JP2011026335A5 - - Google Patents

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Publication number
JP2011026335A5
JP2011026335A5 JP2010223566A JP2010223566A JP2011026335A5 JP 2011026335 A5 JP2011026335 A5 JP 2011026335A5 JP 2010223566 A JP2010223566 A JP 2010223566A JP 2010223566 A JP2010223566 A JP 2010223566A JP 2011026335 A5 JP2011026335 A5 JP 2011026335A5
Authority
JP
Japan
Prior art keywords
tablet
progesterone
vaginal administration
administration according
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010223566A
Other languages
English (en)
Other versions
JP2011026335A (ja
Filing date
Publication date
Priority claimed from IL12712998A external-priority patent/IL127129A/en
Application filed filed Critical
Publication of JP2011026335A publication Critical patent/JP2011026335A/ja
Publication of JP2011026335A5 publication Critical patent/JP2011026335A5/ja
Pending legal-status Critical Current

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Claims (11)

  1. プロゲステロン６〜２０重量％および発泡剤５〜１２重量％を含む膣投与用錠剤。
  2. 該錠剤に含まれるプロゲステロンが８〜１２重量％である、請求項１に記載の膣投与用錠剤。
  3. 該錠剤に含まれる発泡剤が６〜８重量％である、請求項１または２に記載の膣投与用錠剤。
  4. 該錠剤に含まれる発泡剤が８重量％である、請求項１に記載の膣投与用錠剤。
  5. 該プロゲステロンが微粒子化プロゲステロンである、請求項１に記載の膣投与用錠剤。
  6. 該錠剤に含まれる微粒子化プロゲステロンが少なくとも５０ｍｇである、請求項５に記載の膣投与用錠剤。
  7. 該錠剤に含まれる微粒子化プロゲステロンが約１００ｍｇである、請求項５に記載の膣投与用錠剤。
  8. 乾燥した微粒子化天然プロゲステロン、コロイド無水シリカ、トウモロコシ１５００デンプン、ポビドン３０、ラクトース、アジピン酸、重炭酸ナトリウム、ステアリン酸マグネシウム、およびラウリル硫酸ナトリウムを含む、請求項１に記載の膣投与用錠剤。
  9. 乾燥した微粒子化天然プロゲステロン ８重量％、コロイド無水シリカ ０．２重量％、トウモロコシ１５００デンプン １６．８重量％、ポビドン３０ ３．９重量％、ラクトース ６０．８重量％、アジピン酸 ４．６重量％、重炭酸ナトリウム ３．４重量％、ステアリン酸マグネシウム １．８重量％、およびラウリル硫酸ナトリウム ０．４％を含む、請求項８に記載の膣投与用錠剤。
  10. 膣内に設置後に該錠剤は溶解し、膣内設置後３．０５時間〜９．７５時間のＴｍａｘを提供し、プロゲステロンの膣デリバリー用であることを特徴とする、請求項１に記載の膣投与用錠剤。
  11. （ｉ）水および天然プロゲステロンを含む混合物を調製して、湿潤した天然プロゲステロンを得；
    （ｉｉ）該湿潤した天然プロゲステロンを乾燥して、乾燥した天然プロゲステロンを得；
    （ｉｉｉ）該乾燥した天然プロゲステロンを少なくとも１つの医薬上許容し得る担体および発泡剤と共に混合して、第２混合物を得；および
    （ｉｖ）該第２混合物を直接圧縮により打錠して乾燥した錠剤を形成する；
    ことによって調製される、請求項１に記載の膣投与用錠剤。
JP2010223566A 1998-11-18 2010-10-01 プロゲステロン含有経膣投与用錠剤およびその調製法 Pending JP2011026335A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL12712998A IL127129A (en) 1998-11-18 1998-11-18 Method for preparation of progesterone tablets for vaginal delivery and tablets so prepared

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2000582018A Division JP4667601B2 (ja) 1998-11-18 1999-11-17 プロゲステロン含有経膣投与用錠剤およびその調製法

Publications (2)

Publication Number Publication Date
JP2011026335A JP2011026335A (ja) 2011-02-10
JP2011026335A5 true JP2011026335A5 (ja) 2012-01-26

Family

ID=11072154

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000582018A Expired - Lifetime JP4667601B2 (ja) 1998-11-18 1999-11-17 プロゲステロン含有経膣投与用錠剤およびその調製法
JP2010223566A Pending JP2011026335A (ja) 1998-11-18 2010-10-01 プロゲステロン含有経膣投与用錠剤およびその調製法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2000582018A Expired - Lifetime JP4667601B2 (ja) 1998-11-18 1999-11-17 プロゲステロン含有経膣投与用錠剤およびその調製法

Country Status (8)

Country Link
US (4) US7300664B1 (ja)
EP (2) EP1131052B1 (ja)
JP (2) JP4667601B2 (ja)
AU (1) AU1176200A (ja)
DK (1) DK1131052T3 (ja)
ES (1) ES2390959T3 (ja)
IL (1) IL127129A (ja)
WO (1) WO2000028970A1 (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL127129A (en) * 1998-11-18 2004-06-01 Ferring Bv Method for preparation of progesterone tablets for vaginal delivery and tablets so prepared
FR2821555B1 (fr) * 2001-03-01 2003-05-16 Besins Int Lab Progestatif co-micronise avec un tensioactif, composition pharmaceutique le comprenant, leurs procedes de fabrication et leurs utilisations
PL376949A1 (pl) * 2002-12-20 2006-01-09 Dynogen Pharmaceuticals, Inc. Sposoby leczenia niebolesnych zaburzeń pęcherza moczowego przy użyciu modulatorów podjednostki Ó2Ű kanału wapniowego
EP1492519B1 (en) * 2003-03-21 2006-11-15 Dynogen Pharmaceuticals, Inc. Methods for treating lower urinary tract disorders using antimuscarinics and alpha-2-delta subunit calcium channel modulators
DE10316583A1 (de) 2003-04-10 2004-10-28 B.R.A.H.M.S Aktiengesellschaft Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung
US8828981B2 (en) * 2007-02-06 2014-09-09 George Creasy Progesterone for the treatment or prevention of spontaneous preterm birth
EP2219554A4 (en) * 2007-11-29 2011-05-25 Gregg A Jackson PROGESTER-CONTAINING COMPOSITIONS AND DEVICES
US9107696B2 (en) * 2008-08-06 2015-08-18 Emory University Method of embryo transfer that eliminates transferred air while hormonally inducing implantation and apparatus
WO2011073995A2 (en) 2009-12-14 2011-06-23 Lincoln Pharmaceuticals Limited Liquid vaginal spray of progesterone
FR2997627B1 (fr) * 2012-11-08 2015-01-16 Hra Pharma Lab Produit de co-micronisation comprenant de l'ulipristal acetate
CN114129530A (zh) * 2021-12-08 2022-03-04 南京康川济医药科技有限公司 一种黄体酮缓释组合物及其制备方法

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US3121663A (en) 1956-02-09 1964-02-18 Plough Lab Inc Carbon dioxide releasing laxative suppository
US4252787A (en) * 1976-12-27 1981-02-24 Cambridge Research And Development Group Anti-fertility composition and method
US4310510A (en) * 1976-12-27 1982-01-12 Sherman Kenneth N Self administrable anti-fertility composition
US4187286A (en) * 1979-01-02 1980-02-05 G&W Laboratories, Inc. Contraceptive suppository
US4322399A (en) * 1979-10-19 1982-03-30 Ortho Pharmaceutical Corporation Vaginal suppository
JPS58152809A (ja) * 1982-03-05 1983-09-10 Eisai Co Ltd 安定な発泡性「膣」坐剤
US4583211A (en) * 1982-06-15 1986-04-15 Tokyo Shibaura Denki Kabushiki Kaisha Frequency detecting circuit for digital information reproducing system
JPS6165822A (ja) * 1984-09-06 1986-04-04 Kao Corp 月経困難症治療用膣投与剤
US5116619A (en) 1988-08-30 1992-05-26 Lee Roy Morgan Vaginal progesterone tablet
US5084277A (en) * 1988-08-30 1992-01-28 Greco John C Vaginal progesterone tablet
DK95093D0 (da) * 1993-08-20 1993-08-20 Novo Nordisk As Farmaceutisk formulering indeholdende et hormon
US5543150A (en) * 1993-09-15 1996-08-06 Columbia Laboratories, Inc. Method of progesterone delivery and affect thereof
CH689802A5 (de) * 1995-01-16 1999-11-30 Grapha Holding Ag Einrichtung zur Vereinzelung von stapelweise zugeführten flachen Gegenständen.
US5804277A (en) * 1995-11-30 1998-09-08 The United States Of America As Represented By The Secretary Of The Air Force Three-dimensional fiber weave with cubic symmetry and no zero valued shear moduli
US5958455A (en) * 1996-02-09 1999-09-28 Quadrant Holdings Cambridge Ltd Oral solid dosage forms, methods of making same and compositions thereof
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NZ330596A (en) * 1998-06-05 2001-02-23 Dec Res Intravaginal devices allowing for increased uptake of active ingredients
FR2772617B1 (fr) 1997-12-19 2001-03-09 Besins Iscovesco Lab Comprime de progesterone et son procede de preparation
FR2777784B1 (fr) * 1998-04-27 2004-03-19 Arepa Composition pharmaceutique a base d'estrogene et de progesterone
IL127129A (en) * 1998-11-18 2004-06-01 Ferring Bv Method for preparation of progesterone tablets for vaginal delivery and tablets so prepared
US20070178139A1 (en) * 1998-11-18 2007-08-02 Yankov Vladimir I Vaginally administratable progesterone-containing tablets and method for preparing same
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