JP2011506400A5 - - Google Patents
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- Publication number
- JP2011506400A5 JP2011506400A5 JP2010537456A JP2010537456A JP2011506400A5 JP 2011506400 A5 JP2011506400 A5 JP 2011506400A5 JP 2010537456 A JP2010537456 A JP 2010537456A JP 2010537456 A JP2010537456 A JP 2010537456A JP 2011506400 A5 JP2011506400 A5 JP 2011506400A5
- Authority
- JP
- Japan
- Prior art keywords
- drug substance
- suspension
- solvent
- drug
- high pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940088679 drug related substance Drugs 0.000 description 13
- 239000008186 active pharmaceutical agent Substances 0.000 description 12
- 239000000725 suspension Substances 0.000 description 7
- 239000002245 particle Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 238000000265 homogenisation Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- VPNYRYCIDCJBOM-UHFFFAOYSA-M Glycopyrronium bromide Chemical compound [Br-].C1[N+](C)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 VPNYRYCIDCJBOM-UHFFFAOYSA-M 0.000 description 2
- 238000005054 agglomeration Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 229940015042 glycopyrrolate Drugs 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 239000012296 anti-solvent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- -1 it after drying Substances 0.000 description 1
- 238000010902 jet-milling Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07123165 | 2007-12-13 | ||
| PCT/EP2008/067364 WO2009074666A1 (en) | 2007-12-13 | 2008-12-11 | Organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011506400A JP2011506400A (ja) | 2011-03-03 |
| JP2011506400A5 true JP2011506400A5 (cg-RX-API-DMAC7.html) | 2012-02-16 |
Family
ID=39387173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010537456A Pending JP2011506400A (ja) | 2007-12-13 | 2008-12-11 | 有機化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100266696A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2229148B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2011506400A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20100095587A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101896165B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008334547B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0820745A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2707594C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2460576T3 (cg-RX-API-DMAC7.html) |
| PL (1) | PL2229148T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2229148E (cg-RX-API-DMAC7.html) |
| RU (1) | RU2496479C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009074666A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9469630B2 (en) | 2010-10-18 | 2016-10-18 | Sumitomo Dainippon Pharma Co., Ltd. | Sustained-release formulation for injection |
| CN103501791B (zh) * | 2011-05-03 | 2016-05-18 | 奇斯药制品公司 | 用于通过吸入给药的改良皮质类固醇悬浮制剂 |
| GB201307659D0 (en) | 2013-04-26 | 2013-06-12 | Korea Coast Guard Commissioner | Preparation of drug particles by micronisation |
| US9393202B2 (en) * | 2013-04-26 | 2016-07-19 | Chiesi Farmaceutici S.P.A | Particle size reduction of an antimuscarinic compound |
| PT107433B (pt) * | 2014-01-28 | 2018-12-04 | Hovione Farm S A | Processo de redução e controlo do tamanho de partícula |
| HRP20260435T1 (hr) | 2014-09-09 | 2026-05-08 | Vectura Limited | Formulacija koja sadrži glikopirolat, postupak i uređaj |
| CN106749008A (zh) * | 2015-11-23 | 2017-05-31 | 北京九和药业有限公司 | 一种马来酸茚达特罗的微粉化方法及其应用 |
| PT109030B (pt) | 2015-12-15 | 2019-09-25 | Hovione Farmaciência, S.A. | Preparação de partículas inaláveis de zafirlucaste |
| US9925168B2 (en) * | 2016-01-22 | 2018-03-27 | Chiesi Farmaceutici S.P.A. | Preparation of micronized particles of an antimuscarinic compound by hydrodynamic cavitation |
| ES2805434T3 (es) | 2016-07-29 | 2021-02-12 | Inke Sa | Procedimiento de estabilización de tamaño de partícula |
| CN112137957B (zh) * | 2019-06-26 | 2022-07-29 | 长风药业股份有限公司 | 一种药用吸入气雾剂及其制备方法 |
| US20240293317A1 (en) * | 2020-04-20 | 2024-09-05 | Board Of Regents, The University Of Texas System | Lipid nanoparticle (lnp) delivery systems and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4440337A1 (de) * | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
| IT1303692B1 (it) * | 1998-11-03 | 2001-02-23 | Chiesi Farma Spa | Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione. |
| GB0008660D0 (en) * | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
| GB0016040D0 (en) * | 2000-06-29 | 2000-08-23 | Glaxo Group Ltd | Novel process for preparing crystalline particles |
| EP2283817B1 (en) * | 2000-11-30 | 2016-05-18 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
| ITMI20020681A1 (it) * | 2002-03-29 | 2003-09-29 | Acs Dobfar Spa | Procedimento per la produzione di nanoparticelle di paclitaxel ed albumina |
| ITMI20022674A1 (it) * | 2002-12-18 | 2004-06-19 | Chiesi Farma Spa | Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione. |
| CA2559915C (en) * | 2004-03-23 | 2013-07-02 | Novartis Ag | Micronization of pharmaceutically active agents |
| GB0409703D0 (en) * | 2004-04-30 | 2004-06-02 | Vectura Ltd | Pharmaceutical compositions |
| CN101102740A (zh) * | 2005-01-07 | 2008-01-09 | 卫材R&D管理有限公司 | 药用组合物以及其制备方法 |
| EP2484382A1 (en) * | 2005-03-30 | 2012-08-08 | Schering Corporation | Medicament comprising a phosphodiesterase IV inhibitor in an inhalable form |
| RU2008108176A (ru) * | 2005-08-26 | 2009-10-10 | Астразенека Аб (Se) | Комбинация соединений, которая может быть применена в лечении респеративных заболеваний, особенно хронического обструктивного заболевания легких (copd) и астмы |
| US8530463B2 (en) * | 2007-05-07 | 2013-09-10 | Hale Biopharma Ventures Llc | Multimodal particulate formulations |
-
2008
- 2008-12-11 WO PCT/EP2008/067364 patent/WO2009074666A1/en not_active Ceased
- 2008-12-11 KR KR1020107012911A patent/KR20100095587A/ko not_active Ceased
- 2008-12-11 PT PT88594122T patent/PT2229148E/pt unknown
- 2008-12-11 CA CA2707594A patent/CA2707594C/en not_active Expired - Fee Related
- 2008-12-11 PL PL08859412T patent/PL2229148T3/pl unknown
- 2008-12-11 US US12/745,806 patent/US20100266696A1/en not_active Abandoned
- 2008-12-11 JP JP2010537456A patent/JP2011506400A/ja active Pending
- 2008-12-11 CN CN2008801205834A patent/CN101896165B/zh not_active Expired - Fee Related
- 2008-12-11 BR BRPI0820745-3A patent/BRPI0820745A2/pt not_active IP Right Cessation
- 2008-12-11 ES ES08859412.2T patent/ES2460576T3/es active Active
- 2008-12-11 EP EP08859412.2A patent/EP2229148B1/en not_active Revoked
- 2008-12-11 RU RU2010128248/15A patent/RU2496479C2/ru not_active IP Right Cessation
- 2008-12-11 AU AU2008334547A patent/AU2008334547B2/en not_active Ceased
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