JP2011501675A5 - - Google Patents
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- Publication number
- JP2011501675A5 JP2011501675A5 JP2010530341A JP2010530341A JP2011501675A5 JP 2011501675 A5 JP2011501675 A5 JP 2011501675A5 JP 2010530341 A JP2010530341 A JP 2010530341A JP 2010530341 A JP2010530341 A JP 2010530341A JP 2011501675 A5 JP2011501675 A5 JP 2011501675A5
- Authority
- JP
- Japan
- Prior art keywords
- sdf
- mutant protein
- amino acid
- modified
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims description 22
- 101710088580 Stromal cell-derived factor 1 Proteins 0.000 claims description 22
- 102000008300 Mutant Proteins Human genes 0.000 claims description 15
- 108010021466 Mutant Proteins Proteins 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 5
- 238000000978 circular dichroism spectroscopy Methods 0.000 claims description 3
- 238000012986 modification Methods 0.000 claims description 3
- 230000004048 modification Effects 0.000 claims description 3
- 238000012423 maintenance Methods 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims 12
- 108020004414 DNA Proteins 0.000 claims 4
- 102000053602 DNA Human genes 0.000 claims 4
- 210000004897 n-terminal region Anatomy 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07450189A EP2053060A1 (en) | 2007-10-24 | 2007-10-24 | SDF-1-based glyocosaminoglycan antagonists and methods of using same |
| PCT/EP2008/008960 WO2009053064A1 (en) | 2007-10-24 | 2008-10-23 | Sdf-1-based glycosaminoglycan antagonists and methods of using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011501675A JP2011501675A (ja) | 2011-01-13 |
| JP2011501675A5 true JP2011501675A5 (enExample) | 2013-11-07 |
Family
ID=39133777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010530341A Pending JP2011501675A (ja) | 2007-10-24 | 2008-10-23 | Ｓｄｆ−１を基礎としたグリコサミノグリカンアンタゴニスト、及びその使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100298203A1 (enExample) |
| EP (2) | EP2053060A1 (enExample) |
| JP (1) | JP2011501675A (enExample) |
| KR (1) | KR20100085041A (enExample) |
| CN (1) | CN101835800A (enExample) |
| AU (1) | AU2008315614A1 (enExample) |
| BR (1) | BRPI0818009A2 (enExample) |
| CA (1) | CA2702502A1 (enExample) |
| EA (1) | EA201000688A1 (enExample) |
| IL (1) | IL205300A0 (enExample) |
| MX (1) | MX2010004025A (enExample) |
| NZ (1) | NZ584278A (enExample) |
| WO (1) | WO2009053064A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201200470A1 (ru) * | 2009-09-11 | 2012-08-30 | Протаффин Биотехнологие Аг | Композиция для лечения опосредуемого cxcl8 воспаления легкого |
| CN102094043B (zh) * | 2010-11-23 | 2012-11-07 | 山东农业大学 | 猪趋化因子cxcl12基因及其应用 |
| EP2686344A1 (en) | 2011-03-16 | 2014-01-22 | Protaffin Biotechnologie AG | Fgfr1-based antagonists with improved glycosaminoglycan affinity and methods of using same |
| WO2013007704A2 (en) | 2011-07-08 | 2013-01-17 | Protaffin Biotechnologie Ag | Novel sdf-1-based glycosaminoglycan antagonist and methods of using same |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5364894A (en) * | 1993-03-31 | 1994-11-15 | Tremco, Inc. | Emulsification of asphalt and modified asphalt with primary emulsifier polymers comprised of acrylic acid type monomers |
| JP2000507596A (ja) * | 1996-04-02 | 2000-06-20 | プロジェニクス・ファーマスーティカルス・インコーポレーテッド | Ｃｄ４▲上＋▼細胞のｈｉｖ―１感染を防ぐ方法 |
| AU5811001A (en) * | 2000-05-09 | 2001-11-20 | Univ British Columbia | Cxcr4 antagonist treatment of hematopoietic cells |
| WO2004094465A2 (en) * | 2003-04-23 | 2004-11-04 | The Board Of Trustees Of The University Of Illinois Office Of Technology Management University Of Illinois At Urbana-Champaign | Synthetic molecules that mimic chemokines |
| AT412785B (de) * | 2003-12-04 | 2005-07-25 | Kungl Andreas J Dr | Gag-bindungsproteine |
| US7662221B2 (en) * | 2006-06-23 | 2010-02-16 | Johns Manville | Spray applied building wrap coating material, spray applied building wrap, and building construction assembly |
| AT504685B1 (de) * | 2006-12-20 | 2009-01-15 | Protaffin Biotechnologie Ag | Fusionsproteine |
-
2007
- 2007-10-24 EP EP07450189A patent/EP2053060A1/en not_active Withdrawn
-
2008
- 2008-10-23 CN CN200880113405A patent/CN101835800A/zh active Pending
- 2008-10-23 MX MX2010004025A patent/MX2010004025A/es not_active Application Discontinuation
- 2008-10-23 NZ NZ584278A patent/NZ584278A/en not_active IP Right Cessation
- 2008-10-23 WO PCT/EP2008/008960 patent/WO2009053064A1/en not_active Ceased
- 2008-10-23 BR BRPI0818009 patent/BRPI0818009A2/pt not_active IP Right Cessation
- 2008-10-23 CA CA2702502A patent/CA2702502A1/en not_active Abandoned
- 2008-10-23 KR KR1020107008264A patent/KR20100085041A/ko not_active Ceased
- 2008-10-23 AU AU2008315614A patent/AU2008315614A1/en not_active Abandoned
- 2008-10-23 EP EP08842736A patent/EP2203473A1/en not_active Withdrawn
- 2008-10-23 JP JP2010530341A patent/JP2011501675A/ja active Pending
- 2008-10-23 EA EA201000688A patent/EA201000688A1/ru unknown
- 2008-10-23 US US12/738,976 patent/US20100298203A1/en not_active Abandoned
-
2010
- 2010-04-22 IL IL205300A patent/IL205300A0/en unknown
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