CA2328136C - Intramolecularly-quenched near infrared fluorescent probes - Google Patents

Intramolecularly-quenched near infrared fluorescent probes Download PDF

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Publication number
CA2328136C
CA2328136C CA002328136A CA2328136A CA2328136C CA 2328136 C CA2328136 C CA 2328136C CA 002328136 A CA002328136 A CA 002328136A CA 2328136 A CA2328136 A CA 2328136A CA 2328136 C CA2328136 C CA 2328136C
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CA
Canada
Prior art keywords
probe
fluorochrome
fluorescence
fluorochromes
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002328136A
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English (en)
French (fr)
Other versions
CA2328136A1 (en
Inventor
Ralph Weissleder
Ching-Hsuan Tung
Umar Mahmood
Lee Josephson
Alexei Bogdanov
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General Hospital Corp
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General Hospital Corp
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Publication of CA2328136A1 publication Critical patent/CA2328136A1/en
Application granted granted Critical
Publication of CA2328136C publication Critical patent/CA2328136C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Peptides Or Proteins (AREA)
  • Luminescent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Glass Compositions (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Surface Treatment Of Glass (AREA)
CA002328136A 1998-05-14 1999-05-13 Intramolecularly-quenched near infrared fluorescent probes Expired - Lifetime CA2328136C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/079,447 US6083486A (en) 1998-05-14 1998-05-14 Intramolecularly-quenched near infrared fluorescent probes
US09/079,447 1998-05-14
PCT/US1999/010589 WO1999058161A1 (en) 1998-05-14 1999-05-13 Intramolecularly-quenched near infrared fluorescent probes

Publications (2)

Publication Number Publication Date
CA2328136A1 CA2328136A1 (en) 1999-11-18
CA2328136C true CA2328136C (en) 2009-03-24

Family

ID=22150620

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002328136A Expired - Lifetime CA2328136C (en) 1998-05-14 1999-05-13 Intramolecularly-quenched near infrared fluorescent probes

Country Status (8)

Country Link
US (1) US6083486A (OSRAM)
EP (2) EP1077731B1 (OSRAM)
JP (2) JP4726297B2 (OSRAM)
AT (1) ATE473017T1 (OSRAM)
AU (1) AU770216B2 (OSRAM)
CA (1) CA2328136C (OSRAM)
DE (1) DE69942563D1 (OSRAM)
WO (1) WO1999058161A1 (OSRAM)

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AU4077799A (en) 1999-11-29
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WO1999058161A1 (en) 1999-11-18
EP1077731B1 (en) 2010-07-07
ATE473017T1 (de) 2010-07-15
AU770216B2 (en) 2004-02-19
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