JP2011182794A5 - - Google Patents

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Publication number
JP2011182794A5
JP2011182794A5 JP2011062697A JP2011062697A JP2011182794A5 JP 2011182794 A5 JP2011182794 A5 JP 2011182794A5 JP 2011062697 A JP2011062697 A JP 2011062697A JP 2011062697 A JP2011062697 A JP 2011062697A JP 2011182794 A5 JP2011182794 A5 JP 2011182794A5
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JP
Japan
Prior art keywords
library
polypeptide
amino acid
polynucleotide
acid residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2011062697A
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English (en)
Japanese (ja)
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JP5358604B2 (ja
JP2011182794A (ja
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Publication of JP2011182794A publication Critical patent/JP2011182794A/ja
Publication of JP2011182794A5 publication Critical patent/JP2011182794A5/ja
Application granted granted Critical
Publication of JP5358604B2 publication Critical patent/JP5358604B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2011062697A 2003-06-27 2011-03-22 ルックスルー突然変異誘発 Expired - Lifetime JP5358604B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48328203P 2003-06-27 2003-06-27
US60/483,282 2003-06-27

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2006517625A Division JP4791960B2 (ja) 2003-06-27 2004-06-25 ルックスルー突然変異誘発

Publications (3)

Publication Number Publication Date
JP2011182794A JP2011182794A (ja) 2011-09-22
JP2011182794A5 true JP2011182794A5 (https=) 2012-02-09
JP5358604B2 JP5358604B2 (ja) 2013-12-04

Family

ID=33563915

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006517625A Expired - Lifetime JP4791960B2 (ja) 2003-06-27 2004-06-25 ルックスルー突然変異誘発
JP2011062697A Expired - Lifetime JP5358604B2 (ja) 2003-06-27 2011-03-22 ルックスルー突然変異誘発

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2006517625A Expired - Lifetime JP4791960B2 (ja) 2003-06-27 2004-06-25 ルックスルー突然変異誘発

Country Status (14)

Country Link
US (1) US20050136428A1 (https=)
EP (1) EP1660655B1 (https=)
JP (2) JP4791960B2 (https=)
KR (1) KR20060034650A (https=)
CN (1) CN1836041A (https=)
AU (1) AU2004254352A1 (https=)
BR (1) BRPI0412007A (https=)
CA (1) CA2542192C (https=)
ES (1) ES2609102T3 (https=)
IL (1) IL172736A0 (https=)
NO (1) NO20060108L (https=)
RU (1) RU2005140664A (https=)
WO (1) WO2005003345A2 (https=)
ZA (1) ZA200510460B (https=)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7329725B1 (en) * 2003-10-29 2008-02-12 Nastech Pharmaceutical Company Inc. Phage displayed Trp cage ligands
CA2572961C (en) 2004-07-06 2016-08-16 Bioren, Inc. Universal antibody libraries
CA2573259A1 (en) * 2004-07-06 2006-02-09 Bioren Inc. High affinity anti-tnf-alpha antibodies and method
JP4939410B2 (ja) 2004-07-06 2012-05-23 バイオレン,インク. 強化された特性を持つ変性ポリペプチドを発生させるためのルックスルー変異誘発
WO2006094234A1 (en) * 2005-03-03 2006-09-08 Xencor, Inc. Methods for the design of libraries of protein variants
US20080207467A1 (en) * 2005-03-03 2008-08-28 Xencor, Inc. Methods for the design of libraries of protein variants
CA2605697A1 (en) * 2005-04-26 2006-11-02 Bioren, Inc. Method of producing human igg antibodies with enhanced effector functions
KR20080068004A (ko) * 2005-08-15 2008-07-22 아라나 테라퓨틱스 리미티드 뉴 월드 영장류 구조형성영역을 가진 조작 항체
JP2009515516A (ja) * 2005-11-14 2009-04-16 バイオレン・インク 推定成熟cdrのブラスティングならびにコホートライブラリの作製およびスクリーニングによる抗体の超ヒト化
WO2007086994A1 (en) * 2005-11-15 2007-08-02 Balyasnikova Irina V Single chain fragment of monoclonal antibody 9b9 and uses thereof
CA2634080A1 (en) 2005-12-20 2007-06-28 Arana Therapeutics Limited Anti-inflammatory dab
CN101400703B (zh) 2006-02-01 2013-05-08 赛法隆澳大利亚控股有限公司 结构域抗体构建体
US7704953B2 (en) * 2006-02-17 2010-04-27 Mdrna, Inc. Phage displayed cell binding peptides
WO2007112054A2 (en) * 2006-03-23 2007-10-04 Sea Lane Biotechnologies, Llc Facilitation of translocation of molecules through the gastrointestinal tract
EP2024393A2 (en) 2006-05-15 2009-02-18 Sea Lane Biotechnologies,llc. Neutralizing antibodies to influenza viruses
WO2007136840A2 (en) * 2006-05-20 2007-11-29 Codon Devices, Inc. Nucleic acid library design and assembly
EP2057191A1 (en) 2006-08-18 2009-05-13 Ablynx N.V. Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
EP2069558B1 (en) * 2006-10-02 2013-05-01 Sea Lane Biotechnologies,llc. Design and construction of diverse synthetic peptide and polypeptide libraries
US20080287320A1 (en) * 2006-10-04 2008-11-20 Codon Devices Libraries and their design and assembly
KR20100028031A (ko) * 2007-06-06 2010-03-11 다니스코 유에스 인크. 단백질 특성의 개선 방법
WO2009009045A2 (en) * 2007-07-10 2009-01-15 The Scripps Research Institute Escape libraries of target polypeptides
US8680019B2 (en) * 2007-08-10 2014-03-25 Protelica, Inc. Universal fibronectin Type III binding-domain libraries
US8470966B2 (en) 2007-08-10 2013-06-25 Protelica, Inc. Universal fibronectin type III binding-domain libraries
US20090176654A1 (en) * 2007-08-10 2009-07-09 Protelix, Inc. Universal fibronectin type III binding-domain libraries
EP2220120A2 (en) 2007-11-27 2010-08-25 Ablynx N.V. Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
WO2009121004A2 (en) 2008-03-28 2009-10-01 Sea Lane Biotechnologies, Llc Neutralizing molecules to viral antigens
EP2131245A3 (en) * 2008-06-02 2012-08-01 ASML Netherlands BV Lithographic apparatus and its focus determination method
WO2010115995A2 (en) 2009-04-10 2010-10-14 Ablynx Nv Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
NZ595461A (en) 2009-04-10 2013-01-25 Ablynx Nv Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
ES2643034T3 (es) 2009-06-05 2017-11-21 Ablynx N.V. Construcciones de Nanobody contra el virus respiratorio sincicial humano (VRSH) trivalentes para la prevención y/o el tratamiento de infecciones de las vías respiratorias
ES2652340T3 (es) * 2009-07-17 2018-02-01 Bioatla Llc Selección y evolución simultáneas e integradas de rendimiento y expresión de proteínas humanas en huéspedes de producción
GB0914691D0 (en) * 2009-08-21 2009-09-30 Lonza Biologics Plc Immunoglobulin variants
EP2494046B1 (en) 2009-10-30 2018-09-12 Novartis AG Universal fibronectin type iii bottom-side binding domain libraries
WO2011064382A1 (en) 2009-11-30 2011-06-03 Ablynx N.V. Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections
CN107903321A (zh) 2010-07-30 2018-04-13 诺华有限公司 纤连蛋白摇篮分子和其库
EP2647704B1 (en) 2010-12-01 2017-11-01 Mitsubishi Tanabe Pharma Corporation Polynucleotide construct capable of presenting fab in acellular translation system, and method for manufacturing and screening fab using same
US10138302B2 (en) 2011-09-23 2018-11-27 Ablynx N.V. Methods for treating rheumatoid arthritis by administering interleukin-6 receptor antibodies
SG11201404532XA (en) 2012-03-02 2014-08-28 Ablynx Nv Pseudomonas aeruginosa pcrv binding single variable domain antibodies
US9777055B2 (en) * 2012-04-20 2017-10-03 Thomas Jefferson University Engineered antibody for inhibition of fibrosis
NZ725398A (en) * 2012-05-25 2018-05-25 Chr Hansen As Variants of chymosin with improved milk-clotting properties
WO2014087010A1 (en) 2012-12-07 2014-06-12 Ablynx N.V. IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
KR101600899B1 (ko) * 2012-12-11 2016-03-09 주식회사 셀레믹스 초병렬적 핵산 합성법을 통한 dna 라이브러리의 동시 합성 방법
US20140314741A1 (en) * 2013-04-18 2014-10-23 Developmen Center For Biotechnology Human Antibody against Interleukin-20 and Treatment for Inflammatory Diseases
US9416197B2 (en) 2013-11-01 2016-08-16 Ibc Pharmaceuticals, Inc. Bispecific antibodies that neutralize both TNF-α and IL-6: novel therapeutic agent for autoimmune disease
CN104805507B (zh) * 2014-01-29 2019-01-22 杭州康万达医药科技有限公司 噬菌体展示文库及其应用和制备方法
RU2739004C1 (ru) 2014-02-26 2020-12-21 Кхр. Хансен А/С Варианты химозина с улучшенными молокосвертывающими свойствами
CA2963712A1 (en) 2014-10-21 2016-04-28 Ablynx Nv Treatment of il-6r related diseases
WO2016207214A1 (en) 2015-06-22 2016-12-29 Chr. Hansen A/S Variants of chymosin with improved properties
MX2018002366A (es) 2015-08-31 2018-04-11 Chr Hansen As Variantes de quimosina con propiedades mejoradas.
IL260185B (en) * 2016-01-08 2022-09-01 Momotaro Gene Inc A combination therapy using reic/dkk-3 gene and a checkpoint inhibitor
CA3024211A1 (en) 2016-05-19 2017-11-23 Chr. Hansen A/S Variants of chymosin with improved milk-clotting properties
JP7395251B2 (ja) 2016-05-19 2023-12-11 セーホーエル.ハンセン アクティーゼルスカブ 改善された凝乳特性を有するキモシン変異体
EP4282969A3 (en) 2016-09-02 2024-01-31 Lentigen Technology, Inc. Compositions and methods for treating cancer with duocars
MX2020006297A (es) 2017-12-15 2020-12-07 Aleta Biotherapeutics Inc Variantes de cd19.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2078518T3 (es) * 1990-04-05 1995-12-16 Roberto Crea Mutagenesis por desplazamiento completo.
EP0748338A4 (en) * 1994-03-04 2001-03-28 Merck & Co Inc IN VITRO MATURATION OF ANTIBODIES BY MEANS OF ALANINE 'SCANNING' MUTAGENESIS
AU784983B2 (en) * 1999-12-15 2006-08-17 Genentech Inc. Shotgun scanning, a combinatorial method for mapping functional protein epitopes

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