JP2010539104A5 - - Google Patents
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- Publication number
- JP2010539104A5 JP2010539104A5 JP2010524320A JP2010524320A JP2010539104A5 JP 2010539104 A5 JP2010539104 A5 JP 2010539104A5 JP 2010524320 A JP2010524320 A JP 2010524320A JP 2010524320 A JP2010524320 A JP 2010524320A JP 2010539104 A5 JP2010539104 A5 JP 2010539104A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrocarbyl
- aryl
- heteroaryl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*(C1)*C(*I)C*1(C)c(cc1)ccc1C(Nc1c(*)cccc1)=O Chemical compound C*(C1)*C(*I)C*1(C)c(cc1)ccc1C(Nc1c(*)cccc1)=O 0.000 description 5
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97235307P | 2007-09-14 | 2007-09-14 | |
| US4395708P | 2008-04-10 | 2008-04-10 | |
| PCT/CA2008/001610 WO2009033281A1 (en) | 2007-09-14 | 2008-09-12 | Cancer combination therapy with a selective inhibitor of histone deacetylase hdac1, hdac2 and/or hdac3 and a microtubule stabilizer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010539104A JP2010539104A (ja) | 2010-12-16 |
| JP2010539104A5 true JP2010539104A5 (enExample) | 2012-03-08 |
Family
ID=40451522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010524320A Pending JP2010539104A (ja) | 2007-09-14 | 2008-09-12 | ヒストンデアセチラーゼｈｄａｃ１、ｈｄａｃ２および／またはｈｄａｃ３の選択的阻害剤ならびに微小管安定剤による癌の組合せ治療 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090124631A1 (enExample) |
| JP (1) | JP2010539104A (enExample) |
| KR (1) | KR20100072024A (enExample) |
| CN (1) | CN101861151B (enExample) |
| TW (1) | TW200924777A (enExample) |
| WO (1) | WO2009033281A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
| US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
| AU2009289649B2 (en) | 2008-09-03 | 2016-05-05 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
| JP6295081B2 (ja) * | 2011-02-24 | 2018-03-14 | バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ | フラザノベンゾイミダゾールに対する薬物応答のバイオマーカーとしてのアセチル化チューブリンの使用 |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| WO2012118782A1 (en) | 2011-02-28 | 2012-09-07 | Repligen Corporation | Histone deacetylase inhibitors |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US8822460B2 (en) | 2012-04-06 | 2014-09-02 | Janssen Pharmaceutica Nv | Fused cyclopentyl antagonists of CCR2 |
| CN103570625A (zh) * | 2012-07-19 | 2014-02-12 | 南京英派药业有限公司 | N-(3-杂芳基芳基)-4-芳基芳基甲酰胺和类似物作为Hedgehog通路抑制剂及其应用 |
| ES2627010T3 (es) | 2012-07-19 | 2017-07-26 | Janssen Pharmaceutica, N.V. | Antagonistas de octahidro-ciclopentapirrolilo de CCR2 |
| US9145412B2 (en) | 2012-11-02 | 2015-09-29 | Acetylon Pharmaceuticals, Inc. | Selective HDAC1 and HDAC2 inhibitors |
| EP2968565A2 (en) * | 2013-03-14 | 2016-01-20 | Genentech, Inc. | Methods of treating cancer and preventing cancer drug resistance |
| RU2665554C2 (ru) | 2013-03-15 | 2018-08-31 | Байомарин Фармасьютикал Инк. | Ингибиторы hdac |
| CN107205988A (zh) | 2014-07-07 | 2017-09-26 | 埃斯泰隆制药公司 | 利用组蛋白脱乙酰酶抑制剂治疗白血病 |
| CA2970500C (en) | 2014-12-12 | 2023-08-29 | Acetylon Pharmaceuticals, Inc. | Piperidine derivatives as hdac1/2 inhibitors |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| CA3043618A1 (en) * | 2016-11-23 | 2018-05-31 | Regenacy Pharmaceuticals, Llc | Piperazine derivatives as selective hdac1,2 inhibitors |
| US10507250B2 (en) * | 2017-09-08 | 2019-12-17 | Institute Of Nuclear Energy Research, Atomic Energy Council, Executive Yuan | Precursor of a histone deacetylase inhibitor PET imaging compound for tracking cerebral neurodegenerative and tumor diseases |
| JP7050165B2 (ja) | 2018-02-26 | 2022-04-07 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｂｖ複製阻害剤としての置換ピロリジン化合物 |
| CA3113819A1 (en) * | 2018-10-10 | 2020-04-16 | Regenacy Pharmaceuticals, Llc | Pyrimidine and pyrazine hdac1,2 inhibitors |
| AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| US20240374569A1 (en) * | 2021-09-22 | 2024-11-14 | Henry Ford Health System | Hdac3 inhibitors for the treatment of langerhans cell histiocytosis and langerhans cell sarcoma |
| CA3240229A1 (en) | 2021-12-03 | 2023-06-08 | Tango Therapeutics, Inc. | Novel hdac inhibitors and therapeutic use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6897220B2 (en) * | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| AU2005225471B2 (en) * | 2004-03-26 | 2011-05-12 | Methylgene Inc. | Inhibitors of histone deacetylase |
-
2008
- 2008-09-12 CN CN200880116080.XA patent/CN101861151B/zh not_active Expired - Fee Related
- 2008-09-12 TW TW097135270A patent/TW200924777A/zh unknown
- 2008-09-12 WO PCT/CA2008/001610 patent/WO2009033281A1/en not_active Ceased
- 2008-09-12 US US12/209,419 patent/US20090124631A1/en not_active Abandoned
- 2008-09-12 JP JP2010524320A patent/JP2010539104A/ja active Pending
- 2008-09-12 KR KR1020107008151A patent/KR20100072024A/ko not_active Ceased
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