05-05 | 2009-01-27 | Adherex Technologies, Inc. | Compounds and methods for modulating OB-cadherin-mediated function |
| US6472367B1 (en) * | 1998-05-05 | 2002-10-29 | Adherex Technologies, Inc. | Compounds and methods for modulating OB-cadherin mediated cell adhesion |
| US6680175B2 (en) * | 1998-05-05 | 2004-01-20 | Adherex Technologies, Inc. | Methods for diagnosing and evaluating cancer |
| US6638911B1 (en) * | 1998-05-05 | 2003-10-28 | Adherex Technologies Inc. | Compounds and methods for modulating desmosomal cadherin-mediated functions |
| US6787136B1 (en) * | 1999-09-03 | 2004-09-07 | The Brigham And Women's Hospital, Inc. | Methods and compositions for treatment of inflammatory disease using cadherin-11 modulating agents |
| PT1207905E (pt) * | 1999-09-03 | 2010-12-07 | Brigham & Womens Hospital | Métodos e composições para o tratamento de doença inflamatória utilizando agentes moduladores da caderina-11 |
| US20040110755A1 (en) * | 2002-08-13 | 2004-06-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Combination therapy with p38 MAP kinase inhibitors and their pharmaceutical compositions |
| WO2004048411A2 (en) * | 2002-11-14 | 2004-06-10 | Adherex Technologies, Inc. | Compounds and methods for modulating desmosomal and atypical cadherin-mediated cell adhesion |
| US6952969B2 (en) * | 2003-09-30 | 2005-10-11 | The Aerospace Corporation | Ceramic ball bearing fracture test method |
| WO2006089397A1 (en) * | 2005-02-22 | 2006-08-31 | Gemin X Biotechnologies Inc. | Methods for treating arthritis using triheterocyclic compounds |
| HUE031207T2 (hu) * | 2008-01-11 | 2017-07-28 | Adheron Therapeutics Inc | Cadherin-11 EC1 domén elleni antitestek gyulladásos ízületi rendellenességek kezeléséhez |
| CN101998966A (zh) | 2008-02-11 | 2011-03-30 | 诺瓦提斯公司 | 使用钙黏着蛋白11(cdh11)拮抗剂的方法 |
| AU2010242338B2 (en) * | 2009-05-01 | 2013-12-19 | Perseus Proteomics Inc. | Anti-cadherin antibody |
| CA2805112A1 (en) | 2010-07-15 | 2012-01-19 | Synovex Corporation | Humanized antibodies targeting the ec1 domain of cadherin-11 and related compositions and methods |
-
2009
- 2009-01-09 HU HUE09700394A patent/HUE031207T2/hu unknown
- 2009-01-09 US US12/811,921 patent/US8591888B2/en active Active
- 2009-01-09 JP JP2010542284A patent/JP5511684B2/ja not_active Expired - Fee Related
- 2009-01-09 WO PCT/US2009/000162 patent/WO2009089062A2/en not_active Ceased
- 2009-01-09 DK DK09700394.1T patent/DK2242769T3/en active
- 2009-01-09 CA CA2711394A patent/CA2711394A1/en not_active Abandoned
- 2009-01-09 SI SI200931574T patent/SI2242769T1/sl unknown
- 2009-01-09 BR BRPI0906492A patent/BRPI0906492A2/pt not_active IP Right Cessation
- 2009-01-09 EP EP09700394.1A patent/EP2242769B1/en active Active
- 2009-01-09 EP EP16194905.2A patent/EP3181588A1/en not_active Withdrawn
- 2009-01-09 AU AU2009204467A patent/AU2009204467B2/en not_active Ceased
- 2009-01-09 PL PL09700394T patent/PL2242769T3/pl unknown
- 2009-01-09 CN CN200980101955.3A patent/CN101952316B/zh active Active
- 2009-01-09 ES ES09700394.1T patent/ES2611102T3/es active Active
- 2009-01-09 MX MX2010007551A patent/MX2010007551A/es active IP Right Grant
- 2009-04-22 US US12/427,993 patent/US7972846B2/en active Active
-
2010
- 2010-07-08 IL IL206880A patent/IL206880A/en not_active IP Right Cessation
- 2010-07-15 US US12/837,110 patent/US20110045003A1/en not_active Abandoned
-
2013
- 2013-11-01 US US14/070,106 patent/US9315568B2/en active Active
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