JP2011504874A5 - - Google Patents

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Publication number
JP2011504874A5
JP2011504874A5 JP2010520356A JP2010520356A JP2011504874A5 JP 2011504874 A5 JP2011504874 A5 JP 2011504874A5 JP 2010520356 A JP2010520356 A JP 2010520356A JP 2010520356 A JP2010520356 A JP 2010520356A JP 2011504874 A5 JP2011504874 A5 JP 2011504874A5
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JP
Japan
Prior art keywords
vertebrate
target gene
chylomicron
nucleic acid
gene expression
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JP2010520356A
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English (en)
Japanese (ja)
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JP2011504874A (ja
JP5429884B2 (ja
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Priority claimed from PCT/JP2008/003523 external-priority patent/WO2009069313A1/en
Publication of JP2011504874A publication Critical patent/JP2011504874A/ja
Publication of JP2011504874A5 publication Critical patent/JP2011504874A5/ja
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JP2010520356A 2007-11-28 2008-11-28 内因性カイロミクロンを利用した、標的遺伝子の発現を抑制する核酸のデリバリーシステム Active JP5429884B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99079607P 2007-11-28 2007-11-28
US60/990,796 2007-11-28
PCT/JP2008/003523 WO2009069313A1 (en) 2007-11-28 2008-11-28 System for delivering nucleic acids for suppressing target gene expression by utilizing endogenous chylomicron

Publications (3)

Publication Number Publication Date
JP2011504874A JP2011504874A (ja) 2011-02-17
JP2011504874A5 true JP2011504874A5 (https=) 2012-01-19
JP5429884B2 JP5429884B2 (ja) 2014-02-26

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JP2010520356A Active JP5429884B2 (ja) 2007-11-28 2008-11-28 内因性カイロミクロンを利用した、標的遺伝子の発現を抑制する核酸のデリバリーシステム

Country Status (5)

Country Link
US (2) US8329670B2 (https=)
EP (1) EP2215229B1 (https=)
JP (1) JP5429884B2 (https=)
CN (1) CN101874111B (https=)
WO (1) WO2009069313A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2606910B1 (en) * 2010-08-20 2018-10-17 National University Corporation Tokyo Medical and Dental University Pharmaceutical composition for transcolonic absorption
CN102198276B (zh) * 2011-04-01 2013-03-27 山西医科大学 乳糜微粒作为肝脏靶向基因治疗载体的应用
CN102198277A (zh) * 2011-04-01 2011-09-28 山西医科大学 一种基因治疗肝癌的双靶向性载体及其制备方法
WO2014187315A1 (zh) * 2013-05-21 2014-11-27 成都先导药物开发有限公司 一种化合物给药前体及药物载体制剂
CN104178515B (zh) * 2013-05-21 2018-08-31 成都先导药物开发有限公司 一种化合物的细胞透膜的方法
EP3063317B1 (en) 2013-10-28 2020-06-03 DOTS Technology Corp. Allergen detection
JP2015199264A (ja) 2014-04-08 2015-11-12 ブラザー工業株式会社 液体吐出装置
US10487103B2 (en) 2015-03-24 2019-11-26 Gifu University Oligonucleotide derivative, oligonucleotide construct using the same, and methods for producing them
WO2017094745A1 (ja) * 2015-12-01 2017-06-08 国立大学法人大阪大学 核酸を含む経腸投与用組成物
JP7692829B2 (ja) 2019-07-30 2025-06-16 塩野義製薬株式会社 Ｍｕｒｆ１を標的とする核酸医薬

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4331670A1 (de) * 1993-09-17 1995-03-23 Hoechst Ag Neue Antisense-Oligonucleotide gegen HSV-1 sowie deren Herstellung
DE4338704A1 (de) * 1993-11-12 1995-05-18 Hoechst Ag Stabilisierte Oligonucleotide und deren Verwendung
US6251433B1 (en) * 1996-08-13 2001-06-26 Chiron Corporation Polycationic polymers
AU2004275876B2 (en) * 2003-09-25 2011-03-31 Coley Pharmaceutical Gmbh Nucleic acid-lipophilic conjugates
JP2005168485A (ja) 2003-11-20 2005-06-30 Tsutomu Suzuki ｓｉＲＮＡの設計方法
JP4706019B2 (ja) 2005-07-08 2011-06-22 国立大学法人東京農工大学 アプタマーの同定方法

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