JP2010538973A5 - - Google Patents
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- Publication number
- JP2010538973A5 JP2010538973A5 JP2010523158A JP2010523158A JP2010538973A5 JP 2010538973 A5 JP2010538973 A5 JP 2010538973A5 JP 2010523158 A JP2010523158 A JP 2010523158A JP 2010523158 A JP2010523158 A JP 2010523158A JP 2010538973 A5 JP2010538973 A5 JP 2010538973A5
- Authority
- JP
- Japan
- Prior art keywords
- platelets
- leukocytes
- inflammatory
- fluid
- blood cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000265 leukocyte Anatomy 0.000 claims description 50
- 210000001772 blood platelet Anatomy 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 28
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 15
- 206010061218 Inflammation Diseases 0.000 claims description 15
- 239000011575 calcium Substances 0.000 claims description 15
- 229910052791 calcium Inorganic materials 0.000 claims description 15
- 239000002738 chelating agent Substances 0.000 claims description 15
- 230000004054 inflammatory process Effects 0.000 claims description 15
- 230000000770 proinflammatory effect Effects 0.000 claims description 14
- 239000000126 substance Substances 0.000 claims description 13
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 230000004968 inflammatory condition Effects 0.000 claims description 11
- 230000002757 inflammatory effect Effects 0.000 claims description 11
- 208000024891 symptom Diseases 0.000 claims description 11
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 9
- 239000012528 membrane Substances 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 6
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 6
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims description 6
- 239000003112 inhibitor Substances 0.000 claims description 6
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 4
- 206010040047 Sepsis Diseases 0.000 claims description 4
- 239000012472 biological sample Substances 0.000 claims description 4
- 210000001124 body fluid Anatomy 0.000 claims description 4
- 239000010839 body fluid Substances 0.000 claims description 4
- 230000002612 cardiopulmonary effect Effects 0.000 claims description 4
- 208000020832 chronic kidney disease Diseases 0.000 claims description 4
- 230000000415 inactivating effect Effects 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 239000000523 sample Substances 0.000 claims description 4
- VILCJCGEZXAXTO-UHFFFAOYSA-N 2,2,2-tetramine Chemical compound NCCNCCNCCN VILCJCGEZXAXTO-UHFFFAOYSA-N 0.000 claims description 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims description 3
- 208000004990 Cardiorenal syndrome Diseases 0.000 claims description 3
- RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 claims description 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 3
- 206010053159 Organ failure Diseases 0.000 claims description 3
- 201000004681 Psoriasis Diseases 0.000 claims description 3
- 206010063837 Reperfusion injury Diseases 0.000 claims description 3
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 claims description 3
- 230000001154 acute effect Effects 0.000 claims description 3
- 208000006673 asthma Diseases 0.000 claims description 3
- 210000003169 central nervous system Anatomy 0.000 claims description 3
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 201000011200 hepatorenal syndrome Diseases 0.000 claims description 3
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims description 3
- 210000003734 kidney Anatomy 0.000 claims description 3
- 210000004185 liver Anatomy 0.000 claims description 3
- 201000006417 multiple sclerosis Diseases 0.000 claims description 3
- 210000004165 myocardium Anatomy 0.000 claims description 3
- 235000006408 oxalic acid Nutrition 0.000 claims description 3
- 210000000496 pancreas Anatomy 0.000 claims description 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 3
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 claims description 3
- 235000019982 sodium hexametaphosphate Nutrition 0.000 claims description 3
- 208000011580 syndromic disease Diseases 0.000 claims description 3
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 3
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 3
- 108010067225 Cell Adhesion Molecules Proteins 0.000 claims description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
- 102000008395 cell adhesion mediator activity proteins Human genes 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 210000000224 granular leucocyte Anatomy 0.000 claims description 2
- 229960003444 immunosuppressant agent Drugs 0.000 claims description 2
- 230000001861 immunosuppressant effect Effects 0.000 claims description 2
- 239000003018 immunosuppressive agent Substances 0.000 claims description 2
- 230000003248 secreting effect Effects 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims 17
- 239000012510 hollow fiber Substances 0.000 claims 11
- 210000004369 blood Anatomy 0.000 claims 6
- 239000008280 blood Substances 0.000 claims 6
- -1 polyethylene Polymers 0.000 claims 3
- 229920002492 poly(sulfone) Polymers 0.000 claims 2
- 229920000515 polycarbonate Polymers 0.000 claims 2
- 239000004417 polycarbonate Substances 0.000 claims 2
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 1
- 239000004677 Nylon Substances 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 208000033626 Renal failure acute Diseases 0.000 claims 1
- 201000011040 acute kidney failure Diseases 0.000 claims 1
- 208000012998 acute renal failure Diseases 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 208000028208 end stage renal disease Diseases 0.000 claims 1
- 201000000523 end stage renal failure Diseases 0.000 claims 1
- 229920001778 nylon Polymers 0.000 claims 1
- 229920000110 poly(aryl ether sulfone) Polymers 0.000 claims 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 1
- 229920002239 polyacrylonitrile Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920000139 polyethylene terephthalate Polymers 0.000 claims 1
- 239000005020 polyethylene terephthalate Substances 0.000 claims 1
- 239000004926 polymethyl methacrylate Substances 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 230000009919 sequestration Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96939407P | 2007-08-31 | 2007-08-31 | |
| US60/969,394 | 2007-08-31 | ||
| PCT/US2008/074804 WO2009029801A2 (en) | 2007-08-31 | 2008-08-29 | Selective cytopheresis devices and related methods thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014015748A Division JP6027556B2 (ja) | 2007-08-31 | 2014-01-30 | 選択的細胞吸着除去装置およびその関連方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010538973A JP2010538973A (ja) | 2010-12-16 |
| JP2010538973A5 true JP2010538973A5 (enExample) | 2011-10-13 |
| JP5769418B2 JP5769418B2 (ja) | 2015-08-26 |
Family
ID=40388135
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010523158A Active JP5769418B2 (ja) | 2007-08-31 | 2008-08-29 | 選択的細胞吸着除去装置およびその関連方法 |
| JP2014015748A Active JP6027556B2 (ja) | 2007-08-31 | 2014-01-30 | 選択的細胞吸着除去装置およびその関連方法 |
| JP2016202237A Pending JP2017080400A (ja) | 2007-08-31 | 2016-10-14 | 選択的細胞吸着除去装置およびその関連方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014015748A Active JP6027556B2 (ja) | 2007-08-31 | 2014-01-30 | 選択的細胞吸着除去装置およびその関連方法 |
| JP2016202237A Pending JP2017080400A (ja) | 2007-08-31 | 2016-10-14 | 選択的細胞吸着除去装置およびその関連方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (13) | US8251941B2 (enExample) |
| EP (2) | EP2187957A4 (enExample) |
| JP (3) | JP5769418B2 (enExample) |
| KR (2) | KR20120093397A (enExample) |
| CN (2) | CN101842111A (enExample) |
| AU (1) | AU2008293431B2 (enExample) |
| BR (1) | BRPI0816165A2 (enExample) |
| CA (2) | CA2789592C (enExample) |
| DK (1) | DK3789056T3 (enExample) |
| ES (1) | ES3033913T3 (enExample) |
| FI (1) | FI3789056T3 (enExample) |
| MX (1) | MX2010002351A (enExample) |
| NZ (1) | NZ583591A (enExample) |
| WO (1) | WO2009029801A2 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2009525781A (ja) | 2006-02-02 | 2009-07-16 | イノベーティブ バイオ セラピーズ | 細胞をベースとする体外治療装置および送達システム |
| US20090081296A1 (en) * | 2006-02-02 | 2009-03-26 | Humes H David | Extracorporeal cell-based therapeutic device and delivery system |
| WO2008083965A2 (de) * | 2007-01-13 | 2008-07-17 | Membrana Gmbh | Vorrichtung zur entfernung von leukozyten aus blut |
| ES3033913T3 (en) * | 2007-08-31 | 2025-08-11 | Seastar Medical Inc | Selective cytopheresis devices |
| ES2639183T3 (es) | 2007-09-19 | 2017-10-25 | The Charles Stark Draper Laboratory, Inc. | Estructuras microfluídicas con sección transversal circular |
| AU2008354310B2 (en) * | 2008-04-01 | 2014-02-20 | Gambro Lundia Ab | An apparatus and a method for monitoring a vascular access |
| AU2009327485A1 (en) | 2008-06-18 | 2010-06-24 | Cytopherx, Inc. | Methods for propagation of renal precursor cells |
| DE102008045127A1 (de) * | 2008-09-01 | 2010-03-04 | Heinrich, Hans-Werner, Prof. Dr. | Filtersystem zur extrakorporalen Abreicherung von aktivierten Polymorphkernigen Granuloyzten (Polymorphonuclear leukocytes-PMNs) |
| EP2314672B1 (en) * | 2008-09-25 | 2015-04-15 | Gambro Lundia AB | Hybrid bioartificial kidney |
| US20110082563A1 (en) * | 2009-10-05 | 2011-04-07 | The Charles Stark Draper Laboratory, Inc. | Microscale multiple-fluid-stream bioreactor for cell culture |
| CA2776613A1 (en) | 2009-10-07 | 2011-04-14 | University Of Pittsburgh - Of The Commonwealth System Of Higher Educatio N | Devices, systems and methods for cell modification |
| US8926543B2 (en) * | 2009-10-08 | 2015-01-06 | Otsuka Pharmaceutical Co., Ltd. | Immunoactivation blood perfusion filter for the treatment of malignant tumors |
| US8425662B2 (en) | 2010-04-02 | 2013-04-23 | Battelle Memorial Institute | Methods for associating or dissociating guest materials with a metal organic framework, systems for associating or dissociating guest materials within a series of metal organic frameworks, and gas separation assemblies |
| US20110250578A1 (en) * | 2010-04-13 | 2011-10-13 | Northern Alberta Institute Of Technology | Ventilator test lung and trigger assembly |
| CA2814586C (en) * | 2010-10-15 | 2024-01-30 | Cytopherx, Inc. | Cytopheretic cartridge and use thereof |
| US9199026B2 (en) * | 2011-01-07 | 2015-12-01 | Somerset Group Enterprises, Inc. | Modular extracorporeal systems and methods for treating blood-borne diseases |
| US10314594B2 (en) | 2012-12-14 | 2019-06-11 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| US10813630B2 (en) | 2011-08-09 | 2020-10-27 | Corquest Medical, Inc. | Closure system for atrial wall |
| US10307167B2 (en) | 2012-12-14 | 2019-06-04 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| US20150246169A1 (en) * | 2011-10-14 | 2015-09-03 | Cytopherx, Inc. | Cartridge and method for increasing myocardial function |
| CA2852220A1 (en) * | 2011-10-14 | 2013-07-18 | Cytopherx, Inc. | Cartridge and method for increasing myocardial function |
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| HK1205964A1 (en) * | 2012-03-01 | 2015-12-31 | Medical Device Works Nv | Kit and devices for organ perfusion |
| JP2014061285A (ja) * | 2012-08-31 | 2014-04-10 | Asahi Kasei Medical Co Ltd | 臓器炎症抑制用基材及びデバイス |
| US20140142689A1 (en) | 2012-11-21 | 2014-05-22 | Didier De Canniere | Device and method of treating heart valve malfunction |
| WO2014193597A1 (en) * | 2013-05-02 | 2014-12-04 | University Of Vermont And State Agricultural College | Leptin for treating systemic inflammatory response syndrome |
| US9566443B2 (en) | 2013-11-26 | 2017-02-14 | Corquest Medical, Inc. | System for treating heart valve malfunction including mitral regurgitation |
| CN104689403A (zh) * | 2013-12-08 | 2015-06-10 | 杨海龙 | 悬吊式回输血器 |
| WO2015095553A1 (en) * | 2013-12-20 | 2015-06-25 | Nephrogenesis, Llc | Methods and apparatus for kidney dialysis |
| CN103725599B (zh) * | 2014-01-14 | 2015-05-27 | 刘韬 | 一种流体膜过滤细胞分离装置 |
| WO2015153370A2 (en) | 2014-03-29 | 2015-10-08 | Labib Mohamed E | Blood processing cartridges and systems, and methods for extracorporeal blood therapies |
| US20170165334A1 (en) * | 2015-12-11 | 2017-06-15 | Tianxin Wang | Methods to Treat Diseases with Protein, Peptide, Antigen Modification and Hemopurification |
| JP2017525489A (ja) * | 2014-08-26 | 2017-09-07 | スリーエム イノベイティブ プロパティズ カンパニー | 炎症性メディエーター並びに顆粒球及び単球を血液から除去するためのシステム |
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| US10842626B2 (en) | 2014-12-09 | 2020-11-24 | Didier De Canniere | Intracardiac device to correct mitral regurgitation |
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| US10426884B2 (en) | 2015-06-26 | 2019-10-01 | Novaflux Inc. | Cartridges and systems for outside-in flow in membrane-based therapies |
| WO2017053805A1 (en) | 2015-09-24 | 2017-03-30 | Labib Mohamed E | Cartridges for hollow fibre membrane-based therapies |
| EP4321215A3 (en) * | 2016-06-23 | 2024-04-17 | Hemanext Inc. | Methods for managing adverse events in patient populations requiring transfusion |
| CN109416357B (zh) | 2016-06-30 | 2022-07-15 | 西门子医疗系统荷兰有限公司 | 用于检测包含多个细胞的体液样本中的分析物的设备、系统和方法 |
| EP3576806B1 (en) * | 2017-02-03 | 2024-12-04 | NxStage Medical Inc. | Multiple mode treatment devices methods and systems |
| IT201700038389A1 (it) * | 2017-04-07 | 2018-10-07 | In10Sivecare S R L | Apparecchiatura per il trattamento extracorporeo del sangue |
| EP3388140A1 (en) * | 2017-04-10 | 2018-10-17 | Gambro Lundia AB | Extracorporeal blood circuit |
| EP3400976A1 (en) * | 2017-05-12 | 2018-11-14 | Universitat Rovira i Virgili | Device and method for the preparation of platelet rich plasma |
| CN107224624B (zh) * | 2017-06-12 | 2023-12-15 | 谢华南 | 血液透析器、血液透析装置及血液透析方法 |
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| EP3473327A1 (en) | 2017-10-19 | 2019-04-24 | 3M Innovative Properties Company | Integrated fluid treatment device, and process using such device |
| CN112055601B (zh) | 2017-12-28 | 2024-08-20 | 艾赛普公司 | 用于处理出血流体以便自体输注的系统和方法 |
| EP3735281B1 (en) | 2018-01-05 | 2024-11-27 | Path Ex, Inc. | Device for the capture and removal of disease material from fluids |
| US11419969B2 (en) * | 2019-03-26 | 2022-08-23 | Nuwellis, Inc. | Neonatal and pediatric blood filtration system |
| FR3097770B1 (fr) | 2019-06-27 | 2024-03-01 | I Sep | Système et procédé de traitement de liquide hémorragique pour de l’autotransfusion |
| US20220273855A1 (en) * | 2019-08-01 | 2022-09-01 | Seastar Medical, Inc. | Device and method for preparing a donor organ for transplantation |
| KR20230016032A (ko) * | 2019-11-19 | 2023-01-31 | 이뮤니컴 인코포레이티드 | 생물학적 유체로부터 면역 억제제를 제거하기 위한 시스템 및 방법 |
| DE102020104117A1 (de) * | 2020-02-18 | 2021-08-19 | Universität des Saarlandes | Vorrichtung zum Entfernen eines Gases aus einer wässrigen Flüssigkeit |
| CN111939599B (zh) * | 2020-07-14 | 2024-01-12 | 山东中保康医疗器具有限公司 | 富血小板血浆的制备方法及装置 |
| CN113686605B (zh) * | 2021-08-16 | 2023-07-07 | 北京林业大学 | 一种花粉管超薄切片及其制备方法 |
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- 2008-08-29 BR BRPI0816165-8A2A patent/BRPI0816165A2/pt not_active IP Right Cessation
- 2008-08-29 CN CN200880113549A patent/CN101842111A/zh active Pending
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