JP2011500843A5 - - Google Patents

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Publication number
JP2011500843A5
JP2011500843A5 JP2010531275A JP2010531275A JP2011500843A5 JP 2011500843 A5 JP2011500843 A5 JP 2011500843A5 JP 2010531275 A JP2010531275 A JP 2010531275A JP 2010531275 A JP2010531275 A JP 2010531275A JP 2011500843 A5 JP2011500843 A5 JP 2011500843A5
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JP
Japan
Prior art keywords
monoclonal antibody
antibody
subject
protein
activated protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2010531275A
Other languages
English (en)
Japanese (ja)
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JP2011500843A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/081110 external-priority patent/WO2009055669A2/en
Publication of JP2011500843A publication Critical patent/JP2011500843A/ja
Publication of JP2011500843A5 publication Critical patent/JP2011500843A5/ja
Withdrawn legal-status Critical Current

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JP2010531275A 2007-10-26 2008-10-24 活性化プロテインｃおよび不活性化プロテインｃに対するモノクロナール抗体 Withdrawn JP2011500843A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98309207P 2007-10-26 2007-10-26
PCT/US2008/081110 WO2009055669A2 (en) 2007-10-26 2008-10-24 Monoclonal antibodies against activated and unactivated protein c

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2012236531A Division JP2013049694A (ja) 2007-10-26 2012-10-26 活性化プロテインｃおよび不活性化プロテインｃに対するモノクロナール抗体
JP2014136566A Division JP6117741B2 (ja) 2007-10-26 2014-07-02 活性化プロテインｃおよび不活性化プロテインｃに対するモノクロナール抗体

Publications (2)

Publication Number Publication Date
JP2011500843A JP2011500843A (ja) 2011-01-06
JP2011500843A5 true JP2011500843A5 (https=) 2012-12-06

Family

ID=40289112

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2010531275A Withdrawn JP2011500843A (ja) 2007-10-26 2008-10-24 活性化プロテインｃおよび不活性化プロテインｃに対するモノクロナール抗体
JP2012236531A Pending JP2013049694A (ja) 2007-10-26 2012-10-26 活性化プロテインｃおよび不活性化プロテインｃに対するモノクロナール抗体
JP2014136566A Active JP6117741B2 (ja) 2007-10-26 2014-07-02 活性化プロテインｃおよび不活性化プロテインｃに対するモノクロナール抗体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2012236531A Pending JP2013049694A (ja) 2007-10-26 2012-10-26 活性化プロテインｃおよび不活性化プロテインｃに対するモノクロナール抗体
JP2014136566A Active JP6117741B2 (ja) 2007-10-26 2014-07-02 活性化プロテインｃおよび不活性化プロテインｃに対するモノクロナール抗体

Country Status (13)

Country Link
US (3) US8153766B2 (https=)
EP (1) EP2205638B1 (https=)
JP (3) JP2011500843A (https=)
KR (2) KR20150092358A (https=)
CN (3) CN105153308A (https=)
AU (1) AU2008316661B2 (https=)
BR (1) BRPI0818865A2 (https=)
CA (1) CA2703738C (https=)
IL (2) IL205284A (https=)
MX (1) MX2010004615A (https=)
RU (2) RU2539729C2 (https=)
WO (1) WO2009055669A2 (https=)
ZA (1) ZA201105704B (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201700360VA (en) * 2012-03-16 2017-03-30 Regeneron Pharma Non-human animals expressing ph-sensitive immunoglobulin sequences
CN104812402A (zh) * 2012-11-29 2015-07-29 拜尔健康护理有限责任公司 针对活化蛋白C (aPC)的单克隆抗体
HK1215174A1 (zh) * 2012-11-29 2016-08-19 Bayer Healthcare Llc 針對活化蛋白c的人源化單克隆抗體及其用途
WO2015041310A1 (ja) 2013-09-20 2015-03-26 中外製薬株式会社 抗プロテインｃ抗体による出血性疾患の治療
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
WO2015179435A1 (en) * 2014-05-19 2015-11-26 Bayer Healthcare Llc Optimized humanized monoclonal antibodies against activated protein c and uses thereof
US11077187B2 (en) 2015-11-17 2021-08-03 Oklahoma Medical Research Foundation Epitope of optimized humanized monoclonal antibodies against activated protein C and uses thereof
NZ754713A (en) 2016-12-21 2025-11-28 Teneobio Inc Anti-bcma heavy chain-only antibodies
IL271194B2 (en) 2017-06-20 2024-10-01 Teneobio Inc Anti-bcma heavy chain-only antibodies
WO2019009407A1 (ja) * 2017-07-07 2019-01-10 第一三共株式会社 抗プロテインｃ抗体
WO2019016392A1 (en) 2017-07-20 2019-01-24 Nbe-Therapeutics Ag HUMAN ANTIBODIES BINDING TO ROR2
EP3971572A1 (en) * 2017-09-13 2022-03-23 B.R.A.H.M.S GmbH Proadrenomedullin as a marker for abnormal platelet levels
WO2020051277A1 (en) * 2018-09-06 2020-03-12 Board Of Regents, The University Of Texas System Treatment and prevention of hemophilic arthropathy with an antibody against endothelial cell protein c receptor (epcr)
JP7248788B2 (ja) * 2018-10-18 2023-03-29 オクラホマ メディカル リサーチ ファウンデーション 疾患活動性を特徴付ける全身性エリテマトーデス（ｓｌｅ）疾患活動性免疫指標のバイオマーカー
CN109897108B (zh) * 2019-03-11 2021-04-02 上海恒赛生物科技有限公司 抗人内皮蛋白c受体的羊驼单域抗体及应用
CN115611986B (zh) * 2021-07-13 2025-08-12 上海莱士血液制品股份有限公司 针对人活化蛋白c的单克隆抗体及其制备和应用
CA3245346A1 (en) * 2022-03-04 2023-09-07 Coagulant Therapeutics Corporation Camelid antibodies directed against activated protein C and their uses
CN118370814A (zh) * 2023-01-20 2024-07-23 上海莱士血液制品股份有限公司 一种抗aPC单克隆抗体的制剂及其应用
KR20250000042A (ko) 2023-06-23 2025-01-02 충남대학교산학협력단 절단 반응성 펩타이드를 발현하는 키메라 t 세포 및 이를 포함하는 감염 질환 치료용 조성물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7247453B1 (en) * 1988-12-30 2007-07-24 Oklahoma Medical Research Foundation Calcium binding recombinant antibody against protein C
US5202253A (en) * 1988-12-30 1993-04-13 Oklahoma Medical Research Foundation Monoclonal antibody specific for protein C and antibody purification method
US5279956A (en) * 1991-06-24 1994-01-18 The Scripps Research Institute Activated protein C polypeptides and anti-peptide antibodies, diagnostic methods and systems for inhibiting activated protein C
US5695993A (en) 1994-08-12 1997-12-09 Oklahoma Medical Research Foundation Cloning and regulation of an endothelial cell protein C/activated protein C receptor
US6953568B1 (en) 1998-08-25 2005-10-11 Oklahoma Medical Research Foundation Targeting of molecules to large vessel endothelium using EPCR
ATE464374T1 (de) * 2000-10-02 2010-04-15 Oklahoma Med Res Found Assay zum schnellen nachweis vom humanen aktivierten protein c und hochspezifischer monoklonaler antikörper dagegen
US7423128B2 (en) 2004-11-03 2008-09-09 Amgen Fremont Inc. Anti-properdin antibodies, and methods for making and using same

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