CN101683343A - (2-咪唑啉-2-基氨基)喹喔啉的制药应用 - Google Patents
(2-咪唑啉-2-基氨基)喹喔啉的制药应用 Download PDFInfo
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/496,262 US5856329A (en) | 1995-06-28 | 1995-06-28 | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury |
| US08/496262 | 1995-06-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN96196328A Division CN1197391A (zh) | 1995-06-28 | 1996-06-17 | 应用(2－咪唑啉－2－基氨基)喹喔啉治疗视神经损伤的方法 |
Publications (1)
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|---|---|
| CN101683343A true CN101683343A (zh) | 2010-03-31 |
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| CN96196328A Pending CN1197391A (zh) | 1995-06-28 | 1996-06-17 | 应用(2－咪唑啉－2－基氨基)喹喔啉治疗视神经损伤的方法 |
| CN200910178530A Pending CN101683343A (zh) | 1995-06-28 | 1996-06-17 | (2-咪唑啉-2-基氨基)喹喔啉的制药应用 |
| CN2006101011051A Expired - Lifetime CN1943577B (zh) | 1995-06-28 | 1996-06-17 | (2-咪唑啉-2-基氨基)喹喔啉在制备用于治疗视神经损伤的药物中的应用 |
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| CN96196328A Pending CN1197391A (zh) | 1995-06-28 | 1996-06-17 | 应用(2－咪唑啉－2－基氨基)喹喔啉治疗视神经损伤的方法 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2006101011051A Expired - Lifetime CN1943577B (zh) | 1995-06-28 | 1996-06-17 | (2-咪唑啉-2-基氨基)喹喔啉在制备用于治疗视神经损伤的药物中的应用 |
Country Status (14)
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|---|---|
| US (1) | US5856329A (enExample) |
| EP (3) | EP1611891B1 (enExample) |
| JP (3) | JP4621306B2 (enExample) |
| KR (1) | KR19990028403A (enExample) |
| CN (3) | CN1197391A (enExample) |
| AT (2) | ATE322267T1 (enExample) |
| AU (1) | AU715742B2 (enExample) |
| BR (1) | BR9609219A (enExample) |
| CA (1) | CA2225626C (enExample) |
| DE (2) | DE69636012T3 (enExample) |
| DK (1) | DK0835110T4 (enExample) |
| ES (2) | ES2333339T3 (enExample) |
| PT (1) | PT835110E (enExample) |
| WO (1) | WO1997001339A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6294563B1 (en) | 1994-10-27 | 2001-09-25 | Allergan Sales, Inc. | Combinations of prostaglandins and brimonidine or derivatives thereof |
| US6194415B1 (en) * | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| US5856329A (en) * | 1995-06-28 | 1999-01-05 | Allergan | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury |
| WO1999025350A1 (en) * | 1997-11-14 | 1999-05-27 | Alcon Laboratories, Inc. | Treatment of diabetic retinopathy |
| WO2004073708A1 (en) | 1998-12-17 | 2004-09-02 | Dean Thomas R | Brinzolamide and brimonidine for treating ocular conditions |
| US6247473B1 (en) | 1999-02-18 | 2001-06-19 | Third Millenium Trust | System and method for testing the neuroprotective or neuroregenerative effects of drugs |
| JP2003514015A (ja) * | 1999-11-12 | 2003-04-15 | アルコン，インコーポレイテッド | 眼の状態を処置するためのニューロフィリンリガンド |
| US6294553B1 (en) * | 2000-02-15 | 2001-09-25 | Allergan Sales, Inc. | Method for treating ocular pain |
| DE10013318A1 (de) * | 2000-03-17 | 2001-09-20 | Merck Patent Gmbh | Formulierung enthaltend Chinoxalinderivate |
| WO2002005853A2 (en) * | 2000-07-14 | 2002-01-24 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| DE10035620B4 (de) * | 2000-07-21 | 2005-07-14 | *Acri.Tec Gesellschaft für ophthalmologische Produkte mbH | Verwendung von Taurin als neuroprotektives Agens in der Ophthalmologie |
| AU2002248284A1 (en) * | 2000-11-01 | 2002-08-06 | Allergan, Inc. | Compositions for treatment of ocular neovascularization |
| US20030082183A1 (en) * | 2000-11-01 | 2003-05-01 | Wheeler Larry A. | Methods and compositions for treatment of ocular neovascularization and neural injury |
| US7642258B2 (en) * | 2002-04-19 | 2010-01-05 | Allergan, Inc. | Combination of brimonidine and timolol for topical ophthalmic use |
| US7030149B2 (en) * | 2002-04-19 | 2006-04-18 | Allergan, Inc. | Combination of brimonidine timolol for topical ophthalmic use |
| US8529927B2 (en) * | 2004-04-30 | 2013-09-10 | Allergan, Inc. | Alpha-2 agonist polymeric drug delivery systems |
| US20050244463A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| US8425929B2 (en) * | 2004-04-30 | 2013-04-23 | Allergan, Inc. | Sustained release intraocular implants and methods for preventing retinal dysfunction |
| AU2005257883A1 (en) * | 2004-06-04 | 2006-01-05 | Washington University | Methods and compositions for treating neuropathies |
| US7534795B2 (en) * | 2005-10-25 | 2009-05-19 | Allergan, Inc. | Compounds and their use related to compositions for treating disease |
| US8067433B2 (en) | 2005-11-09 | 2011-11-29 | Zalicus Inc. | Methods, compositions, and kits for the treatment of ophthalmic disorders |
| CA2641501A1 (en) * | 2006-02-06 | 2007-08-16 | Nicox S.A. | Nitrooxy-comprising derivatives of apraclonidine and brimodnidine as al pha2 -adrenergic receptor agonists |
| US8969415B2 (en) * | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| WO2009023752A1 (en) * | 2007-08-15 | 2009-02-19 | Allergan, Inc. | Adrenergic compounds |
| US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| NZ628266A (en) | 2009-11-09 | 2016-02-26 | Allergan Inc | Compositions and methods for stimulating hair growth |
| US9522153B2 (en) | 2009-12-22 | 2016-12-20 | Allergan, Inc. | Compositions and methods for lowering intraocular pressure |
| JP6511401B2 (ja) | 2013-02-15 | 2019-05-15 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 持続型薬物送達インプラント |
| WO2015129809A1 (ja) * | 2014-02-28 | 2015-09-03 | 国立大学法人京都大学 | 虚血性眼疾患の処置用の医薬組成物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4029792A (en) * | 1972-02-29 | 1977-06-14 | Pfizer Inc. | (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents |
| US4587257A (en) * | 1984-12-14 | 1986-05-06 | Alcon Laboratories, Inc. | Control of ocular bleeding using clonidine derivatives |
| US5180721A (en) * | 1989-05-22 | 1993-01-19 | Allergan, Inc. | Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure |
| US5021410A (en) * | 1989-05-22 | 1991-06-04 | Allergan, Inc. | Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure |
| US5077292A (en) * | 1989-10-12 | 1991-12-31 | Allergan, Inc. | (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same |
| US5021416A (en) * | 1989-10-31 | 1991-06-04 | Allergan, Inc. | Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure |
| US5215991A (en) * | 1990-01-26 | 1993-06-01 | Allergan, Inc. | Combination of selective alpha-adrenergic agonists and Na+ /H+ ex |
| CN1137755A (zh) † | 1993-12-17 | 1996-12-11 | 普罗克特和甘保尔公司 | 用作α-2肾上腺素能受体兴奋剂的6-(2-咪唑啉基氨基)喹喔啉化合物 |
| WO1996013267A2 (en) * | 1994-10-27 | 1996-05-09 | Allergan | Combinations of prostaglandins and brimonidine or derivatives thereof for the treatment of glaucoma |
| US5856329A (en) * | 1995-06-28 | 1999-01-05 | Allergan | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury |
| US6194415B1 (en) * | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
-
1995
- 1995-06-28 US US08/496,262 patent/US5856329A/en not_active Expired - Lifetime
-
1996
- 1996-06-17 KR KR1019970709719A patent/KR19990028403A/ko not_active Ceased
- 1996-06-17 CA CA002225626A patent/CA2225626C/en not_active Expired - Lifetime
- 1996-06-17 AT AT96923317T patent/ATE322267T1/de active
- 1996-06-17 DE DE69636012T patent/DE69636012T3/de not_active Expired - Lifetime
- 1996-06-17 CN CN96196328A patent/CN1197391A/zh active Pending
- 1996-06-17 AU AU63864/96A patent/AU715742B2/en not_active Expired
- 1996-06-17 CN CN200910178530A patent/CN101683343A/zh active Pending
- 1996-06-17 CN CN2006101011051A patent/CN1943577B/zh not_active Expired - Lifetime
- 1996-06-17 DK DK96923317.0T patent/DK0835110T4/da active
- 1996-06-17 AT AT05028359T patent/ATE447956T1/de not_active IP Right Cessation
- 1996-06-17 ES ES05028359T patent/ES2333339T3/es not_active Expired - Lifetime
- 1996-06-17 JP JP50445497A patent/JP4621306B2/ja not_active Expired - Lifetime
- 1996-06-17 WO PCT/US1996/010468 patent/WO1997001339A1/en not_active Ceased
- 1996-06-17 EP EP05076936A patent/EP1611891B1/en not_active Expired - Lifetime
- 1996-06-17 BR BR9609219A patent/BR9609219A/pt not_active Application Discontinuation
- 1996-06-17 DE DE69638072T patent/DE69638072D1/de not_active Expired - Lifetime
- 1996-06-17 PT PT96923317T patent/PT835110E/pt unknown
- 1996-06-17 EP EP05028359A patent/EP1642581B1/en not_active Expired - Lifetime
- 1996-06-17 ES ES96923317T patent/ES2262157T5/es not_active Expired - Lifetime
- 1996-06-17 EP EP96923317A patent/EP0835110B2/en not_active Expired - Lifetime
-
2006
- 2006-01-05 JP JP2006000809A patent/JP2006241138A/ja not_active Withdrawn
-
2010
- 2010-10-15 JP JP2010232760A patent/JP2011042668A/ja active Pending
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