JP2010540519A5 - - Google Patents
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- JP2010540519A5 JP2010540519A5 JP2010526924A JP2010526924A JP2010540519A5 JP 2010540519 A5 JP2010540519 A5 JP 2010540519A5 JP 2010526924 A JP2010526924 A JP 2010526924A JP 2010526924 A JP2010526924 A JP 2010526924A JP 2010540519 A5 JP2010540519 A5 JP 2010540519A5
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- JP
- Japan
- Prior art keywords
- composition
- drug
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims description 32
- 229940079593 drugs Drugs 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 23
- IMZMKUWMOSJXDT-UHFFFAOYSA-N Cromoglicic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims description 11
- 229960000265 cromoglicic acid Drugs 0.000 claims description 11
- 210000000138 Mast Cells Anatomy 0.000 claims description 9
- ZCVMWBYGMWKGHF-UHFFFAOYSA-N Ketotifene Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2CC(=O)C2=C1C=CS2 ZCVMWBYGMWKGHF-UHFFFAOYSA-N 0.000 claims description 8
- 230000001225 therapeutic Effects 0.000 claims description 7
- 208000008589 Obesity Diseases 0.000 claims description 6
- 235000020824 obesity Nutrition 0.000 claims description 6
- 239000003381 stabilizer Substances 0.000 claims description 6
- LENZDBCJOHFCAS-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 4
- 229940009997 Cromolyn Drugs 0.000 claims description 4
- 229960003630 Ketotifen Fumarate Drugs 0.000 claims description 4
- RQTOOFIXOKYGAN-UHFFFAOYSA-N Nedocromil Chemical compound CCN1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1OC(C(O)=O)=CC(=O)C1=C2 RQTOOFIXOKYGAN-UHFFFAOYSA-N 0.000 claims description 4
- 229960002259 Nedocromil Sodium Drugs 0.000 claims description 4
- 229940035504 Tromethamine Drugs 0.000 claims description 4
- 229960004958 ketotifen Drugs 0.000 claims description 4
- 229960004398 nedocromil Drugs 0.000 claims description 4
- JQEKDNLKIVGXAU-UHFFFAOYSA-L nedocromil sodium Chemical compound [Na+].[Na+].CCN1C(C([O-])=O)=CC(=O)C2=C1C(CCC)=C1OC(C([O-])=O)=CC(=O)C1=C2 JQEKDNLKIVGXAU-UHFFFAOYSA-L 0.000 claims description 4
- 229960000281 trometamol Drugs 0.000 claims description 4
- 229940120894 Cromolyn Sodium Drugs 0.000 claims description 3
- 206010020751 Hypersensitivity Diseases 0.000 claims description 3
- 206010012601 Diabetes mellitus Diseases 0.000 claims description 2
- 201000010238 heart disease Diseases 0.000 claims description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- 210000003625 Skull Anatomy 0.000 claims 1
- 125000005431 alkyl carboxamide group Chemical group 0.000 claims 1
- 210000004027 cells Anatomy 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 3
- 201000005794 allergic hypersensitivity disease Diseases 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000000087 stabilizing Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96040807P | 2007-09-28 | 2007-09-28 | |
| US60/960,408 | 2007-09-28 | ||
| PCT/US2008/011026 WO2009045291A2 (en) | 2007-09-28 | 2008-09-24 | Mast cell stabilizers in the treatment of obesity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540519A JP2010540519A (ja) | 2010-12-24 |
| JP2010540519A5 true JP2010540519A5 (fi) | 2012-11-08 |
| JP5460600B2 JP5460600B2 (ja) | 2014-04-02 |
Family
ID=40523802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010526924A Active JP5460600B2 (ja) | 2007-09-28 | 2008-09-24 | 肥満症治療における肥満細胞安定化薬 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8445435B2 (fi) |
| EP (1) | EP2205243A4 (fi) |
| JP (1) | JP5460600B2 (fi) |
| CN (1) | CN101808642B (fi) |
| WO (1) | WO2009045291A2 (fi) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8445437B2 (en) | 2006-07-27 | 2013-05-21 | The Brigham And Women's Hospital, Inc. | Treatment and prevention of cardiovascular disease using mast cell stabilizers |
| JP5736370B2 (ja) * | 2009-06-25 | 2015-06-17 | ネステク ソシエテ アノニム | 過敏性腸症候群の診断方法 |
| CN102204871A (zh) * | 2011-06-01 | 2011-10-05 | 王青 | 一种减肥用组合物 |
| CN102846679A (zh) * | 2012-08-14 | 2013-01-02 | 王青 | 一种具有减肥作用的组合物 |
| AU2015213681B2 (en) | 2014-02-10 | 2020-03-12 | Respivant Sciences Gmbh | Mast cell stabilizers for lung disease treatment |
| US9962363B2 (en) | 2014-02-10 | 2018-05-08 | Patara Pharma, LLC | Mast cell stabilizers treatment for systemic disorders |
| US10238625B2 (en) | 2015-08-07 | 2019-03-26 | Respivant Sciences Gmbh | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
| WO2017027402A1 (en) | 2015-08-07 | 2017-02-16 | Patara Pharma, LLC | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
| CA3010615C (en) | 2016-01-14 | 2024-02-20 | Beth Israel Deaconess Medical Center, Inc. | Mast-cell modulators and uses thereof |
| JP2019528320A (ja) | 2016-08-31 | 2019-10-10 | レシュピファント サイエンシス ゲゼルシャフト ミット ベシュレンクター ハフトゥングＲｅｓｐｉｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ | 特発性肺線維症による慢性咳の治療のためのクロモリン組成物 |
| WO2018067341A1 (en) | 2016-10-07 | 2018-04-12 | Patara Pharma, LLC | Cromolyn compositions for treatment of pulmonary fibrosis |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4634699A (en) | 1983-11-30 | 1987-01-06 | Burroughs Wellcome Co. | Branched chain phenothiazine |
| US4923892A (en) | 1985-08-17 | 1990-05-08 | Burroughs Wellcome Co. | Tricyclic aromatic compounds |
| GB8520662D0 (en) | 1985-08-17 | 1985-09-25 | Wellcome Found | Tricyclic aromatic compounds |
| JPH08510252A (ja) | 1993-05-10 | 1996-10-29 | セプラコール・インコーポレーテッド | 光学的に純粋な（＋）‐ジロイトンを用いた方法および組成 |
| US5624949A (en) | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| US6225327B1 (en) | 1996-04-18 | 2001-05-01 | Alcon Laboratories, Inc. | Compounds which inhibit human conjunctival mast cell degranulation for treating ocular allergic-type complications |
| WO1998056381A1 (en) | 1997-06-09 | 1998-12-17 | Bridge Pharma, Inc. | Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use |
| JP2001509480A (ja) | 1997-07-09 | 2001-07-24 | アンドロソリューションズ，インク． | 男性勃起機能不全を治療するための改良された方法及び組成物 |
| US6232297B1 (en) | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
| US6777429B1 (en) | 1999-07-23 | 2004-08-17 | Novartis Ag | Ophthalmic composition |
| US20040092511A1 (en) * | 1999-12-10 | 2004-05-13 | Billstein Stephan Anthony | Pharmaceutical combinations and their use in treating gastrointestinal and abdominal viscera disorders |
| US20040115290A1 (en) | 2001-06-20 | 2004-06-17 | Tripp Matthew L. | Modulation of inflammation by hops fractions and derivatives |
| AU2002352974A1 (en) * | 2001-11-29 | 2003-06-10 | Emisphere Technologies, Inc. | Formulations for oral administration of cromolyn sodium |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| EP1492784A4 (en) * | 2002-03-28 | 2006-03-29 | Merck & Co Inc | SUBSTITUTED 2,3-DIPHENYLPYRIDINES |
| DE10301371A1 (de) | 2003-01-16 | 2004-08-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische Kombination zur Prophylaxe oder Therapie von kardiovaskulären, kardiopulmonalen, pulmonalen oder renalen Krankheiten |
| US20060263350A1 (en) * | 2003-09-26 | 2006-11-23 | Fairfield Clinical Trials Llc | Combination antihistamine medication |
| EP1895986A2 (en) | 2005-05-09 | 2008-03-12 | Azur Pharma | Formulations of mast cell stabilizing agents for delivery to the colon |
| US8003684B2 (en) | 2006-02-21 | 2011-08-23 | Cornerstone Therapeutics, Inc. | Crystal form and pharmaceutical compositions of (+)-R-zileuton |
| US8445437B2 (en) | 2006-07-27 | 2013-05-21 | The Brigham And Women's Hospital, Inc. | Treatment and prevention of cardiovascular disease using mast cell stabilizers |
-
2008
- 2008-09-24 JP JP2010526924A patent/JP5460600B2/ja active Active
- 2008-09-24 WO PCT/US2008/011026 patent/WO2009045291A2/en active Application Filing
- 2008-09-24 US US12/232,789 patent/US8445435B2/en active Active
- 2008-09-24 CN CN200880108966XA patent/CN101808642B/zh not_active Expired - Fee Related
- 2008-09-24 EP EP08835091A patent/EP2205243A4/en not_active Withdrawn
-
2013
- 2013-04-15 US US13/863,113 patent/US8785383B2/en active Active
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