JP2011503135A - 洗浄液 - Google Patents
洗浄液 Download PDFInfo
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- JP2011503135A JP2011503135A JP2010533513A JP2010533513A JP2011503135A JP 2011503135 A JP2011503135 A JP 2011503135A JP 2010533513 A JP2010533513 A JP 2010533513A JP 2010533513 A JP2010533513 A JP 2010533513A JP 2011503135 A JP2011503135 A JP 2011503135A
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- JP
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- Prior art keywords
- cleaning liquid
- liquid according
- cleaning
- silicone oil
- vitreous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000004140 cleaning Methods 0.000 title claims abstract description 68
- 239000007788 liquid Substances 0.000 title claims abstract description 39
- 239000012530 fluid Substances 0.000 claims abstract description 30
- 230000009545 invasion Effects 0.000 claims abstract description 25
- 229920002545 silicone oil Polymers 0.000 claims description 50
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 23
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 23
- -1 polyethylene Polymers 0.000 claims description 14
- 238000001356 surgical procedure Methods 0.000 claims description 14
- 230000002207 retinal effect Effects 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 3
- 235000015097 nutrients Nutrition 0.000 claims description 3
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 150000005846 sugar alcohols Polymers 0.000 claims 1
- 239000000243 solution Substances 0.000 description 19
- 229920001296 polysiloxane Polymers 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 15
- 210000001525 retina Anatomy 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 10
- 239000008280 blood Substances 0.000 description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 229940008099 dimethicone Drugs 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 206010038848 Retinal detachment Diseases 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 235000010290 biphenyl Nutrition 0.000 description 3
- 239000004305 biphenyl Substances 0.000 description 3
- 125000006267 biphenyl group Chemical group 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 210000004127 vitreous body Anatomy 0.000 description 3
- 241001631457 Cannula Species 0.000 description 2
- 108010024636 Glutathione Proteins 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229960003180 glutathione Drugs 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229940057874 phenyl trimethicone Drugs 0.000 description 2
- 230000004264 retinal detachment Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- XWCWTBUSKMRLEI-UHFFFAOYSA-N 2,2-diphenylethyl-[2,2-diphenylethyl(dimethyl)silyl]oxy-dimethylsilane Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)C[Si](C)(C)O[Si](C)(C)CC(C=1C=CC=CC=1)C1=CC=CC=C1 XWCWTBUSKMRLEI-UHFFFAOYSA-N 0.000 description 1
- UMVZEWHYBHAICZ-UHFFFAOYSA-N 2-phenylethyl(silyloxy)silane Chemical compound [SiH3]O[SiH2]CCC1=CC=CC=C1 UMVZEWHYBHAICZ-UHFFFAOYSA-N 0.000 description 1
- 102100032368 Coiled-coil domain-containing protein 110 Human genes 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 101000868824 Homo sapiens Coiled-coil domain-containing protein 110 Proteins 0.000 description 1
- RGMZNZABJYWAEC-UHFFFAOYSA-N Methyltris(trimethylsiloxy)silane Chemical compound C[Si](C)(C)O[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C RGMZNZABJYWAEC-UHFFFAOYSA-N 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 206010047571 Visual impairment Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 210000001742 aqueous humor Anatomy 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 125000006165 cyclic alkyl group Chemical group 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- ANXXYABAFAQBOT-UHFFFAOYSA-N dodecyl-methyl-bis(trimethylsilyloxy)silane Chemical compound CCCCCCCCCCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C ANXXYABAFAQBOT-UHFFFAOYSA-N 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- PNJMJEXVQAFSBS-UHFFFAOYSA-N hexyl-methyl-bis(trimethylsilyloxy)silane Chemical compound CCCCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C PNJMJEXVQAFSBS-UHFFFAOYSA-N 0.000 description 1
- 239000011796 hollow space material Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229940113601 irrigation solution Drugs 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229940073663 methyl trimethicone Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 210000003786 sclera Anatomy 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 210000002301 subretinal fluid Anatomy 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- SCRSFLUHMDMRFP-UHFFFAOYSA-N trimethyl-(methyl-octyl-trimethylsilyloxysilyl)oxysilane Chemical compound CCCCCCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C SCRSFLUHMDMRFP-UHFFFAOYSA-N 0.000 description 1
- WZKPOPMJOWWSBZ-UHFFFAOYSA-N trimethyl-[phenyl-[phenyl-bis(trimethylsilyloxy)silyl]oxy-trimethylsilyloxysilyl]oxysilane Chemical compound C=1C=CC=CC=1[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 WZKPOPMJOWWSBZ-UHFFFAOYSA-N 0.000 description 1
- ZQTYRTSKQFQYPQ-UHFFFAOYSA-N trisiloxane Chemical compound [SiH3]O[SiH2]O[SiH3] ZQTYRTSKQFQYPQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
Abstract
Description
Claims (19)
- 非ニュートン流体を用いた外科的侵襲のための洗浄液。
- 請求項1に記載の洗浄液において、
硝子体外科および網膜外科のための洗浄液。 - 請求項1または2に記載の洗浄液において、
シリコーン油、2〜4個の炭素原子を有する多価アルコール、酸化ポリエチレン含有液および/または酸化ポリプロピレン含有液またはこれらの混合物から選択した少なくとも1つの流体を含む洗浄液。 - 請求項1から3までのいずれか一項に記載の洗浄液において、
1g/cm3未満の濃度および0.1〜100mPasの粘度を有する少なくとも1種類のシリコーン油を含有する洗浄液。 - 請求項3または4に記載の洗浄液において、
前記シリコーン油の濃度が、0.80〜0.98g/cm3である洗浄液。 - 請求項1から5までのいずれか一項に記載の洗浄液において、
0.5〜50mPasの範囲の粘度を有する洗浄液。 - 請求項1から6までのいずれか一項に記載の洗浄液において、
前記粘度が、2〜10mPasの範囲である洗浄液。 - 請求項1から7までのいずれか一項に記載の洗浄液において、
前記シリコーン油が直鎖状シロキサンである洗浄液。 - 請求項1から8までのいずれか一項に記載の洗浄液において、
前記シリコーン油が、置換されたポリジメチルシロキサンまたは置換されていないポリジメチルシロキサンである洗浄液。 - 請求項1から9までのいずれか一項に記載の洗浄液において、
前記シリコーン油が、2〜10のシロキサン単位を有するシロキサンから生成される洗浄液。 - 請求項1から10までのいずれか一項に記載の洗浄液において、
前記シリコーン油がフェニル置換されている洗浄液。 - 請求項1から11までのいずれか一項に記載の洗浄液において、
付加的にセミフルオロアルカンを含有する洗浄液。 - 請求項12に記載の洗浄液において、
溶液の濃度が1g/cm3未満となるような比率でシリコーン油とセミフルオロアルカンとを含有する洗浄液。 - 請求項12または13に記載の洗浄液において、
50:1〜1:2の比率でシリコーン油とセミフルオロアルカンとを含有する洗浄液。 - 請求項1から14までのいずれか一項に記載の洗浄液において、
付加的に1つ以上の作用物質を含有する洗浄液。 - 請求項15に記載の洗浄液において、
1つ以上の不水溶性の作用物質を含有する洗浄液。 - 請求項8から10までのいずれか一項に記載の洗浄液において、
1つ以上の薬、抗生剤および/または栄養剤を含有する洗浄液。 - 請求項1から11までのいずれか一項に記載の洗浄液の使用法において、
硝子体外科および網膜外科で用いることを特徴とする使用法。 - 請求項1から11までのいずれか一項に記載の洗浄液の使用法において、
眼の後方領域における侵襲時に眼を洗浄するために用いる使用法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE200710055046 DE102007055046A1 (de) | 2007-11-19 | 2007-11-19 | Infusionslösung |
DE102007055046.6 | 2007-11-19 | ||
PCT/EP2008/009769 WO2009065565A1 (de) | 2007-11-19 | 2008-11-19 | Spüllösung |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011503135A true JP2011503135A (ja) | 2011-01-27 |
JP5490009B2 JP5490009B2 (ja) | 2014-05-14 |
Family
ID=40512289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010533513A Active JP5490009B2 (ja) | 2007-11-19 | 2008-11-19 | 洗浄液 |
Country Status (7)
Country | Link |
---|---|
US (1) | US9023898B2 (ja) |
EP (1) | EP2224910B1 (ja) |
JP (1) | JP5490009B2 (ja) |
CN (2) | CN104274487B (ja) |
DE (1) | DE102007055046A1 (ja) |
HK (1) | HK1147448A1 (ja) |
WO (1) | WO2009065565A1 (ja) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2335735A1 (en) * | 2009-12-14 | 2011-06-22 | Novaliq GmbH | Pharmaceutical composition for treatment of dry eye syndrome |
DE102010010430A1 (de) * | 2010-03-05 | 2011-09-08 | Fluoron Gmbh | Füllmaterial für ophthalmologische Implantate |
KR101656121B1 (ko) | 2010-03-17 | 2016-09-08 | 노바리크 게엠베하 | 안압 증가를 치료하기 위한 약학 조성물 |
EP2444063A1 (en) * | 2010-10-20 | 2012-04-25 | Novaliq GmbH | Liquid pharmaceutical compositions for the delivery of active ingredients |
EP2462921A1 (en) | 2010-11-11 | 2012-06-13 | Novaliq GmbH | Liquid pharmaceutical compositions for the treatment of a posterior eye disease |
KR101773648B1 (ko) | 2011-05-25 | 2017-08-31 | 노바리크 게엠베하 | 조갑에 투여를 위한 제약학적 조성물 |
CN103596554A (zh) | 2011-05-25 | 2014-02-19 | 诺瓦利克有限责任公司 | 基于半氟化烷烃类的外用药物组合物 |
PL2806886T3 (pl) | 2012-01-23 | 2017-08-31 | Novaliq Gmbh | Stabilizowane kompozycje białkowe oparte na semifluorowanych alkanach |
EP3488847B1 (en) | 2012-09-12 | 2023-11-08 | Novaliq GmbH | Semifluorinated alkane compositions |
CN106511322B (zh) | 2012-09-12 | 2021-09-17 | 诺瓦利克有限责任公司 | 包含半氟化烷烃的混合物的组合物 |
US20140335172A1 (en) * | 2013-05-10 | 2014-11-13 | The University Of Hong Kong | Ophthalmological rinsing agent and methods therefof |
MX370207B (es) | 2013-07-23 | 2019-12-05 | Novaliq Gmbh | Composiciones estabilizadas de anticuerpos. |
US10702689B2 (en) | 2015-03-26 | 2020-07-07 | Becton, Dickinson And Company | Auto-stop vent plug |
US10201667B2 (en) | 2015-03-26 | 2019-02-12 | Becton, Dickinson And Company | IV membrane attachment systems and methods |
US10232130B2 (en) | 2015-03-26 | 2019-03-19 | Becton, Dickinson And Company | Anti-run dry membrane |
US10646648B2 (en) | 2015-04-01 | 2020-05-12 | Becton, Dickinson And Company | IV flow management systems and methods |
JP6642935B2 (ja) | 2015-09-30 | 2020-02-12 | ノバリック ゲーエムベーハー | 眼投与用の半フッ素化化合物 |
PL3355990T3 (pl) | 2015-09-30 | 2019-11-29 | Novaliq Gmbh | Semifluorowane związki oraz ich kompozycje |
JP2019520357A (ja) | 2016-06-23 | 2019-07-18 | ノバリック ゲーエムベーハー | 局所投与方法 |
AU2017329772B2 (en) | 2016-09-22 | 2023-02-02 | Novaliq Gmbh | Pharmaceutical compositions for use in the therapy of blepharitis |
ES2965677T3 (es) | 2016-09-23 | 2024-04-16 | Novaliq Gmbh | Composiciones oftálmicas que comprenden ciclosporina |
WO2018193093A1 (en) | 2017-04-21 | 2018-10-25 | Novaliq Gmbh | Iodine compositions |
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KR20200059272A (ko) | 2017-09-27 | 2020-05-28 | 노바리크 게엠베하 | 안구 질환의 치료에서의 사용을 위한 라타노프로스트를 포함하는 안과적 조성물 |
WO2019068763A1 (en) | 2017-10-04 | 2019-04-11 | Novaliq Gmbh | OPHTHALMIC COMPOSITIONS COMPRISING F6H8 |
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- 2007-11-19 DE DE200710055046 patent/DE102007055046A1/de not_active Ceased
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2008
- 2008-11-19 CN CN201410465400.XA patent/CN104274487B/zh active Active
- 2008-11-19 US US12/743,697 patent/US9023898B2/en active Active
- 2008-11-19 CN CN200880116516A patent/CN101861141A/zh active Pending
- 2008-11-19 EP EP20080852010 patent/EP2224910B1/de active Active
- 2008-11-19 JP JP2010533513A patent/JP5490009B2/ja active Active
- 2008-11-19 WO PCT/EP2008/009769 patent/WO2009065565A1/de active Application Filing
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JPH06145045A (ja) * | 1992-11-05 | 1994-05-24 | Koken Co Ltd | 網膜剥離治療用シリコ−ンオイル及びその製造方法 |
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JP2003531168A (ja) * | 2000-04-21 | 2003-10-21 | インスパイアー ファーマシューティカルズ,インコーポレイティド | ニコチン・アセチルコリン受容体アゴニストによるドライ・アイ疾患の治療方法 |
Also Published As
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CN104274487A (zh) | 2015-01-14 |
CN104274487B (zh) | 2018-09-07 |
EP2224910A1 (de) | 2010-09-08 |
JP5490009B2 (ja) | 2014-05-14 |
US9023898B2 (en) | 2015-05-05 |
HK1147448A1 (en) | 2011-08-12 |
DE102007055046A1 (de) | 2009-05-28 |
CN101861141A (zh) | 2010-10-13 |
WO2009065565A1 (de) | 2009-05-28 |
US20100274215A1 (en) | 2010-10-28 |
EP2224910B1 (de) | 2014-03-12 |
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