JP2010540541A - レチノール関連疾患を治療するための方法及び化合物 - Google Patents

レチノール関連疾患を治療するための方法及び化合物 Download PDF

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Publication number
JP2010540541A
JP2010540541A JP2010527024A JP2010527024A JP2010540541A JP 2010540541 A JP2010540541 A JP 2010540541A JP 2010527024 A JP2010527024 A JP 2010527024A JP 2010527024 A JP2010527024 A JP 2010527024A JP 2010540541 A JP2010540541 A JP 2010540541A
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Japan
Prior art keywords
alkyl
formula
compound
optionally substituted
butyl
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JP2010527024A
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English (en)
Japanese (ja)
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JP2010540541A5 (fr
Inventor
マタ，ネイサン，エル．
ファン，キム，ビー．
ブイ，タム，ヴィー．
ハッダク，ムスタファ
Original Assignee
リヴィジョン セラピューティクス，インク．
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Application filed by リヴィジョン セラピューティクス，インク． filed Critical リヴィジョン セラピューティクス，インク．
Publication of JP2010540541A publication Critical patent/JP2010540541A/ja
Publication of JP2010540541A5 publication Critical patent/JP2010540541A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2010527024A 2007-09-27 2008-09-16 レチノール関連疾患を治療するための方法及び化合物 Pending JP2010540541A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97576507P 2007-09-27 2007-09-27
US98132207P 2007-10-19 2007-10-19
PCT/US2008/076499 WO2009042444A2 (fr) 2007-09-27 2008-09-16 Procédés et composés pour le traitement de maladies liées au rétinol

Publications (2)

Publication Number Publication Date
JP2010540541A true JP2010540541A (ja) 2010-12-24
JP2010540541A5 JP2010540541A5 (fr) 2011-11-04

Family

ID=40512081

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010527024A Pending JP2010540541A (ja) 2007-09-27 2008-09-16 レチノール関連疾患を治療するための方法及び化合物

Country Status (8)

Country Link
EP (1) EP2205234A4 (fr)
JP (1) JP2010540541A (fr)
KR (1) KR20100097098A (fr)
CN (1) CN101873852A (fr)
AU (1) AU2008305303A1 (fr)
CA (1) CA2699773A1 (fr)
IL (1) IL204728A0 (fr)
WO (1) WO2009042444A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012524024A (ja) * 2009-04-16 2012-10-11 武田薬品工業株式会社 （とりわけ）糖尿病の予防または治療に有用なｎ−アシル−ｎ’−フェニルピペラジンの誘導体
JP5374377B2 (ja) * 2007-10-18 2013-12-25 武田薬品工業株式会社 複素環化合物
WO2016063934A1 (fr) * 2014-10-24 2016-04-28 武田薬品工業株式会社 Composé hétérocyclique
WO2016063933A1 (fr) * 2014-10-24 2016-04-28 武田薬品工業株式会社 Composé hétérocyclique

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8980924B2 (en) 2010-11-24 2015-03-17 The Trustees Of Columbia University In The City Of New York Non-retinoid RBP4 antagonist for treatment of age-related macular degeneration and stargardt disease
KR20140001224A (ko) * 2010-12-02 2014-01-06 다이이찌 산쿄 가부시키가이샤 수식 1 개 사슬 폴리뉴클레오티드
US9333202B2 (en) 2012-05-01 2016-05-10 The Trustees Of Columbia University In The City Of New York Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease
EP2968304B1 (fr) 2013-03-14 2018-10-10 The Trustees of Columbia University in the City of New York 4-phénylpipéridines, leur préparation et leur utilisation
US9637450B2 (en) 2013-03-14 2017-05-02 The Trustees Of Columbia University In The City Of New York Octahydrocyclopentapyrroles, their preparation and use
US9938291B2 (en) 2013-03-14 2018-04-10 The Trustess Of Columbia University In The City Of New York N-alkyl-2-phenoxyethanamines, their preparation and use
US9944644B2 (en) 2013-03-14 2018-04-17 The Trustees Of Columbia University In The City Of New York Octahydropyrrolopyrroles their preparation and use
BR112016025356B1 (pt) 2014-04-30 2023-04-18 The Trustees Of Columbia University In The City Of New York Compostos de 4-fenilpiperidinas substituídas, composições e seus usos

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2526534A (en) * 1948-07-03 1950-10-17 Dow Chemical Co Di-(aryloxy)-methanes
US4255152A (en) * 1978-09-05 1981-03-10 Ciba-Geigy Corporation Process for the dyeing of hydrophobic fibres

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS577480A (en) * 1980-06-16 1982-01-14 Sankyo Co Ltd 4-alkoxy-6-phenoxymethyl-2-pyrone derivative
WO2005070126A2 (fr) * 2004-01-08 2005-08-04 The Regents Of The University Of Colorado Systemes et procedes pour le traitement de maladies inflammatoires et proliferantes humaines, et des plaies avec le gene ucp et/ou l'anticorps anti-fas ou autre inhibiteur, eventuellement avec un inhibiteur du metabolisme d'acide gras et/ou un inhibiteur du metabolisme de glucose et applications associees
WO2005092062A2 (fr) * 2004-03-19 2005-10-06 Myriad Genetics, Inc. Composes destines aux troubles neurodegeneratifs
WO2005116010A1 (fr) * 2004-05-26 2005-12-08 Merck Frosst Canada Ltd. Agoniste du recepteur ep4, compositions et methodes associees ep4 receptor agonist, compositions and methods thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2526534A (en) * 1948-07-03 1950-10-17 Dow Chemical Co Di-(aryloxy)-methanes
US4255152A (en) * 1978-09-05 1981-03-10 Ciba-Geigy Corporation Process for the dyeing of hydrophobic fibres

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN7013002950; Ｊ．　Ｍｅｄ．　Ｃｈｅｍ． ４９（２３）, 2006, ｐｐ．　６６３８-６６４１ *
JPN7013002951; Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ　Ｌｅｔｔｅｒｓ １７, 2007, ｐｐ．　４３４７-４３５０ *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5374377B2 (ja) * 2007-10-18 2013-12-25 武田薬品工業株式会社 複素環化合物
JP2012524024A (ja) * 2009-04-16 2012-10-11 武田薬品工業株式会社 （とりわけ）糖尿病の予防または治療に有用なｎ−アシル−ｎ’−フェニルピペラジンの誘導体
WO2016063934A1 (fr) * 2014-10-24 2016-04-28 武田薬品工業株式会社 Composé hétérocyclique
WO2016063933A1 (fr) * 2014-10-24 2016-04-28 武田薬品工業株式会社 Composé hétérocyclique
EA033446B1 (ru) * 2014-10-24 2019-10-31 Takeda Pharmaceuticals Co Гетероциклическое соединение для лечения дегенерации желтого пятна и/или болезни штаргардта
JP2020007347A (ja) * 2014-10-24 2020-01-16 武田薬品工業株式会社 複素環化合物
US10975043B2 (en) 2014-10-24 2021-04-13 Takeda Pharmaceutical Company Limited Heterocyclic compound
JP6995094B2 (ja) 2014-10-24 2022-02-21 武田薬品工業株式会社 複素環化合物

Also Published As

Publication number Publication date
EP2205234A2 (fr) 2010-07-14
CN101873852A (zh) 2010-10-27
AU2008305303A1 (en) 2009-04-02
WO2009042444A2 (fr) 2009-04-02
KR20100097098A (ko) 2010-09-02
CA2699773A1 (fr) 2009-04-02
EP2205234A4 (fr) 2010-12-22
IL204728A0 (en) 2010-11-30
WO2009042444A3 (fr) 2009-05-14

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