ES2530215T3 - Análogos de oligorribonucleótidos inmunoestimulantes que contienen restos de oligofosfato modificados - Google Patents
Análogos de oligorribonucleótidos inmunoestimulantes que contienen restos de oligofosfato modificados Download PDFInfo
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- ES2530215T3 ES2530215T3 ES08847550.4T ES08847550T ES2530215T3 ES 2530215 T3 ES2530215 T3 ES 2530215T3 ES 08847550 T ES08847550 T ES 08847550T ES 2530215 T3 ES2530215 T3 ES 2530215T3
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- synthetic oligonucleotide
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- General Engineering & Computer Science (AREA)
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- Pulmonology (AREA)
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- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US2049 | 1995-08-08 | ||
| US204907P | 2007-11-06 | 2007-11-06 | |
| PCT/IB2008/002940 WO2009060281A2 (en) | 2007-11-06 | 2008-10-30 | Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties |
Publications (1)
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| ES2530215T3 true ES2530215T3 (es) | 2015-02-27 |
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| Country | Link |
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| EP (1) | EP2207787B1 (enExample) |
| JP (1) | JP5753382B2 (enExample) |
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| DK (1) | DK2207787T3 (enExample) |
| ES (1) | ES2530215T3 (enExample) |
| HR (1) | HRP20150131T1 (enExample) |
| PT (1) | PT2207787E (enExample) |
| WO (1) | WO2009060281A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20030129251A1 (en) * | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
| EP1631576A4 (en) * | 2003-06-11 | 2010-08-25 | Idera Pharmaceuticals Inc | STABILIZED IMMUNOMODULATION OLIGONUCLEOTIDES |
| CA2536139A1 (en) * | 2003-09-25 | 2005-04-07 | Coley Pharmaceutical Group, Inc. | Nucleic acid-lipophilic conjugates |
| DK2056845T3 (da) | 2006-08-08 | 2017-11-27 | Rheinische Friedrich-Wilhelms-Universität Bonn | Struktur og anvendelse af 5'-phosphat-oligonukleotider |
| KR20100068422A (ko) * | 2007-10-09 | 2010-06-23 | 콜리 파마슈티칼 게엠베하 | 변경된 당 잔기를 함유하는 면역자극성 올리고뉴클레오티드 유사체 |
| US9738680B2 (en) | 2008-05-21 | 2017-08-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
| WO2012079115A1 (en) * | 2010-12-14 | 2012-06-21 | Commonwealth Scientific And Industrial Research Organisation | Immunostimulatory oligonucleotides |
| EP2508530A1 (en) * | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
| US20140287023A1 (en) * | 2013-02-11 | 2014-09-25 | Mcgill University | 5'-triphosphate oligoribonucleotides |
| US9861574B2 (en) | 2013-04-09 | 2018-01-09 | Duke University | 2-fluoro-modified RNAs as immunostimulators |
| KR102755601B1 (ko) | 2015-10-14 | 2025-01-17 | 바이오-패쓰 홀딩스 인크. | 리포좀 제제를 위한 p-에톡시 핵산 |
| CA3034637A1 (en) | 2016-09-16 | 2018-03-22 | Bio-Path Holdings, Inc. | Combination therapy with liposomal antisense oligonucleotides |
| WO2018172546A1 (en) | 2017-03-24 | 2018-09-27 | Rigontec Gmbh | Method for designing rig-i ligands |
| MX2019011824A (es) | 2017-04-03 | 2020-01-09 | Univ Duke | Composiciones y métodos de inducción diferencial de la muerte celular y de la expresión del interferón. |
| CA3058018A1 (en) | 2017-04-19 | 2018-10-25 | Bio-Path Holdings, Inc. | P-ethoxy nucleic acids for stat3 inhibition |
| EP3612160A4 (en) | 2017-04-19 | 2021-01-20 | Bio-Path Holdings, Inc. | P-ETHOXY NUCLEIC ACIDS TO INHIBIT BCL2 |
| WO2020260547A1 (en) | 2019-06-27 | 2020-12-30 | Rigontec Gmbh | Design method for optimized rig-i ligands |
| US20230348903A1 (en) * | 2020-05-19 | 2023-11-02 | Hudson Institute of Medical Research | Oligonucleotides |
| WO2025032348A1 (en) * | 2023-08-10 | 2025-02-13 | Harness Therapeutics Limited | Functional nucleic acid |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3534017A (en) | 1967-03-14 | 1970-10-13 | Kyowa Hakko Kogyo Kk | Process for the preparation of nucleoside-5'-diphosphates and triphosphates and mono- and oligo-nucleotidyl-nucleoside-5'-diphosphates and triphosphates |
| FR1566530A (enExample) | 1967-03-14 | 1969-05-09 | ||
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| ATE75483T1 (de) | 1981-10-23 | 1992-05-15 | Molecular Biosystems Inc | Oligonukleotides heilmittel und dessen herstellungsverfahren. |
| US5023243A (en) | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| FR2567892B1 (fr) * | 1984-07-19 | 1989-02-17 | Centre Nat Rech Scient | Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons |
| AU643141B2 (en) | 1991-03-15 | 1993-11-04 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| US5451569A (en) | 1994-04-19 | 1995-09-19 | Hong Kong University Of Science And Technology R & D Corporation Limited | Pulmonary drug delivery system |
| US6111095A (en) * | 1995-06-07 | 2000-08-29 | Merck & Co., Inc. | Capped synthetic RNA, analogs, and aptamers |
| US6770748B2 (en) | 1997-03-07 | 2004-08-03 | Takeshi Imanishi | Bicyclonucleoside and oligonucleotide analogue |
| DE19935303A1 (de) * | 1999-07-28 | 2001-02-08 | Aventis Pharma Gmbh | Oligonukleotide zur Inhibierung der Expression von humanem eg5 |
| US6268790B1 (en) | 2000-03-24 | 2001-07-31 | Trw Inc. | Anti-theft method and apparatus |
| WO2003008432A1 (en) | 2001-07-16 | 2003-01-30 | Isis Pharmaceuticals, Inc. | Process for the preparation of alpha modified nucleoside triphosphates and compounds therefrom |
| RU2004128943A (ru) | 2002-02-28 | 2005-04-20 | Байота, Инк. (Us) | Средства, имитирующие нуклеотиды, и их пролекарственные формы |
| EP1499187B1 (en) * | 2002-04-04 | 2015-06-17 | Zoetis Belgium S.A. | Immunostimulatory g,u-containing oligoribonucleotides |
| CA2555390C (en) * | 2004-02-19 | 2014-08-05 | Coley Pharmaceutical Group, Inc. | Immunostimulatory viral rna oligonucleotides |
| WO2006063072A2 (en) * | 2004-12-08 | 2006-06-15 | 3M Innovative Properties Company | Immunomodulatory compositions, combinations and methods |
| US20060178334A1 (en) * | 2005-02-04 | 2006-08-10 | City Of Hope | Double-stranded and single-stranded RNA molecules with 5 ' triphosphates and their use for inducing interferon |
| US8076068B2 (en) | 2005-09-14 | 2011-12-13 | Gunther Hartmann | Method for determining immunostimulatory activity of RNA oligonucleotides |
| EA200800943A1 (ru) * | 2005-09-27 | 2008-12-30 | Коли Фармасьютикал Гмбх | Модуляция tlr-опосредуемых иммунных ответов с использованием олигонуклеотидов-адаптеров |
| EP1937812A2 (en) * | 2005-10-12 | 2008-07-02 | Cancer Research Technology Limited | Methods and compositions for treating immune disorders |
| JP5473336B2 (ja) * | 2006-02-15 | 2014-04-16 | アディウタイド・ファーマスーティカルズ・ゲーエムベーハー | オリゴヌクレオチドの処方に関する組成物および方法 |
| JP5761911B2 (ja) * | 2006-04-07 | 2015-08-12 | イデラ ファーマシューティカルズ インコーポレイテッドＩｄｅｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｔｌｒ７およびｔｌｒ８に対する安定化免疫調節ｒｎａ（ｓｉｍｒａ）化合物 |
| EP1920775B1 (en) | 2006-10-10 | 2012-12-19 | Gunther Prof. Dr. Hartmann | 5'Triphosphate oligonucleotide induces anti-viral response |
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2008
- 2008-10-30 DK DK08847550.4T patent/DK2207787T3/en active
- 2008-10-30 PT PT88475504T patent/PT2207787E/pt unknown
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- 2008-10-30 AU AU2008326187A patent/AU2008326187B2/en not_active Ceased
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- 2008-10-30 JP JP2010531606A patent/JP5753382B2/ja not_active Expired - Fee Related
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- 2008-10-30 US US12/741,634 patent/US8349812B2/en not_active Expired - Fee Related
- 2008-10-30 WO PCT/IB2008/002940 patent/WO2009060281A2/en not_active Ceased
- 2008-10-30 EP EP08847550.4A patent/EP2207787B1/en not_active Revoked
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Also Published As
| Publication number | Publication date |
|---|---|
| US20100260788A1 (en) | 2010-10-14 |
| AU2008326187A1 (en) | 2009-05-14 |
| EP2207787B1 (en) | 2014-11-12 |
| JP5753382B2 (ja) | 2015-07-22 |
| CA2704853C (en) | 2017-08-15 |
| JP2011502979A (ja) | 2011-01-27 |
| EP2207787A2 (en) | 2010-07-21 |
| CA2704853A1 (en) | 2009-05-14 |
| US9156875B2 (en) | 2015-10-13 |
| US8349812B2 (en) | 2013-01-08 |
| AU2008326187B2 (en) | 2014-12-04 |
| DK2207787T3 (en) | 2015-02-09 |
| US20130164333A1 (en) | 2013-06-27 |
| HRP20150131T1 (hr) | 2015-04-10 |
| WO2009060281A2 (en) | 2009-05-14 |
| WO2009060281A3 (en) | 2009-08-13 |
| PT2207787E (pt) | 2015-02-17 |
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