JP2011234679A - 反芻家畜乳中の高度不飽和脂肪酸含量増加方法、及び、当該方法に用いられる医薬剤又は飼料組成物 - Google Patents
反芻家畜乳中の高度不飽和脂肪酸含量増加方法、及び、当該方法に用いられる医薬剤又は飼料組成物 Download PDFInfo
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Abstract
【解決手段】反芻家畜の乳腺組織細胞中のfatty acid desaturase 2(FADS2)をコードする遺伝子の発現及び/又は該酵素の活性を、酢酸、メナキノン−4、アラキドン酸などの栄養素を含有する動物医薬又は飼料組成物を反芻家畜に投与又は給与することにより高めて、乳腺組織細胞及び乳中の高度不飽和脂肪酸含量を効率的に高める。
【選択図】なし
Description
(1)反芻家畜に、反芻家畜の乳腺組織細胞中のfatty acid desaturase 2(FADS2)をコードする遺伝子の発現及び/又は該酵素の活性を高める栄養素を与える(投与又は給与する)ことを特徴とする、反芻家畜乳中の高度不飽和脂肪酸含量を高める方法。
(2)反芻家畜に、反芻家畜の乳腺組織細胞中のfatty acid desaturase 2(FADS2)をコードする遺伝子の発現及び/又は該酵素の活性を高める栄養素を与える(投与又は給与する)ことを特徴とする、高度不飽和脂肪酸含量が高まった反芻家畜乳を生産(製造)する方法。
(3)反芻家畜の乳腺組織細胞に、該細胞中のfatty acid desaturase 2(FADS2)をコードする遺伝子の発現及び/又は該酵素の活性を高める栄養素を供給することを特徴とする、該遺伝子の発現及び/又は該酵素の活性を高める方法。
(4)反芻家畜の乳腺組織細胞に、該細胞中のfatty acid desaturase 2(FADS2)をコードする遺伝子の発現及び/又は該酵素の活性を高める栄養素を供給することを特徴とする、該細胞中の高度不飽和脂肪酸含量を高める方法。
(5)栄養素が、酢酸、メナキノン−4、アラキドン酸から選ばれる少なくとも1つであることを特徴とする、(1)〜(4)のいずれか1つに記載の方法。
(6)反芻家畜が牛(特に、乳牛)であることを特徴とする、(1)〜(5)のいずれか1つに記載の方法。
(8)反芻家畜の乳腺組織細胞中のfatty acid desaturase 2(FADS2)をコードする遺伝子の発現及び/又は該酵素の活性を高める栄養素を有効成分とすることを特徴とする、動物医薬としての該遺伝子発現及び/又は該酵素活性促進剤。
(9)反芻家畜の乳腺組織細胞中のfatty acid desaturase 2(FADS2)をコードする遺伝子の発現及び/又は該酵素の活性を高める栄養素を配合してなることを特徴とする、反芻家畜乳中の高度不飽和脂肪酸含量を高める反芻家畜用飼料組成物。
(10)栄養素が、酢酸、メナキノン−4、アラキドン酸から選ばれる少なくとも1つであることを特徴とする、(7)〜(9)のいずれか1つに記載の剤又は飼料組成物。
(11)反芻家畜が牛(特に、乳牛)であることを特徴とする(7)〜(10)のいずれか1つに記載の剤又は飼料組成物。
FADS2をコードする遺伝子の発現に対する各種ホルモンの影響を見るために、以下の試験を行った。
FADS2をコードする遺伝子の発現に対する各種栄養素添加の影響を見るために、以下の試験を行った。
結果を図5に示したが、アラキドン酸及びメナキノン−4は、濃度依存的にFADS2をコードする遺伝子の発現を上昇させた。
分化後のウシ乳腺上皮細胞にアラキドン酸及びメナキノン−4を500μMの濃度で添加し、24時間培養後の細胞ミクロソームのFADS2活性をフェナシーレブロミドにより脂肪酸を誘導化し、高速液体クロマトグラフィー(HPLC)で定量する方法で測定した。基質はリノール酸を用い、活性は1分間に1nmolのγ−リノレン酸を産生する活性を1Uとした。
Claims (11)
- 反芻家畜に、反芻家畜の乳腺組織細胞中のfatty acid desaturase 2(FADS2)をコードする遺伝子の発現及び/又は該酵素の活性を高める栄養素を与えることを特徴とする、反芻家畜乳中の高度不飽和脂肪酸含量を高める方法。
- 反芻家畜に、反芻家畜の乳腺組織細胞中のfatty acid desaturase 2(FADS2)をコードする遺伝子の発現及び/又は該酵素の活性を高める栄養素を与えることを特徴とする、高度不飽和脂肪酸含量が高まった反芻家畜乳を生産する方法。
- 反芻家畜の乳腺組織細胞に、該細胞中のfatty acid desaturase 2(FADS2)をコードする遺伝子の発現及び/又は該酵素の活性を高める栄養素を供給することを特徴とする、該遺伝子の発現及び/又は該酵素の活性を高める方法。
- 反芻家畜の乳腺組織細胞に、該細胞中のfatty acid desaturase 2(FADS2)をコードする遺伝子の発現及び/又は該酵素の活性を高める栄養素を供給することを特徴とする、該細胞中の高度不飽和脂肪酸含量を高める方法。
- 栄養素が、酢酸、メナキノン−4、アラキドン酸から選ばれる少なくとも1つであることを特徴とする、請求項1〜4のいずれか1項に記載の方法。
- 反芻家畜が牛であることを特徴とする、請求項1〜5のいずれか1項に記載の方法。
- 反芻家畜の乳腺組織細胞中のfatty acid desaturase 2(FADS2)をコードする遺伝子の発現及び/又は該酵素の活性を高める栄養素を有効成分とすることを特徴とする、反芻家畜乳中の高度不飽和脂肪酸含量増加剤。
- 反芻家畜の乳腺組織細胞中のfatty acid desaturase 2(FADS2)をコードする遺伝子の発現及び/又は該酵素の活性を高める栄養素を有効成分とすることを特徴とする、該遺伝子発現及び/又は該酵素活性促進剤。
- 反芻家畜の乳腺組織細胞中のfatty acid desaturase 2(FADS2)をコードする遺伝子の発現及び/又は該酵素の活性を高める栄養素を配合してなることを特徴とする、反芻家畜乳中の高度不飽和脂肪酸含量を高める反芻家畜用飼料組成物。
- 栄養素が、酢酸、メナキノン−4、アラキドン酸から選ばれる少なくとも1つであることを特徴とする、請求項7〜9のいずれか1項に記載の剤又は飼料組成物。
- 反芻家畜が牛であることを特徴とする請求項7〜10のいずれか1項に記載の剤又は飼料組成物。
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