JP2011501941A - Ｉｌ−２３レセプターのアンタゴニストおよびその使用 - Google Patents
Ｉｌ−２３レセプターのアンタゴニストおよびその使用 Download PDFInfo
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- JP2011501941A JP2011501941A JP2010514184A JP2010514184A JP2011501941A JP 2011501941 A JP2011501941 A JP 2011501941A JP 2010514184 A JP2010514184 A JP 2010514184A JP 2010514184 A JP2010514184 A JP 2010514184A JP 2011501941 A JP2011501941 A JP 2011501941A
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- Prior art keywords
- compound
- amino acid
- acid
- leucine
- side chain
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| US95866007P | 2007-07-06 | 2007-07-06 | |
| PCT/IB2008/002490 WO2009007849A2 (en) | 2007-07-06 | 2008-07-07 | Il-23 receptor antagonists and uses thereof |
Publications (2)
| Publication Number | Publication Date |
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| JP2011501941A true JP2011501941A (ja) | 2011-01-20 |
| JP2011501941A5 JP2011501941A5 (enExample) | 2011-08-25 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2661445A2 (en) | 2011-01-04 | 2013-11-13 | Universität Zürich | Modulators of il-12 and/or il-23 for the prevention or treatment of alzheimer's disease |
| EP2670418A4 (en) * | 2011-02-04 | 2015-06-17 | Aegis Therapeutics Llc | ORAL BIO-AVAILABLE PEPTIDARY MATERIAL COMPOSITIONS AND METHOD THEREFOR |
| USRE49026E1 (en) * | 2011-06-14 | 2022-04-12 | Medical Diagnostic Laboratories, Llc | Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof |
| US9605027B2 (en) * | 2011-06-14 | 2017-03-28 | Medical Diagnostic Laboratories, Llc | Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof |
| US8946150B2 (en) | 2011-06-14 | 2015-02-03 | Medical Diagnostic Laboratories, LLC. | Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof |
| JP6279467B2 (ja) | 2011-06-27 | 2018-02-14 | ガルデルマ・リサーチ・アンド・デヴェロップメント | ざ瘡についての新規ｔｈ１７分化マーカーおよびその使用 |
| EP2723890B1 (en) * | 2011-06-27 | 2019-10-09 | Galderma Research & Development | New th17 differentiation markers for acne and uses thereof |
| US9273093B2 (en) | 2012-10-11 | 2016-03-01 | Protagonist Therapeutics, Inc. | α4β7 peptide dimer antagonists |
| CZ304514B6 (cs) * | 2012-11-23 | 2014-06-11 | Biotechnologický Ústav Av Čr, V.V.I. | Polypeptidy pro léčbu autoimunitních chorob založenou na blokaci receptoru pro lidský cytokin IL-23 |
| SI2968443T1 (sl) | 2013-03-15 | 2022-01-31 | Protagonist Therapeutics, Inc. | Analogi hepcidina in njihova uporaba |
| KR102787208B1 (ko) | 2014-05-16 | 2025-03-27 | 프로타고니스트 테라퓨틱스, 인코포레이티드 | α4β7 인테그린 티오에테르 펩티드 길항제 |
| CN107206254B (zh) | 2014-07-17 | 2021-08-24 | 领导医疗有限公司 | 白细胞介素-23受体的口服肽抑制剂以及其治疗炎症性肠病的用途 |
| US9809623B2 (en) | 2014-10-01 | 2017-11-07 | Protagonist Therapeutics, Inc. | α4β7 peptide monomer and dimer antagonists |
| US10301371B2 (en) | 2014-10-01 | 2019-05-28 | Protagonist Therapeutics, Inc. | Cyclic monomer and dimer peptides having integrin antagonist activity |
| BR112018000691A2 (pt) * | 2015-07-15 | 2018-09-18 | Protagonist Therapeutics Inc | inibidores peptídicos do receptor de interleucina-23 e seu uso para tratar doenças inflamatórias |
| US10787490B2 (en) | 2015-07-15 | 2020-09-29 | Protaganist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| US20190002503A1 (en) | 2015-12-30 | 2019-01-03 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
| CA3017926C (en) | 2016-03-23 | 2023-10-10 | Protagonist Therapeutics, Inc. | Methods for synthesizing .alpha.4.beta.7 peptide antagonists |
| WO2018022937A1 (en) * | 2016-07-27 | 2018-02-01 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 and their use to treat inflammatory diseases |
| EP3681900A4 (en) | 2017-09-11 | 2021-09-08 | Protagonist Therapeutics, Inc. | OPIOID AGONIST PEPTIDES AND THEIR USES |
| EP4501952A3 (en) | 2018-02-08 | 2025-04-16 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| CN108618100B (zh) * | 2018-05-10 | 2021-07-27 | 广东天企生物科技有限公司 | 一种具有鲜味和增鲜特性的四肽及其用途 |
| AU2020311395A1 (en) | 2019-07-10 | 2022-02-03 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| CA3168135A1 (en) | 2020-01-15 | 2021-07-22 | Janssen Biotech, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| PL4090670T3 (pl) | 2020-01-15 | 2025-07-28 | Janssen Biotech, Inc | Peptydowe inhibitory receptora interleukiny-23 i ich zastosowanie w leczeniu chorób zapalnych |
| WO2022109328A1 (en) | 2020-11-20 | 2022-05-27 | Janssen Pharmaceutica Nv | Compositions of peptide inhibitors of interleukin-23 receptor |
| JP2024525732A (ja) | 2021-07-14 | 2024-07-12 | ヤンセン バイオテツク，インコーポレーテツド | インターロイキン－２３受容体の脂質化ペプチド阻害剤 |
| KR20250028290A (ko) * | 2022-06-30 | 2025-02-28 | 사노피 | 선택적 il-23 수용체 길항제로서의 새로운 펩티드 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000061165A1 (en) * | 1999-04-13 | 2000-10-19 | Smithkline Beecham Corporation | Conserved adhesin motif and methods of use thereof |
| AU7445900A (en) * | 1999-09-27 | 2001-04-30 | Chugai Seiyaku Kabushiki Kaisha | Novel hemopoietin receptor protein, nr12 |
| EP1601694B1 (en) * | 2003-03-10 | 2009-08-26 | Schering Corporation | Uses of il-23 antagonists; related reagents |
| WO2005085866A1 (en) * | 2004-02-27 | 2005-09-15 | Novartis Ag | Screening assay for modulators of interaction between interleukin-12 and/or -23 with their receptors |
| JP2008542685A (ja) * | 2005-05-05 | 2008-11-27 | ヴァロリザーシヨン・アッシュエスジ，ソシエテ・アン・コマンディット | サイトカイン受容体修飾因子及びその使用 |
-
2008
- 2008-07-07 EP EP08807150A patent/EP2288621A4/en not_active Withdrawn
- 2008-07-07 AU AU2008273814A patent/AU2008273814A1/en not_active Abandoned
- 2008-07-07 US US12/666,028 patent/US20100190710A1/en not_active Abandoned
- 2008-07-07 WO PCT/IB2008/002490 patent/WO2009007849A2/en not_active Ceased
- 2008-07-07 CA CA2692037A patent/CA2692037A1/en not_active Abandoned
- 2008-07-07 CN CN2008800236017A patent/CN101990547A/zh active Pending
- 2008-07-07 JP JP2010514184A patent/JP2011501941A/ja not_active Withdrawn
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2009
- 2009-12-15 IL IL202752A patent/IL202752A0/en unknown
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|---|---|
| AU2008273814A1 (en) | 2009-01-15 |
| CN101990547A (zh) | 2011-03-23 |
| WO2009007849A2 (en) | 2009-01-15 |
| IL202752A0 (en) | 2011-08-01 |
| EP2288621A2 (en) | 2011-03-02 |
| US20100190710A1 (en) | 2010-07-29 |
| EP2288621A4 (en) | 2012-01-04 |
| CA2692037A1 (en) | 2009-01-15 |
| WO2009007849A3 (en) | 2011-01-06 |
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