JP2011503203A5 - - Google Patents

Info

Publication number

JP2011503203A5

JP2011503203A5 JP2010534210A JP2010534210A JP2011503203A5 JP 2011503203 A5 JP2011503203 A5 JP 2011503203A5 JP 2010534210 A JP2010534210 A JP 2010534210A JP 2010534210 A JP2010534210 A JP 2010534210A JP 2011503203 A5 JP2011503203 A5 JP 2011503203A5

Authority

JP

Japan

Prior art keywords

hapten

conjugate

ligand

adjuvants

deflection

Prior art date

2008-11-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000002671 adjuvant Substances 0.000 claims 43
• 239000003446 ligand Substances 0.000 claims 35
• 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 6
• 108090000695 Cytokines Proteins 0.000 claims 4
• 102000004127 Cytokines Human genes 0.000 claims 4
• OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 4
• 150000002224 folic acids Chemical class 0.000 claims 4
• PIGTXFOGKFOFTO-FVFWYJKVSA-N (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-carboxy-4-formyl-8-hydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group O([C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)C[C@@H](O)[C@]1(CCC(C[C@H]14)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O PIGTXFOGKFOFTO-FVFWYJKVSA-N 0.000 claims 2
• 102100037850 Interferon gamma Human genes 0.000 claims 2
• 102000006992 Interferon-alpha Human genes 0.000 claims 2
• 108010047761 Interferon-alpha Proteins 0.000 claims 2
• 108010074328 Interferon-gamma Proteins 0.000 claims 2
• 102000013462 Interleukin-12 Human genes 0.000 claims 2
• 108010065805 Interleukin-12 Proteins 0.000 claims 2
• 108010002350 Interleukin-2 Proteins 0.000 claims 2
• 102000000588 Interleukin-2 Human genes 0.000 claims 2
• 241001465754 Metazoa Species 0.000 claims 2
• OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 2
• NKVLDFAVEWLOCX-GUSKIFEASA-N [(2s,3r,4s,5r,6r)-3-[(2s,3r,4s,5r,6s)-5-[(2s,3r,4s,5r)-4-[(2s,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-3,5-dihydroxyoxan-2-yl]oxy-3,4-dihydroxy-6-methyloxan-2-yl]oxy-4,5-dihydroxy-6-methyloxan-2-yl] (4ar,5r,6as,6br,9s,10s,12ar)-10-[(2r,3r,4s, Chemical group O([C@H]1[C@H](O)CO[C@H]([C@@H]1O)O[C@H]1[C@H](C)O[C@H]([C@@H]([C@@H]1O)O)O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](C)O[C@H]1OC(=O)[C@]12CCC(C)(C)CC1C1=CCC3[C@@]([C@@]1(C[C@H]2O)C)(C)CCC1[C@]3(C)CC[C@@H]([C@@]1(C)C=O)O[C@@H]1O[C@@H]([C@H]([C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)CO2)O)[C@H]1O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O1)O)O)C(=O)NCCCCCCCCCCCC)[C@@H]1OC[C@](O)(CO)[C@H]1O NKVLDFAVEWLOCX-GUSKIFEASA-N 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 2
• 108020005243 folate receptor Proteins 0.000 claims 2
• 102000006815 folate receptor Human genes 0.000 claims 2
• 235000019152 folic acid Nutrition 0.000 claims 2
• 239000011724 folic acid Substances 0.000 claims 2
• 229960000304 folic acid Drugs 0.000 claims 2
• 229960001438 immunostimulant agent Drugs 0.000 claims 2
• 230000003308 immunostimulating effect Effects 0.000 claims 2
• 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 2
• OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical group CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims 2
• 125000006501 nitrophenyl group Chemical group 0.000 claims 2
• 230000001717 pathogenic effect Effects 0.000 claims 2
• 239000001397 quillaja saponaria molina bark Substances 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 229930182490 saponin Natural products 0.000 claims 2
• 150000007949 saponins Chemical group 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 230000000977 initiatory effect Effects 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• 0 *NC(Nc(cc1)cc(C(O)=O)c1C(c(ccc(O)c1)c1O1)=C(C=C2)C1=CC2=O)=S Chemical compound *NC(Nc(cc1)cc(C(O)=O)c1C(c(ccc(O)c1)c1O1)=C(C=C2)C1=CC2=O)=S 0.000 description 1