JP2011502979A5 - - Google Patents

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Publication number
JP2011502979A5
JP2011502979A5 JP2010531606A JP2010531606A JP2011502979A5 JP 2011502979 A5 JP2011502979 A5 JP 2011502979A5 JP 2010531606 A JP2010531606 A JP 2010531606A JP 2010531606 A JP2010531606 A JP 2010531606A JP 2011502979 A5 JP2011502979 A5 JP 2011502979A5
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JP
Japan
Prior art keywords
orn
group
cancer
triphosphate
subject
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JP2010531606A
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English (en)
Japanese (ja)
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JP5753382B2 (ja
JP2011502979A (ja
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Priority claimed from PCT/IB2008/002940 external-priority patent/WO2009060281A2/en
Publication of JP2011502979A publication Critical patent/JP2011502979A/ja
Publication of JP2011502979A5 publication Critical patent/JP2011502979A5/ja
Application granted granted Critical
Publication of JP5753382B2 publication Critical patent/JP5753382B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010531606A 2007-11-06 2008-10-30 修飾されたオリゴリン酸基を含有する免疫賦活オリゴリボヌクレオチドアナログ Expired - Fee Related JP5753382B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US204907P 2007-11-06 2007-11-06
US61/002,049 2007-11-06
PCT/IB2008/002940 WO2009060281A2 (en) 2007-11-06 2008-10-30 Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties

Publications (3)

Publication Number Publication Date
JP2011502979A JP2011502979A (ja) 2011-01-27
JP2011502979A5 true JP2011502979A5 (enExample) 2015-02-19
JP5753382B2 JP5753382B2 (ja) 2015-07-22

Family

ID=40626260

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010531606A Expired - Fee Related JP5753382B2 (ja) 2007-11-06 2008-10-30 修飾されたオリゴリン酸基を含有する免疫賦活オリゴリボヌクレオチドアナログ

Country Status (10)

Country Link
US (2) US8349812B2 (enExample)
EP (1) EP2207787B1 (enExample)
JP (1) JP5753382B2 (enExample)
AU (1) AU2008326187B2 (enExample)
CA (1) CA2704853C (enExample)
DK (1) DK2207787T3 (enExample)
ES (1) ES2530215T3 (enExample)
HR (1) HRP20150131T1 (enExample)
PT (1) PT2207787E (enExample)
WO (1) WO2009060281A2 (enExample)

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CA2536139A1 (en) * 2003-09-25 2005-04-07 Coley Pharmaceutical Group, Inc. Nucleic acid-lipophilic conjugates
DK2056845T3 (da) 2006-08-08 2017-11-27 Rheinische Friedrich-Wilhelms-Universität Bonn Struktur og anvendelse af 5'-phosphat-oligonukleotider
KR20100068422A (ko) * 2007-10-09 2010-06-23 콜리 파마슈티칼 게엠베하 변경된 당 잔기를 함유하는 면역자극성 올리고뉴클레오티드 유사체
US9738680B2 (en) 2008-05-21 2017-08-22 Rheinische Friedrich-Wilhelms-Universität Bonn 5′ triphosphate oligonucleotide with blunt end and uses thereof
WO2012079115A1 (en) * 2010-12-14 2012-06-21 Commonwealth Scientific And Industrial Research Organisation Immunostimulatory oligonucleotides
EP2508530A1 (en) * 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
US20140287023A1 (en) * 2013-02-11 2014-09-25 Mcgill University 5'-triphosphate oligoribonucleotides
US9861574B2 (en) 2013-04-09 2018-01-09 Duke University 2-fluoro-modified RNAs as immunostimulators
KR102755601B1 (ko) 2015-10-14 2025-01-17 바이오-패쓰 홀딩스 인크. 리포좀 제제를 위한 p-에톡시 핵산
CA3034637A1 (en) 2016-09-16 2018-03-22 Bio-Path Holdings, Inc. Combination therapy with liposomal antisense oligonucleotides
WO2018172546A1 (en) 2017-03-24 2018-09-27 Rigontec Gmbh Method for designing rig-i ligands
MX2019011824A (es) 2017-04-03 2020-01-09 Univ Duke Composiciones y métodos de inducción diferencial de la muerte celular y de la expresión del interferón.
CA3058018A1 (en) 2017-04-19 2018-10-25 Bio-Path Holdings, Inc. P-ethoxy nucleic acids for stat3 inhibition
EP3612160A4 (en) 2017-04-19 2021-01-20 Bio-Path Holdings, Inc. P-ETHOXY NUCLEIC ACIDS TO INHIBIT BCL2
WO2020260547A1 (en) 2019-06-27 2020-12-30 Rigontec Gmbh Design method for optimized rig-i ligands
US20230348903A1 (en) * 2020-05-19 2023-11-02 Hudson Institute of Medical Research Oligonucleotides
WO2025032348A1 (en) * 2023-08-10 2025-02-13 Harness Therapeutics Limited Functional nucleic acid

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JP5473336B2 (ja) * 2006-02-15 2014-04-16 アディウタイド・ファーマスーティカルズ・ゲーエムベーハー オリゴヌクレオチドの処方に関する組成物および方法
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