JP2011504104A5 - - Google Patents
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- Publication number
- JP2011504104A5 JP2011504104A5 JP2010533510A JP2010533510A JP2011504104A5 JP 2011504104 A5 JP2011504104 A5 JP 2011504104A5 JP 2010533510 A JP2010533510 A JP 2010533510A JP 2010533510 A JP2010533510 A JP 2010533510A JP 2011504104 A5 JP2011504104 A5 JP 2011504104A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- pharmaceutical composition
- poxvirus
- permease
- suicide gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 26
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 230000000694 effects Effects 0.000 claims 7
- 108090000301 Membrane transport proteins Proteins 0.000 claims 4
- 102000003939 Membrane transport proteins Human genes 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 102000000311 Cytosine Deaminase Human genes 0.000 claims 3
- 108010080611 Cytosine Deaminase Proteins 0.000 claims 3
- 241000700618 Vaccinia virus Species 0.000 claims 3
- 230000002950 deficient Effects 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 101100502554 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) FCY1 gene Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000002997 osteoclast Anatomy 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 108091000036 uracil phosphoribosyltransferase Proteins 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 101100226898 Candida albicans (strain SC5314 / ATCC MYA-2876) FCA1 gene Proteins 0.000 claims 1
- 108050000190 Cytosine permeases Proteins 0.000 claims 1
- 101000807008 Homo sapiens Uracil phosphoribosyltransferase homolog Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 101100502558 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) FCY2 gene Proteins 0.000 claims 1
- 102100037717 Uracil phosphoribosyltransferase homolog Human genes 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108010087864 purine permease Proteins 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07301557.0 | 2007-11-19 | ||
| EP07301557 | 2007-11-19 | ||
| PCT/EP2008/009720 WO2009065546A1 (en) | 2007-11-19 | 2008-11-17 | Poxviral oncolytic vectors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011504104A JP2011504104A (ja) | 2011-02-03 |
| JP2011504104A5 true JP2011504104A5 (enExample) | 2011-12-08 |
| JP5710261B2 JP5710261B2 (ja) | 2015-04-30 |
Family
ID=40377657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010533510A Active JP5710261B2 (ja) | 2007-11-19 | 2008-11-17 | ポックスウイルス腫瘍細胞崩壊性ベクター |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US8778328B2 (enExample) |
| EP (1) | EP2212345B1 (enExample) |
| JP (1) | JP5710261B2 (enExample) |
| KR (1) | KR101542276B1 (enExample) |
| CN (2) | CN102703389B (enExample) |
| AU (1) | AU2008328257B2 (enExample) |
| BR (1) | BRPI0820576B1 (enExample) |
| CA (1) | CA2705869C (enExample) |
| CO (1) | CO6210754A2 (enExample) |
| CR (1) | CR11519A (enExample) |
| DK (1) | DK2212345T3 (enExample) |
| EC (1) | ECSP10010288A (enExample) |
| ES (1) | ES2567564T3 (enExample) |
| HU (1) | HUE028637T2 (enExample) |
| IL (2) | IL204538A (enExample) |
| MX (1) | MX2010005269A (enExample) |
| NZ (1) | NZ584199A (enExample) |
| PL (1) | PL2212345T3 (enExample) |
| RU (1) | RU2503717C2 (enExample) |
| WO (1) | WO2009065546A1 (enExample) |
| ZA (1) | ZA201003461B (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9687515B2 (en) * | 2007-11-19 | 2017-06-27 | Transgene S.A. | Poxviral oncolytic vectors |
| AU2008328258B2 (en) * | 2007-11-19 | 2013-09-26 | Transgene Sa | Poxviral oncolytic vectors |
| JP2012515146A (ja) | 2009-01-13 | 2012-07-05 | トランジェーヌ、ソシエテ、アノニム | 免疫刺激のためのサッカロマイセス・セレビシエのミトコンドリア核酸画分の使用 |
| KR20120026526A (ko) | 2009-05-12 | 2012-03-19 | 트랜스진 에스.에이. | 불멸화 조류 세포주 및 그의 용도 |
| AU2010270313B2 (en) | 2009-07-10 | 2014-05-22 | Transgene Sa | Biomarker for selecting patients and related methods |
| CA2709292A1 (en) | 2009-07-10 | 2011-01-10 | The Governors Of The University Of Alberta | Oncolytic viruses and methods for treating neoplastic disorders |
| WO2013004658A1 (en) | 2011-07-01 | 2013-01-10 | Transgene Sa | Formulations of 5-fluorocytosine and uses thereof. |
| KR101370620B1 (ko) * | 2011-08-05 | 2014-03-06 | 한국생명공학연구원 | 다람쥐폭스바이러스를 유효성분으로 포함하는 암 예방 및 치료용 약학적 조성물 |
| TWI690322B (zh) | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
| JP6657115B2 (ja) * | 2014-04-10 | 2020-03-04 | トランジェーヌＴｒａｎｓｇｅｎｅ | ポックスウイルス腫瘍細胞崩壊性ベクター |
| DK3552615T3 (da) | 2014-07-16 | 2022-02-14 | Transgene | Onkolytisk virus til ekspression af immun-checkpoint-modulatorer |
| WO2016009017A1 (en) | 2014-07-16 | 2016-01-21 | Institut Gustave-Roussy | Combination of oncolytic virus with immune checkpoint modulators |
| DK3226894T3 (da) | 2014-12-01 | 2019-10-21 | Transgene Sa | Stabile flydende vacciniavirus-formuleringer |
| EP3256156B1 (en) | 2015-02-13 | 2025-02-12 | Transgene | Immunotherapeutic vaccine and antibody combination therapy |
| WO2016131945A1 (en) | 2015-02-20 | 2016-08-25 | Transgene Sa | Combination product with autophagy modulator |
| US10639366B2 (en) | 2015-02-25 | 2020-05-05 | Memorial Sloan Kettering Cancer Center | Use of inactivated nonreplicating modified vaccinia virus Ankara (MVA) as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors |
| KR20180006916A (ko) | 2015-04-17 | 2018-01-19 | 메모리얼 슬로안-케터링 캔서 센터 | 고형 종양에 대한 면역치료제로서 mva 또는 mva델타e3l의 용도 |
| AU2017222686B2 (en) | 2016-02-25 | 2021-12-23 | Memorial Sloan Kettering Cancer Center | Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human Flt3L or GM-CSF for cancer immunotherapy |
| KR20180130500A (ko) | 2016-02-25 | 2018-12-07 | 메모리얼 슬로안 케터링 캔서 센터 | 인간 flt3l을 발현하는 재조합 mva 또는 mvaδe3l 및 고형 종양에 대한 면역요법제로서 그의 용도 |
| CA3023022A1 (en) | 2016-05-04 | 2017-11-09 | Transgene Sa | Combination therapy with cpg tlr9 ligand |
| EP3486322B1 (en) * | 2016-07-13 | 2021-09-29 | National University Corporation Tottori University | Method for producing vaccinia virus expressing foreign gene |
| EP3522920A2 (en) | 2016-10-10 | 2019-08-14 | Transgene SA | Immunotherapeutic product and mdsc modulator combination therapy |
| WO2018091680A1 (en) | 2016-11-18 | 2018-05-24 | Transgene Sa | Cowpox-based oncolytic vectors |
| US20190330655A1 (en) | 2016-12-28 | 2019-10-31 | Transgene Sa | Oncolytic viruses and therapeutic molecules |
| EP3621646A4 (en) | 2017-05-12 | 2021-06-02 | Memorial Sloan Kettering Cancer Center | VACCINIA VIRUS MUTANTS FOR CANCER IMMUNOTHERAPY |
| KR102684237B1 (ko) | 2017-06-21 | 2024-07-11 | 트랜스진 | 개인 맞춤형 백신 |
| WO2019020543A1 (en) | 2017-07-28 | 2019-01-31 | Transgene Sa | ONCOLYTIC VIRUSES EXPRESSING AGENTS TARGETING METABOLIC IMMUNE MODULATORS |
| BR112020018117A2 (pt) | 2018-03-07 | 2020-12-22 | Transgene | Vírus da pseudovaríola (pcpv), métodos para gerar o pcpv e para amplificar o pcpv, composição, método de tratamento, método para inibir o crescimento de células tumorais, uso ou método e método para induzir ou estimular e/ ou reorientar uma resposta imune |
| CN110396504A (zh) * | 2018-04-25 | 2019-11-01 | 江苏省原子医学研究所 | 一种具有肿瘤靶向性的重组痘苗病毒及其制备方法、用途 |
| CN112261951A (zh) * | 2018-05-02 | 2021-01-22 | 通尼克斯制药控股有限公司 | 包含合成嵌合痘苗病毒的干细胞及其使用方法 |
| WO2020011754A1 (en) | 2018-07-09 | 2020-01-16 | Transgene | Chimeric vaccinia viruses |
| EP3617230A1 (en) | 2018-09-03 | 2020-03-04 | BioInvent International AB | Novel antibodies and nucleotide sequences, and uses thereof |
| CN116162654A (zh) | 2018-09-15 | 2023-05-26 | 纪念斯隆凯特琳癌症中心 | 用于癌症免疫疗法的重组痘病毒 |
| BR112021011730A2 (pt) * | 2018-12-21 | 2021-08-31 | Ottawa Hospital Research Institute | Vetores de ortopoxvírus modificados |
| SG11202106898VA (en) * | 2018-12-28 | 2021-07-29 | Transgene Sa | M2-defective poxvirus |
| WO2020136232A1 (en) | 2018-12-28 | 2020-07-02 | Transgene Sa | Immunosuppressive m2 protein |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| US20220275347A1 (en) * | 2019-08-09 | 2022-09-01 | Km Biologics Co., Ltd. | Oncolytic vaccinia virus |
| AU2020385683A1 (en) | 2019-11-18 | 2022-06-30 | Janssen Biotech, Inc. | Vaccines based on mutant CALR and JAK2 and their uses |
| EP3842065A1 (en) | 2019-12-23 | 2021-06-30 | Transgene | Process for designing a recombinant poxvirus for a therapeutic vaccine |
| WO2022009052A2 (en) | 2020-07-06 | 2022-01-13 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| WO2022148736A1 (en) | 2021-01-05 | 2022-07-14 | Transgene | Vectorization of muc1 t cell engager |
| WO2023025899A2 (en) | 2021-08-26 | 2023-03-02 | Transgene | Delivery system for targeting genes of the interferon pathway |
| TW202321458A (zh) | 2021-09-22 | 2023-06-01 | 瑞典商生物創新國際公司 | 新穎抗體組合及其用途 |
| WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
| WO2023213763A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab |
| US20260071233A1 (en) | 2022-06-10 | 2026-03-12 | Transgene | Recombinant virus expressing interleukin-12 |
| US20260015405A1 (en) | 2022-07-01 | 2026-01-15 | Transgene | Fusion protein comprising a surfactant-protein-d and a member of the tnfsf |
| JP2025526369A (ja) | 2022-07-27 | 2025-08-13 | アストラゼネカ・アクチエボラーグ | Ｐｄ－１／ｐｄ－ｌ１阻害剤を有するインターロイキン１２を発現する組換えウイルスの組み合わせ |
| CN120380015A (zh) | 2022-08-18 | 2025-07-25 | 特兰斯吉恩公司 | 嵌合痘病毒 |
| WO2026041811A1 (en) | 2024-08-23 | 2026-02-26 | Transgene | Recombinant poxvirus and method for regulating the expression of toxic conditional gene products of said recombinant poxvirus in a producing cell |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5364773A (en) * | 1991-03-07 | 1994-11-15 | Virogenetics Corporation | Genetically engineered vaccine strain |
| US5833975A (en) | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
| AU625584B2 (en) * | 1989-03-08 | 1992-07-16 | Health Research Inc. | Recombinant poxvirus host selection system |
| US5863542A (en) * | 1991-03-07 | 1999-01-26 | Virogenetics Corporation | Recombinant attenuated ALVAC canaryopox virus containing heterologous HIV or SIV inserts |
| US5759552A (en) | 1991-03-07 | 1998-06-02 | Virogenetics Corporation | Marek's disease virus recombinant poxvirus vaccine |
| JP3602530B2 (ja) * | 1991-03-07 | 2004-12-15 | ヴァイロジェネティクス コーポレイション | 遺伝子操作したワクチン菌株 |
| GB9105383D0 (en) * | 1991-03-14 | 1991-05-01 | Immunology Ltd | An immunotherapeutic for cervical cancer |
| US5762924A (en) * | 1992-06-16 | 1998-06-09 | Commonwealth Scientific And Industrial Research Organisation | Recombinant entomopoxvirus |
| FR2777570A1 (fr) * | 1998-04-17 | 1999-10-22 | Transgene Sa | Mutant ayant une activite phosphoribosyl transferase |
| CA2375189C (en) * | 1999-05-28 | 2010-02-09 | The Government Of The United States Of America | A combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector |
| EP1615661A2 (en) | 2003-04-15 | 2006-01-18 | Sanofi Pasteur Limited | Tumor antigens bfa5 for prevention and/or treatment of cancer |
| RU2376371C2 (ru) * | 2003-06-18 | 2009-12-20 | Дженелюкс Корпорейшн | Модифицированные рекомбинантные вакцинирующие вирусы и другие микроорганизмы и их применение |
| CA2709292A1 (en) * | 2009-07-10 | 2011-01-10 | The Governors Of The University Of Alberta | Oncolytic viruses and methods for treating neoplastic disorders |
-
2008
- 2008-11-17 US US12/743,407 patent/US8778328B2/en active Active
- 2008-11-17 ES ES08852947.4T patent/ES2567564T3/es active Active
- 2008-11-17 AU AU2008328257A patent/AU2008328257B2/en active Active
- 2008-11-17 HU HUE08852947A patent/HUE028637T2/en unknown
- 2008-11-17 KR KR1020107010922A patent/KR101542276B1/ko active Active
- 2008-11-17 BR BRPI0820576-0A patent/BRPI0820576B1/pt active IP Right Grant
- 2008-11-17 DK DK08852947.4T patent/DK2212345T3/en active
- 2008-11-17 RU RU2010124616/10A patent/RU2503717C2/ru active
- 2008-11-17 CA CA2705869A patent/CA2705869C/en active Active
- 2008-11-17 EP EP08852947.4A patent/EP2212345B1/en active Active
- 2008-11-17 CN CN201210160650.3A patent/CN102703389B/zh active Active
- 2008-11-17 JP JP2010533510A patent/JP5710261B2/ja active Active
- 2008-11-17 CN CN200880116834.1A patent/CN101868474B/zh active Active
- 2008-11-17 PL PL08852947T patent/PL2212345T3/pl unknown
- 2008-11-17 WO PCT/EP2008/009720 patent/WO2009065546A1/en not_active Ceased
- 2008-11-17 MX MX2010005269A patent/MX2010005269A/es active IP Right Grant
- 2008-11-17 NZ NZ584199A patent/NZ584199A/en unknown
-
2010
- 2010-03-16 IL IL204538A patent/IL204538A/en active IP Right Grant
- 2010-05-17 ZA ZA2010/03461A patent/ZA201003461B/en unknown
- 2010-06-18 EC EC2010010288A patent/ECSP10010288A/es unknown
- 2010-06-18 CO CO10073782A patent/CO6210754A2/es not_active Application Discontinuation
- 2010-06-18 CR CR11519A patent/CR11519A/es not_active Application Discontinuation
-
2012
- 2012-06-26 IL IL220653A patent/IL220653A/en active IP Right Grant
- 2012-09-15 US US13/620,983 patent/US20130039891A1/en not_active Abandoned
-
2013
- 2013-02-27 US US13/778,235 patent/US9884080B2/en active Active
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