JP2011088897A5 - - Google Patents
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- Publication number
- JP2011088897A5 JP2011088897A5 JP2010253233A JP2010253233A JP2011088897A5 JP 2011088897 A5 JP2011088897 A5 JP 2011088897A5 JP 2010253233 A JP2010253233 A JP 2010253233A JP 2010253233 A JP2010253233 A JP 2010253233A JP 2011088897 A5 JP2011088897 A5 JP 2011088897A5
- Authority
- JP
- Japan
- Prior art keywords
- apo
- ligand
- formulation
- metal ions
- divalent metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Claims (1)
- 製剤に存在する一つ又は複数の二価金属イオンの濃度がApo−2リガンドに対して<2Xモル比である、前記Apo−2リガンド及び前記一つ又は複数の二価金属イオンを含んでなる製剤。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14134299P | 1999-06-28 | 1999-06-28 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001506824A Division JP5118796B2 (ja) | 1999-06-28 | 2000-06-26 | 二価の金属イオンを利用したApo−2リガンドの製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011088897A JP2011088897A (ja) | 2011-05-06 |
JP2011088897A5 true JP2011088897A5 (ja) | 2012-02-02 |
Family
ID=22495287
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001506824A Expired - Lifetime JP5118796B2 (ja) | 1999-06-28 | 2000-06-26 | 二価の金属イオンを利用したApo−2リガンドの製造方法 |
JP2010253233A Pending JP2011088897A (ja) | 1999-06-28 | 2010-11-11 | 二価の金属イオンを利用したApo−2リガンドの製造方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001506824A Expired - Lifetime JP5118796B2 (ja) | 1999-06-28 | 2000-06-26 | 二価の金属イオンを利用したApo−2リガンドの製造方法 |
Country Status (12)
Country | Link |
---|---|
US (3) | US7855066B1 (ja) |
EP (3) | EP2339003A3 (ja) |
JP (2) | JP5118796B2 (ja) |
KR (1) | KR100674528B1 (ja) |
CN (2) | CN101633692A (ja) |
AU (3) | AU6338200A (ja) |
CA (1) | CA2377585A1 (ja) |
ES (1) | ES2392392T3 (ja) |
IL (2) | IL147029A0 (ja) |
MX (1) | MXPA01013236A (ja) |
NZ (2) | NZ515990A (ja) |
WO (1) | WO2001000832A1 (ja) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
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US20020106728A1 (en) * | 2000-06-20 | 2002-08-08 | Genentech, Inc. | NS4 nucleic acids and polypeptides and methods of use for the treatment of body weight disorders |
EP1873244A3 (en) * | 1999-06-02 | 2008-04-02 | Genentech, Inc. | Methods and compositions for inhibiting neoplastic cell growth |
EP2339003A3 (en) * | 1999-06-28 | 2011-10-19 | Genentech, Inc. | Apo-2 ligand substitutional variants |
US20040186051A1 (en) * | 2001-10-02 | 2004-09-23 | Kelley Robert F | Apo-2 ligand variants and uses thereof |
ES2351786T3 (es) * | 2001-11-13 | 2011-02-10 | Genentech, Inc. | Formulaciones con ligando apo2/trail y usos de las mismas. |
US7842668B1 (en) | 2001-11-13 | 2010-11-30 | Genentech, Inc. | Apo-2 ligand/trail formulations |
AU2007200478A1 (en) * | 2001-11-13 | 2007-02-22 | Genentech, Inc. | APO2 ligand/trail formulations |
US7741285B2 (en) | 2001-11-13 | 2010-06-22 | Genentech, Inc. | APO-2 ligand/trail formulations |
CA2489348A1 (en) | 2002-06-24 | 2003-12-31 | Genentech, Inc. | Apo-2 ligand/trail variants and uses thereof |
GB0328261D0 (en) * | 2003-12-05 | 2004-01-07 | Univ Groningen | Improved cytokine design |
JP5014116B2 (ja) | 2004-03-11 | 2012-08-29 | ジェネンテック, インコーポレイテッド | ポリペプチドの精製 |
JP5237638B2 (ja) | 2004-08-06 | 2013-07-17 | ジェネンテック, インコーポレイテッド | バイオマーカーを用いたアッセイおよび方法 |
WO2006017859A2 (en) | 2004-08-06 | 2006-02-16 | Genentech, Inc. | Assays and methods using biomarkers |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
ES2380119T3 (es) | 2005-08-16 | 2012-05-08 | Genentech, Inc. | Sensibilidad apoptótica a APO2L/TRAIL analizando la expresión de GalNac-T14 en células/tejidos |
GB0524316D0 (en) * | 2005-11-29 | 2006-01-04 | Medical Res Council | Tumour necrosis factor-related apoptosis-inducing ligands (TRAILs) |
US20100316639A1 (en) | 2009-06-16 | 2010-12-16 | Genentech, Inc. | Biomarkers for igf-1r inhibitor therapy |
CA2834776A1 (en) | 2011-05-03 | 2012-11-08 | Genentech, Inc. | Therapeutic apo2l/trail polypeptides and death receptor agonist antibodies |
CN102775491A (zh) * | 2011-05-09 | 2012-11-14 | 中国人民解放军第二军医大学 | 单链化的人凋亡素2配体三聚体蛋白质的制法和用途 |
CN102443055B (zh) * | 2011-10-26 | 2017-07-28 | 浙江海正药业股份有限公司 | 一种重组人肿瘤坏死因子相关凋亡诱导配体的纯化工艺 |
JP6355425B2 (ja) * | 2014-05-20 | 2018-07-11 | キヤノン株式会社 | システムおよびその制御方法 |
US11279768B1 (en) | 2015-04-03 | 2022-03-22 | Precision Biologics, Inc. | Anti-cancer antibodies, combination therapies, and uses thereof |
US10906951B2 (en) * | 2015-07-29 | 2021-02-02 | Onk Therapeutics Limited | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
JP2019518713A (ja) * | 2016-03-16 | 2019-07-04 | メリマック ファーマシューティカルズ インコーポレーティッド | 癌療法のための改変trail |
JP7429622B2 (ja) * | 2020-08-26 | 2024-02-08 | 株式会社オハラ | 光学ガラスの製造方法 |
Family Cites Families (35)
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US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
AU2353384A (en) | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
EP0257956B2 (en) | 1986-08-19 | 2000-11-22 | Genentech, Inc. | Use of polypeptide growth factors and cytokines for the manufacture of a device and of a dispersion |
EP0397687B1 (en) | 1987-12-21 | 1994-05-11 | The University Of Toledo | Agrobacterium mediated transformation of germinating plant seeds |
US6063763A (en) * | 1989-04-28 | 2000-05-16 | Schering Aktiengesellschaft | Protease-resistant thrombomodulin analogs |
DK168302B1 (da) | 1989-06-29 | 1994-03-07 | Danisco | Fremgangsmåde til indføring af molekyler, især genetisk materiale i planteceller |
EP1132471A3 (de) | 1989-09-12 | 2001-11-28 | F. Hoffmann-La Roche Ag | TNF-bindende Proteine |
WO1992003478A1 (en) | 1990-08-17 | 1992-03-05 | Genentech, Inc. | Metal ion mediated receptor binding of polypeptide hormones |
US5206161A (en) | 1991-02-01 | 1993-04-27 | Genentech, Inc. | Human plasma carboxypeptidase B |
AU1757092A (en) | 1991-03-28 | 1992-11-02 | Genentech Inc. | Stable growth hormone metal ion formulations |
US6387650B1 (en) * | 1995-06-07 | 2002-05-14 | Biocontrol Systems, Inc. | Method and composition for detecting bacterial contamination in food products |
KR100510234B1 (ko) * | 1995-06-29 | 2005-11-25 | 임뮤넥스 코포레이션 | 세포소멸을 유도하는 시토킨 |
DE19547933A1 (de) * | 1995-12-22 | 1997-06-26 | Boehringer Mannheim Gmbh | Multimere Formen von IL-16, Verfahren zu ihrer Herstellung und Verwendung |
US6030945A (en) * | 1996-01-09 | 2000-02-29 | Genentech, Inc. | Apo-2 ligand |
AU5711196A (en) | 1996-03-14 | 1997-10-01 | Human Genome Sciences, Inc. | Apoptosis inducing molecule i |
WO1997046686A2 (en) | 1996-06-07 | 1997-12-11 | Amgen Inc. | Tumor necrosis factor-related polypeptide |
EA199900256A1 (ru) | 1996-10-03 | 2000-02-28 | Байотерапиз, Инк. | Нуклеотидная и белковая последовательность маммастатина и способы применения |
CA2665133A1 (en) | 1996-10-25 | 1998-05-07 | Human Genome Sciences, Inc. | Neutrokine .alpha. |
DE69740107D1 (de) | 1996-12-23 | 2011-03-10 | Immunex Corp | Rezeptor aktivator von nf-kappa b, rezeptor is mitglied der tnf rezeptor superfamilie |
SK288559B6 (sk) | 1997-04-16 | 2018-05-02 | Amgen, Inc. | Nukleová kyselina, polypeptid, expresný vektor a hostiteľská bunka; proteín viažuci osteoprotegerín a spôsob jeho prípravy, protilátka a liečivo na prevenciu alebo liečenie chorôb kostí |
EP1860187B1 (en) | 1997-05-15 | 2011-07-13 | Genentech, Inc. | Apo-2 receptor |
DK1009817T3 (da) | 1997-08-26 | 2010-01-18 | Genentech Inc | RTD-receptor |
WO1999036535A1 (en) * | 1998-01-15 | 1999-07-22 | Genentech, Inc. | Apo-2 ligand |
SE9802454D0 (sv) | 1998-07-08 | 1998-07-08 | Pharmacia & Upjohn Ab | Production of peptides |
EP2339003A3 (en) * | 1999-06-28 | 2011-10-19 | Genentech, Inc. | Apo-2 ligand substitutional variants |
WO2001018055A1 (en) | 1999-09-10 | 2001-03-15 | Eli Lilly And Company | Flint analog compounds and formulations thereof |
WO2001018041A2 (en) | 1999-09-10 | 2001-03-15 | Eli Lilly And Company | Flint proteins and formulations thereof |
US20040186051A1 (en) * | 2001-10-02 | 2004-09-23 | Kelley Robert F | Apo-2 ligand variants and uses thereof |
ES2351786T3 (es) * | 2001-11-13 | 2011-02-10 | Genentech, Inc. | Formulaciones con ligando apo2/trail y usos de las mismas. |
CN100500841C (zh) * | 2005-10-10 | 2009-06-17 | 华东理工大学 | 一种表达可溶性trail蛋白的方法 |
-
2000
- 2000-06-26 EP EP10010653A patent/EP2339003A3/en not_active Withdrawn
- 2000-06-26 NZ NZ515990A patent/NZ515990A/en not_active IP Right Cessation
- 2000-06-26 CN CN200910145880A patent/CN101633692A/zh active Pending
- 2000-06-26 CN CNB008119589A patent/CN100526463C/zh not_active Expired - Lifetime
- 2000-06-26 IL IL14702900A patent/IL147029A0/xx unknown
- 2000-06-26 WO PCT/US2000/017579 patent/WO2001000832A1/en active Search and Examination
- 2000-06-26 ES ES00950255T patent/ES2392392T3/es not_active Expired - Lifetime
- 2000-06-26 AU AU63382/00A patent/AU6338200A/en not_active Abandoned
- 2000-06-26 EP EP00950255A patent/EP1194555B1/en not_active Expired - Lifetime
- 2000-06-26 JP JP2001506824A patent/JP5118796B2/ja not_active Expired - Lifetime
- 2000-06-26 KR KR1020017016748A patent/KR100674528B1/ko active IP Right Grant
- 2000-06-26 CA CA002377585A patent/CA2377585A1/en not_active Abandoned
- 2000-06-26 EP EP10010654A patent/EP2311956A1/en not_active Withdrawn
- 2000-06-26 MX MXPA01013236A patent/MXPA01013236A/es active IP Right Grant
- 2000-06-26 NZ NZ537920A patent/NZ537920A/en not_active IP Right Cessation
-
2001
- 2001-12-11 IL IL147029A patent/IL147029A/en active IP Right Grant
-
2005
- 2005-09-16 AU AU2005211561A patent/AU2005211561B2/en not_active Expired
-
2006
- 2006-09-28 US US11/528,948 patent/US7855066B1/en not_active Expired - Fee Related
- 2006-11-22 US US11/603,584 patent/US20070161564A1/en not_active Abandoned
-
2008
- 2008-11-21 AU AU2008249162A patent/AU2008249162A1/en not_active Abandoned
-
2010
- 2010-11-11 JP JP2010253233A patent/JP2011088897A/ja active Pending
- 2010-12-10 US US12/928,422 patent/US20120077740A1/en not_active Abandoned
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