JP2011173928A - 癌処置のためのエポチロンの使用 - Google Patents
癌処置のためのエポチロンの使用 Download PDFInfo
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- JP2011173928A JP2011173928A JP2011128592A JP2011128592A JP2011173928A JP 2011173928 A JP2011173928 A JP 2011173928A JP 2011128592 A JP2011128592 A JP 2011128592A JP 2011128592 A JP2011128592 A JP 2011128592A JP 2011173928 A JP2011173928 A JP 2011173928A
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- 230000005945 translocation Effects 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 231100000925 very toxic Toxicity 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9803905.0A GB9803905D0 (en) | 1998-02-25 | 1998-02-25 | Organic compounds |
| GBGB9803907.6A GB9803907D0 (en) | 1998-02-25 | 1998-02-25 | Organic compounds |
| GB9803905.0 | 1998-02-25 | ||
| GB9803907.6 | 1998-02-25 | ||
| GBGB9805937.1A GB9805937D0 (en) | 1998-03-19 | 1998-03-19 | Organic compounds |
| GB9805937.1 | 1998-03-19 | ||
| GB9805936.3 | 1998-03-19 | ||
| GBGB9805936.3A GB9805936D0 (en) | 1998-03-19 | 1998-03-19 | Organic compounds |
| US09/233,993 | 1999-01-19 | ||
| US09/233,993 US6302838B1 (en) | 1998-02-25 | 1999-01-19 | Cancer treatment with epothilones |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000533117A Division JP2002504511A (ja) | 1998-02-25 | 1999-02-23 | 癌処置のためのエポチロンの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011173928A true JP2011173928A (ja) | 2011-09-08 |
| JP2011173928A5 JP2011173928A5 (enExample) | 2012-07-26 |
Family
ID=27451759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011128592A Pending JP2011173928A (ja) | 1998-02-25 | 2011-06-08 | 癌処置のためのエポチロンの使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US6302838B1 (enExample) |
| JP (1) | JP2011173928A (enExample) |
| AT (1) | ATE483462T1 (enExample) |
| DE (1) | DE69942827D1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| CA2273083C (en) | 1996-12-03 | 2012-09-18 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| FR2775187B1 (fr) * | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
| US6596875B2 (en) * | 2000-02-07 | 2003-07-22 | James David White | Method for synthesizing epothilones and epothilone analogs |
| US20050042275A1 (en) * | 1999-08-04 | 2005-02-24 | Jean-Claude Sonntag | Epothilone compositions |
| US7740841B1 (en) * | 2000-01-28 | 2010-06-22 | Sunnybrook Health Science Center | Therapeutic method for reducing angiogenesis |
| US6489314B1 (en) * | 2001-04-03 | 2002-12-03 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
| US6893859B2 (en) | 2001-02-13 | 2005-05-17 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
| HUP0303175A2 (hu) * | 2001-02-20 | 2003-12-29 | Bristol-Myers Squibb Co. | Epotilonszármazékok alkalmazása makacs tumorok kezelésére alkalmas gyógyszerkészítmény előállítására |
| ES2326264T3 (es) * | 2001-02-27 | 2009-10-06 | Novartis Ag | Combinacion que comprende un inhibidor de transduccion de señal y un derivado epotilona. |
| SI1372650T1 (sl) * | 2001-03-19 | 2009-04-30 | Novartis Ag | Kombinacije, ki obsegajo antidiaroično sredstvo in epotilon ali epotilonski derivat |
| US6906188B2 (en) * | 2001-04-30 | 2005-06-14 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Method for synthesizing epothilones and epothilone analogs |
| US20070203346A1 (en) * | 2001-04-30 | 2007-08-30 | Oregon State University | Method for synthesizing epothilones and epothilone analogs |
| TWI315982B (en) * | 2001-07-19 | 2009-10-21 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
| TWI287986B (en) * | 2001-12-13 | 2007-10-11 | Novartis Ag | Use of Epothilones for the treatment of the carcinoid syndrome |
| KR20040078123A (ko) * | 2002-01-14 | 2004-09-08 | 노파르티스 아게 | 에포틸론 및 대사길항물질을 포함하는 조합물 |
| EP1340498A1 (en) * | 2002-03-01 | 2003-09-03 | Schering Aktiengesellschaft | Use of epothilones in the treatment of brain diseases associated with proliferative processes |
| BR0309711A (pt) * | 2002-05-01 | 2005-02-09 | Novartis Ag | Método para o tratamento de doenças do câncer |
| AU2003296878A1 (en) * | 2002-05-20 | 2004-12-13 | Kosan Biosciences, Inc. | Methods to administer epothilone d |
| RU2379032C9 (ru) * | 2002-06-10 | 2010-03-27 | Новартис Аг | Комбинации, включающие эпотилоны, и их фармацевтическое применение |
| SI1767535T1 (sl) | 2002-08-23 | 2010-03-31 | Sloan Kettering Inst Cancer | Sinteza epotilonov njihovih intermediatov analogov in uporaba le teh |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US20060142354A1 (en) * | 2002-10-15 | 2006-06-29 | Woltering Eugene A | Use of epothilone derivatives for the treatment of hyperparathyroidism |
| AU2004247626B8 (en) * | 2003-05-15 | 2011-05-19 | Arqule, Inc. | Imidazothiazoles and imidazoxazole derivatives as inhibitors of p38 |
| JP2009513486A (ja) * | 2003-06-27 | 2009-04-02 | ノバルティス アクチエンゲゼルシャフト | エポチロンでの癌処置 |
| EP1663214A1 (en) * | 2003-09-02 | 2006-06-07 | Novartis AG | Cancer treatment with epothilones |
| US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| WO2006010082A1 (en) * | 2004-07-08 | 2006-01-26 | Arqule, Inc. | 1,4-disubstituted naphtalenes as inhibitors of p38 map kinase |
| WO2006044869A1 (en) * | 2004-10-19 | 2006-04-27 | Arqule, Inc. | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase |
| WO2006055742A1 (en) * | 2004-11-18 | 2006-05-26 | Bristol-Myers Squibb Company | Enteric coated bead comprising epothilone or epothilone analog, and preparation and administration thereof |
| EP1883627B1 (en) | 2005-05-18 | 2018-04-18 | Pharmascience Inc. | Bir domain binding compounds |
| US8168383B2 (en) | 2006-04-14 | 2012-05-01 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
| EP2450437B1 (en) | 2006-04-14 | 2017-05-17 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
| SG171682A1 (en) | 2006-05-16 | 2011-06-29 | Aegera Therapeutics Inc | Iap bir domain binding compounds |
| EP2361254A1 (en) * | 2008-12-05 | 2011-08-31 | ArQule, Inc. | Raf inhibitors and their uses |
| KR20120013336A (ko) * | 2009-03-25 | 2012-02-14 | 노파르티스 아게 | 약물 및 ｓｉＲＮＡ를 함유하는 제약 조성물 |
| EP3263583A1 (en) | 2010-02-12 | 2018-01-03 | Pharmascience Inc. | Iap bir domain binding compounds |
| CN103037903A (zh) | 2010-05-18 | 2013-04-10 | 天蓝制药公司 | 用于治疗自身免疫性疾病或其它疾病的组合物和方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
| ES2178093T5 (es) | 1995-11-17 | 2009-02-16 | Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) | Derivados de epotilon y su preparacion. |
| CA2273083C (en) | 1996-12-03 | 2012-09-18 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| IL134419A0 (en) | 1997-08-09 | 2001-04-30 | Schering Ag | Epothilone derivatives, process for the preparation thereof and pharmaceutical compositions containing the same |
-
1999
- 1999-01-19 US US09/233,993 patent/US6302838B1/en not_active Expired - Lifetime
- 1999-02-23 DE DE69942827T patent/DE69942827D1/de not_active Expired - Lifetime
- 1999-02-23 AT AT99910257T patent/ATE483462T1/de active
-
2011
- 2011-06-08 JP JP2011128592A patent/JP2011173928A/ja active Pending
Non-Patent Citations (6)
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| JPN5001008509; Ｊ． Ｂｉｏ． Ｃｈｅｍ． Ｖｏｌ． ２７２, 1997, ２５３４-２５４１ * |
| JPN5001008510; Ａｎｇｅｗ． Ｃｈｅｍ． Ｉｎｔ． Ｅｄ． Ｅｎｇｌ． Ｖｏｌ． ３６, 1997, ２０９３-２０９６ * |
| JPN5001008513; Ｃａｎｃｅｒ Ｒｅｓ Ｖｏｌ． ５５, 1995, ２３２５-２３３３ * |
| JPN5001008516; Ｎａｔｕｒｅ Ｖｏｌ．３８７, 1997, ２６８-２７２ * |
| JPN5001008520; Ｊ． Ｂｉｏｌ． Ｃｈｅｍ． Ｖｏｌ．２７２, 1997, １７１１８-１７１２５ * |
| JPN6013024137; ＧＵＣＨＥＬＡＡＲ， Ｈ．-Ｊ．: Ｃｌｉｎｉｃａｌ Ｏｎｃｏｌｏｇｙ Ｖｏｌ．６, 1994, ｐ．４０-４８ * |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69942827D1 (de) | 2010-11-18 |
| US6302838B1 (en) | 2001-10-16 |
| ATE483462T1 (de) | 2010-10-15 |
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