JP2011508657A - プロセス強化マイクロ流体装置 - Google Patents
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Abstract
Description
図4は、データ点が△で表された図3に示された本発明の実施の形態を、データ点が●で表された図2の装置と比較した、毎分のミリリットルで表された流量の関数としての平方メートルおよびケルビン毎のワットで表された、測定された全体の熱伝達係数のグラフである。図3に示された構造により生じた二次流動により、テストした全ての流量で約50から100W/m2Kの熱伝達の優位性が生じるのがこのグラフから分かる。テストした装置の両方とも、寸法と容量がほぼ同じであり、各場合における反応体通路の総内容積は5.6±0.1ミリリットルであった。それゆえ、熱交換性能は典型的に、流量と共に減少し、F1およびF2での反応体通路の分岐により、局部的な流量が2回、効果的に半分になるにもかかわらず、本発明の装置の優れた性能が明らかに確立されている。流量が少なくても改善された熱交換性能は、既にマイクロ流体装置である図2の比較の装置に対してさえ、本発明の装置により、プロセス強化が行われたことを示している。
図10A〜10Gは、特に、連続チャンバ34の他の採り得る形態を示す、本発明のいくつかの代わりの実施の形態による反応体通路の部分を画成する多数の代わりの壁構造の断面平面図である。先の実施の形態に示されたチャンバは、図10Fのものに概して対応し、ここで、支柱58が、潜在的に、図10Aの実施の形態におけるような大きな開放区域または「自由区域」を有するチャンバ34に対して、チャンバ34の圧力抵抗を増加させるように働くであろう。他方で、支柱58のない実施の形態は、支柱58の上流に小さな死空間(流体流パターンにおける遅く動く地点)を有する傾向が少ないであろう。図10Gの実施の形態は、分割・向直し壁44の下流側に三角形の受け構造60を含むことによって、死空間の全ての虞を実質的に避け、したがって、死空間の区域に収集して、反応体通路を詰まらせることのある、固体懸濁物などの固体または沈殿反応を取り扱うのに特に推奨される。
図13は、単一の装置の一部として配列された、図9に示されたものにおおよそ対応する本発明の様々な代わりの実施の形態による多数のテスト反応通路の断面平面図である。上述した混合テストを、図に示されたテスト反応通路70〜82の各々に行った。その結果が、図2の装置の比較テストと共に、以下の表Iに示されている。
12,14,24 容積
16,18,20,22 水平壁
26 反応体通路
34 チャンバ
40 出口
42 入口
44 分割・向直し壁
58 支柱
Claims (10)
- 少なくとも1つの反応体通路およびその中に画成された1つ以上の熱制御通路を備えたマイクロ流体装置であって、前記1つ以上の熱制御通路は、各々が壁により境が形成された2つの容積内に位置し、配置され、前記壁は略平面で互いに平行であり、前記反応体通路は、前記略平面の壁の間に位置し、該略平面の壁と該略平面の壁の間に延在する壁により画成され、前記反応体通路は多数の連続チャンバを備え、該チャンバの各々は、前記反応体通路を少なくとも2つの副通路に分割する分割部、および分割された前記副通路を合流させる合流部を備え、前記副通路の少なくとも一方の通路の方向の変化が少なくとも90度であることを特徴とするマイクロ流体装置。
- 前記多数のチャンバの別のものが直後に続くチャンバの各々が、前記連続したチャンバの対応して狭くなる入口を形成する徐々に狭くなる出口、および直ぐ上流の通路に交差するように向けられ、前記チャンバの入口のすぐ下流に位置する分割・向直し壁をさらに備え、該分割・向直し壁の上流側が窪んだ表面を有することを特徴とする請求項1記載のマイクロ流体装置。
- 前記通路の方向の変化が90度より大きいことを特徴とする請求項1または2記載のマイクロ流体装置。
- 前記通路の方向の変化が、前記副通路の少なくとも2つの通路の方向変化であることを特徴とする請求項1から3いずれか1項記載のマイクロ流体装置。
- 前記反応体通路が、前記略平面の壁に対して垂直な方向に一定の高さを有することを特徴とする請求項1から4いずれか1項記載のマイクロ流体装置。
- 前記反応体通路が、(1)開放容積、(2)前記略平面の壁の間に延在する壁の容積、および(3)前記略平面の壁の間の延在する壁の間の任意の他の容積からなる総容積の少なくとも40%の前記開放容積を有することを特徴とする請求項1から5いずれか1項記載のマイクロ流体装置。
- 前記少なくとも2つ副通路が、少なくとも2つの副通路および1つ以上の補助副通路を含むことを特徴とする請求項1から6いずれか1項記載のマイクロ流体装置。
- ガラス、ガラスセラミック、およびセラミックの内の少なくとも1種類以上から形成されることを特徴とする請求項1から7いずれか1項記載のマイクロ流体装置。
- 前記多数の連続チャンバが、前記反応体通路の容積の少なくとも50%に沿って延在することを特徴とする請求項1から8いずれか1項記載のマイクロ流体装置。
- 前記反応体通路が、少なくとも2つの分岐に1回以上分岐していることを特徴とする請求項1から9いずれか1項記載のマイクロ流体装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07301225A EP2017000B1 (en) | 2007-07-11 | 2007-07-11 | Process intensified microfluidic devices |
PCT/US2008/008535 WO2009009129A1 (en) | 2007-07-11 | 2008-07-11 | Process intensified microfluidic devices |
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JP2014056426A Division JP6204235B2 (ja) | 2007-07-11 | 2014-03-19 | プロセス強化マイクロ流体装置 |
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JP2011508657A true JP2011508657A (ja) | 2011-03-17 |
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Application Number | Title | Priority Date | Filing Date |
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JP2010516065A Pending JP2011508657A (ja) | 2007-07-11 | 2008-07-11 | プロセス強化マイクロ流体装置 |
JP2014056426A Active JP6204235B2 (ja) | 2007-07-11 | 2014-03-19 | プロセス強化マイクロ流体装置 |
JP2017166629A Active JP6674933B2 (ja) | 2007-07-11 | 2017-08-31 | プロセス強化マイクロ流体装置 |
JP2020039661A Active JP7049381B2 (ja) | 2007-07-11 | 2020-03-09 | プロセス強化マイクロ流体装置 |
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JP2014056426A Active JP6204235B2 (ja) | 2007-07-11 | 2014-03-19 | プロセス強化マイクロ流体装置 |
JP2017166629A Active JP6674933B2 (ja) | 2007-07-11 | 2017-08-31 | プロセス強化マイクロ流体装置 |
JP2020039661A Active JP7049381B2 (ja) | 2007-07-11 | 2020-03-09 | プロセス強化マイクロ流体装置 |
Country Status (13)
Country | Link |
---|---|
US (1) | US7939033B2 (ja) |
EP (1) | EP2017000B1 (ja) |
JP (4) | JP2011508657A (ja) |
KR (1) | KR101666635B1 (ja) |
CN (1) | CN101873890B (ja) |
AU (1) | AU2008275602A1 (ja) |
BR (1) | BRPI0813700A2 (ja) |
CA (1) | CA2693463A1 (ja) |
MX (1) | MX2010000485A (ja) |
RU (1) | RU2010104674A (ja) |
TW (1) | TWI363656B (ja) |
WO (1) | WO2009009129A1 (ja) |
ZA (1) | ZA201000944B (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2018505040A (ja) * | 2014-12-08 | 2018-02-22 | ロンザ リミテッドLonza Limited | 流体混合構造、連続反応ユニット、連続反応反応器、およびその使用方法 |
JP2020529309A (ja) * | 2017-07-31 | 2020-10-08 | コーニング インコーポレイテッド | 改善されたプロセス強化フローリアクタ |
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EP2017000B1 (en) * | 2007-07-11 | 2012-09-05 | Corning Incorporated | Process intensified microfluidic devices |
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HUE056621T2 (hu) | 2016-04-08 | 2022-03-28 | Ineos Europe Ag | Polimerizációs egység és polimerizációs eljárás |
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CN101873890A (zh) | 2010-10-27 |
BRPI0813700A2 (pt) | 2014-12-30 |
TW201107029A (en) | 2011-03-01 |
RU2010104674A (ru) | 2011-08-20 |
KR20100049060A (ko) | 2010-05-11 |
TWI363656B (en) | 2012-05-11 |
JP2014147930A (ja) | 2014-08-21 |
EP2017000B1 (en) | 2012-09-05 |
WO2009009129A1 (en) | 2009-01-15 |
CA2693463A1 (en) | 2009-01-15 |
JP6674933B2 (ja) | 2020-04-01 |
AU2008275602A1 (en) | 2009-01-15 |
JP2020114585A (ja) | 2020-07-30 |
ZA201000944B (en) | 2010-10-27 |
JP6204235B2 (ja) | 2017-09-27 |
MX2010000485A (es) | 2016-01-27 |
US7939033B2 (en) | 2011-05-10 |
JP2018051553A (ja) | 2018-04-05 |
CN101873890B (zh) | 2013-07-24 |
EP2017000A1 (en) | 2009-01-21 |
US20090028763A1 (en) | 2009-01-29 |
KR101666635B1 (ko) | 2016-10-14 |
JP7049381B2 (ja) | 2022-04-06 |
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