RU2496479C2 - Органические соединения - Google Patents
Органические соединения Download PDFInfo
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- RU2496479C2 RU2496479C2 RU2010128248/15A RU2010128248A RU2496479C2 RU 2496479 C2 RU2496479 C2 RU 2496479C2 RU 2010128248/15 A RU2010128248/15 A RU 2010128248/15A RU 2010128248 A RU2010128248 A RU 2010128248A RU 2496479 C2 RU2496479 C2 RU 2496479C2
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- RU
- Russia
- Prior art keywords
- suspension
- particles
- particle size
- glycopyrrolate
- drug
- Prior art date
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- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-L malate(2-) Chemical compound [O-]C(=O)C(O)CC([O-])=O BJEPYKJPYRNKOW-UHFFFAOYSA-L 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 description 1
- 229950001768 milveterol Drugs 0.000 description 1
- 229960002744 mometasone furoate Drugs 0.000 description 1
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- KCEHVJZZIGJAAW-FERBBOLQSA-N olodaterol hydrochloride Chemical compound Cl.C1=CC(OC)=CC=C1CC(C)(C)NC[C@H](O)C1=CC(O)=CC2=C1OCC(=O)N2 KCEHVJZZIGJAAW-FERBBOLQSA-N 0.000 description 1
- 229960002657 orciprenaline Drugs 0.000 description 1
- 229960000797 oxitropium Drugs 0.000 description 1
- NVOYVOBDTVTBDX-PMEUIYRNSA-N oxitropium Chemical compound CC[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1 NVOYVOBDTVTBDX-PMEUIYRNSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960004017 salmeterol Drugs 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000002047 solid lipid nanoparticle Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 238000004441 surface measurement Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229960000195 terbutaline Drugs 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 description 1
- 229960000257 tiotropium bromide Drugs 0.000 description 1
- MQLXPRBEAHBZTK-SEINRUQRSA-M tiotropium bromide hydrate Chemical compound O.[Br-].C[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 MQLXPRBEAHBZTK-SEINRUQRSA-M 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000001238 wet grinding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Pyrrole Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07123165.8 | 2007-12-13 | ||
| EP07123165 | 2007-12-13 | ||
| PCT/EP2008/067364 WO2009074666A1 (en) | 2007-12-13 | 2008-12-11 | Organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010128248A RU2010128248A (ru) | 2012-01-20 |
| RU2496479C2 true RU2496479C2 (ru) | 2013-10-27 |
Family
ID=39387173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010128248/15A RU2496479C2 (ru) | 2007-12-13 | 2008-12-11 | Органические соединения |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100266696A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2229148B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2011506400A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20100095587A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101896165B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008334547B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0820745A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2707594C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2460576T3 (cg-RX-API-DMAC7.html) |
| PL (1) | PL2229148T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2229148E (cg-RX-API-DMAC7.html) |
| RU (1) | RU2496479C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009074666A1 (cg-RX-API-DMAC7.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2723549C2 (ru) * | 2016-01-22 | 2020-06-16 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Получение микронизированных частиц соли гликопиррония с помощью гидродинамической кавитации |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9469630B2 (en) | 2010-10-18 | 2016-10-18 | Sumitomo Dainippon Pharma Co., Ltd. | Sustained-release formulation for injection |
| CN103501791B (zh) * | 2011-05-03 | 2016-05-18 | 奇斯药制品公司 | 用于通过吸入给药的改良皮质类固醇悬浮制剂 |
| GB201307659D0 (en) | 2013-04-26 | 2013-06-12 | Korea Coast Guard Commissioner | Preparation of drug particles by micronisation |
| US9393202B2 (en) * | 2013-04-26 | 2016-07-19 | Chiesi Farmaceutici S.P.A | Particle size reduction of an antimuscarinic compound |
| PT107433B (pt) * | 2014-01-28 | 2018-12-04 | Hovione Farm S A | Processo de redução e controlo do tamanho de partícula |
| HRP20260435T1 (hr) | 2014-09-09 | 2026-05-08 | Vectura Limited | Formulacija koja sadrži glikopirolat, postupak i uređaj |
| CN106749008A (zh) * | 2015-11-23 | 2017-05-31 | 北京九和药业有限公司 | 一种马来酸茚达特罗的微粉化方法及其应用 |
| PT109030B (pt) | 2015-12-15 | 2019-09-25 | Hovione Farmaciência, S.A. | Preparação de partículas inaláveis de zafirlucaste |
| ES2805434T3 (es) | 2016-07-29 | 2021-02-12 | Inke Sa | Procedimiento de estabilización de tamaño de partícula |
| CN112137957B (zh) * | 2019-06-26 | 2022-07-29 | 长风药业股份有限公司 | 一种药用吸入气雾剂及其制备方法 |
| US20240293317A1 (en) * | 2020-04-20 | 2024-09-05 | Board Of Regents, The University Of Texas System | Lipid nanoparticle (lnp) delivery systems and uses thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004054545A1 (en) * | 2002-12-18 | 2004-07-01 | Chiesi Farmaceutici S.P.A. | Preparation of sterile aqueous suspensions comprising micronised crystalline active ingredients for inhalation |
| WO2005089718A2 (en) * | 2004-03-23 | 2005-09-29 | Novartis Ag | Pharmaceutical compositions |
| WO2005105043A2 (en) * | 2004-04-30 | 2005-11-10 | Vectura Limited | Pharmaceutical compositions |
| WO2006105401A2 (en) * | 2005-03-30 | 2006-10-05 | Schering Corporation | Medicaments and methods combining an anticholinergic, a corticosteroid, and a long acting beta agonist |
| EP1834624A1 (en) * | 2005-01-07 | 2007-09-19 | Eisai R&D Management Co., Ltd. | Medicinal composition and process for producing the same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4440337A1 (de) * | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
| IT1303692B1 (it) * | 1998-11-03 | 2001-02-23 | Chiesi Farma Spa | Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione. |
| GB0008660D0 (en) * | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
| GB0016040D0 (en) * | 2000-06-29 | 2000-08-23 | Glaxo Group Ltd | Novel process for preparing crystalline particles |
| EP2283817B1 (en) * | 2000-11-30 | 2016-05-18 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
| ITMI20020681A1 (it) * | 2002-03-29 | 2003-09-29 | Acs Dobfar Spa | Procedimento per la produzione di nanoparticelle di paclitaxel ed albumina |
| RU2008108176A (ru) * | 2005-08-26 | 2009-10-10 | Астразенека Аб (Se) | Комбинация соединений, которая может быть применена в лечении респеративных заболеваний, особенно хронического обструктивного заболевания легких (copd) и астмы |
| US8530463B2 (en) * | 2007-05-07 | 2013-09-10 | Hale Biopharma Ventures Llc | Multimodal particulate formulations |
-
2008
- 2008-12-11 WO PCT/EP2008/067364 patent/WO2009074666A1/en not_active Ceased
- 2008-12-11 KR KR1020107012911A patent/KR20100095587A/ko not_active Ceased
- 2008-12-11 PT PT88594122T patent/PT2229148E/pt unknown
- 2008-12-11 CA CA2707594A patent/CA2707594C/en not_active Expired - Fee Related
- 2008-12-11 PL PL08859412T patent/PL2229148T3/pl unknown
- 2008-12-11 US US12/745,806 patent/US20100266696A1/en not_active Abandoned
- 2008-12-11 JP JP2010537456A patent/JP2011506400A/ja active Pending
- 2008-12-11 CN CN2008801205834A patent/CN101896165B/zh not_active Expired - Fee Related
- 2008-12-11 BR BRPI0820745-3A patent/BRPI0820745A2/pt not_active IP Right Cessation
- 2008-12-11 ES ES08859412.2T patent/ES2460576T3/es active Active
- 2008-12-11 EP EP08859412.2A patent/EP2229148B1/en not_active Revoked
- 2008-12-11 RU RU2010128248/15A patent/RU2496479C2/ru not_active IP Right Cessation
- 2008-12-11 AU AU2008334547A patent/AU2008334547B2/en not_active Ceased
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004054545A1 (en) * | 2002-12-18 | 2004-07-01 | Chiesi Farmaceutici S.P.A. | Preparation of sterile aqueous suspensions comprising micronised crystalline active ingredients for inhalation |
| WO2005089718A2 (en) * | 2004-03-23 | 2005-09-29 | Novartis Ag | Pharmaceutical compositions |
| WO2005105043A2 (en) * | 2004-04-30 | 2005-11-10 | Vectura Limited | Pharmaceutical compositions |
| EP1834624A1 (en) * | 2005-01-07 | 2007-09-19 | Eisai R&D Management Co., Ltd. | Medicinal composition and process for producing the same |
| WO2006105401A2 (en) * | 2005-03-30 | 2006-10-05 | Schering Corporation | Medicaments and methods combining an anticholinergic, a corticosteroid, and a long acting beta agonist |
Non-Patent Citations (1)
| Title |
|---|
| HECQ J. Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine // International journal of pharmaceutics 299, 2005, pp.167-177. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2723549C2 (ru) * | 2016-01-22 | 2020-06-16 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Получение микронизированных частиц соли гликопиррония с помощью гидродинамической кавитации |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2707594A1 (en) | 2009-06-18 |
| BRPI0820745A2 (pt) | 2015-06-16 |
| EP2229148A1 (en) | 2010-09-22 |
| KR20100095587A (ko) | 2010-08-31 |
| EP2229148B1 (en) | 2014-03-05 |
| ES2460576T3 (es) | 2014-05-13 |
| CN101896165A (zh) | 2010-11-24 |
| WO2009074666A1 (en) | 2009-06-18 |
| CA2707594C (en) | 2015-08-18 |
| AU2008334547A1 (en) | 2009-06-18 |
| RU2010128248A (ru) | 2012-01-20 |
| PT2229148E (pt) | 2014-05-26 |
| US20100266696A1 (en) | 2010-10-21 |
| AU2008334547B2 (en) | 2011-06-30 |
| CN101896165B (zh) | 2013-07-17 |
| PL2229148T3 (pl) | 2014-08-29 |
| JP2011506400A (ja) | 2011-03-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20171212 |