JP2011505336A - 骨髄異形成症候群治療のためのシチジンアナログ - Google Patents

骨髄異形成症候群治療のためのシチジンアナログ Download PDF

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JP2011505336A
JP2011505336A JP2010532071A JP2010532071A JP2011505336A JP 2011505336 A JP2011505336 A JP 2011505336A JP 2010532071 A JP2010532071 A JP 2010532071A JP 2010532071 A JP2010532071 A JP 2010532071A JP 2011505336 A JP2011505336 A JP 2011505336A
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patients
aza
azacitidine
azacytidine
treatment
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JP2011505336A5 (https=
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シー．エル．ベアクフ
トホマス バククストロム ジャイ
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Celgene Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2010532071A 2007-11-01 2008-11-03 骨髄異形成症候群治療のためのシチジンアナログ Pending JP2011505336A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US98463807P 2007-11-01 2007-11-01
US99278107P 2007-12-06 2007-12-06
US3409308P 2008-03-05 2008-03-05
US8606908P 2008-08-04 2008-08-04
US9085208P 2008-08-21 2008-08-21
PCT/US2008/012430 WO2009058394A1 (en) 2007-11-01 2008-11-03 Cytidine analogs for treatment of myelodysplastic syndromes

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JP2011505336A true JP2011505336A (ja) 2011-02-24
JP2011505336A5 JP2011505336A5 (https=) 2011-12-22

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US (1) US20100311683A1 (https=)
EP (1) EP2211870A1 (https=)
JP (1) JP2011505336A (https=)
CA (1) CA2742252A1 (https=)
WO (1) WO2009058394A1 (https=)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
JP2023504857A (ja) * 2019-12-06 2023-02-07 ナネクサ・アクチボラグ 医薬組成物の製造のための新規プロセス
JP2023548111A (ja) * 2020-10-27 2023-11-15 ブイオーアール バイオファーマ インコーポレーテッド 造血悪性腫瘍を治療するための組成物および方法

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US8404716B2 (en) 2002-10-15 2013-03-26 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
US11116782B2 (en) 2002-10-15 2021-09-14 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
CA2545942C (en) 2003-11-14 2012-07-10 Lorus Therapeutics Inc. Aryl imidazoles and their use as anti-cancer agents
PL3692983T3 (pl) * 2008-05-15 2021-12-27 Celgene Corporation Doustne formulacje analogów cytydyny i sposoby ich zastosowania
US8492361B2 (en) 2009-02-10 2013-07-23 Celgene Corporation Methods for treating non-small cell lung cancer using 5-azacytidine
CN103619864A (zh) 2011-03-31 2014-03-05 细胞基因国际有限公司 5-氮杂胞苷的合成
WO2013022872A1 (en) * 2011-08-10 2013-02-14 Celgene Corporation Gene methylation biomarkers and methods of use thereof
TW201700103A (zh) 2011-11-01 2017-01-01 西建公司 利用胞嘧啶核苷類似物之口服配方治療癌症的方法
KR101987861B1 (ko) 2011-11-03 2019-06-11 밀레니엄 파머슈티컬스 인코퍼레이티드 Nedd-8 활성화 효소 억제제 및 저메틸화제의 투여
US9493500B2 (en) * 2012-07-19 2016-11-15 Richard Daifuku Fluorinated pyrimidine analogs and methods of use thereof
JP6431520B2 (ja) * 2013-03-15 2018-11-28 エピジェネティクス・ファーマ・エルエルシー フッ化ピリミジン類縁体及びその使用方法
WO2015051304A1 (en) 2013-10-04 2015-04-09 Aptose Biosciences Inc. Compositions, biomarkers and their use in treatment of cancer
AU2015305449B2 (en) 2014-08-22 2021-05-06 Celgene Corporation Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
US20190054103A1 (en) * 2016-02-26 2019-02-21 Epigenetics Pharma, Llc Method of treatment of tp53 wild-type tumors with 2',2'-difluoro-5-aza-2'-deoxycytidine or prodrugs thereof
WO2017189647A1 (en) * 2016-04-26 2017-11-02 Memorial Sloan Kettering Cancer Center Methods and compositions for the treatment of myelodysplastic syndrome
WO2019089511A1 (en) 2017-10-30 2019-05-09 Aptose Biosciences Inc. Aryl imidazoles for the treatment of cancer

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WO2006063111A2 (en) * 2004-12-10 2006-06-15 Supergen, Inc. Pharmaceutical formulations cytidine analogs and derivatives
JP2010502602A (ja) * 2006-08-30 2010-01-28 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法

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US6096757A (en) * 1998-12-21 2000-08-01 Schering Corporation Method for treating proliferative diseases
CN1342146A (zh) * 1999-03-18 2002-03-27 塞尔基因公司 取代的1－氧代－和1,3－二氧代异吲哚啉及其在用于减少炎性细胞因子含量的药物组合物中的用途
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US7968569B2 (en) * 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
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JP2010502602A (ja) * 2006-08-30 2010-01-28 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023504857A (ja) * 2019-12-06 2023-02-07 ナネクサ・アクチボラグ 医薬組成物の製造のための新規プロセス
JP7828278B2 (ja) 2019-12-06 2026-03-11 ナネクサ・アクチボラグ 医薬組成物の製造のための新規プロセス
JP2023548111A (ja) * 2020-10-27 2023-11-15 ブイオーアール バイオファーマ インコーポレーテッド 造血悪性腫瘍を治療するための組成物および方法

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US20100311683A1 (en) 2010-12-09
CA2742252A1 (en) 2009-05-07
WO2009058394A1 (en) 2009-05-07

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