JP2011508767A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011508767A5 JP2011508767A5 JP2010541098A JP2010541098A JP2011508767A5 JP 2011508767 A5 JP2011508767 A5 JP 2011508767A5 JP 2010541098 A JP2010541098 A JP 2010541098A JP 2010541098 A JP2010541098 A JP 2010541098A JP 2011508767 A5 JP2011508767 A5 JP 2011508767A5
- Authority
- JP
- Japan
- Prior art keywords
- bosentan
- solvent
- anhydrous
- mixture
- production method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN12MU2008 | 2008-01-01 | ||
| IN12/MUM/2008 | 2008-01-01 | ||
| IN836/MUM/2008 | 2008-04-09 | ||
| IN836MU2008 | 2008-04-09 | ||
| PCT/GB2009/000009 WO2009083739A1 (en) | 2008-01-01 | 2009-01-02 | Method of synthesis of bosentan, its polymorphic forms and its salts |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011508767A JP2011508767A (ja) | 2011-03-17 |
| JP2011508767A5 true JP2011508767A5 (enExample) | 2012-02-23 |
| JP5535082B2 JP5535082B2 (ja) | 2014-07-02 |
Family
ID=40424567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010541098A Expired - Fee Related JP5535082B2 (ja) | 2008-01-01 | 2009-01-02 | ボセンタン、その多形形態及びその塩の合成方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8481730B2 (enExample) |
| EP (2) | EP2248805A3 (enExample) |
| JP (1) | JP5535082B2 (enExample) |
| KR (1) | KR20100113542A (enExample) |
| AU (1) | AU2009203174B2 (enExample) |
| CA (1) | CA2711043A1 (enExample) |
| NZ (1) | NZ586900A (enExample) |
| WO (1) | WO2009083739A1 (enExample) |
| ZA (1) | ZA201005014B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004287875B2 (en) | 2003-11-05 | 2011-06-02 | Bausch + Lomb Ireland Limited | Modulators of cellular adhesion |
| CA2711043A1 (en) | 2008-01-01 | 2009-07-09 | Cipla Limited | Method of synthesis of bosentan, its polymorphic forms and its salts |
| US8716477B2 (en) | 2009-11-12 | 2014-05-06 | Ranbaxy Laboratories Limited | Crystalline forms of bosentan salts and processes for their preparation |
| JP5356323B2 (ja) * | 2010-07-01 | 2013-12-04 | 富士化学工業株式会社 | 新規な非晶質ボセンタン及びその製造方法 |
| WO2012002547A1 (ja) * | 2010-07-02 | 2012-01-05 | 富士化学工業株式会社 | ボセンタン固体分散体 |
| JP5850576B2 (ja) * | 2010-07-06 | 2016-02-03 | 富士化学工業株式会社 | ボセンタン固体分散体 |
| US20130245259A1 (en) | 2012-03-16 | 2013-09-19 | Natco Pharma Limited | Process for the preparation of bosentan monohydrate |
| ITMI20120701A1 (it) | 2012-04-27 | 2013-10-28 | Dipharma Francis Srl | Procedimento per la purificazione di un composto benzensolfonammidico |
| EP4406950A3 (en) | 2012-07-25 | 2025-04-23 | Bausch + Lomb Ireland Limited | Lfa-1 inhibitor and polymorph thereof |
| EP2890694A4 (en) | 2012-08-31 | 2015-12-30 | Rao Davuluri Ramamohan | 4-TERT-BUTYL-N- [6- (2-HYDROXYETHOXY) -5- (2-METHOXYPHENOXY) -2 (2-PYRIMIDINYL) -PYRIMIDIN-4-YL) -BENZENESULFONAMIDE SODIUM |
| KR102004422B1 (ko) | 2012-12-20 | 2019-07-26 | 제일약품주식회사 | 보센탄 일수화물의 제조방법, 이에 사용되는 신규 중간체 및 이의 제조방법 |
| EP2958914B1 (en) | 2013-02-21 | 2020-07-15 | Adverio Pharma GmbH | Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridino-3-yl]pyrimidino-5-yl}methyl carbamate |
| KR102259824B1 (ko) * | 2018-07-24 | 2021-06-02 | 주식회사 마더스제약 | 보센탄을 함유한 약학 제제 |
| US20250144095A1 (en) * | 2022-02-03 | 2025-05-08 | The Johns Hopkins University | Compositions and methods for treatment of connective tissue disorders |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| US6136971A (en) | 1998-07-17 | 2000-10-24 | Roche Colorado Corporation | Preparation of sulfonamides |
| MXPA02006660A (es) * | 2000-01-07 | 2002-12-13 | Transform Pharmaceuticals Inc | Formacion, identificacion y analisis de diversas formas solidas de alto rendimiento. |
| WO2001055120A1 (en) | 2000-01-25 | 2001-08-02 | F. Hoffmann-La Roche Ag | Preparation of sulfonamides |
| US8288401B2 (en) * | 2007-05-08 | 2012-10-16 | Generics [Uk] Limited | Polymorphic forms |
| AU2008272685B2 (en) * | 2007-06-29 | 2013-04-18 | Generics [Uk] Limited | Process for introduction of hydroxyethoxy side chain in bosentan |
| EP2205591A1 (en) | 2007-10-11 | 2010-07-14 | Actavis Group PTC EHF | Novel polymorphs of bosentan |
| JP2011500780A (ja) * | 2007-10-24 | 2011-01-06 | ジェネリクス・（ユーケー）・リミテッド | 新規結晶形 |
| CA2711043A1 (en) | 2008-01-01 | 2009-07-09 | Cipla Limited | Method of synthesis of bosentan, its polymorphic forms and its salts |
| WO2009093127A2 (en) * | 2008-01-24 | 2009-07-30 | Actavis Group Ptc Ehf | Substantially pure and a stable crystalline form of bosentan |
| EP2294056A1 (en) * | 2008-05-23 | 2011-03-16 | Synthon B.V. | Bosentan salts |
-
2009
- 2009-01-02 CA CA2711043A patent/CA2711043A1/en not_active Abandoned
- 2009-01-02 NZ NZ586900A patent/NZ586900A/xx not_active IP Right Cessation
- 2009-01-02 WO PCT/GB2009/000009 patent/WO2009083739A1/en not_active Ceased
- 2009-01-02 EP EP10172685A patent/EP2248805A3/en not_active Withdrawn
- 2009-01-02 AU AU2009203174A patent/AU2009203174B2/en not_active Ceased
- 2009-01-02 KR KR1020107017092A patent/KR20100113542A/ko not_active Abandoned
- 2009-01-02 EP EP09700123A patent/EP2238118A1/en not_active Withdrawn
- 2009-01-02 JP JP2010541098A patent/JP5535082B2/ja not_active Expired - Fee Related
- 2009-01-02 US US12/811,279 patent/US8481730B2/en not_active Expired - Fee Related
-
2010
- 2010-07-15 ZA ZA2010/05014A patent/ZA201005014B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011508767A5 (enExample) | ||
| JP5535082B2 (ja) | ボセンタン、その多形形態及びその塩の合成方法 | |
| US20140031554A1 (en) | Process for preparing racemic nicotine | |
| WO2016045480A1 (zh) | 一种奥贝胆酸的制备方法 | |
| WO2010091877A2 (en) | Process for producing ambrisentan | |
| JP5584709B2 (ja) | ５−（２−｛［６−（２，２−ジフルオロ−２−フェニルエトキシ）ヘキシル］アミノ｝−１−ヒドロキシエチル）−８−ヒドロキシキノリン−２（１ｈ）−オンの製造方法 | |
| CN111303051A (zh) | 制5-(3,6-二氢-2,6-二氧-4-三氟甲基-1(2h)-嘧啶基)苯硫酚方法 | |
| JP2004051592A (ja) | ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法 | |
| CA2470560C (en) | A process for producing phenserine and its analog | |
| CN107879992B (zh) | 一种(1-甲基-1h-[1,2,4]三唑-3-基)-甲醇的制备方法 | |
| KR20100118747A (ko) | 사포그릴레이트 염산염의 개선된 제조방법 | |
| JP5301676B2 (ja) | （３ｓ，４ｓ）−４−（（ｒ）−２−（ベンジルオキシ）トリデシル）−３−ヘキシル−２−オキセタノンの製造方法及びそれに用いられる新規な中間体 | |
| JP6248202B2 (ja) | シロドシン及びその中間体の製造方法 | |
| US9321712B2 (en) | Process for the preparation of ospemifene | |
| CN107286070A (zh) | (r)‑2‑(2,5‑二氟苯基)吡咯烷的合成方法及中间体 | |
| WO2018010651A1 (zh) | 一种奥贝胆酸及其中间体的制备方法 | |
| CN109942446A (zh) | 一种普瑞巴林的制备方法 | |
| WO2012056468A1 (en) | A process for the preparation of bosentan | |
| US20070249839A1 (en) | Process for the Preparation of Losartan Potassium Form I | |
| CN111960989B (zh) | 一种4-溴咔唑制备方法 | |
| CN102020600B (zh) | 一种吲哚-2-羧酸的合成方法 | |
| US20110166351A1 (en) | Method for preparing 5-[2-(methylthio)ethoxy]pyrimidine-2-amine | |
| CN118930594A (zh) | 合成脱氧胸苷的方法 | |
| CN103965130B (zh) | 一种帕立骨化醇中间体的制备方法 | |
| CN102516156A (zh) | 一种2-（（1-苄基-4-哌啶基）-羟基-甲基）-5,6-二甲氧基-1-茚酮的合成方法 |