JP2010538633A5 - - Google Patents
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- JP2010538633A5 JP2010538633A5 JP2010524578A JP2010524578A JP2010538633A5 JP 2010538633 A5 JP2010538633 A5 JP 2010538633A5 JP 2010524578 A JP2010524578 A JP 2010524578A JP 2010524578 A JP2010524578 A JP 2010524578A JP 2010538633 A5 JP2010538633 A5 JP 2010538633A5
- Authority
- JP
- Japan
- Prior art keywords
- mage
- protein
- nucleotide sequence
- use according
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- SSOORFWOBGFTHL-OTEJMHTDSA-N (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-oxopentanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O SSOORFWOBGFTHL-OTEJMHTDSA-N 0.000 claims 36
- 108090000623 proteins and genes Proteins 0.000 claims 23
- 239000002773 nucleotide Substances 0.000 claims 21
- 125000003729 nucleotide group Chemical group 0.000 claims 21
- 239000000523 sample Substances 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 9
- 101710188053 Protein D Proteins 0.000 claims 9
- 101710132893 Resolvase Proteins 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 108020004414 DNA Proteins 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 7
- 230000011987 methylation Effects 0.000 claims 7
- 238000007069 methylation reaction Methods 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 108091034117 Oligonucleotide Proteins 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 230000004927 fusion Effects 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 239000002955 immunomodulating agent Substances 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
- 108091027568 Single-stranded nucleotide Proteins 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical group NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 101710154606 Hemagglutinin Proteins 0.000 claims 1
- 101001005719 Homo sapiens Melanoma-associated antigen 3 Proteins 0.000 claims 1
- 102100025082 Melanoma-associated antigen 3 Human genes 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 1
- 101710176177 Protein A56 Proteins 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 102000008235 Toll-Like Receptor 9 Human genes 0.000 claims 1
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 239000000185 hemagglutinin Substances 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 208000037798 influenza B Diseases 0.000 claims 1
- 229940035032 monophosphoryl lipid a Drugs 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- 239000013610 patient sample Substances 0.000 claims 1
- 229920002704 polyhistidine Polymers 0.000 claims 1
- 238000010791 quenching Methods 0.000 claims 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 1
- 230000003252 repetitive effect Effects 0.000 claims 1
- 229930182490 saponin Natural products 0.000 claims 1
- 150000007949 saponins Chemical class 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- 229930003799 tocopherol Natural products 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- 229940044655 toll-like receptor 9 agonist Drugs 0.000 claims 1
- 239000007762 w/o emulsion Substances 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96012807P | 2007-09-17 | 2007-09-17 | |
| US60/960,128 | 2007-09-17 | ||
| PCT/GB2008/003142 WO2009037438A1 (en) | 2007-09-17 | 2008-09-17 | Improved detection of mage-a expression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010538633A JP2010538633A (ja) | 2010-12-16 |
| JP2010538633A5 true JP2010538633A5 (https=) | 2011-06-16 |
| JP5406839B2 JP5406839B2 (ja) | 2014-02-05 |
Family
ID=40239643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010524578A Expired - Fee Related JP5406839B2 (ja) | 2007-09-17 | 2008-09-17 | Ｍａｇｅ−ａ発現の改良された検出 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US8481700B2 (https=) |
| EP (2) | EP2201131B8 (https=) |
| JP (1) | JP5406839B2 (https=) |
| KR (1) | KR20100085917A (https=) |
| CN (1) | CN101932723B (https=) |
| AU (1) | AU2008300397A1 (https=) |
| BR (1) | BRPI0817008A2 (https=) |
| CA (2) | CA2699853A1 (https=) |
| CO (1) | CO6260156A2 (https=) |
| CR (1) | CR11504A (https=) |
| DO (1) | DOP2010000076A (https=) |
| EA (1) | EA017879B1 (https=) |
| IL (1) | IL204525A0 (https=) |
| MA (1) | MA31753B1 (https=) |
| MX (1) | MX2010002965A (https=) |
| NZ (2) | NZ596545A (https=) |
| WO (2) | WO2009037438A1 (https=) |
| ZA (1) | ZA201001878B (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012037128A2 (en) * | 2010-09-14 | 2012-03-22 | The University Of North Carolina At Chapel Hill | Methods and kits for detecting melanoma |
| WO2012129488A2 (en) * | 2011-03-23 | 2012-09-27 | Virginia Commonwealth University | Gene signatures associated with rejection or recurrence of cancer |
| CN102251033B (zh) * | 2011-07-05 | 2013-03-20 | 北京大学人民医院 | 基于mage-a3基因辅助诊断多发性骨髓瘤患者的定量检测试剂盒 |
| EP2948566B1 (en) * | 2013-01-24 | 2025-03-26 | California Institute of Technology | Chromophore-based characterization and detection methods |
| ES2859645T3 (es) | 2013-03-14 | 2021-10-04 | Mayo Found Medical Education & Res | Detección de neoplasia |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| CN107208162B (zh) | 2015-02-26 | 2020-12-29 | 株式会社日立高新技术 | 核酸分子的构建方法 |
| CN107532124B (zh) | 2015-03-27 | 2022-08-09 | 精密科学公司 | 检测食管疾病 |
| CN105100961B (zh) * | 2015-07-23 | 2018-03-13 | 华为技术有限公司 | 视频缩略图生成方法及生成装置 |
| CN108138235B (zh) | 2015-08-31 | 2022-04-15 | 梅约医药教育及研究基金会 | 检测胃肿瘤 |
| DE102016005947B3 (de) | 2016-05-16 | 2017-06-08 | Dimo Dietrich | Verfahren zur Abschätzung der Prognose und zur Prädiktion des Ansprechens auf eine Immuntherapie von Patienten mit malignen Erkrankungen |
| US11685955B2 (en) | 2016-05-16 | 2023-06-27 | Dimo Dietrich | Method for predicting response of patients with malignant diseases to immunotherapy |
| US10294518B2 (en) | 2016-09-16 | 2019-05-21 | Fluxion Biosciences, Inc. | Methods and systems for ultra-sensitive detection of genomic alterations |
| US20200010907A1 (en) | 2017-03-17 | 2020-01-09 | Mdxhealth Sa | Mgmt epigenetic deep-sequencing assay |
| US20180271710A1 (en) * | 2017-03-22 | 2018-09-27 | Bragi GmbH | Wireless earpiece for tinnitus therapy |
| US11433074B2 (en) | 2017-06-22 | 2022-09-06 | Triact Therapeutics, Inc. | Methods of treating glioblastoma |
| US11628144B2 (en) | 2017-09-29 | 2023-04-18 | Triact Therapeutics, Inc. | Iniparib formulations and uses thereof |
| US11441182B2 (en) * | 2018-08-08 | 2022-09-13 | Virginia Commonwealth University | Multiplexed and recyclable single-molecule sensors for quantitative analysis of nucleic-acid biomarkers |
| CN109540856B (zh) * | 2018-11-08 | 2022-01-28 | 南京师范大学 | 一种基于荧光共振能量转移检测不同亚型乳腺癌细胞的试剂 |
| CN111551978B (zh) * | 2020-05-08 | 2022-09-27 | 中国辐射防护研究院 | 一种放射性土壤样品采样过程不确定度的评定方法 |
| WO2023108145A1 (en) * | 2021-12-10 | 2023-06-15 | Nuprobe Usa, Inc. | Universal probes for amplification and detection of nucleic acids |
| WO2024102722A1 (en) | 2022-11-07 | 2024-05-16 | Neoimmunetech, Inc. | Methods of treating a tumor with an unmethylated mgmt promoter |
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| US4437975A (en) | 1977-07-20 | 1984-03-20 | Mobil Oil Corporation | Manufacture of lube base stock oil |
| CA1340843C (en) | 1987-07-31 | 1999-12-07 | J. Lawrence Burg | Selective amplification of target polynucleotide sequences |
| CA2005589C (en) | 1988-12-16 | 2001-02-06 | Akzo Nobel Nv | Self-sustained, sequence replication system |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| DK0671948T3 (da) | 1992-06-25 | 1997-09-01 | Smithkline Beecham Biolog | Vaccinepræparat indeholdende adjuvanser |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| ATE509102T1 (de) | 1994-07-15 | 2011-05-15 | Univ Iowa Res Found | Immunomodulatorische oligonukleotide |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US6117635A (en) * | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US6303347B1 (en) | 1997-05-08 | 2001-10-16 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US6291430B1 (en) * | 1997-09-12 | 2001-09-18 | Ludwig Institute For Cancer Research | Mage-3 peptides presented by HLA class II molecules |
| PT1053325E (pt) | 1998-02-05 | 2006-05-31 | Glaxosmithkline Biolog Sa | Derivados de antigenios associados a tumores da familia mage e, sequencias de acidos nucleicos que os codificam, utilizados para a preparacao de proteinas de fusao e de composicoes para vacinacao. |
| US6768000B1 (en) | 1998-06-12 | 2004-07-27 | Intergen Company | Multi-fluorescent hairpin energy transfer oligonucleotides |
| US7049302B1 (en) | 1998-08-10 | 2006-05-23 | Antigenics Inc. | Compositions of CPG and saponin adjuvants and uses thereof |
| US6667037B1 (en) | 1998-10-09 | 2003-12-23 | Ludwig Institute For Cancer Research | Isolated peptides which bind to HLA-B35 molecules, larger peptides which contain these, nucleic acid molecules encoding peptides, and uses thereof |
| DE60014076T2 (de) | 1999-04-19 | 2005-10-13 | Glaxosmithkline Biologicals S.A. | Adjuvans-zusammensetzung, enthaltend saponin und ein immunstimulatorisches oligonukleotid |
| US6331393B1 (en) * | 1999-05-14 | 2001-12-18 | University Of Southern California | Process for high-throughput DNA methylation analysis |
| WO2001075172A1 (en) * | 2000-03-31 | 2001-10-11 | University Of Southern California | Epigenetic sequences for esophageal adenocarcinoma |
| ES2281520T3 (es) | 2001-03-15 | 2007-10-01 | Jacques Schrenzel | Deteccion de staphylococcus aureus resistente a meticilina (sarm). |
| US20030134404A1 (en) | 2001-11-26 | 2003-07-17 | Lochrie Michael A. | Methods for producing stocks of recombinant AAV virions |
| EP1482795B1 (en) | 2002-02-04 | 2009-11-11 | Corixa Corporation | New immunoeffector compounds |
| DE10215770A1 (de) * | 2002-04-10 | 2003-10-30 | Michael Giesing | Verfahren zum Nachweis methylierter und/oder nichtmethylierter Cytosine in Nukleinsäuren, dessen Verwendung sowie entsprechende Analysekits |
| WO2004067726A2 (en) | 2003-01-29 | 2004-08-12 | Keck Graduate Institute | Isothermal reactions for the amplification of oligonucleotides |
| WO2004087957A2 (en) * | 2003-04-03 | 2004-10-14 | Oncomethylome Sciences S.A. | Hypermethylated genes and cervical cancer |
| US7881873B2 (en) * | 2003-04-29 | 2011-02-01 | The Jackson Laboratory | Systems and methods for statistical genomic DNA based analysis and evaluation |
| DE10329240A1 (de) | 2003-06-24 | 2005-01-20 | Epigenomics Ag | Verfahren zur Analyse des Cytosin-Methylierungsstatus von Cancer-Testis-Antigenen für eine individualisierte Immuntherapie |
| DE10338308B4 (de) * | 2003-08-15 | 2006-10-19 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungen in DNA |
| WO2005042713A2 (en) | 2003-10-28 | 2005-05-12 | The Johns Hopkins University | Quantitative multiplex methylation-specific pcr |
| US20050130170A1 (en) * | 2003-12-16 | 2005-06-16 | Jeanne Harvey | Identification and verification of methylation marker sequences |
| US20080096199A1 (en) * | 2004-10-11 | 2008-04-24 | Reimo Tetzner | Method for the Carry-Over Protection In Dna Amplification Systems Targeting Methylation Analysis Achieved by a Modified Pre-Treatment of Nucleic Acids |
| US20070059753A1 (en) * | 2005-09-15 | 2007-03-15 | Tatiana Vener | Detecting gene methylation |
| GB0612342D0 (en) * | 2006-06-21 | 2006-08-02 | Glaxosmithkline Biolog Sa | Method |
| GB0700374D0 (en) * | 2007-01-09 | 2007-02-14 | Oncomethylome Sciences S A | NDRG family methylation markers |
| US8911937B2 (en) * | 2007-07-19 | 2014-12-16 | Brainreader Aps | Method for detecting methylation status by using methylation-independent primers |
-
2008
- 2008-09-17 CA CA2699853A patent/CA2699853A1/en not_active Abandoned
- 2008-09-17 NZ NZ596545A patent/NZ596545A/xx not_active IP Right Cessation
- 2008-09-17 BR BRPI0817008A patent/BRPI0817008A2/pt not_active IP Right Cessation
- 2008-09-17 EA EA201000334A patent/EA017879B1/ru not_active IP Right Cessation
- 2008-09-17 WO PCT/GB2008/003142 patent/WO2009037438A1/en not_active Ceased
- 2008-09-17 KR KR1020107008201A patent/KR20100085917A/ko not_active Abandoned
- 2008-09-17 CA CA2699856A patent/CA2699856C/en active Active
- 2008-09-17 WO PCT/GB2008/003145 patent/WO2009037441A1/en not_active Ceased
- 2008-09-17 EP EP08806301.1A patent/EP2201131B8/en active Active
- 2008-09-17 US US12/678,702 patent/US8481700B2/en not_active Expired - Fee Related
- 2008-09-17 JP JP2010524578A patent/JP5406839B2/ja not_active Expired - Fee Related
- 2008-09-17 NZ NZ583796A patent/NZ583796A/en not_active IP Right Cessation
- 2008-09-17 US US12/678,706 patent/US9050280B2/en active Active
- 2008-09-17 EP EP08806298A patent/EP2198045A1/en not_active Withdrawn
- 2008-09-17 CN CN200880117371.0A patent/CN101932723B/zh not_active Expired - Fee Related
- 2008-09-17 AU AU2008300397A patent/AU2008300397A1/en not_active Abandoned
- 2008-09-17 MX MX2010002965A patent/MX2010002965A/es not_active Application Discontinuation
-
2010
- 2010-03-11 DO DO2010000076A patent/DOP2010000076A/es unknown
- 2010-03-16 ZA ZA2010/01878A patent/ZA201001878B/en unknown
- 2010-03-16 IL IL204525A patent/IL204525A0/en unknown
- 2010-03-19 CO CO10033047A patent/CO6260156A2/es not_active Application Discontinuation
- 2010-04-01 MA MA32736A patent/MA31753B1/fr unknown
- 2010-06-16 CR CR11504A patent/CR11504A/es not_active Application Discontinuation
-
2013
- 2013-06-13 US US13/917,108 patent/US20130302363A1/en not_active Abandoned
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2015
- 2015-06-08 US US14/733,152 patent/US10053724B2/en active Active
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