JP2011500757A - Fc含有タンパク質の精製方法 - Google Patents

Fc含有タンパク質の精製方法 Download PDF

Info

Publication number
JP2011500757A
JP2011500757A JP2010530429A JP2010530429A JP2011500757A JP 2011500757 A JP2011500757 A JP 2011500757A JP 2010530429 A JP2010530429 A JP 2010530429A JP 2010530429 A JP2010530429 A JP 2010530429A JP 2011500757 A JP2011500757 A JP 2011500757A
Authority
JP
Japan
Prior art keywords
protein
resin
containing protein
free
blue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2010530429A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011500757A5 (enExample
Inventor
ウオン−デュバル,アレックス
Original Assignee
メルク セローノ ソシエテ アノニム
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メルク セローノ ソシエテ アノニム filed Critical メルク セローノ ソシエテ アノニム
Publication of JP2011500757A publication Critical patent/JP2011500757A/ja
Publication of JP2011500757A5 publication Critical patent/JP2011500757A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/22Affinity chromatography or related techniques based upon selective absorption processes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
JP2010530429A 2007-10-22 2008-10-21 Fc含有タンパク質の精製方法 Withdrawn JP2011500757A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07118983 2007-10-22
US722307P 2007-12-11 2007-12-11
PCT/EP2008/064210 WO2009053360A1 (en) 2007-10-22 2008-10-21 Method for purifying an fc-containing protein

Publications (2)

Publication Number Publication Date
JP2011500757A true JP2011500757A (ja) 2011-01-06
JP2011500757A5 JP2011500757A5 (enExample) 2011-12-08

Family

ID=38961834

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010530429A Withdrawn JP2011500757A (ja) 2007-10-22 2008-10-21 Fc含有タンパク質の精製方法

Country Status (7)

Country Link
US (1) US20100256337A1 (enExample)
EP (1) EP2203465A1 (enExample)
JP (1) JP2011500757A (enExample)
AU (1) AU2008314689A1 (enExample)
CA (1) CA2701221A1 (enExample)
IL (1) IL204949A0 (enExample)
WO (1) WO2009053360A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016502528A (ja) * 2012-11-27 2016-01-28 アルテオジェン インコーポレイテッド タンパク質とFcドメインを融合した融合タンパク質の安定化用組成物
JP2017521389A (ja) * 2014-06-13 2017-08-03 ルピン・リミテッド TNFR:Fc融合タンパク質の精製方法
US9821059B2 (en) 2014-10-17 2017-11-21 Alteogen Inc. Composition for stabilizing protein and pharmaceutical formulation comprising the same

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE038947T2 (hu) 2005-08-26 2018-12-28 Ares Trading Sa Eljárás glikozilált béta-interferon elõállítására
WO2009053358A1 (en) * 2007-10-22 2009-04-30 Merck Serono S.A. Method for purifying fc-fusion proteins
JP5728392B2 (ja) 2009-03-05 2015-06-03 バイオジェン アイデック エムエー インコーポレイティドBiogen Idec Inc. 免疫グロブリンの精製
KR20160119134A (ko) * 2014-02-04 2016-10-12 바스프 에스이 특이적 안트라퀴논 염료-리간드 구조를 사용한 항체, 항체 단편 또는 이들의 조작된 변이체의 정제 방법
EP2918641A1 (en) * 2014-03-13 2015-09-16 Basf Se Method for purification of antibodies, antibody fragments or engineered variants thereof using specific anthraquinone dye-ligand structures
CN115812077A (zh) 2020-05-08 2023-03-17 高山免疫科学股份有限公司 April和baff抑制性免疫调节蛋白及其使用方法
CN120904317A (zh) * 2025-09-28 2025-11-07 中国医学科学院输血研究所 一种两步亲和层析法制备犬用免疫球蛋白的方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966843A (en) * 1982-11-01 1990-10-30 Cetus Corporation Expression of interferon genes in Chinese hamster ovary cells
ATE148171T1 (de) * 1989-02-21 1997-02-15 Univ Washington Modifizierte formen von fortpflanzungshormonen
US5338835A (en) * 1989-02-21 1994-08-16 Washington University CTP-extended form of FSH
SG63617A1 (en) 1991-01-18 1999-03-30 Amgen Boulder Inc Methods for treating tumar necrosis factor mediated diseases
US5508261A (en) * 1991-06-18 1996-04-16 University Of Medicine & Dentistry Of New Jersey Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same
SE9201073D0 (sv) * 1992-04-03 1992-04-03 Kabi Pharmacia Ab Protein formulation
US6162905A (en) * 1996-11-07 2000-12-19 Ibsa Institut Biochimique S.A. FSH and LH separation and purification process
US5883073A (en) * 1997-04-03 1999-03-16 Washington University Single-chain double-alpha peptide
US5990288A (en) * 1997-10-21 1999-11-23 Vitro Diagnostics, Inc. Method for purifying FSH
US7431921B2 (en) * 1999-08-27 2008-10-07 Maxygen Aps Interferon beta-like molecules
EP1261622B1 (en) * 2000-02-22 2007-03-07 Applied Research Systems ARS Holding N.V. Purified recombinant hlh having a specific bioactivity and process for purification thereof
CA2405550A1 (en) * 2000-04-12 2001-10-25 Human Genome Sciences, Inc. Albumin fusion proteins
US20030017550A1 (en) * 2001-01-22 2003-01-23 Pang Danny Zhong Der DNA sequences encoding fusion proteins comprising IFN-beta and TM-alpha1
US7226903B2 (en) * 2001-10-10 2007-06-05 Neose Technologies, Inc. Interferon beta: remodeling and glycoconjugation of interferon beta
AU2002364586A1 (en) * 2001-12-21 2003-07-30 Delta Biotechnology Limited Albumin fusion proteins
TWI353991B (en) * 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
ES2333128T3 (es) * 2003-12-22 2010-02-17 Ares Trading S.A. Metodo para purificar fsh.
SI1809663T1 (sl) * 2004-11-09 2009-02-28 Ares Trading Sa Postopek za äśiĺ äśenje fsh
HUE038947T2 (hu) * 2005-08-26 2018-12-28 Ares Trading Sa Eljárás glikozilált béta-interferon elõállítására
US8604175B2 (en) * 2005-12-09 2013-12-10 Ares Trading S.A. Method for purifying FSH or a FSH mutant
EP1981908B1 (en) * 2006-01-17 2010-11-10 Merck Serono SA Novel fsh glycosylation variant d3n
WO2009053358A1 (en) * 2007-10-22 2009-04-30 Merck Serono S.A. Method for purifying fc-fusion proteins

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016502528A (ja) * 2012-11-27 2016-01-28 アルテオジェン インコーポレイテッド タンパク質とFcドメインを融合した融合タンパク質の安定化用組成物
US9474803B2 (en) 2012-11-27 2016-10-25 Alteogen Inc. Composition for stabilizing fusion protein in which protein and FC domain are fused
JP2017521389A (ja) * 2014-06-13 2017-08-03 ルピン・リミテッド TNFR:Fc融合タンパク質の精製方法
US9821059B2 (en) 2014-10-17 2017-11-21 Alteogen Inc. Composition for stabilizing protein and pharmaceutical formulation comprising the same

Also Published As

Publication number Publication date
CA2701221A1 (en) 2009-04-30
IL204949A0 (en) 2010-11-30
EP2203465A1 (en) 2010-07-07
US20100256337A1 (en) 2010-10-07
AU2008314689A1 (en) 2009-04-30
WO2009053360A1 (en) 2009-04-30

Similar Documents

Publication Publication Date Title
US8513393B2 (en) Process for the purification of Fc-containing proteins
US8168185B2 (en) Process for the purification of anti CD-25 antibodies
AU2007291282B2 (en) Process for the purification of Fc-fusion proteins
US20100249381A1 (en) Method for Purifying FC-Fusion Proteins
JP2011500757A (ja) Fc含有タンパク質の精製方法
US20250197497A1 (en) Methods for purifying heterodimeric, multispecific antibodies
NZ574626A (en) Process for removing free Fc-moieties from fluids comprising Fc-containing proteins using ion exchange chromatography
JP2010501622A (ja) Fc−融合タンパク質の精製法
RU2820588C2 (ru) Способы очистки гетеродимерных полиспецифических антител

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111020

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20111020

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20120918