JP2011502979A5 - - Google Patents

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Publication number
JP2011502979A5
JP2011502979A5 JP2010531606A JP2010531606A JP2011502979A5 JP 2011502979 A5 JP2011502979 A5 JP 2011502979A5 JP 2010531606 A JP2010531606 A JP 2010531606A JP 2010531606 A JP2010531606 A JP 2010531606A JP 2011502979 A5 JP2011502979 A5 JP 2011502979A5
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JP
Japan
Prior art keywords
orn
group
cancer
triphosphate
subject
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JP2010531606A
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English (en)
Japanese (ja)
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JP5753382B2 (ja
JP2011502979A (ja
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Priority claimed from PCT/IB2008/002940 external-priority patent/WO2009060281A2/en
Publication of JP2011502979A publication Critical patent/JP2011502979A/ja
Publication of JP2011502979A5 publication Critical patent/JP2011502979A5/ja
Application granted granted Critical
Publication of JP5753382B2 publication Critical patent/JP5753382B2/ja
Expired - Fee Related legal-status Critical Current
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JP2010531606A 2007-11-06 2008-10-30 修飾されたオリゴリン酸基を含有する免疫賦活オリゴリボヌクレオチドアナログ Expired - Fee Related JP5753382B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US204907P 2007-11-06 2007-11-06
US61/002,049 2007-11-06
PCT/IB2008/002940 WO2009060281A2 (en) 2007-11-06 2008-10-30 Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties

Publications (3)

Publication Number Publication Date
JP2011502979A JP2011502979A (ja) 2011-01-27
JP2011502979A5 true JP2011502979A5 (enExample) 2015-02-19
JP5753382B2 JP5753382B2 (ja) 2015-07-22

Family

ID=40626260

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010531606A Expired - Fee Related JP5753382B2 (ja) 2007-11-06 2008-10-30 修飾されたオリゴリン酸基を含有する免疫賦活オリゴリボヌクレオチドアナログ

Country Status (10)

Country Link
US (2) US8349812B2 (enExample)
EP (1) EP2207787B1 (enExample)
JP (1) JP5753382B2 (enExample)
AU (1) AU2008326187B2 (enExample)
CA (1) CA2704853C (enExample)
DK (1) DK2207787T3 (enExample)
ES (1) ES2530215T3 (enExample)
HR (1) HRP20150131T1 (enExample)
PT (1) PT2207787E (enExample)
WO (1) WO2009060281A2 (enExample)

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US20030129251A1 (en) * 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
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JP4989225B2 (ja) * 2003-09-25 2012-08-01 コーリー ファーマシューティカル グループ,インコーポレイテッド 核酸親油性接合体
JP2010500011A (ja) 2006-08-08 2010-01-07 ガンサー ハートマン 5’リン酸オリゴヌクレオチドの構造および使用
CN101820908A (zh) * 2007-10-09 2010-09-01 科利制药公司 包含改性糖部分的免疫刺激寡核苷酸类似物
US9738680B2 (en) * 2008-05-21 2017-08-22 Rheinische Friedrich-Wilhelms-Universität Bonn 5′ triphosphate oligonucleotide with blunt end and uses thereof
WO2012079115A1 (en) * 2010-12-14 2012-06-21 Commonwealth Scientific And Industrial Research Organisation Immunostimulatory oligonucleotides
EP2508530A1 (en) * 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
US20140287023A1 (en) * 2013-02-11 2014-09-25 Mcgill University 5'-triphosphate oligoribonucleotides
WO2014169049A1 (en) 2013-04-09 2014-10-16 Duke University 2' fluoro-modified rnas as immunostimulators
EP3362563A1 (en) 2015-10-14 2018-08-22 Bio-Path Holdings, Inc. P-ethoxy nucleic acids for liposomal formulation
SG11201901667TA (en) 2016-09-16 2019-03-28 Bio Path Holdings Inc Combination therapy with liposomal antisense oligonucleotides
WO2018172546A1 (en) 2017-03-24 2018-09-27 Rigontec Gmbh Method for designing rig-i ligands
US11613756B2 (en) 2017-04-03 2023-03-28 Duke University Compositions and methods for differential induction of cell death and interferon expression
WO2018195249A1 (en) 2017-04-19 2018-10-25 Bio-Path Holdings, Inc. P-ethoxy nucleic acids for stat3 inhibition
US12234457B2 (en) 2017-04-19 2025-02-25 Bio-Path Holdings, Inc. P-ethoxy nucleic acids for BCL2 inhibition
WO2020260547A1 (en) 2019-06-27 2020-12-30 Rigontec Gmbh Design method for optimized rig-i ligands
CN115916978A (zh) * 2020-05-19 2023-04-04 哈德森医学研究所 寡核苷酸
AU2024321134A1 (en) * 2023-08-10 2026-02-19 Harness Therapeutics Limited Functional nucleic acid

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