JP2011504874A5 - - Google Patents

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Publication number
JP2011504874A5
JP2011504874A5 JP2010520356A JP2010520356A JP2011504874A5 JP 2011504874 A5 JP2011504874 A5 JP 2011504874A5 JP 2010520356 A JP2010520356 A JP 2010520356A JP 2010520356 A JP2010520356 A JP 2010520356A JP 2011504874 A5 JP2011504874 A5 JP 2011504874A5
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JP
Japan
Prior art keywords
vertebrate
target gene
chylomicron
nucleic acid
gene expression
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JP2010520356A
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English (en)
Japanese (ja)
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JP5429884B2 (ja
JP2011504874A (ja
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Priority claimed from PCT/JP2008/003523 external-priority patent/WO2009069313A1/en
Publication of JP2011504874A publication Critical patent/JP2011504874A/ja
Publication of JP2011504874A5 publication Critical patent/JP2011504874A5/ja
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Publication of JP5429884B2 publication Critical patent/JP5429884B2/ja
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JP2010520356A 2007-11-28 2008-11-28 内因性カイロミクロンを利用した、標的遺伝子の発現を抑制する核酸のデリバリーシステム Active JP5429884B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99079607P 2007-11-28 2007-11-28
US60/990,796 2007-11-28
PCT/JP2008/003523 WO2009069313A1 (en) 2007-11-28 2008-11-28 System for delivering nucleic acids for suppressing target gene expression by utilizing endogenous chylomicron

Publications (3)

Publication Number Publication Date
JP2011504874A JP2011504874A (ja) 2011-02-17
JP2011504874A5 true JP2011504874A5 (https=) 2012-01-19
JP5429884B2 JP5429884B2 (ja) 2014-02-26

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ID=40678225

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Application Number Title Priority Date Filing Date
JP2010520356A Active JP5429884B2 (ja) 2007-11-28 2008-11-28 内因性カイロミクロンを利用した、標的遺伝子の発現を抑制する核酸のデリバリーシステム

Country Status (5)

Country Link
US (2) US8329670B2 (https=)
EP (1) EP2215229B1 (https=)
JP (1) JP5429884B2 (https=)
CN (1) CN101874111B (https=)
WO (1) WO2009069313A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9731025B2 (en) 2010-08-20 2017-08-15 National University Corporation Tokyo Medical And Dental University Pharmaceutical composition for transcolonic absorption
CN102198276B (zh) * 2011-04-01 2013-03-27 山西医科大学 乳糜微粒作为肝脏靶向基因治疗载体的应用
CN102198277A (zh) * 2011-04-01 2011-09-28 山西医科大学 一种基因治疗肝癌的双靶向性载体及其制备方法
EP3029059B1 (en) * 2013-05-21 2018-07-04 Hitgen Ltd. Compound administration precursor and medicament carrier preparation
WO2014187313A1 (zh) * 2013-05-21 2014-11-27 成都先导药物开发有限公司 一种化合物的细胞透膜的方法
WO2015066027A2 (en) 2013-10-28 2015-05-07 Dots Devices, Inc. Allergen detection
JP2015199264A (ja) 2014-04-08 2015-11-12 ブラザー工業株式会社 液体吐出装置
WO2016152980A1 (ja) * 2015-03-24 2016-09-29 国立大学法人岐阜大学 オリゴヌクレオチド誘導体及びそれを用いたオリゴヌクレオチド構築物並びにそれらの製造方法
WO2017094745A1 (ja) * 2015-12-01 2017-06-08 国立大学法人大阪大学 核酸を含む経腸投与用組成物
WO2021020412A1 (ja) 2019-07-30 2021-02-04 塩野義製薬株式会社 Ｍｕｒｆ１を標的とする核酸医薬

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4331670A1 (de) * 1993-09-17 1995-03-23 Hoechst Ag Neue Antisense-Oligonucleotide gegen HSV-1 sowie deren Herstellung
DE4338704A1 (de) * 1993-11-12 1995-05-18 Hoechst Ag Stabilisierte Oligonucleotide und deren Verwendung
JP4320054B2 (ja) * 1996-08-13 2009-08-26 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド ポリヌクレオチド送達のための組成物および方法
CA2536139A1 (en) * 2003-09-25 2005-04-07 Coley Pharmaceutical Group, Inc. Nucleic acid-lipophilic conjugates
JP2005168485A (ja) 2003-11-20 2005-06-30 Tsutomu Suzuki ｓｉＲＮＡの設計方法
JP4706019B2 (ja) 2005-07-08 2011-06-22 国立大学法人東京農工大学 アプタマーの同定方法

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