JP2011501941A5 - - Google Patents
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- JP2011501941A5 JP2011501941A5 JP2010514184A JP2010514184A JP2011501941A5 JP 2011501941 A5 JP2011501941 A5 JP 2011501941A5 JP 2010514184 A JP2010514184 A JP 2010514184A JP 2010514184 A JP2010514184 A JP 2010514184A JP 2011501941 A5 JP2011501941 A5 JP 2011501941A5
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- JP
- Japan
- Prior art keywords
- leucine
- amine
- acid
- alpha
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000003975 aryl alkyl amines Chemical class 0.000 claims description 66
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| US20130302343A1 (en) | 2011-01-04 | 2013-11-14 | Charité Universitätsmedizin Berlin | Modulators of il-12 and/or il-23 for the prevention or treatment of alzheimer's disease |
| US20130034597A1 (en) * | 2011-02-04 | 2013-02-07 | Aegis Therapeutics Llc | Orally bioavailable peptide drug compositions and methods thereof |
| USRE49026E1 (en) * | 2011-06-14 | 2022-04-12 | Medical Diagnostic Laboratories, Llc | Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof |
| US9605027B2 (en) * | 2011-06-14 | 2017-03-28 | Medical Diagnostic Laboratories, Llc | Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof |
| US8946150B2 (en) | 2011-06-14 | 2015-02-03 | Medical Diagnostic Laboratories, LLC. | Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof |
| WO2013000870A1 (en) * | 2011-06-27 | 2013-01-03 | Galderma Research & Development | New th17 differentiation markers for acne and uses thereof |
| EP2723889B1 (en) | 2011-06-27 | 2019-11-06 | Galderma Research & Development | New th17 differentiation markers for acne and uses thereof |
| US9273093B2 (en) | 2012-10-11 | 2016-03-01 | Protagonist Therapeutics, Inc. | α4β7 peptide dimer antagonists |
| CZ2012829A3 (cs) * | 2012-11-23 | 2014-06-11 | Biotechnologický Ústav Av Čr, V.V.I. | Polypeptidy pro léčbu autoimunitních chorob založenou na blokaci receptoru pro lidský cytokin IL-23 |
| AU2014232954B2 (en) | 2013-03-15 | 2018-08-09 | Protagonist Therapeutics, Inc. | Hepcidin analogues and uses therof |
| ES2890600T3 (es) | 2014-05-16 | 2022-01-20 | Protagonist Therapeutics Inc | Péptidos de tioéter antagonistas de integrina alfa4beta7 |
| CN107206254B (zh) | 2014-07-17 | 2021-08-24 | 领导医疗有限公司 | 白细胞介素-23受体的口服肽抑制剂以及其治疗炎症性肠病的用途 |
| CA2962642A1 (en) | 2014-10-01 | 2016-04-07 | Protagonist Therapeutics, Inc. | Novel .alpha.4.beta.7 peptide monomer and dimer antagonists |
| US10301371B2 (en) | 2014-10-01 | 2019-05-28 | Protagonist Therapeutics, Inc. | Cyclic monomer and dimer peptides having integrin antagonist activity |
| US10787490B2 (en) | 2015-07-15 | 2020-09-29 | Protaganist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| EA035733B9 (ru) * | 2015-07-15 | 2021-01-14 | Протагонист Терепьютикс, Инк. | Пептидные ингибиторы рецептора интерлейкина-23 и их применение для лечения воспалительных заболеваний |
| US20190002503A1 (en) | 2015-12-30 | 2019-01-03 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
| US10407468B2 (en) | 2016-03-23 | 2019-09-10 | Protagonist Therapeutics, Inc. | Methods for synthesizing α4β7 peptide antagonists |
| WO2018022937A1 (en) * | 2016-07-27 | 2018-02-01 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 and their use to treat inflammatory diseases |
| EP3681900A4 (en) | 2017-09-11 | 2021-09-08 | Protagonist Therapeutics, Inc. | OPIOID AGONIST PEPTIDES AND THEIR USES |
| EP4501952A3 (en) | 2018-02-08 | 2025-04-16 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| CN108618100B (zh) * | 2018-05-10 | 2021-07-27 | 广东天企生物科技有限公司 | 一种具有鲜味和增鲜特性的四肽及其用途 |
| CN116082455A (zh) | 2019-07-10 | 2023-05-09 | 领导医疗有限公司 | 白细胞介素-23受体的肽抑制剂及其用于治疗炎症性疾病的用途 |
| MA58373B1 (fr) | 2020-01-15 | 2025-07-31 | Janssen Biotech, Inc. | Inhibiteurs peptidiques du récepteur de l'interleukine-23 et leur utilisation pour traiter des maladies inflammatoires |
| WO2021146454A1 (en) | 2020-01-15 | 2021-07-22 | Janssen Biotech, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| MX2023005994A (es) | 2020-11-20 | 2023-08-11 | Janssen Pharmaceutica Nv | Composiciones de inhibidores peptidicos del receptor de interleucina-23. |
| EP4370146A4 (en) | 2021-07-14 | 2025-05-21 | Janssen Biotech, Inc. | Lipidated peptide inhibitors of the interleukin-23 receptor |
| IL317902A (en) * | 2022-06-30 | 2025-02-01 | Sanofi Sa | New peptides as selective antagonists of the IL-23 receptor |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000061165A1 (en) * | 1999-04-13 | 2000-10-19 | Smithkline Beecham Corporation | Conserved adhesin motif and methods of use thereof |
| EP1221482B1 (en) * | 1999-09-27 | 2005-12-28 | Chugai Seiyaku Kabushiki Kaisha | Hemopoietin receptor protein, nr12 |
| BRPI0408247A (pt) * | 2003-03-10 | 2006-03-01 | Schering Corp | usos de antagonistas e agonistas de il-23 e reagentes relacionados |
| WO2005085866A1 (en) * | 2004-02-27 | 2005-09-15 | Novartis Ag | Screening assay for modulators of interaction between interleukin-12 and/or -23 with their receptors |
| US20090048161A1 (en) * | 2005-05-05 | 2009-02-19 | Valorisation Hsj, Societe En Commandite | Cytokine receptor modulators and uses thereof |
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2008
- 2008-07-07 US US12/666,028 patent/US20100190710A1/en not_active Abandoned
- 2008-07-07 AU AU2008273814A patent/AU2008273814A1/en not_active Abandoned
- 2008-07-07 JP JP2010514184A patent/JP2011501941A/ja not_active Withdrawn
- 2008-07-07 WO PCT/IB2008/002490 patent/WO2009007849A2/en not_active Ceased
- 2008-07-07 CA CA2692037A patent/CA2692037A1/en not_active Abandoned
- 2008-07-07 EP EP08807150A patent/EP2288621A4/en not_active Withdrawn
- 2008-07-07 CN CN2008800236017A patent/CN101990547A/zh active Pending
-
2009
- 2009-12-15 IL IL202752A patent/IL202752A0/en unknown
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