JP2011506941A5 - - Google Patents
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- Publication number
- JP2011506941A5 JP2011506941A5 JP2010537302A JP2010537302A JP2011506941A5 JP 2011506941 A5 JP2011506941 A5 JP 2011506941A5 JP 2010537302 A JP2010537302 A JP 2010537302A JP 2010537302 A JP2010537302 A JP 2010537302A JP 2011506941 A5 JP2011506941 A5 JP 2011506941A5
- Authority
- JP
- Japan
- Prior art keywords
- seprase
- cancer
- esophagus
- colon
- stomach
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 claims 15
- 108010072257 fibroblast activation protein alpha Proteins 0.000 claims 15
- 239000012634 fragment Substances 0.000 claims 13
- 229920001184 polypeptide Polymers 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 10
- 208000026900 bile duct neoplasm Diseases 0.000 claims 10
- 210000001072 colon Anatomy 0.000 claims 10
- 210000003238 esophagus Anatomy 0.000 claims 10
- 210000003128 head Anatomy 0.000 claims 10
- 210000004072 lung Anatomy 0.000 claims 10
- 210000003739 neck Anatomy 0.000 claims 10
- 230000000694 effects Effects 0.000 claims 6
- 108010036226 antigen CYFRA21.1 Proteins 0.000 claims 5
- 210000000013 bile duct Anatomy 0.000 claims 5
- 238000001514 detection method Methods 0.000 claims 5
- 208000014829 head and neck neoplasm Diseases 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 5
- 210000002784 stomach Anatomy 0.000 claims 5
- 201000000498 stomach carcinoma Diseases 0.000 claims 5
- 206010004593 Bile duct cancer Diseases 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 4
- 206010017758 gastric cancer Diseases 0.000 claims 4
- 208000026037 malignant tumor of neck Diseases 0.000 claims 4
- 201000011549 stomach cancer Diseases 0.000 claims 4
- 101000603202 Homo sapiens Nicotinamide N-methyltransferase Proteins 0.000 claims 3
- 102100038951 Nicotinamide N-methyltransferase Human genes 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- NJHLGKJQFKUSEA-UHFFFAOYSA-N n-[2-(4-hydroxyphenyl)ethyl]-n-methylnitrous amide Chemical compound O=NN(C)CCC1=CC=C(O)C=C1 NJHLGKJQFKUSEA-UHFFFAOYSA-N 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07023897.7 | 2007-12-10 | ||
| EP07023897A EP2071337A1 (en) | 2007-12-10 | 2007-12-10 | Seprase as a marker for cancer |
| EP08015310 | 2008-08-29 | ||
| EP08015310.9 | 2008-08-29 | ||
| PCT/EP2008/010385 WO2009074275A1 (en) | 2007-12-10 | 2008-12-08 | Seprase as a marker for cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011506941A JP2011506941A (ja) | 2011-03-03 |
| JP2011506941A5 true JP2011506941A5 (enExample) | 2011-10-06 |
| JP5563988B2 JP5563988B2 (ja) | 2014-07-30 |
Family
ID=40373548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010537302A Expired - Fee Related JP5563988B2 (ja) | 2007-12-10 | 2008-12-08 | 癌のマーカーとしてのセプラーゼ |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8980573B2 (enExample) |
| EP (1) | EP2223115B1 (enExample) |
| JP (1) | JP5563988B2 (enExample) |
| KR (1) | KR101202220B1 (enExample) |
| CN (1) | CN101896818B (enExample) |
| AT (1) | ATE524740T1 (enExample) |
| AU (1) | AU2008335855B2 (enExample) |
| BR (1) | BRPI0820793A2 (enExample) |
| CA (1) | CA2706115A1 (enExample) |
| DK (1) | DK2223115T3 (enExample) |
| ES (1) | ES2372442T3 (enExample) |
| MX (1) | MX2010004671A (enExample) |
| PL (1) | PL2223115T3 (enExample) |
| WO (1) | WO2009074275A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8213005B2 (en) | 2003-07-22 | 2012-07-03 | King Saud University | Method for discriminating between benign and malignant prostate tumors |
| WO2010000467A1 (en) * | 2008-07-03 | 2010-01-07 | F. Hoffmann-La Roche Ag | Asc as a marker for lung cancer |
| KR20120123056A (ko) | 2009-12-20 | 2012-11-07 | 아스튜트 메디컬 인코포레이티드 | 신손상 및 신부전을 진단 및 예측하는 방법 및 조성물 |
| EP2531620B1 (en) * | 2010-02-05 | 2016-12-14 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| AU2011316986A1 (en) * | 2010-10-20 | 2013-06-06 | Rush University Medical Center | Lung cancer tests |
| JP2014509736A (ja) * | 2011-03-11 | 2014-04-21 | エフ．ホフマン−ラ ロシュ アーゲー | 慢性閉塞性肺疾患（ｃｏｐｄ）のマーカーとしてのセプラーゼ |
| ES2578477T3 (es) * | 2011-03-11 | 2016-07-27 | Roche Diagniostics Gmbh | ASC como marcador de la enfermedad pulmonar obstructiva crónica (EPOC) |
| CN102435748B (zh) * | 2011-11-25 | 2014-07-16 | 广东药学院 | 一种双抗夹心酶联免疫检测试剂盒及其制备方法 |
| WO2013086359A1 (en) | 2011-12-08 | 2013-06-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| EA201492284A1 (ru) | 2012-06-27 | 2015-11-30 | Берг Ллк | Применение маркеров в диагностике и лечении рака предстательной железы |
| WO2014072465A1 (en) | 2012-11-09 | 2014-05-15 | Roche Diagnostics Gmbh | In vitro capture and analysis of circulating tumor cells |
| MX2015006757A (es) * | 2012-11-30 | 2015-11-30 | Applied Proteomics Inc | Método para la evaluación de la presencia de o riesgo de tumores de colon. |
| ES2681955T3 (es) | 2013-01-17 | 2018-09-17 | Astute Medical, Inc. | Métodos y composiciones para el diagnóstico y pronóstico de lesión renal e insuficiencia renal |
| US9753037B2 (en) | 2013-03-15 | 2017-09-05 | Rush University Medical Center | Biomarker panel for detecting lung cancer |
| CN103267852B (zh) * | 2013-05-15 | 2015-03-25 | 中国医学科学院北京协和医院 | 成纤维激活蛋白α在制备胰腺癌预后试剂盒中的用途 |
| KR101619122B1 (ko) | 2013-08-14 | 2016-05-10 | 연세대학교 산학협력단 | 탈메틸화 의존적 ａｓｃ 발현을 촉진시켜서 대장암 종양세포의 사멸감수성을 증진시키는 항암제 병용 투여용 후보물질의 스크리닝 방법 |
| EP3080299B1 (en) | 2013-12-09 | 2020-09-30 | Rush University Medical Center | Biomarkers of rapid progression in advanced non-small cell lung cancer |
| PL230661B1 (pl) * | 2014-01-29 | 2018-11-30 | Centrum Onkologii Inst Im Marii Sklodowskiej Curie Oddzial W Gliwicach | Metoda predykcyjna in vitro do przewidywania i/lub wykluczenia obecnosci raka pluc, zastosowanie in vitro metody predykcyjnej oraz zestaw testowy do wykrywania in vitro raka pluc |
| EP2916134B1 (en) * | 2014-03-05 | 2017-08-16 | Roche Diagnostics GmbH | Use of Seprase for differential diagnosis of acute dyspnea |
| EP4242329A3 (en) | 2014-12-08 | 2023-10-25 | Berg LLC | Use of markers including filamin a in the diagnosis and treatment of prostate cancer |
| WO2016146174A1 (en) * | 2015-03-17 | 2016-09-22 | Biontech Ag | Compositions and methods for diagnosis and treatment of cancer |
| EP3281016A1 (en) | 2015-04-10 | 2018-02-14 | Applied Proteomics Inc. | Protein biomarker panels for detecting colorectal cancer and advanced adenoma |
| JP2018035137A (ja) | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ | 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用 |
| CA3029926C (en) * | 2016-07-25 | 2023-01-03 | Shizuoka Prefecture | Diagnostic biomarker for extrahepatic bile duct cancer, intrahepatic bile duct cancer or gallbladder cancer |
| US20200237936A1 (en) | 2016-12-14 | 2020-07-30 | Purdue Research Foundation | Fibroblast activation protein (fap)-targeted imaging and therapy |
| DE102017010455A1 (de) * | 2017-06-13 | 2018-12-13 | Forschungszentrum Jülich GmbH | Verfahren zum Nachweis von Aggregaten biotherapeutischer Substanzen in einer Probe |
| US20210231669A1 (en) * | 2017-09-05 | 2021-07-29 | Oncotag Diagnotics Co., LTD | Method for diagnosing pancreatic cancer using methionyl-trna synthetase, and pancreatic cancer diagnostic kit using same |
| WO2022007283A1 (zh) * | 2020-07-08 | 2022-01-13 | 深圳霁因生物医药转化研究院 | 用于诊断fap表达异常相关疾病的试剂盒、方法及计算机可读存储介质 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0953639A1 (en) * | 1998-04-30 | 1999-11-03 | Boehringer Ingelheim International GmbH | FAPalpha-specific antibody with improved producibility |
| WO2005043121A2 (en) | 2003-10-31 | 2005-05-12 | Vitatex, Inc. | Blood test prototypes and methods for the detection of circulating tumor and endothelial cells |
| JP2008517914A (ja) * | 2004-10-22 | 2008-05-29 | ジェネンコー・インターナショナル・インク | ヒトの抗体の分離方法 |
| EP1760076A1 (en) * | 2005-09-02 | 2007-03-07 | Ferring B.V. | FAP Inhibitors |
| KR20150003157A (ko) * | 2005-12-19 | 2015-01-08 | 트러스티즈 오브 터프츠 칼리지 | 소프트 단백질분해효소 억제자 및 이의 프로-소프트 폼 |
-
2008
- 2008-12-08 ES ES08859952T patent/ES2372442T3/es active Active
- 2008-12-08 JP JP2010537302A patent/JP5563988B2/ja not_active Expired - Fee Related
- 2008-12-08 AT AT08859952T patent/ATE524740T1/de active
- 2008-12-08 CN CN200880119930.1A patent/CN101896818B/zh active Active
- 2008-12-08 KR KR1020107012678A patent/KR101202220B1/ko not_active Expired - Fee Related
- 2008-12-08 BR BRPI0820793-3A patent/BRPI0820793A2/pt not_active IP Right Cessation
- 2008-12-08 PL PL08859952T patent/PL2223115T3/pl unknown
- 2008-12-08 EP EP08859952A patent/EP2223115B1/en active Active
- 2008-12-08 WO PCT/EP2008/010385 patent/WO2009074275A1/en not_active Ceased
- 2008-12-08 AU AU2008335855A patent/AU2008335855B2/en not_active Ceased
- 2008-12-08 MX MX2010004671A patent/MX2010004671A/es active IP Right Grant
- 2008-12-08 CA CA2706115A patent/CA2706115A1/en not_active Abandoned
- 2008-12-08 DK DK08859952.7T patent/DK2223115T3/da active
-
2010
- 2010-06-02 US US12/791,946 patent/US8980573B2/en active Active
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