JP2010540509A5 - - Google Patents
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- Publication number
- JP2010540509A5 JP2010540509A5 JP2010526364A JP2010526364A JP2010540509A5 JP 2010540509 A5 JP2010540509 A5 JP 2010540509A5 JP 2010526364 A JP2010526364 A JP 2010526364A JP 2010526364 A JP2010526364 A JP 2010526364A JP 2010540509 A5 JP2010540509 A5 JP 2010540509A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- compound according
- compound
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000000753 cycloalkyl group Chemical group 0.000 claims 8
- 150000002148 esters Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 230000002062 proliferating effect Effects 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000003003 spiro group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0719038.2 | 2007-09-28 | ||
| GB0719038A GB0719038D0 (en) | 2007-09-28 | 2007-09-28 | Compound |
| GB0806844.7 | 2008-04-15 | ||
| GB0806844A GB0806844D0 (en) | 2008-04-15 | 2008-04-15 | Compound |
| PCT/GB2008/003305 WO2009040556A1 (en) | 2007-09-28 | 2008-09-29 | Pyrimidine derivatives as protein kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013230231A Division JP5863196B2 (ja) | 2007-09-28 | 2013-11-06 | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540509A JP2010540509A (ja) | 2010-12-24 |
| JP2010540509A5 true JP2010540509A5 (OSRAM) | 2011-10-06 |
| JP5410432B2 JP5410432B2 (ja) | 2014-02-05 |
Family
ID=40199600
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010526364A Active JP5410432B2 (ja) | 2007-09-28 | 2008-09-29 | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
| JP2013230231A Expired - Fee Related JP5863196B2 (ja) | 2007-09-28 | 2013-11-06 | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013230231A Expired - Fee Related JP5863196B2 (ja) | 2007-09-28 | 2013-11-06 | プロテインキナーゼ阻害剤としてのピリミジン誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8563542B2 (OSRAM) |
| EP (2) | EP2205603B1 (OSRAM) |
| JP (2) | JP5410432B2 (OSRAM) |
| CN (1) | CN101878216B (OSRAM) |
| CA (1) | CA2700979C (OSRAM) |
| ES (2) | ES2585110T3 (OSRAM) |
| PL (2) | PL2610256T3 (OSRAM) |
| RU (2) | RU2478100C2 (OSRAM) |
| WO (1) | WO2009040556A1 (OSRAM) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602007008837D1 (de) | 2006-02-14 | 2010-10-14 | Vertex Pharma | Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine |
| CA2695753A1 (en) | 2007-08-15 | 2009-02-19 | Vertex Pharmaceuticals Incorporated | Compounds useful as protein kinases inhibitors |
| MX2010003249A (es) | 2007-09-25 | 2010-11-09 | Takeda Pharmaceutical | Inhibidores de quinasas símil polo. |
| CN101878216B (zh) | 2007-09-28 | 2013-07-10 | 西克拉塞尔有限公司 | 作为蛋白激酶抑制剂的嘧啶衍生物 |
| CN102076691A (zh) | 2008-06-23 | 2011-05-25 | 维泰克斯制药公司 | 蛋白激酶抑制剂 |
| KR20110039278A (ko) | 2008-06-23 | 2011-04-15 | 버텍스 파마슈티칼스 인코포레이티드 | 단백질 키나제 억제제 |
| AU2010262905B2 (en) | 2009-06-17 | 2015-04-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| NZ599356A (en) | 2009-09-25 | 2013-08-30 | Vertex Pharma | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
| KR20120096474A (ko) | 2009-09-25 | 2012-08-30 | 버텍스 파마슈티칼스 인코포레이티드 | 단백질 키나제 억제제로서 유용한 피리미딘 유도체의 제조 방법 |
| MX2012014158A (es) | 2010-06-04 | 2013-02-07 | Hoffmann La Roche | Derivados de aminopirimidina como moduladores de proteina cinasa rica repeticiones leucina 2 (lrrk2). |
| ES2653967T3 (es) | 2010-11-10 | 2018-02-09 | Genentech, Inc. | Derivados de pirazol aminopirimidina como moduladores de LRRK2 |
| KR20140014110A (ko) | 2010-12-16 | 2014-02-05 | 버텍스 파마슈티칼스 인코포레이티드 | 인플루엔자 바이러스 복제의 억제제 |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| GB201205752D0 (en) * | 2012-03-30 | 2012-05-16 | Cyclacel Ltd | Treatment |
| US9676792B2 (en) * | 2013-03-15 | 2017-06-13 | Dana-Farber Cancer Institute, Inc. | Pyrimido-diazepinone compounds and methods of treating disorders |
| KR20160034379A (ko) | 2013-07-25 | 2016-03-29 | 다나-파버 캔서 인스티튜트 인크. | 전사 인자의 억제제 및 그의 용도 |
| ES2741444T3 (es) | 2013-11-13 | 2020-02-11 | Vertex Pharma | Inhibidores de la replicación de virus de la gripe |
| EP3068782B1 (en) | 2013-11-13 | 2018-05-23 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
| US10793571B2 (en) | 2014-01-31 | 2020-10-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| US10150756B2 (en) | 2014-01-31 | 2018-12-11 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
| KR101517414B1 (ko) * | 2014-04-24 | 2015-05-04 | 고려대학교 산학협력단 | 염증성 질환의 예방 또는 치료용 약학 조성물 |
| RU2017104897A (ru) | 2014-08-08 | 2018-09-10 | Дана-Фарбер Кэнсер Инститьют, Инк. | Производные диазепана и их применения |
| CN107148424B (zh) | 2014-12-16 | 2021-01-08 | 凯拉治疗股份公司 | 用于诱导细胞因子的环状二核苷酸 |
| WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| WO2016183116A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
| CA2986441A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| KR20180051576A (ko) | 2015-09-11 | 2018-05-16 | 다나-파버 캔서 인스티튜트 인크. | 아세트아미드 티에노트리아졸로디아제핀 및 그의 용도 |
| CN108472300A (zh) | 2015-09-11 | 2018-08-31 | 达纳-法伯癌症研究所股份有限公司 | 氰基噻吩并三唑并二氮杂环庚三烯及其用途 |
| WO2017066428A1 (en) | 2015-10-13 | 2017-04-20 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Brd4-kinase inhibitors as cancer therapeutics |
| PE20181298A1 (es) | 2015-11-25 | 2018-08-07 | Dana Farber Cancer Inst Inc | Inhibidores de bromodominio bivalentes y usos de los mismos |
| CN107151250B (zh) * | 2016-03-04 | 2020-03-27 | 安徽省新星药物开发有限责任公司 | 嘧啶类七元环化合物、其制备方法、药用组合物及其应用 |
| CN109311901A (zh) * | 2016-04-07 | 2019-02-05 | 达纳-法伯癌症研究所有限公司 | 嘧啶并-二氮杂卓酮激酶骨架化合物及治疗pi3k介导的病变的方法 |
| JP2021501785A (ja) | 2017-11-02 | 2021-01-21 | カリコ ライフ サイエンシーズ エルエルシー | 統合的ストレス経路の調節剤 |
| US20200347033A1 (en) * | 2017-11-02 | 2020-11-05 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
| EP4013502B8 (en) | 2019-08-16 | 2025-10-22 | Cyclacel Pharmaceuticals, Inc. | Process for the preparation of a pyrimidino-diazepine derivative |
| JP7736311B2 (ja) | 2019-08-16 | 2025-09-09 | サイクラセル リミテッド | ピリミジノジアゼピン誘導体の結晶性形態 |
| AU2020356484A1 (en) * | 2019-09-27 | 2022-03-17 | Dana-Farber Cancer Institute, Inc. | ERK5 degraders as therapeutics in cancer and inflammatory diseases |
| WO2023196943A1 (en) | 2022-04-08 | 2023-10-12 | Inhibrx, Inc. | Dr5 agonist and plk1 inhibitor or cdk inhibitor combination therapy |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9117635D0 (en) | 1991-08-15 | 1991-10-02 | British Telecomm | Phase shifter |
| GB0302220D0 (en) | 2003-01-30 | 2003-03-05 | Cyclacel Ltd | Use |
| US6861422B2 (en) | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
| KR100983462B1 (ko) * | 2003-02-26 | 2010-09-27 | 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 | 디하이드로프테리디논, 이의 제조방법 및 약제로서의 이의 용도 |
| WO2005117944A2 (en) | 2004-05-26 | 2005-12-15 | The Texas A & M University System | Hsp20 inhibits amyloidogenesis and neurotoxicity |
| CN101068815B (zh) * | 2004-10-04 | 2012-09-05 | 千禧药品公司 | 有效作为蛋白激酶抑制剂的内酰胺化合物 |
| BRPI0611705A2 (pt) | 2005-06-24 | 2016-11-16 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de composto |
| US7439358B2 (en) | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
| DE602007008837D1 (de) | 2006-02-14 | 2010-10-14 | Vertex Pharma | Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine |
| TW200808325A (en) * | 2006-07-06 | 2008-02-16 | Astrazeneca Ab | Novel compounds |
| JP5087640B2 (ja) * | 2007-03-22 | 2012-12-05 | 武田薬品工業株式会社 | Ｐｌｋ１阻害剤として有用な置換ピリミドジアゼピン |
| MX2010003249A (es) * | 2007-09-25 | 2010-11-09 | Takeda Pharmaceutical | Inhibidores de quinasas símil polo. |
| CN101878216B (zh) * | 2007-09-28 | 2013-07-10 | 西克拉塞尔有限公司 | 作为蛋白激酶抑制剂的嘧啶衍生物 |
| WO2009067547A1 (en) * | 2007-11-19 | 2009-05-28 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
| WO2010083505A1 (en) | 2009-01-19 | 2010-07-22 | The Trustees Of The University Of Pennsylvania | Method of treating cancer using a survivin inhibitor |
| GB201205752D0 (en) | 2012-03-30 | 2012-05-16 | Cyclacel Ltd | Treatment |
-
2008
- 2008-09-29 CN CN2008801182902A patent/CN101878216B/zh active Active
- 2008-09-29 CA CA2700979A patent/CA2700979C/en active Active
- 2008-09-29 EP EP20080806455 patent/EP2205603B1/en active Active
- 2008-09-29 JP JP2010526364A patent/JP5410432B2/ja active Active
- 2008-09-29 ES ES13156251.4T patent/ES2585110T3/es active Active
- 2008-09-29 US US12/680,353 patent/US8563542B2/en active Active
- 2008-09-29 EP EP13156251.4A patent/EP2610256B1/en active Active
- 2008-09-29 PL PL13156251.4T patent/PL2610256T3/pl unknown
- 2008-09-29 WO PCT/GB2008/003305 patent/WO2009040556A1/en not_active Ceased
- 2008-09-29 PL PL08806455T patent/PL2205603T3/pl unknown
- 2008-09-29 RU RU2010116759/04A patent/RU2478100C2/ru active
- 2008-09-29 ES ES08806455T patent/ES2457394T3/es active Active
-
2013
- 2013-02-26 RU RU2013108456A patent/RU2623221C2/ru active
- 2013-06-05 US US13/910,349 patent/US9133199B2/en active Active
- 2013-11-06 JP JP2013230231A patent/JP5863196B2/ja not_active Expired - Fee Related
-
2015
- 2015-08-07 US US14/820,711 patent/US9493471B2/en not_active Expired - Fee Related
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