JP2011042668A5 - - Google Patents
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- Publication number
- JP2011042668A5 JP2011042668A5 JP2010232760A JP2010232760A JP2011042668A5 JP 2011042668 A5 JP2011042668 A5 JP 2011042668A5 JP 2010232760 A JP2010232760 A JP 2010232760A JP 2010232760 A JP2010232760 A JP 2010232760A JP 2011042668 A5 JP2011042668 A5 JP 2011042668A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- adrenergic receptor
- receptor agonist
- composition according
- intravitreal administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 10
- 208000017442 Retinal disease Diseases 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 6
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical group C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims 4
- 229960003679 brimonidine Drugs 0.000 claims 4
- 239000007909 solid dosage form Substances 0.000 claims 4
- -1 2-imidazolin-2-ylamino group Chemical group 0.000 claims 3
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 208000022873 Ocular disease Diseases 0.000 claims 2
- 208000030533 eye disease Diseases 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000008297 liquid dosage form Substances 0.000 claims 1
- 210000001328 optic nerve Anatomy 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 0 C*1C=NC(I(C)(*)=C*(/C=C/C2(C)*)NC(C)=NCCCN)=C2N=C1 Chemical compound C*1C=NC(I(C)(*)=C*(/C=C/C2(C)*)NC(C)=NCCCN)=C2N=C1 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/496,262 US5856329A (en) | 1995-06-28 | 1995-06-28 | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006000809A Division JP2006241138A (ja) | 1995-06-28 | 2006-01-05 | 網膜障害を処置するための医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011042668A JP2011042668A (ja) | 2011-03-03 |
| JP2011042668A5 true JP2011042668A5 (enExample) | 2012-03-01 |
Family
ID=23971914
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50445497A Expired - Lifetime JP4621306B2 (ja) | 1995-06-28 | 1996-06-17 | 眼の神経損傷の処置に（２−イミダゾリン−２−イルアミノ）キノキサリンを使用する方法 |
| JP2006000809A Withdrawn JP2006241138A (ja) | 1995-06-28 | 2006-01-05 | 網膜障害を処置するための医薬組成物 |
| JP2010232760A Pending JP2011042668A (ja) | 1995-06-28 | 2010-10-15 | 網膜障害を処置するための医薬組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50445497A Expired - Lifetime JP4621306B2 (ja) | 1995-06-28 | 1996-06-17 | 眼の神経損傷の処置に（２−イミダゾリン−２−イルアミノ）キノキサリンを使用する方法 |
| JP2006000809A Withdrawn JP2006241138A (ja) | 1995-06-28 | 2006-01-05 | 網膜障害を処置するための医薬組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5856329A (enExample) |
| EP (3) | EP1642581B1 (enExample) |
| JP (3) | JP4621306B2 (enExample) |
| KR (1) | KR19990028403A (enExample) |
| CN (3) | CN101683343A (enExample) |
| AT (2) | ATE447956T1 (enExample) |
| AU (1) | AU715742B2 (enExample) |
| BR (1) | BR9609219A (enExample) |
| CA (1) | CA2225626C (enExample) |
| DE (2) | DE69638072D1 (enExample) |
| DK (1) | DK0835110T4 (enExample) |
| ES (2) | ES2262157T5 (enExample) |
| PT (1) | PT835110E (enExample) |
| WO (1) | WO1997001339A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6294563B1 (en) | 1994-10-27 | 2001-09-25 | Allergan Sales, Inc. | Combinations of prostaglandins and brimonidine or derivatives thereof |
| US5856329A (en) * | 1995-06-28 | 1999-01-05 | Allergan | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury |
| US6194415B1 (en) * | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| WO1999025350A1 (en) * | 1997-11-14 | 1999-05-27 | Alcon Laboratories, Inc. | Treatment of diabetic retinopathy |
| US6242442B1 (en) | 1998-12-17 | 2001-06-05 | Alcon Laboratories, Inc. | Brinzolamide and brimonidine for treating ocular conditions |
| US6247473B1 (en) | 1999-02-18 | 2001-06-19 | Third Millenium Trust | System and method for testing the neuroprotective or neuroregenerative effects of drugs |
| WO2001035948A2 (en) * | 1999-11-12 | 2001-05-25 | Alcon Universal Ltd. | Neurophilin ligands for treating ocular conditions |
| US6294553B1 (en) * | 2000-02-15 | 2001-09-25 | Allergan Sales, Inc. | Method for treating ocular pain |
| DE10013318A1 (de) * | 2000-03-17 | 2001-09-20 | Merck Patent Gmbh | Formulierung enthaltend Chinoxalinderivate |
| CN101897704B (zh) * | 2000-07-14 | 2014-10-29 | 阿勒根公司 | 含有α-2肾上腺素能激动剂的组合物 |
| DE10035620B4 (de) * | 2000-07-21 | 2005-07-14 | *Acri.Tec Gesellschaft für ophthalmologische Produkte mbH | Verwendung von Taurin als neuroprotektives Agens in der Ophthalmologie |
| AU2002248284A1 (en) * | 2000-11-01 | 2002-08-06 | Allergan, Inc. | Compositions for treatment of ocular neovascularization |
| US20030082183A1 (en) * | 2000-11-01 | 2003-05-01 | Wheeler Larry A. | Methods and compositions for treatment of ocular neovascularization and neural injury |
| US7030149B2 (en) | 2002-04-19 | 2006-04-18 | Allergan, Inc. | Combination of brimonidine timolol for topical ophthalmic use |
| US7642258B2 (en) * | 2002-04-19 | 2010-01-05 | Allergan, Inc. | Combination of brimonidine and timolol for topical ophthalmic use |
| US8529927B2 (en) * | 2004-04-30 | 2013-09-10 | Allergan, Inc. | Alpha-2 agonist polymeric drug delivery systems |
| US20050244463A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| US8425929B2 (en) * | 2004-04-30 | 2013-04-23 | Allergan, Inc. | Sustained release intraocular implants and methods for preventing retinal dysfunction |
| EP3006040B1 (en) * | 2004-06-04 | 2017-11-22 | Washington University | Methods and compositions for treating neuropathies |
| US7534795B2 (en) * | 2005-10-25 | 2009-05-19 | Allergan, Inc. | Compounds and their use related to compositions for treating disease |
| US20070225217A1 (en) | 2005-11-09 | 2007-09-27 | Combinatorx, Incorporated | Methods, compositions, and kits for the treatment of medical conditions |
| EP1981852A1 (en) | 2006-02-06 | 2008-10-22 | NicOx S.A. | Nitrooxy-comprising derivatives of apraclonidine and brimodnidine as al pha2 -adrenergic receptor agonists |
| US8969415B2 (en) * | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| RU2491284C2 (ru) * | 2007-08-15 | 2013-08-27 | Аллерган, Инк. | Адренергические соединения |
| US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| AU2010314990B2 (en) | 2009-11-09 | 2015-10-01 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| US9522153B2 (en) | 2009-12-22 | 2016-12-20 | Allergan, Inc. | Compositions and methods for lowering intraocular pressure |
| US20140234389A1 (en) | 2013-02-15 | 2014-08-21 | Allergan, Inc. | Sustained drug delivery implant |
| JP6628252B2 (ja) * | 2014-02-28 | 2020-01-08 | 国立大学法人京都大学 | 虚血性眼疾患の処置用の医薬組成物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4029792A (en) * | 1972-02-29 | 1977-06-14 | Pfizer Inc. | (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents |
| US4587257A (en) * | 1984-12-14 | 1986-05-06 | Alcon Laboratories, Inc. | Control of ocular bleeding using clonidine derivatives |
| US5180721A (en) * | 1989-05-22 | 1993-01-19 | Allergan, Inc. | Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure |
| US5021410A (en) * | 1989-05-22 | 1991-06-04 | Allergan, Inc. | Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure |
| US5077292A (en) * | 1989-10-12 | 1991-12-31 | Allergan, Inc. | (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same |
| US5021416A (en) * | 1989-10-31 | 1991-06-04 | Allergan, Inc. | Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure |
| US5215991A (en) * | 1990-01-26 | 1993-06-01 | Allergan, Inc. | Combination of selective alpha-adrenergic agonists and Na+ /H+ ex |
| SG44628A1 (en) † | 1993-12-17 | 1997-12-19 | Procter & Gamble | 6-(2-imidazolinylamino) Quinoxaline compounds useful as alpha-2 adrenoceptor agonists |
| WO1996013267A2 (en) * | 1994-10-27 | 1996-05-09 | Allergan | Combinations of prostaglandins and brimonidine or derivatives thereof for the treatment of glaucoma |
| US6194415B1 (en) * | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| US5856329A (en) * | 1995-06-28 | 1999-01-05 | Allergan | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury |
-
1995
- 1995-06-28 US US08/496,262 patent/US5856329A/en not_active Expired - Lifetime
-
1996
- 1996-06-17 BR BR9609219A patent/BR9609219A/pt not_active Application Discontinuation
- 1996-06-17 AU AU63864/96A patent/AU715742B2/en not_active Expired
- 1996-06-17 ES ES96923317T patent/ES2262157T5/es not_active Expired - Lifetime
- 1996-06-17 CN CN200910178530A patent/CN101683343A/zh active Pending
- 1996-06-17 DK DK96923317.0T patent/DK0835110T4/da active
- 1996-06-17 ES ES05028359T patent/ES2333339T3/es not_active Expired - Lifetime
- 1996-06-17 EP EP05028359A patent/EP1642581B1/en not_active Expired - Lifetime
- 1996-06-17 CN CN96196328A patent/CN1197391A/zh active Pending
- 1996-06-17 KR KR1019970709719A patent/KR19990028403A/ko not_active Ceased
- 1996-06-17 EP EP96923317A patent/EP0835110B2/en not_active Expired - Lifetime
- 1996-06-17 JP JP50445497A patent/JP4621306B2/ja not_active Expired - Lifetime
- 1996-06-17 PT PT96923317T patent/PT835110E/pt unknown
- 1996-06-17 AT AT05028359T patent/ATE447956T1/de not_active IP Right Cessation
- 1996-06-17 DE DE69638072T patent/DE69638072D1/de not_active Expired - Lifetime
- 1996-06-17 CN CN2006101011051A patent/CN1943577B/zh not_active Expired - Lifetime
- 1996-06-17 AT AT96923317T patent/ATE322267T1/de active
- 1996-06-17 CA CA002225626A patent/CA2225626C/en not_active Expired - Lifetime
- 1996-06-17 EP EP05076936A patent/EP1611891B1/en not_active Expired - Lifetime
- 1996-06-17 DE DE69636012T patent/DE69636012T3/de not_active Expired - Lifetime
- 1996-06-17 WO PCT/US1996/010468 patent/WO1997001339A1/en not_active Ceased
-
2006
- 2006-01-05 JP JP2006000809A patent/JP2006241138A/ja not_active Withdrawn
-
2010
- 2010-10-15 JP JP2010232760A patent/JP2011042668A/ja active Pending
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