JP2011504375A5 - - Google Patents
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- Publication number
- JP2011504375A5 JP2011504375A5 JP2010535876A JP2010535876A JP2011504375A5 JP 2011504375 A5 JP2011504375 A5 JP 2011504375A5 JP 2010535876 A JP2010535876 A JP 2010535876A JP 2010535876 A JP2010535876 A JP 2010535876A JP 2011504375 A5 JP2011504375 A5 JP 2011504375A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- seq
- complex
- spacer
- conjugate according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical group 0.000 claims 20
- 108020004707 nucleic acids Proteins 0.000 claims 18
- 102000039446 nucleic acids Human genes 0.000 claims 18
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 239000002131 composite material Substances 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 125000006850 spacer group Chemical group 0.000 claims 5
- 230000026683 transduction Effects 0.000 claims 5
- 238000010361 transduction Methods 0.000 claims 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 3
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 108091027967 Small hairpin RNA Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 125000002091 cationic group Chemical group 0.000 claims 2
- 239000006143 cell culture medium Substances 0.000 claims 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 2
- 239000004055 small Interfering RNA Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 108020005544 Antisense RNA Proteins 0.000 claims 1
- 108091028075 Circular RNA Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 108091007494 Nucleic acid- binding domains Proteins 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- 108010039918 Polylysine Proteins 0.000 claims 1
- 108020005093 RNA Precursors Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 239000003184 complementary RNA Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229920000724 poly(L-arginine) polymer Polymers 0.000 claims 1
- 108010011110 polyarginine Proteins 0.000 claims 1
- 229920000656 polylysine Polymers 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99012407P | 2007-11-26 | 2007-11-26 | |
| PCT/KR2008/006962 WO2009069935A2 (en) | 2007-11-26 | 2008-11-26 | Pharmaceutical compositions and methods for delivering nucleic acids into cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011504375A JP2011504375A (ja) | 2011-02-10 |
| JP2011504375A5 true JP2011504375A5 (enExample) | 2012-01-05 |
Family
ID=40679127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010535876A Pending JP2011504375A (ja) | 2007-11-26 | 2008-11-26 | 細胞の中に核酸を導入する医薬組成物及びその方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7981446B2 (enExample) |
| EP (1) | EP2220228A4 (enExample) |
| JP (1) | JP2011504375A (enExample) |
| KR (1) | KR20100109912A (enExample) |
| WO (1) | WO2009069935A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602006016468D1 (de) * | 2005-11-04 | 2010-10-07 | Forhumantech Co Ltd | Verfahren zur abgabe von fusionspolypeptid in eine zelle |
| WO2011133112A1 (en) * | 2010-04-20 | 2011-10-27 | National University Of Singapore | Cell penetrating peptide derived from the premembrane protein of flavivirus |
| WO2013044116A1 (en) * | 2011-09-21 | 2013-03-28 | Yale University | Antimicrobial compositions and methods of use thereof |
| CN103088065B (zh) * | 2013-01-25 | 2014-12-10 | 北京银杏德济生物技术有限公司 | 一种能够大规模并快速高纯度地诱导间充质干细胞转决定成造血干细胞的方法 |
| EP3429567B1 (en) | 2016-03-16 | 2024-01-10 | The J. David Gladstone Institutes | Methods and compositions for treating obesity and/or diabetes and for identifying candidate treatment agents |
| GR1010063B (el) * | 2019-11-11 | 2021-08-20 | Αριστοτελειο Πανεπιστημιο Θεσσαλονικης-Ειδικος Λογαριασμος Κονδυλιων Ερευνας | Μεθοδος για την αναπτυξη μιας πλατφορμας για την παραγωγη δυναμενων για μεταφορα μεσω πεπτιδιου μεταγωγης (ptd), in vitro μεταγραφομενων (ivt) mrna θεραπευτικων |
| CN114644686B (zh) * | 2022-03-24 | 2023-09-05 | 中国人民解放军陆军军医大学 | 一种用于dna疫苗递送系统及其应用和dna疫苗 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4651893A (en) * | 1992-06-26 | 1994-01-24 | Immunex Corporation | Novel tyrosine kinase |
| US6103521A (en) * | 1995-02-06 | 2000-08-15 | Cell Genesys, Inc. | Multispecific chimeric receptors |
| US6051429A (en) * | 1995-06-07 | 2000-04-18 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
| US6166191A (en) * | 1996-08-23 | 2000-12-26 | Chiron Corporation | Human polyhomeotic 1(HPH1) acts as an oncogene |
| JP2002511885A (ja) * | 1997-07-24 | 2002-04-16 | ザ パーキン―エルマー コーポレーション | 脂質膜を横切る輸送のための膜透過性構築物 |
| HUP0103329A3 (en) * | 1998-08-25 | 2003-09-29 | Lexigen Pharmaceuticals Corp L | Expression and export of angiostatin and endostatin as immunofusis |
| US6251599B1 (en) * | 1998-11-06 | 2001-06-26 | Selective Genetics, Inc. | Stabilized nucleic acid compositions and methods of preparation and use thereof |
| US6903077B1 (en) * | 1999-01-04 | 2005-06-07 | University Of Vermont And State Agricultural College | Methods and products for delivering nucleic acids |
| US20030104622A1 (en) * | 1999-09-01 | 2003-06-05 | Robbins Paul D. | Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses |
| EP1235914A2 (en) * | 1999-11-24 | 2002-09-04 | Joseph Rosenecker | Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells |
| NZ524386A (en) * | 2000-08-25 | 2005-10-28 | Aventis Pharma Inc | Membrane penetrating peptides and uses thereof |
| GB0103110D0 (en) * | 2000-08-25 | 2001-03-28 | Aventis Pharma Inc | A membrane penetrating peptide encoded by a nuclear localization sequence from human period 1 |
| US7332474B2 (en) * | 2001-10-11 | 2008-02-19 | Amgen Inc. | Peptides and related compounds having thrombopoietic activity |
| KR20030062788A (ko) * | 2002-01-19 | 2003-07-28 | 포휴먼텍(주) | 생체분자 전달 펩타이드 ｍｐｈ1-ｂｔｍ 및 이것을포함하는 생명공학제품 |
| KR20030062789A (ko) | 2002-01-19 | 2003-07-28 | 포휴먼텍(주) | 생체분자 전달 펩타이드 ｓｉｍ2-ｂｔｍ 및 이것을포함하는 생명공학제품 |
| KR100591936B1 (ko) * | 2002-11-12 | 2006-06-22 | 포휴먼텍(주) | 세포내 ｄｎａ／ｒｎａ 전달 방법, 및 이것의 기초 및임상학적 응용 |
| US7166692B2 (en) | 2003-03-04 | 2007-01-23 | Canbrex Bio Science Walkersville, Inc. | Intracellular delivery of small molecules, proteins, and nucleic acids |
| ES2694574T3 (es) * | 2003-05-01 | 2018-12-21 | Cornell Research Foundation, Inc. | Método y complejos portadores para suministrar moléculas a células |
| CA2526506A1 (en) * | 2003-06-09 | 2004-12-16 | Boehringer Ingelheim International Gmbh | Inhibitors of papilloma virus |
| WO2004113497A2 (en) * | 2003-06-09 | 2004-12-29 | University Of Florida | Gene delivery to tumors |
| CA2545653C (en) * | 2003-11-21 | 2014-07-08 | Anp Technologies, Inc. | Asymmetrically branched polymer conjugates and microarray assays |
| US20060035815A1 (en) * | 2004-05-04 | 2006-02-16 | Nastech Pharmaceutical Company Inc. | Pharmaceutical compositions for delivery of ribonucleic acid to a cell |
| US20060024331A1 (en) * | 2004-08-02 | 2006-02-02 | Ester Fernandez-Salas | Toxin compounds with enhanced membrane translocation characteristics |
| DE602006016468D1 (de) | 2005-11-04 | 2010-10-07 | Forhumantech Co Ltd | Verfahren zur abgabe von fusionspolypeptid in eine zelle |
| EP1797901A1 (en) * | 2005-12-16 | 2007-06-20 | Diatos | Cell penetrating peptide conjugates for delivering nucleic acids into cells |
| KR101574630B1 (ko) * | 2006-07-24 | 2015-12-07 | (주)앰브로시아 | 허혈성 질환의 완화 및 치료를 위한 약학 조성물 및 그를 전달하기 위한 방법 |
| CN101511872A (zh) * | 2006-08-29 | 2009-08-19 | 为人技术株式会社 | 用于抑制凋亡的药物组合物及其递送方法 |
| KR20080076622A (ko) * | 2007-02-16 | 2008-08-20 | 포항공과대학교 산학협력단 | 올리고머화된 단백질 전달체와 이를 이용한 세포내바이러스 벡터 전달 방법 |
-
2008
- 2008-11-24 US US12/277,000 patent/US7981446B2/en not_active Expired - Fee Related
- 2008-11-26 EP EP08854303A patent/EP2220228A4/en not_active Withdrawn
- 2008-11-26 WO PCT/KR2008/006962 patent/WO2009069935A2/en not_active Ceased
- 2008-11-26 JP JP2010535876A patent/JP2011504375A/ja active Pending
- 2008-11-26 KR KR1020107013994A patent/KR20100109912A/ko not_active Withdrawn
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