JP2022541517A5 - - Google Patents
Info
- Publication number
- JP2022541517A5 JP2022541517A5 JP2022502910A JP2022502910A JP2022541517A5 JP 2022541517 A5 JP2022541517 A5 JP 2022541517A5 JP 2022502910 A JP2022502910 A JP 2022502910A JP 2022502910 A JP2022502910 A JP 2022502910A JP 2022541517 A5 JP2022541517 A5 JP 2022541517A5
- Authority
- JP
- Japan
- Prior art keywords
- adc
- alkyl
- pharmaceutically acceptable
- acceptable salt
- thiol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962876590P | 2019-07-19 | 2019-07-19 | |
| US62/876,590 | 2019-07-19 | ||
| US202063019212P | 2020-05-01 | 2020-05-01 | |
| US63/019,212 | 2020-05-01 | ||
| PCT/US2020/042815 WO2021016204A1 (en) | 2019-07-19 | 2020-07-20 | Antibody-sting agonist conjugates and their use in immunotherapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022541517A JP2022541517A (ja) | 2022-09-26 |
| JP2022541517A5 true JP2022541517A5 (https=) | 2023-07-26 |
| JP7576779B2 JP7576779B2 (ja) | 2024-11-01 |
Family
ID=71995149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022502910A Active JP7576779B2 (ja) | 2019-07-19 | 2020-07-20 | 抗体－ｓｔｉｎｇアゴニスト複合体および免疫療法におけるそれらの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US11033635B2 (https=) |
| EP (1) | EP3999118A1 (https=) |
| JP (1) | JP7576779B2 (https=) |
| KR (1) | KR20220054794A (https=) |
| CN (2) | CN117838878A (https=) |
| AU (1) | AU2020315802A1 (https=) |
| BR (1) | BR112022000854A2 (https=) |
| CA (1) | CA3147890A1 (https=) |
| IL (1) | IL289866A (https=) |
| MX (1) | MX2022000815A (https=) |
| TW (1) | TWI877186B (https=) |
| WO (1) | WO2021016204A1 (https=) |
| ZA (1) | ZA202201988B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3147890A1 (en) * | 2019-07-19 | 2021-01-28 | Immunesensor Therapeutics, Inc. | Antibody-sting agonist conjugates and their use in immunotherapy |
| WO2022225827A1 (en) * | 2021-04-21 | 2022-10-27 | Merck Sharp & Dohme Llc | Novel forms of cyclic dinucleotide compounds |
| CA3222082A1 (en) * | 2021-06-25 | 2022-12-29 | Gary Brandt | Bis-benzimidazole sting agonist immunoconjugates, and uses thereof |
| US20240417486A1 (en) * | 2021-10-04 | 2024-12-19 | Bolt Biotherapeutics, Inc. | Asymmetric bis-benzimidazole sting agonist immunoconjugates and uses thereof |
| CN118524854A (zh) * | 2021-12-17 | 2024-08-20 | 北京加科思新药研发有限公司 | 包含可用作sting激动剂的新型化合物的化合物-连接基构建体及其用途 |
| TW202434307A (zh) * | 2023-01-18 | 2024-09-01 | 大陸商泰勵生物科技（上海）有限公司 | 抗體偶聯藥物及其用途 |
| CN120813607A (zh) * | 2023-02-28 | 2025-10-17 | 卫材R&D管理有限公司 | 抗psma抗体、缀合物和使用方法 |
| WO2025007108A2 (en) * | 2023-06-30 | 2025-01-02 | Immunogenesis, Inc. | Compositions comprising sting agonists and methods of use for treating glioma |
| CN117343111B (zh) * | 2023-12-04 | 2024-02-06 | 康羽生命科学技术(苏州)有限公司 | 核苷修饰物n2-异丁酰-2'-甲氧基鸟苷的制备方法 |
| CN120204418A (zh) * | 2023-12-27 | 2025-06-27 | 上海迪诺医药科技有限公司 | 环状二核苷酸化合物、其偶联物及应用 |
| WO2026035986A1 (en) | 2024-08-07 | 2026-02-12 | Bighat Biosciences, Inc. | Humanized anti-cdh17 antibodies and use of the same |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2556752C (en) | 2004-02-23 | 2016-02-02 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
| DK1791565T3 (en) * | 2004-09-23 | 2016-08-01 | Genentech Inc | Cysteingensplejsede antibodies and conjugates |
| RU2014124984A (ru) | 2011-12-05 | 2016-01-27 | Идженика Биотерапьютикс, Инк. | Конъюгаты антитело-лекарственное средство и родственные соединения, композиции и способы |
| US9504756B2 (en) | 2012-05-15 | 2016-11-29 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
| KR102222186B1 (ko) | 2015-08-13 | 2021-03-03 | 머크 샤프 앤드 돔 코포레이션 | Sting 효능제로서 시클릭 디-뉴클레오티드 화합물 |
| GB2552041A (en) * | 2015-12-07 | 2018-01-10 | Opi Vi - Ip Holdco Llc | Compositions of antibody construct-agonist conjugates and methods thereof |
| DE212016000029U1 (de) | 2015-12-07 | 2017-07-30 | Opi Vi - Ip Holdco Llc | Zusammensetzungen von Antikörperkonstrukt-Agonist-Konjugaten |
| US20170158772A1 (en) | 2015-12-07 | 2017-06-08 | Opi Vi - Ip Holdco Llc | Compositions of antibody construct - agonist conjugates and methods of use thereof |
| NZ746112A (en) | 2016-03-18 | 2023-01-27 | Immune Sensor Llc | Cyclic di-nucleotide compounds and methods of use |
| AU2017321609C1 (en) | 2016-08-30 | 2023-11-09 | Dana-Farber Cancer Institute, Inc. | Drug delivery compositions and uses thereof |
| PE20210255A1 (es) * | 2016-12-01 | 2021-02-10 | Takeda Pharmaceuticals Co | Dinucleotido ciclico como agonistas de sting (estimulador de genes de interferon) |
| AU2017378782A1 (en) | 2016-12-20 | 2019-07-04 | Merck Sharp & Dohme Corp. | Combinations of PD-1 antagonists and cyclic dinucleotide sting agonists for cancer treatment |
| WO2018118665A1 (en) * | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Cyclic dinucleotide sting agonists for cancer treatment |
| US20190336615A1 (en) | 2017-01-27 | 2019-11-07 | Silverback Therapeutics, Inc. | Tumor targeting conjugates and methods of use thereof |
| AR113224A1 (es) | 2017-04-28 | 2020-02-19 | Novartis Ag | Conjugados de anticuerpo que comprenden un agonista de sting |
| US11466047B2 (en) | 2017-05-12 | 2022-10-11 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
| EP3505188A1 (en) * | 2017-12-29 | 2019-07-03 | Invivogen | Pro-cyclic dinucleotide conjugates for cytokine induction |
| CA3147890A1 (en) | 2019-07-19 | 2021-01-28 | Immunesensor Therapeutics, Inc. | Antibody-sting agonist conjugates and their use in immunotherapy |
-
2020
- 2020-07-20 CA CA3147890A patent/CA3147890A1/en active Pending
- 2020-07-20 EP EP20753611.1A patent/EP3999118A1/en active Pending
- 2020-07-20 BR BR112022000854A patent/BR112022000854A2/pt unknown
- 2020-07-20 CN CN202311611339.0A patent/CN117838878A/zh active Pending
- 2020-07-20 CN CN202080064941.5A patent/CN114786729B/zh active Active
- 2020-07-20 WO PCT/US2020/042815 patent/WO2021016204A1/en not_active Ceased
- 2020-07-20 KR KR1020227005267A patent/KR20220054794A/ko active Pending
- 2020-07-20 US US16/933,845 patent/US11033635B2/en active Active
- 2020-07-20 AU AU2020315802A patent/AU2020315802A1/en not_active Abandoned
- 2020-07-20 TW TW109124478A patent/TWI877186B/zh active
- 2020-07-20 MX MX2022000815A patent/MX2022000815A/es unknown
- 2020-07-20 JP JP2022502910A patent/JP7576779B2/ja active Active
-
2021
- 2021-05-11 US US17/317,864 patent/US11213592B2/en active Active
- 2021-12-16 US US17/553,624 patent/US12311030B2/en active Active
-
2022
- 2022-01-16 IL IL289866A patent/IL289866A/en unknown
- 2022-02-16 ZA ZA2022/01988A patent/ZA202201988B/en unknown
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