JP2011095273A5 - - Google Patents

Download PDF

Info

Publication number
JP2011095273A5
JP2011095273A5 JP2011005396A JP2011005396A JP2011095273A5 JP 2011095273 A5 JP2011095273 A5 JP 2011095273A5 JP 2011005396 A JP2011005396 A JP 2011005396A JP 2011005396 A JP2011005396 A JP 2011005396A JP 2011095273 A5 JP2011095273 A5 JP 2011095273A5
Authority
JP
Japan
Prior art keywords
probe
fluorescent
target tissue
fluorescent dye
probe according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011005396A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011095273A (ja
JP5171970B2 (ja
Filing date
Publication date
Priority claimed from US09/079,447 external-priority patent/US6083486A/en
Application filed filed Critical
Publication of JP2011095273A publication Critical patent/JP2011095273A/ja
Publication of JP2011095273A5 publication Critical patent/JP2011095273A5/ja
Application granted granted Critical
Publication of JP5171970B2 publication Critical patent/JP5171970B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2011005396A 1998-05-14 2011-01-14 分子内発光抑制式近赤外蛍光プローブ Expired - Lifetime JP5171970B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/079,447 US6083486A (en) 1998-05-14 1998-05-14 Intramolecularly-quenched near infrared fluorescent probes
US09/079,447 1998-05-14

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2000548012A Division JP4726297B2 (ja) 1998-05-14 1999-05-13 分子内発光抑制式近赤外蛍光プローブ

Publications (3)

Publication Number Publication Date
JP2011095273A JP2011095273A (ja) 2011-05-12
JP2011095273A5 true JP2011095273A5 (OSRAM) 2012-04-05
JP5171970B2 JP5171970B2 (ja) 2013-03-27

Family

ID=22150620

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000548012A Expired - Lifetime JP4726297B2 (ja) 1998-05-14 1999-05-13 分子内発光抑制式近赤外蛍光プローブ
JP2011005396A Expired - Lifetime JP5171970B2 (ja) 1998-05-14 2011-01-14 分子内発光抑制式近赤外蛍光プローブ

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2000548012A Expired - Lifetime JP4726297B2 (ja) 1998-05-14 1999-05-13 分子内発光抑制式近赤外蛍光プローブ

Country Status (8)

Country Link
US (1) US6083486A (OSRAM)
EP (2) EP1077731B1 (OSRAM)
JP (2) JP4726297B2 (OSRAM)
AT (1) ATE473017T1 (OSRAM)
AU (1) AU770216B2 (OSRAM)
CA (1) CA2328136C (OSRAM)
DE (1) DE69942563D1 (OSRAM)
WO (1) WO1999058161A1 (OSRAM)

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7255851B2 (en) * 1994-07-01 2007-08-14 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US7087244B2 (en) * 2000-09-28 2006-08-08 Battelle Memorial Institute Thermogelling oligopeptide polymers
US6592847B1 (en) * 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US7547721B1 (en) 1998-09-18 2009-06-16 Bayer Schering Pharma Ag Near infrared fluorescent contrast agent and fluorescence imaging
JP2000095758A (ja) 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
US20030180221A1 (en) * 1998-09-18 2003-09-25 Schering Ag Near infrared fluorescent contrast agent and fluorescence imaging
US7107116B2 (en) * 1999-03-29 2006-09-12 Genex Technologies, Inc. Diffuse optical tomography system and method of use
WO2001089584A2 (en) * 2000-05-23 2001-11-29 Amersham Health As Contrast agents
GB0024351D0 (en) * 2000-10-04 2000-11-22 Amersham Pharm Biotech Uk Ltd Dye-labelled peptide and method
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US6615063B1 (en) 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
EP1379284A4 (en) * 2001-01-05 2007-07-25 Gen Hospital ACTIVE IMAGING PROBES
GB2372256A (en) * 2001-02-14 2002-08-21 Kalibrant Ltd Detectable entity comprising a plurality of detectable units releasably connected together by stimulus-cleavable linkers for use in fluorescence detection
DE10151670A1 (de) * 2001-10-19 2003-05-08 Siemens Ag Bildgebungsverfahren und Bildgebungsvorrichtung, insbesondere für die Kleintierbildgebung
AU2003207438A1 (en) * 2002-01-02 2003-07-24 Visen Medical, Inc. Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor
WO2003061711A2 (en) * 2002-01-16 2003-07-31 Visen Medical, Inc. Chromophore probes for optical imaging
AU2003225763A1 (en) * 2002-03-11 2003-09-29 Visen Medical, Inc. Optical imaging probes
AU2003228418A1 (en) * 2002-03-29 2003-10-13 The General Hospital Corporation Nir-fluorescent cyanine dyes, their synthesis and biological use
US20040022731A1 (en) * 2002-04-26 2004-02-05 Alexei Bogdanov In vivo imaging of apoptosis
US7303741B2 (en) * 2002-09-23 2007-12-04 General Electric Company Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
DE502004003658D1 (de) * 2003-05-30 2007-06-14 Siemens Ag Gerät zum Erfassen wenigstens einer Substanz in einem Stoffwechselprozess eines Lebewesens
US20080102036A1 (en) * 2003-06-04 2008-05-01 Poss Kirtland G Biocompatible Fluorescent Silicon Nanoparticles
EP1635878B1 (en) * 2003-06-25 2010-12-29 Guerbet Peptide conjugate for magnetic resonance imaging of matrix metalloproteinases
US20050106100A1 (en) * 2003-09-03 2005-05-19 Harris Thomas D. Compounds containing matrix metalloproteinase substrates and methods of their use
US9695251B2 (en) 2003-10-31 2017-07-04 The Regents Of The University Of California Activatable cell penetrating peptides with quenched fluorophores
US7985401B2 (en) 2003-10-31 2011-07-26 The Regents Of The University Of California Peptides whose uptake by cells is controllable
NO20035683D0 (no) * 2003-12-18 2003-12-18 Amersham Health As Optisk avbildning av prostatakreft
US20050259779A1 (en) * 2004-05-18 2005-11-24 Siemens Aktiengesellschaft Biomolecular contrast agents for therapy optimization in radiation therapy with proton or ion beams
US7585492B2 (en) 2004-05-18 2009-09-08 Siemens Aktiengesellschaft Biomolecular contrast agents for therapy success and dose monitoring in radiation therapy with proton or ion beams
US20050272967A1 (en) * 2004-05-18 2005-12-08 Siemens Aktiengesellschaft Biomolecular contrast agents with multiple signal variance for therapy planning and control in radiation therapy with proton or ion beams
WO2005110495A1 (en) * 2004-05-18 2005-11-24 Siemens Aktiengesellschaft Biomolecular contrast agents for therapy control in radiation therapy with proton or ion beams
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
JP2006225270A (ja) * 2005-02-15 2006-08-31 Yoshihiro Futamura 性ホルモン修飾作用を有するトリペプチド又はそれを含有する抽出物、エイコサペンタエン酸を結合してなるトリペプチド、それからなる食品製剤、化粧品製剤、子宮内膜症治療剤
US20090209508A1 (en) * 2005-05-16 2009-08-20 Universite De Geneve Compounds for Photochemotherapy
US8227621B2 (en) * 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
KR20080022588A (ko) * 2005-06-30 2008-03-11 브리스톨-마이어스 스퀴브 파마 컴퍼니 영상화제로서의 히드라지드 컨쥬게이트
DK1937676T3 (en) * 2005-09-02 2017-03-06 Visen Medical Inc Biocompatible fluorescent imaging compounds
WO2007028118A2 (en) 2005-09-02 2007-03-08 Visen Medical, Inc. Nicotinic acid and picolinic acid derived near-infrared fluorophores
CN101296927A (zh) 2005-09-02 2008-10-29 Visen医药公司 生物相容的含n,n-二取代磺酰胺的荧光染料标记
US20070148094A1 (en) * 2005-12-22 2007-06-28 Uzgiris Egidijus E Polymeric imaging agents and medical imaging methods
EP1973575B1 (en) 2005-12-22 2019-07-24 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
US8478386B2 (en) 2006-01-10 2013-07-02 Accuvein Inc. Practitioner-mounted micro vein enhancer
US12089951B2 (en) 2006-01-10 2024-09-17 AccuVeiw, Inc. Scanned laser vein contrast enhancer with scanning correlated to target distance
US11253198B2 (en) 2006-01-10 2022-02-22 Accuvein, Inc. Stand-mounted scanned laser vein contrast enhancer
US12295744B2 (en) 2006-01-10 2025-05-13 Accuvein, Inc. Micro vein enhancer with two lasers and two optical detectors configured for removing surface topology
US12408865B2 (en) 2006-01-10 2025-09-09 Accuvein Inc. Vein imaging device with differential image resolution at the center and the extremities of the vein image
US8838210B2 (en) 2006-06-29 2014-09-16 AccuView, Inc. Scanned laser vein contrast enhancer using a single laser
US10238294B2 (en) 2006-06-29 2019-03-26 Accuvein, Inc. Scanned laser vein contrast enhancer using one laser
US10813588B2 (en) 2006-01-10 2020-10-27 Accuvein, Inc. Micro vein enhancer
US11278240B2 (en) 2006-01-10 2022-03-22 Accuvein, Inc. Trigger-actuated laser vein contrast enhancer
US12471844B2 (en) 2006-06-29 2025-11-18 Accuvein, Inc. Scanned laser vein contrast enhancer with full stopping of scanner movement during scan line reversals
US9492117B2 (en) 2006-01-10 2016-11-15 Accuvein, Inc. Practitioner-mounted micro vein enhancer
US8489178B2 (en) 2006-06-29 2013-07-16 Accuvein Inc. Enhanced laser vein contrast enhancer with projection of analyzed vein data
US9854977B2 (en) 2006-01-10 2018-01-02 Accuvein, Inc. Scanned laser vein contrast enhancer using a single laser, and modulation circuitry
US8594770B2 (en) 2006-06-29 2013-11-26 Accuvein, Inc. Multispectral detection and presentation of an object's characteristics
US8730321B2 (en) 2007-06-28 2014-05-20 Accuvein, Inc. Automatic alignment of a contrast enhancement system
US8463364B2 (en) 2009-07-22 2013-06-11 Accuvein Inc. Vein scanner
US8078264B2 (en) 2006-07-11 2011-12-13 Case Western Reserve University Intra-operative molecular imaging
CA2663115C (en) 2006-09-08 2015-04-28 Rhode Island Hospital Treatment, prevention, and reversal of alcohol-induced liver disease
KR20090066289A (ko) 2006-09-08 2009-06-23 로드아일랜드하스피틀 알코올 유발성 뇌 질환의 치료, 예방 및 역행
RU2450832C2 (ru) * 2006-10-25 2012-05-20 Конинклейке Филипс Электроникс Н.В. Контрастные вещества для детекции рака предстательной железы
US9201063B2 (en) * 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US7629125B2 (en) * 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
DK2118206T3 (en) * 2007-02-09 2018-06-18 Visen Medical Inc POLYCYCLOF COLORS AND APPLICATION THEREOF
MY162041A (en) 2007-02-28 2017-05-31 Sanofi Aventis Imaging probes
WO2008109832A2 (en) * 2007-03-08 2008-09-12 Visen Medical, Inc. Viable near-infrared fluorochrome labeled cells and methods of making and using same
US9271653B2 (en) 2007-06-12 2016-03-01 Case Western Reserve University Intra-operative molecular imaging
US7906106B2 (en) 2007-06-27 2011-03-15 General Electric Company In vivo cell trafficking
US8021647B2 (en) 2007-06-29 2011-09-20 General Electric Company In vivo optical imaging
KR20100072167A (ko) 2007-08-03 2010-06-30 사노피-아벤티스 카스파제 이미징 프로브
JP5448397B2 (ja) 2007-09-07 2014-03-19 キヤノン株式会社 基質プローブ、多重核磁気共鳴法による酵素活性の検出方法および酵素活性のイメージング方法
EP2732826B1 (en) 2008-01-18 2017-11-08 Visen Medical, Inc. Fluorescent imaging agents
US20090240139A1 (en) * 2008-03-18 2009-09-24 Steven Yi Diffuse Optical Tomography System and Method of Use
US20090240138A1 (en) * 2008-03-18 2009-09-24 Steven Yi Diffuse Optical Tomography System and Method of Use
WO2009139972A2 (en) * 2008-03-31 2009-11-19 University Of Louisville Research Foundation, Inc. Site specific fluorescence marking and contrast marker for same
JP5278873B2 (ja) * 2008-05-14 2013-09-04 国立大学法人九州工業大学 癌診断用試薬
US20110200525A1 (en) * 2008-10-09 2011-08-18 Patz Jr Edward F Vhh antibody fragments for use in the detection and treatment of cancer
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
GB0823315D0 (en) 2008-12-22 2009-01-28 Ge Healthcare As Fluorescent Probes
KR101043407B1 (ko) * 2009-02-19 2011-06-22 한국과학기술연구원 암 표적성이 우수한 단백질 복합체 및 이의 제조방법
US9155471B2 (en) 2009-05-27 2015-10-13 Lumicell, Inc'. Methods and systems for spatially identifying abnormal cells
US20110021908A1 (en) * 2009-05-27 2011-01-27 Lumicell Diagnostics, Inc. Methods and systems for spatially identifying abnormal cells
EP2453926A4 (en) 2009-07-15 2015-08-12 Univ California PEPTIDES WITH CONTROLLABLE CELLULAR RECORDING
US9061109B2 (en) 2009-07-22 2015-06-23 Accuvein, Inc. Vein scanner with user interface
JP5426026B2 (ja) 2009-07-28 2014-02-26 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 非侵襲性インビボ光学イメージング方法
US8518405B2 (en) 2009-10-08 2013-08-27 The University Of North Carolina At Charlotte Tumor specific antibodies and uses therefor
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
CN102939538A (zh) 2010-05-07 2013-02-20 霍夫曼-拉罗奇有限公司 用于离体检测细胞的诊断方法
US9370589B2 (en) 2010-08-23 2016-06-21 Shimadzu Corporation Switching fluorescent nanoparticle probe and fluorescent particle imaging method using same
EP2633080B1 (en) 2010-10-29 2018-12-05 President and Fellows of Harvard College Method of detecting targets using fluorescently labelled nucleic acid nanotube probes
EP2646059A4 (en) 2010-12-01 2016-07-27 Methodist Hospital System PROTEASE-DERIVABLE POLYPEPTIDES AND USES THEREOF
US9314304B2 (en) 2010-12-08 2016-04-19 Lumicell, Inc. Methods and system for image guided cell ablation with microscopic resolution
US9849197B2 (en) 2011-03-02 2017-12-26 Kyoto University Switching-type fluorescent nanoparticle probe, and fluorescent molecular imaging method using same
EP2683413A1 (en) 2011-03-07 2014-01-15 F.Hoffmann-La Roche Ag In vivo selection of therapeutically active antibodies
US20140099264A1 (en) 2011-03-07 2014-04-10 F. Hoffman-La Roche Ag Means and methods for in vivo testing of therapeutic antibodies
CA2835286C (en) 2011-05-09 2021-03-23 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
US9572787B2 (en) 2011-05-19 2017-02-21 Rhode Island Hospital Inhibition of renal fibrosis
US20150031046A1 (en) * 2011-05-24 2015-01-29 Lijun Dai Bioanalytical Reagent used in Heterogeneous Phase and Usage Method Thereof
DK2736533T3 (en) 2011-07-29 2018-08-06 Avelas Biosciences Inc SELECTIVE SUBMISSION MOLECULES AND METHODS OF USE
JPWO2013081036A1 (ja) * 2011-11-29 2015-04-27 太陽誘電株式会社 マーカ分子
CN104245954A (zh) 2012-03-30 2014-12-24 文森医学公司 细菌成像剂及其使用方法
US9072426B2 (en) 2012-08-02 2015-07-07 AccuVein, Inc Device for detecting and illuminating vasculature using an FPGA
WO2014028057A1 (en) 2012-08-15 2014-02-20 Visen Medical, Inc. Prostate specific antigen agents and methods of using same for prostate cancer imaging
US20150209406A1 (en) 2012-09-07 2015-07-30 Massachusetts Eye And Ear Infirmary Methods and compositions for regenerating hair cells and/or supporting cells
WO2014055253A1 (en) * 2012-10-04 2014-04-10 The General Hospital Corporation Methods of synthesizing and using peg-like fluorochromes
US9650674B2 (en) 2012-10-19 2017-05-16 Bioventures, Llc Nucleic acid probes and methods of using the same
US9950053B2 (en) 2012-10-22 2018-04-24 The Board Of Regents For Oklahoma State University Use of the Salmonella SPP type III secretion proteins as a protective vaccination
US10548962B2 (en) 2012-10-22 2020-02-04 The Board Of Regents For Oklahoma State University Use of the salmonella SPP type III secretion proteins as a protective vaccination
US10376147B2 (en) 2012-12-05 2019-08-13 AccuVeiw, Inc. System and method for multi-color laser imaging and ablation of cancer cells using fluorescence
NL2010040C2 (en) * 2012-12-21 2014-06-24 Internat Inst For Diagnostic And Analitical Affairs B V Cleavable coating material having microbial functionality.
US10029017B2 (en) 2013-01-29 2018-07-24 The Regents Of The University Of California Pretargeted activatable cell penetrating peptide with intracellularly releasable prodrug
CN105102484B (zh) 2013-01-30 2020-03-10 艾维拉斯生物科学公司 选择性递送分子及使用方法
US9439976B2 (en) 2013-02-13 2016-09-13 The Methodist Hospital System Compositions and methods for using cathepsin E cleavable substrates
WO2014160037A2 (en) 2013-03-14 2014-10-02 The Regents Of The University Of California Activatable membrane-interacting peptides and methods of use
KR20160037834A (ko) 2013-03-14 2016-04-06 루미셀, 아이엔씨. 의료 이미징 장치 및 사용 방법
CA2901000C (en) 2013-03-15 2023-03-14 Visen Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
AU2014228504C1 (en) 2013-03-15 2019-10-03 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection
EP3027773B1 (en) 2013-07-30 2020-03-25 President and Fellows of Harvard College Quantitative dna-based imaging and super-resolution imaging
US10610608B2 (en) 2013-08-01 2020-04-07 Rochester Institute Of Technology Modular imaging agents containing amino acids and peptides
EP2848696A1 (en) 2013-09-13 2015-03-18 Sanofi-Aventis Deutschland GmbH Caspase-1 imaging probes
CN104673274A (zh) * 2013-12-02 2015-06-03 复旦大学 一种用于肿瘤转移倾向评估的靶向示踪的酸敏感近红外荧光探针
JP6584322B2 (ja) 2013-12-27 2019-10-02 国立大学法人 東京医科歯科大学 アルツハイマー病及び前頭側頭葉変性症の診断方法、診断薬、治療薬、及びこれら薬剤のスクリーニング方法
US10294510B2 (en) 2014-03-11 2019-05-21 President And Fellows Of Harvard College High-throughput and highly multiplexed imaging with programmable nucleic acid probes
ES2830392T3 (es) 2014-07-23 2021-06-03 Ohio State Innovation Foundation Métodos y composiciones relacionados con fragmentos de anticuerpo que se unen a la glicoproteína 72 asociada a tumores (TAG-72)
US10385380B2 (en) 2014-10-02 2019-08-20 The Regents Of The University Of California Personalized protease assay to measure protease activity in neoplasms
EP3212773B1 (en) 2014-10-29 2021-09-15 Massachusetts Eye and Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
NL2013786B1 (en) * 2014-11-13 2016-10-07 Original G B V Quenched coating.
US10596259B2 (en) 2015-05-20 2020-03-24 The Regents Of The University Of California Tumor radiosensitization with monomethyl auristatin E (MMAE) and derivatives thereof
US11092606B2 (en) 2015-08-07 2021-08-17 President And Fellows Of Harvard College Super resolution imaging of protein-protein interactions
CN106280533B (zh) * 2016-08-17 2018-03-09 赣南师范大学 一种近红外荧光染料及其合成方法和用于寄生虫荧光标记
EP3551765B1 (en) 2016-12-09 2026-02-04 Ultivue, Inc. Improved methods for multiplex imaging using labeled nucleic acid imaging agents
JP6977287B2 (ja) * 2017-03-29 2021-12-08 東ソー株式会社 複数の蛍光物質を用いた標識方法
JP2020520981A (ja) 2017-05-24 2020-07-16 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドRamot At Tel Aviv University Ltd. プロテアーゼのイメージング/検出のための化学発光プローブ
CN111684077B (zh) * 2018-02-06 2024-10-11 简·探针公司 远红染料探针调配物
CN111704716B (zh) * 2020-07-03 2021-07-13 浙江大学 一种荧光聚赖氨酸树枝状大分子、其制备方法和应用
CN116438456A (zh) 2020-09-11 2023-07-14 格里姆普斯生物股份有限公司 用于疾病检测/诊断、分期、监测和治疗的离体蛋白酶活性检测
WO2022147171A1 (en) 2020-12-30 2022-07-07 Hawkeye Bio, Limited Pristine graphene based biosensor for biomarker detection and related core particles, materials compositions methods and systems

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988004777A1 (en) * 1986-12-15 1988-06-30 Ultra Diagnostics Corporation Monomeric phthalocyanine reagents
US5384241A (en) * 1987-09-11 1995-01-24 Enzo Diagnostics, Inc. Specific binding assay compound with inhibitive self-quenching characteristics
ES2061923T3 (es) * 1989-12-27 1994-12-16 Nestle Sa Procedimiento de la reaccion de un dextranomero injertado y de un colorante ftalocianinico y su utilizacion.
US5846703A (en) * 1990-05-15 1998-12-08 Diatron Corporation Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding
CA2082936C (en) * 1990-05-15 2003-09-23 Peter O. G. Arrhenius Fluorescent porphyrin, and fluorescent phthalocyanine-polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes
JPH05507518A (ja) * 1990-05-15 1993-10-28 ダイアトロン・コーポレイション 蛍光ジゴキシン試薬用のフタロシアナトポリエチレングリコールおよびフタロシアナトサッカリド
US5641878A (en) * 1991-05-15 1997-06-24 Diatron Corporation Porphyrin, azaporphyrin, and related fluorescent dyes free of aggregation and serum binding
EP0529002B1 (en) * 1990-05-15 2001-10-04 Hyperion, Inc. Fluorescent porphyrin, and fluorescent phthalocyanine - polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes
WO1994005203A1 (en) * 1992-09-04 1994-03-17 The General Hospital Corporation Biocompatible polymers containing diagnostic or therapeutic moieties
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
US5661035A (en) * 1995-06-07 1997-08-26 The Regents Of The University Of California Voltage sensing by fluorescence resonance energy transfer
DE19539409C2 (de) * 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel für die Nahinfrarot-Diagnostik
JP3896176B2 (ja) * 1996-05-21 2007-03-22 浜松ホトニクス株式会社 近赤外線蛍光トレーサーおよび蛍光イメージング方法
US5928625A (en) * 1997-03-13 1999-07-27 Mallinckrodt Inc. Method of measuring physiological function
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US5876946A (en) * 1997-06-03 1999-03-02 Pharmacopeia, Inc. High-throughput assay

Similar Documents

Publication Publication Date Title
JP2002514610A5 (OSRAM)
Kang et al. NIR fluorescence imaging and treatment for cancer immunotherapy
Chen et al. Advanced near‐infrared light for monitoring and modulating the spatiotemporal dynamics of cell functions in living systems
JP2012520856A5 (OSRAM)
Lyu et al. Semiconducting polymer nanobioconjugates for targeted photothermal activation of neurons
JP4726297B2 (ja) 分子内発光抑制式近赤外蛍光プローブ
Pierce et al. Optical contrast agents and imaging systems for detection and diagnosis of cancer
Ntziachristos Fluorescence molecular imaging
Mulder et al. Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe
Schaafsma et al. The clinical use of indocyanine green as a near‐infrared fluorescent contrast agent for image‐guided oncologic surgery
Kovar et al. A systematic approach to the development of fluorescent contrast agents for optical imaging of mouse cancer models
Maldiney et al. In vitro targeting of avidin-expressing glioma cells with biotinylated persistent luminescence nanoparticles
JP5426026B2 (ja) 非侵襲性インビボ光学イメージング方法
Liu et al. Molecular probes for in vivo optical imaging of immune cells
US10814017B2 (en) Multifunctional infrared-emitting composites
CN102686242B (zh) 用于医药科学的化学上放大的响应策略
CN102026668A (zh) 用于神经成像的包括与病毒组分结合的荧光染料的成像法和组合物
Sano et al. Indocyanine green-labeled polysarcosine for in vivo photoacoustic tumor imaging
BR112017016721B1 (pt) Método de geração de imagem de alta resolução
Papadimitriou et al. Smart polymeric nanoparticles as emerging tools for imaging—the parallel evolution of materials
Zhang et al. Bright semiconductor quantum dots shed new light on precision nanomedicine for various diseases
Solomon et al. Detection of enzyme activity in orthotopic murine breast cancer by fluorescence lifetime imaging using a fluorescence resonance energy transfer–based molecular probe
US20210299281A1 (en) Multiple biomarkers imaging for high specificity
JP2014510075A5 (OSRAM)
Gao Multifunctional quantum dots for cellular and molecular imaging