JP2011152137A5 - - Google Patents

Download PDF

Info

Publication number
JP2011152137A5
JP2011152137A5 JP2011045589A JP2011045589A JP2011152137A5 JP 2011152137 A5 JP2011152137 A5 JP 2011152137A5 JP 2011045589 A JP2011045589 A JP 2011045589A JP 2011045589 A JP2011045589 A JP 2011045589A JP 2011152137 A5 JP2011152137 A5 JP 2011152137A5
Authority
JP
Japan
Prior art keywords
nucleic acid
acid molecule
hpv45
protein
yeast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011045589A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011152137A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2011152137A publication Critical patent/JP2011152137A/ja
Publication of JP2011152137A5 publication Critical patent/JP2011152137A5/ja
Pending legal-status Critical Current

Links

JP2011045589A 2003-09-29 2011-03-02 酵母におけるｈｐｖ４５ｌ１の最適化された発現 Pending JP2011152137A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50681203P 2003-09-29 2003-09-29
US60/506,812 2003-09-29

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2006528190A Division JP5451960B2 (ja) 2003-09-29 2004-09-24 酵母におけるｈｐｖ４５ｌ１の最適化された発現

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014129350A Division JP2014221052A (ja) 2003-09-29 2014-06-24 酵母におけるｈｐｖ４５ｌ１の最適化された発現

Publications (2)

Publication Number Publication Date
JP2011152137A JP2011152137A (ja) 2011-08-11
JP2011152137A5 true JP2011152137A5 (https=) 2013-04-04

Family

ID=34421558

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2006528190A Expired - Lifetime JP5451960B2 (ja) 2003-09-29 2004-09-24 酵母におけるｈｐｖ４５ｌ１の最適化された発現
JP2011045589A Pending JP2011152137A (ja) 2003-09-29 2011-03-02 酵母におけるｈｐｖ４５ｌ１の最適化された発現
JP2014129350A Pending JP2014221052A (ja) 2003-09-29 2014-06-24 酵母におけるｈｐｖ４５ｌ１の最適化された発現
JP2016019712A Pending JP2016136947A (ja) 2003-09-29 2016-02-04 酵母におけるｈｐｖ４５ｌ１の最適化された発現

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2006528190A Expired - Lifetime JP5451960B2 (ja) 2003-09-29 2004-09-24 酵母におけるｈｐｖ４５ｌ１の最適化された発現

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2014129350A Pending JP2014221052A (ja) 2003-09-29 2014-06-24 酵母におけるｈｐｖ４５ｌ１の最適化された発現
JP2016019712A Pending JP2016136947A (ja) 2003-09-29 2016-02-04 酵母におけるｈｐｖ４５ｌ１の最適化された発現

Country Status (33)

Country Link
US (2) US7250170B2 (https=)
EP (1) EP1673106B1 (https=)
JP (4) JP5451960B2 (https=)
KR (1) KR101165278B1 (https=)
CN (1) CN1859923B (https=)
AR (2) AR045804A1 (https=)
AT (1) ATE435029T1 (https=)
AU (1) AU2004277934B2 (https=)
BE (1) BE2015C072I2 (https=)
BR (1) BRPI0414845B8 (https=)
CA (1) CA2539168C (https=)
CY (2) CY1110525T1 (https=)
DE (1) DE602004021828D1 (https=)
DK (1) DK1673106T3 (https=)
ES (1) ES2327530T3 (https=)
FR (1) FR15C0083I2 (https=)
HU (1) HUS1500063I1 (https=)
IL (1) IL174458A (https=)
IS (1) IS2694B (https=)
LT (2) LTPA2015049I1 (https=)
LU (1) LU92902I2 (https=)
MX (1) MXPA06003457A (https=)
MY (1) MY140664A (https=)
NL (1) NL300776I2 (https=)
NO (3) NO339932B1 (https=)
NZ (1) NZ545834A (https=)
PL (1) PL1673106T3 (https=)
PT (1) PT1673106E (https=)
RU (1) RU2360001C2 (https=)
SI (1) SI1673106T1 (https=)
TW (1) TWI350853B (https=)
WO (1) WO2005032586A1 (https=)
ZA (1) ZA200601961B (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0206360D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
US7858098B2 (en) 2002-12-20 2010-12-28 Glaxosmithkline Biologicals, S.A. Vaccine
MY139500A (en) 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast
EP1730175B1 (en) 2004-03-24 2010-04-28 Merck Sharp & Dohme Corp. Optimized expression of hpv 52 l1 in yeast
US7758866B2 (en) 2004-06-16 2010-07-20 Glaxosmithkline Biologicals, S.A. Vaccine against HPV16 and HPV18 and at least another HPV type selected from HPV 31, 45 or 52
AU2006236905B2 (en) 2005-04-15 2010-06-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen
CA2606092A1 (en) * 2005-04-26 2006-11-02 Glaxosmithkline Biologicals S.A. Vaccine
KR100904844B1 (ko) * 2006-08-28 2009-06-25 성균관대학교산학협력단 인유두종 바이러스（ｈｐｖ）유전자를 포함하는자궁경부암의 치료 또는 예방용 ｄｎａ 백신
WO2008112125A1 (en) * 2007-03-09 2008-09-18 Merck & Co., Inc. Papillomavirus vaccine compositions
CN101835797A (zh) 2007-11-23 2010-09-15 上海泽润生物科技有限公司 人乳头状瘤病毒主要衣壳蛋白l1基因及其用途
US9566323B2 (en) 2009-06-19 2017-02-14 Eyegene Inc. Vaccine for cervical cancer
JP6153866B2 (ja) 2010-05-25 2017-06-28 キアゲン ガイサーズバーグ アイエヌシー． 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ
CA2839427C (en) * 2011-06-15 2016-09-27 Chung-Ang University Industry-Academic Cooperation Foundation Method for enhancing the production yield of human papillomavirus l1 protein
US20140127260A1 (en) 2011-06-24 2014-05-08 Ramesh V. Chintala Hpv vaccine formulations comprising aluminum adjuvant and methods of producing same
CN109321592A (zh) * 2012-01-21 2019-02-12 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv18 l1蛋白的方法
CN108624614A (zh) * 2012-03-28 2018-10-09 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv11 l1蛋白的方法
CN104120089B (zh) * 2013-04-26 2019-09-24 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv52 l1蛋白的方法
CN104120088B (zh) * 2013-04-26 2019-09-24 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv58 l1蛋白的方法
CN110295190A (zh) * 2013-05-17 2019-10-01 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv45 l1蛋白的方法
CN112280793B (zh) * 2013-09-29 2022-06-24 上海泽润生物科技有限公司 人乳头瘤病毒基因，及载体，菌株，表达方法
US9782470B2 (en) 2013-10-16 2017-10-10 Merck Sharp & Dohme Corp. Method of obtaining thermostable dried vaccine formulations
CN107002085A (zh) * 2014-09-11 2017-08-01 卡迪拉保健有限公司 具有优异免疫学特性的优异的人乳头瘤病毒抗原和含有其的疫苗
CN106282278B (zh) * 2015-06-29 2021-06-08 广东东阳光药业有限公司 一种人乳头瘤病毒l1蛋白的发酵方法
CN106701798B (zh) * 2015-08-12 2021-09-17 北京康乐卫士生物技术股份有限公司 45型重组人乳头瘤病毒病毒样颗粒及其制备方法
CN109750050B (zh) * 2017-11-07 2023-08-18 上海泽润生物科技有限公司 重组人乳头瘤病毒45亚型蛋白表达
WO2021163002A1 (en) 2020-02-14 2021-08-19 Merck Sharp & Dohme Corp. Hpv vaccine
CN112680462B (zh) * 2020-12-29 2022-02-22 上海博唯生物科技有限公司 一种人乳头瘤病毒35型/hpv35型l1/l2及其制备与应用
CN113073105B (zh) * 2021-03-23 2023-06-13 重庆博唯佰泰生物制药有限公司 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用
EP4380615A1 (en) 2021-08-06 2024-06-12 Merck Sharp & Dohme LLC Hpv vaccine
EP4387660A1 (en) 2021-08-19 2024-06-26 Merck Sharp & Dohme LLC Thermostable lipid nanoparticle and methods of use thereof
WO2024254226A1 (en) 2023-06-09 2024-12-12 Merck Sharp & Dohme Llc Nanoemulsion adjuvant compositions for human papillomavirus vaccines

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3863559B2 (ja) * 1994-05-16 2006-12-27 メルク エンド カンパニー インコーポレーテッド 乳頭腫ウィルスワクチン
AR004464A1 (es) * 1994-11-14 1998-12-16 Merck Sharp & Dohme Un metodo para producir una proteina de capside de papilomavirus
IL117459A (en) * 1995-03-22 2005-11-20 Merck & Co Inc Dna encoding human papillomavirus type 18
IL117591A0 (en) * 1995-03-30 1996-07-23 Merck & Co Inc Synthetic DNA encoding human papillomavirus type 11 L1 protein
DK0969862T3 (da) 1997-02-07 2007-02-12 Merck & Co Inc Syntetisk HIV gag-gener
DE69732378D1 (de) * 1997-05-27 2005-03-03 Hanil Synthetic Fiber Co Ltd Verfahren zur herstellung von rekombinanten eiweissen durch verwendung von hocheffizienten expressionsvektoren aus saccharomyces cerevisiae
EP1002091B1 (en) 1997-07-09 2012-02-29 Coridon Pty Limited Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue
US6991795B1 (en) * 1998-08-14 2006-01-31 Merck & Co., Inc. Protein delivery system using human papillomavirus virus-like particles
AU760633B2 (en) * 1998-08-14 2003-05-22 Merck Sharp & Dohme Corp. Process for purifying human papillomavirus virus-like particles
JP4563582B2 (ja) * 1998-08-14 2010-10-13 メルク・シャープ・エンド・ドーム・コーポレイション ヒトパピローマウイルスのウイルス様粒子を使用するタンパク質送達系
DE69924007T2 (de) * 1998-12-23 2006-04-06 Merck & Co., Inc. Neutralsierungs-assay, das humane papillomavirus-ähnliche partikel verwendet
AU772611B2 (en) * 1999-08-25 2004-05-06 Merck Sharp & Dohme Corp. Synthetic human papillomavirus genes
US6436402B1 (en) * 1999-10-15 2002-08-20 Merck & Co., Inc. Process for making human papillomavirus virus-like particles with improved properties
US7026443B1 (en) * 1999-12-10 2006-04-11 Epimmune Inc. Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions
WO2002008435A1 (en) 2000-07-21 2002-01-31 Glaxo Group Limited Codon-optimized papilloma virus sequences
WO2003068163A2 (en) * 2002-02-14 2003-08-21 Novavax, Inc. Optimization of gene sequences of chimeric virus-like particles for expression in insect cells
GB0206360D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
US7276243B2 (en) 2003-03-24 2007-10-02 Merck & Co., Inc. Optimized expression of HPV31 L1 in yeast

Similar Documents

Publication Publication Date Title
JP2011152137A5 (https=)
JP2014221052A5 (https=)
JP2013533745A5 (https=)
JP2012095652A5 (https=)
JP2011507532A5 (https=)
CA2539168A1 (en) Optimized expression of hpv 45 l1 in yeast
CA2543928A1 (en) Optimized expression of hpv 58 l1 in yeast
RU2005132603A (ru) Оптимизированная экспрессия hpv 31 l1 в дрожжах
EP3199545A3 (en) Computationally optimized broadly reactive antigens for h1n1 influenza
JP2014507144A5 (ja) 慢性ｂ型肝炎感染症のための酵母系免疫療法組成物
RU2006137363A (ru) Оптимизированная экспрессия hpv 52 l1 в дрожжах
HRP20160207T1 (hr) Prokariotska ksiloza izomeraza za konstrukciju kvasaca koji fermentiraju ksilozu
JP2010533737A5 (https=)
JP2015521848A5 (https=)
JP2014508541A5 (https=)
RU2012122166A (ru) Способы получения рекомбинантных белков с увеличенными эффективностями секреции
JP2017500024A5 (https=)
WO2012083445A8 (en) Virus like particle production in plants
JP2007507207A5 (https=)
CA2863981A1 (en) Computationally optimized broadly reactive antigens for h3n2, h2n2, and b influenza viruses
JP2021520836A5 (https=)
CN108330145A (zh) 重组乙肝表面抗原的生产方法
CN104404057A (zh) 一种大鲵虹彩病毒病疫苗及制备方法和应用
CN104087522B (zh) 一种外源表达甲酸脱氢酶的酵母工程菌及其构建方法和应用
HRP20171583T1 (hr) Fermentirajući mikroorganizmi na bazi pentoze