JP2011046748A5 - - Google Patents
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- Publication number
- JP2011046748A5 JP2011046748A5 JP2010274133A JP2010274133A JP2011046748A5 JP 2011046748 A5 JP2011046748 A5 JP 2011046748A5 JP 2010274133 A JP2010274133 A JP 2010274133A JP 2010274133 A JP2010274133 A JP 2010274133A JP 2011046748 A5 JP2011046748 A5 JP 2011046748A5
- Authority
- JP
- Japan
- Prior art keywords
- tween
- polyoxyethylene sorbitan
- virion
- pharmaceutical composition
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 24
- 238000000034 method Methods 0.000 claims 23
- 210000002845 virion Anatomy 0.000 claims 23
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 229920001213 Polysorbate 20 Polymers 0.000 claims 14
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 14
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 14
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 14
- 229920000053 polysorbate 80 Polymers 0.000 claims 14
- 239000004094 surface-active agent Substances 0.000 claims 12
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 11
- 239000000600 sorbitol Substances 0.000 claims 11
- 150000001298 alcohols Chemical class 0.000 claims 9
- 239000002202 Polyethylene glycol Substances 0.000 claims 8
- 229920001223 polyethylene glycol Polymers 0.000 claims 8
- -1 sorbitan ester Chemical class 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 7
- 229920001214 Polysorbate 60 Polymers 0.000 claims 6
- 230000000087 stabilizing effect Effects 0.000 claims 6
- 150000005846 sugar alcohols Polymers 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- 239000004147 Sorbitan trioleate Substances 0.000 claims 3
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims 3
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 claims 3
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 claims 3
- 239000001816 polyoxyethylene sorbitan tristearate Substances 0.000 claims 3
- 235000010988 polyoxyethylene sorbitan tristearate Nutrition 0.000 claims 3
- 235000019337 sorbitan trioleate Nutrition 0.000 claims 3
- 229960000391 sorbitan trioleate Drugs 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 230000008014 freezing Effects 0.000 claims 2
- 238000007710 freezing Methods 0.000 claims 2
- 239000011521 glass Substances 0.000 claims 2
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims 2
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 238000010257 thawing Methods 0.000 claims 2
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 239000001587 sorbitan monostearate Substances 0.000 claims 1
- 235000011076 sorbitan monostearate Nutrition 0.000 claims 1
- 229940035048 sorbitan monostearate Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11068998P | 1998-12-03 | 1998-12-03 | |
| US60/110,689 | 1998-12-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584922A Division JP2002531418A (ja) | 1998-12-03 | 1999-12-02 | アデノ随伴ウイルスの薬学処方物における使用のための賦形剤、およびそれにより構成される薬学処方物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014000095A Division JP2014058578A (ja) | 1998-12-03 | 2014-01-06 | アデノ随伴ウイルスの薬学処方物における使用のための賦形剤、およびそれにより構成される薬学処方物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011046748A JP2011046748A (ja) | 2011-03-10 |
| JP2011046748A5 true JP2011046748A5 (enExample) | 2012-05-24 |
| JP5663285B2 JP5663285B2 (ja) | 2015-02-04 |
Family
ID=22334360
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584922A Pending JP2002531418A (ja) | 1998-12-03 | 1999-12-02 | アデノ随伴ウイルスの薬学処方物における使用のための賦形剤、およびそれにより構成される薬学処方物 |
| JP2010274133A Expired - Lifetime JP5663285B2 (ja) | 1998-12-03 | 2010-12-08 | アデノ随伴ウイルスの薬学処方物における使用のための賦形剤、およびそれにより構成される薬学処方物 |
| JP2014000095A Withdrawn JP2014058578A (ja) | 1998-12-03 | 2014-01-06 | アデノ随伴ウイルスの薬学処方物における使用のための賦形剤、およびそれにより構成される薬学処方物 |
| JP2015241786A Withdrawn JP2016040330A (ja) | 1998-12-03 | 2015-12-11 | アデノ随伴ウイルスの薬学処方物における使用のための賦形剤、およびそれにより構成される薬学処方物 |
| JP2017157878A Pending JP2017206556A (ja) | 1998-12-03 | 2017-08-18 | アデノ随伴ウイルスの薬学処方物における使用のための賦形剤、およびそれにより構成される薬学処方物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584922A Pending JP2002531418A (ja) | 1998-12-03 | 1999-12-02 | アデノ随伴ウイルスの薬学処方物における使用のための賦形剤、およびそれにより構成される薬学処方物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014000095A Withdrawn JP2014058578A (ja) | 1998-12-03 | 2014-01-06 | アデノ随伴ウイルスの薬学処方物における使用のための賦形剤、およびそれにより構成される薬学処方物 |
| JP2015241786A Withdrawn JP2016040330A (ja) | 1998-12-03 | 2015-12-11 | アデノ随伴ウイルスの薬学処方物における使用のための賦形剤、およびそれにより構成される薬学処方物 |
| JP2017157878A Pending JP2017206556A (ja) | 1998-12-03 | 2017-08-18 | アデノ随伴ウイルスの薬学処方物における使用のための賦形剤、およびそれにより構成される薬学処方物 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1144009B1 (enExample) |
| JP (5) | JP2002531418A (enExample) |
| AT (1) | ATE226449T1 (enExample) |
| AU (2) | AU773834B2 (enExample) |
| CA (1) | CA2353417C (enExample) |
| DE (1) | DE69903666T2 (enExample) |
| ES (1) | ES2185417T3 (enExample) |
| PT (1) | PT1144009E (enExample) |
| WO (1) | WO2000032233A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002229823B2 (en) * | 2001-04-04 | 2007-02-15 | Delsitech Oy | Biodegradable carrier and method for preparation thereof |
| WO2003049763A1 (en) | 2001-12-12 | 2003-06-19 | Fh Faulding & Co Limited | Composition for the preservation of viruses |
| US7261882B2 (en) | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
| LT2816118T (lt) | 2005-05-31 | 2018-12-10 | The Regents Of The University Of Colorado, A Body Corporate | Genų pristatymo būdai |
| US8980610B2 (en) * | 2008-11-20 | 2015-03-17 | Biogen Idec Ma Inc. | Arginine inactivation of viruses |
| JP6348064B2 (ja) | 2011-11-22 | 2018-06-27 | ザ チルドレンズ ホスピタル オブ フィラデルフィア | 効率の高いトランスジーン送達のためのウイルスベクター |
| EP4008356A1 (en) | 2016-03-31 | 2022-06-08 | University of Cincinnati | Methods and compositions for the treatment of als |
| EP3510161A4 (en) | 2016-08-23 | 2020-04-22 | Akouos, Inc. | COMPOSITIONS AND METHODS FOR TREATING NON-AGE-ASSOCIATED HEARING DEFICIENCY IN A HUMAN SUBJECT |
| WO2018212271A1 (ja) | 2017-05-18 | 2018-11-22 | 国立大学法人京都大学 | 脊髄小脳変性症３６型の予防又は治療用組成物 |
| CA3084802A1 (en) * | 2017-12-05 | 2019-06-13 | Applied Genetic Technologies Corporation | Formulation optimization for viral particles |
| JP7630443B2 (ja) * | 2019-04-19 | 2025-02-17 | レジェンクスバイオ インコーポレーテッド | アデノ随伴ウイルスベクター製剤及び方法 |
| US20220325250A1 (en) | 2019-08-14 | 2022-10-13 | Leukocare Ag | Method for obtaining efficient compositions comprising viral vectors for vaccination or gene therapy |
| WO2021168362A1 (en) | 2020-02-21 | 2021-08-26 | Akouos, Inc. | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5616487A (en) * | 1994-09-15 | 1997-04-01 | Aastrom Biosciences, Inc. | Stabilized retrovirus compositions |
| FR2751343B1 (fr) * | 1996-07-16 | 1998-12-18 | Transgene Sa | Procede de conservation de virus recombinants infectieux, suspension aqueuse virale et utilisation comme medicament |
| EP0933997A4 (en) * | 1996-09-06 | 2000-08-16 | Chiron Corp | METHODS AND COMPOSITIONS FOR LIVER-SPECIFIC ADMINISTRATION OF THERAPEUTIC MOLECULES USING RECOMBINANT AAV VECTORS |
-
1999
- 1999-12-02 JP JP2000584922A patent/JP2002531418A/ja active Pending
- 1999-12-02 AT AT99964038T patent/ATE226449T1/de not_active IP Right Cessation
- 1999-12-02 CA CA002353417A patent/CA2353417C/en not_active Expired - Lifetime
- 1999-12-02 WO PCT/US1999/028460 patent/WO2000032233A2/en not_active Ceased
- 1999-12-02 EP EP99964038A patent/EP1144009B1/en not_active Expired - Lifetime
- 1999-12-02 PT PT99964038T patent/PT1144009E/pt unknown
- 1999-12-02 AU AU20361/00A patent/AU773834B2/en not_active Expired
- 1999-12-02 DE DE69903666T patent/DE69903666T2/de not_active Expired - Lifetime
- 1999-12-02 ES ES99964038T patent/ES2185417T3/es not_active Expired - Lifetime
-
2004
- 2004-08-27 AU AU2004205308A patent/AU2004205308A1/en not_active Abandoned
-
2010
- 2010-12-08 JP JP2010274133A patent/JP5663285B2/ja not_active Expired - Lifetime
-
2014
- 2014-01-06 JP JP2014000095A patent/JP2014058578A/ja not_active Withdrawn
-
2015
- 2015-12-11 JP JP2015241786A patent/JP2016040330A/ja not_active Withdrawn
-
2017
- 2017-08-18 JP JP2017157878A patent/JP2017206556A/ja active Pending
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