JP2010537624A5 - - Google Patents
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- Publication number
- JP2010537624A5 JP2010537624A5 JP2010500890A JP2010500890A JP2010537624A5 JP 2010537624 A5 JP2010537624 A5 JP 2010537624A5 JP 2010500890 A JP2010500890 A JP 2010500890A JP 2010500890 A JP2010500890 A JP 2010500890A JP 2010537624 A5 JP2010537624 A5 JP 2010537624A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- composition
- rbc
- stem
- bone marrow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cells Anatomy 0.000 claims description 34
- 210000000130 stem cell Anatomy 0.000 claims description 26
- 239000000203 mixture Substances 0.000 claims description 20
- 210000003324 RBC Anatomy 0.000 claims description 18
- 210000001185 Bone Marrow Anatomy 0.000 claims description 10
- 102100016492 CD34 Human genes 0.000 claims description 10
- 108060001251 CD34 Proteins 0.000 claims description 10
- 210000004700 Fetal Blood Anatomy 0.000 claims description 10
- 210000002381 Plasma Anatomy 0.000 claims description 7
- 230000002034 xenobiotic Effects 0.000 claims description 6
- 239000002676 xenobiotic agent Substances 0.000 claims description 6
- 239000000654 additive Substances 0.000 claims description 4
- 230000000996 additive Effects 0.000 claims 2
- 210000003743 Erythrocytes Anatomy 0.000 description 10
- 210000000265 Leukocytes Anatomy 0.000 description 10
- 210000002865 immune cell Anatomy 0.000 description 8
- 210000001772 Blood Platelets Anatomy 0.000 description 6
- 210000004698 Lymphocytes Anatomy 0.000 description 6
- 210000001616 Monocytes Anatomy 0.000 description 6
- 238000005119 centrifugation Methods 0.000 description 6
- 239000002245 particle Substances 0.000 description 5
- 210000000440 Neutrophils Anatomy 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 101700062711 ALD1 Proteins 0.000 description 2
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 description 2
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 description 2
- 101700064591 DHAG Proteins 0.000 description 2
- 210000002397 Granulocyte Precursor Cells Anatomy 0.000 description 2
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 2
- 102100005499 PTPRC Human genes 0.000 description 2
- 101700059076 PTPRC Proteins 0.000 description 2
- 101710029055 SAS2025 Proteins 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 101700062802 adhE Proteins 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000038129 antigens Human genes 0.000 description 2
- 108091007172 antigens Proteins 0.000 description 2
- 229960000070 antineoplastic Monoclonal antibodies Drugs 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 230000000249 desinfective Effects 0.000 description 2
- 101700029304 dhaB Proteins 0.000 description 2
- 101700081403 dhaQ Proteins 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 230000003394 haemopoietic Effects 0.000 description 2
- 229940050526 hydroxyethylstarch Drugs 0.000 description 2
- 102000005614 monoclonal antibodies Human genes 0.000 description 2
- 108010045030 monoclonal antibodies Proteins 0.000 description 2
- 229960000060 monoclonal antibodies Drugs 0.000 description 2
- 230000002335 preservative Effects 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 101700055608 puuC Proteins 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K 2qpq Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 210000003719 B-Lymphocytes Anatomy 0.000 description 1
- 210000004369 Blood Anatomy 0.000 description 1
- 210000000601 Blood Cells Anatomy 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 229920001917 Ficoll Polymers 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 210000003958 Hematopoietic Stem Cells Anatomy 0.000 description 1
- 210000000777 Hematopoietic System Anatomy 0.000 description 1
- ZFGMDIBRIDKWMY-PASTXAENSA-N Heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 1
- 229960002897 Heparin Drugs 0.000 description 1
- 210000000822 Killer Cells, Natural Anatomy 0.000 description 1
- 210000003593 Megakaryocytes Anatomy 0.000 description 1
- 210000000066 Myeloid Cells Anatomy 0.000 description 1
- 210000004940 Nucleus Anatomy 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 210000001744 T-Lymphocytes Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- BPKIGYQJPYCAOW-FFJTTWKXSA-I calcium;potassium;disodium;(2S)-2-hydroxypropanoate;dichloride;dihydroxide;hydrate Chemical compound O.[OH-].[OH-].[Na+].[Na+].[Cl-].[Cl-].[K+].[Ca+2].C[C@H](O)C([O-])=O BPKIGYQJPYCAOW-FFJTTWKXSA-I 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- -1 crystals Substances 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000003260 fluorescence intensity Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003834 intracellular Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 210000001167 myeloblast Anatomy 0.000 description 1
- 230000003287 optical Effects 0.000 description 1
- 230000005298 paramagnetic Effects 0.000 description 1
- 210000001778 pluripotent stem cell Anatomy 0.000 description 1
- 230000001376 precipitating Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 210000001519 tissues Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66421207A | 2007-03-28 | 2007-03-28 | |
| PCT/US2007/015560 WO2008121120A1 (en) | 2007-03-28 | 2007-07-06 | Stem and progenitor cell compositions recovered from bone marrow or cord blood; system and method for preparation thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014112675A Division JP5832591B2 (ja) | 2007-03-28 | 2014-05-30 | 骨髄または臍帯血から回収した幹細胞と前駆細胞の組成物、それらを用意するためのシステムおよび方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010537624A JP2010537624A (ja) | 2010-12-09 |
| JP2010537624A5 true JP2010537624A5 (de) | 2013-06-20 |
Family
ID=39808561
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500890A Pending JP2010537624A (ja) | 2007-03-28 | 2007-07-06 | 骨髄または臍帯血から回収した幹細胞と前駆細胞の組成物、それらを用意するためのシステムおよび方法 |
| JP2014112675A Active JP5832591B2 (ja) | 2007-03-28 | 2014-05-30 | 骨髄または臍帯血から回収した幹細胞と前駆細胞の組成物、それらを用意するためのシステムおよび方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014112675A Active JP5832591B2 (ja) | 2007-03-28 | 2014-05-30 | 骨髄または臍帯血から回収した幹細胞と前駆細胞の組成物、それらを用意するためのシステムおよび方法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2126044A4 (de) |
| JP (2) | JP2010537624A (de) |
| CN (2) | CN103555559B (de) |
| HK (1) | HK1193428A1 (de) |
| WO (1) | WO2008121120A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011095964A1 (en) * | 2010-02-03 | 2011-08-11 | Fuil Technologies Limited | A method and apparatus for separating a liquid component from a liquid medium |
| MX370137B (es) * | 2010-03-18 | 2019-11-29 | Thermogenesis Corp Star | Sistema para purificar ciertas poblaciones celulares en sangre o medula osea por agotamiento. |
| CN102618438A (zh) * | 2012-04-11 | 2012-08-01 | 章毅 | 用于脐带血干细胞的检测和筛查系统 |
| WO2015149098A1 (de) * | 2014-03-31 | 2015-10-08 | Liporegena Gmbh | Vorrichtung zur entnahme und portionierung von fettgewebe |
| EP2987515A1 (de) * | 2014-08-19 | 2016-02-24 | Reapplix APS | Zentrifuge und Verfahren zum Zentrifugieren einer Blutprobe |
| CA2989898C (en) * | 2015-12-29 | 2024-01-16 | Thermogenesis Corporation | Cell separation devices, systems, and methods |
| EP3565614A1 (de) * | 2017-01-08 | 2019-11-13 | Cesca Therapeutics Inc. | Vorrichtungen und verfahren zur bioverarbeitung von zellproben |
| JP7244423B2 (ja) * | 2017-01-11 | 2023-03-22 | スンクワン メディカル ファウンデーション | 脳神経系疾患の治療または診断のための標的タンパク質としてのｐｃｎｔ |
| EP3687593B1 (de) | 2017-09-28 | 2023-04-05 | Terumo Kabushiki Kaisha | System zum sammeln biologischer komponenten und kreislaufinnendruckerfassungsverfahren |
| US11925741B2 (en) | 2017-09-28 | 2024-03-12 | Terumo Kabushiki Kaisha | Biological component collection device with internal pressure sensor and method |
| JP7404357B2 (ja) * | 2018-11-01 | 2023-12-25 | テルモ株式会社 | 生体成分採取システムおよび生体成分採取システムの作動方法 |
| US11697799B2 (en) * | 2019-04-15 | 2023-07-11 | Ossium Health, Inc. | System and method for extraction and cryopreservation of bone marrow |
| CN110093253A (zh) * | 2019-06-04 | 2019-08-06 | 河南省人民医院 | 一次性使用去红细胞骨髓采集袋及方法 |
| CN113980894B (zh) * | 2021-12-27 | 2022-03-15 | 深圳博雅感知医疗科技有限公司 | 制备骨髓浓缩细胞的方法及其用于治疗卵巢早衰的用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6103522A (en) * | 1994-07-20 | 2000-08-15 | Fred Hutchinson Cancer Research Center | Human marrow stromal cell lines which sustain hematopoiesis |
| JPH1084950A (ja) * | 1996-09-13 | 1998-04-07 | Asahi Medical Co Ltd | 造血幹細胞の採取方法、採取器および採取装置 |
| AU731766B2 (en) * | 1997-01-24 | 2001-04-05 | Asahi Kasei Medical Co., Ltd. | Cell separation method |
| JP4412621B2 (ja) * | 1997-01-24 | 2010-02-10 | 旭化成クラレメディカル株式会社 | 細胞分離方法 |
| JPH119270A (ja) * | 1997-06-26 | 1999-01-19 | Asahi Medical Co Ltd | 有核細胞分離回収方法および有核細胞分離回収器 |
| US20020051762A1 (en) * | 1998-01-23 | 2002-05-02 | Shahin Rafii | Purified populations of endothelial progenitor cells |
| US7241281B2 (en) * | 2002-04-08 | 2007-07-10 | Thermogenesis Corporation | Blood component separation method and apparatus |
| ITMI20030897A1 (it) * | 2003-04-30 | 2004-11-01 | Crb Nederland B V | Procedimento e apparecchiatura per frazionare sangue. |
| EP1906729B1 (de) * | 2005-06-02 | 2012-03-28 | Stemcyte, Inc. | Plasmaabgereicherte nicht-hämatozyten-abgereicherte nabelschnurblutprodukte und verfahren zu ihrer verwendung |
-
2007
- 2007-07-06 CN CN201310484895.6A patent/CN103555559B/zh active Active
- 2007-07-06 CN CN200780053147A patent/CN101707891A/zh active Pending
- 2007-07-06 EP EP07796720A patent/EP2126044A4/de not_active Withdrawn
- 2007-07-06 WO PCT/US2007/015560 patent/WO2008121120A1/en active Application Filing
- 2007-07-06 JP JP2010500890A patent/JP2010537624A/ja active Pending
-
2014
- 2014-05-30 JP JP2014112675A patent/JP5832591B2/ja active Active
- 2014-07-08 HK HK14106878.8A patent/HK1193428A1/xx unknown
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